Radiochemistry Commons^™

“Translation Of Hdac6 Pet Imaging Using [18f]Ekz-001 – Cgmp Production And Measurement Of Hdac6 Target Occupancy In Nhps” – A Review, Dania Rahal

Chemistry & Biochemistry Undergraduate Honors Theses

The inhibition of histone deacetylase 6 (HDAC6) has been reported to alleviate the effects of neurodegenerative diseases such as Alzheimer’s disease. The brain-penetrant PET radioligand [¹⁸F]EKZ-001 has high affinity and selectivity towards HDAC6 and therefore suggests great promise in therapeutic treatment studies and development for neurodegenerative diseases. “Translation of HDAC6 PET imaging using [¹⁸F]EKZ-001 – cGMP production and measurement of HDAC6 target occupancy in NHPs” has achieved an effective, fully automated method of producing [¹⁸F]EKZ-001 in compliance with current good manufacturing practices (cGMP) to support the translation of [¹⁸F]EKZ-001 PET for …

Thin Safety Margin: The Sefor Super-Prompt-Critical Transient Experiments, Ozark Mountains, Arkansas 1970–1971, Jerry Havens, Collis Geren

Arkansas Scholarly Editions

Thin Safety Margin charts the history of SEFOR, a twenty-megawatt reactor that operated for three years in the rural Ozark Mountains of Arkansas as part of an internationally sponsored program designed to demonstrate the Doppler effect in plutonium-oxide-fueled fast reactors. Authors Jerry Havens and Collis Geren draw upon this history to assess the accidental explosion risk inherent in using fast reactors to reduce the energy industry’s carbon dioxide emissions.

If a sufficiently powerful fast-neutron explosion were to cause the containment of a reactor such as SEFOR’s to fail, the reactor’s radiotoxic plutonium fuel could vaporize and escape into the surrounding …

Fate Of Some Common Radionuclides Found In Dardanelle Lake, David M. Chittenden Ii

Journal of the Arkansas Academy of Science

Four factors influence the concentrations of radionuclides in Dardanelle Lake water: injections due to fallout and discharge from Nuclear I coupled with losses due to decay, to dilution and to sedimentation. It is possible to estimate the first three factors and to measure monthly changes in the concentrations of Sr-89, Ce-141, Cs-137, Co-38, Ce-144, and Sr-90 - Y-90 during periods when the concentrations of these nuclides are abnormally high (after large releases or the Chinese weapons tests) or abnormally low (during reactor refueling).

Concentration Of Radionuclides In Dardanelle Lake, Arkansas, David M. Chittenden Ii, Larry Mcfadden

Journal of the Arkansas Academy of Science

Concentrations of the nuclides ⁹⁰Sr - ⁹⁰Y, ¹⁴⁴Ce - ¹⁴⁴Pr, ¹³⁷Cs, ³⁸Co, ¹¹⁰ͫAg, ¹⁴¹Ce and ⁸⁹Sr have been measured monthly since November, 1975. The results from the period September, 1976, to August, 1977, depend on the relative intensities of the sources of the radionuclides; emissions from Nuclear I, the Chinese nuclear tests of Fall, 1976, and fallout from older atmospheric tests.