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Medicinal-Pharmaceutical Chemistry Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Medicinal-Pharmaceutical Chemistry
Α-Vinyllysine And Α-Vinylarginine Are Time-Dependent Inhibitors Of Their Cognate Decarboxylases, David B. Berkowitz, Wan Jin Jahng, Michelle L. Pedersen
Α-Vinyllysine And Α-Vinylarginine Are Time-Dependent Inhibitors Of Their Cognate Decarboxylases, David B. Berkowitz, Wan Jin Jahng, Michelle L. Pedersen
Chemistry Department: Faculty Publications
(±)-α-Vinyllysine and (±)-α-vinylarginine display time-dependent inhibition of L-lysine decarboxylase from B. cadaveris, and L-arginine decarboxylase from E. coli, respectively. A complete Kitz-Wilson analysis has been performed using a modification of the Palcic continuous UV assay for decarboxylase activity.
Synthesis Of Higher Α-Chlorovinyl And Α-Bromovinyl Amino Acids: The Amino Protecting Group Determines The Reaction Course, David B. Berkowitz, Michelle L. Pedersen, Wan Jin Jahng
Synthesis Of Higher Α-Chlorovinyl And Α-Bromovinyl Amino Acids: The Amino Protecting Group Determines The Reaction Course, David B. Berkowitz, Michelle L. Pedersen, Wan Jin Jahng
Chemistry Department: Faculty Publications
N-Trifluoroacetyl α-vinyl amino esters are smoothly converted to the corresponding α-chlorovinyl or α-bromovinyl amino esters through the agency of phenyselenyl chloride or phenylselenyl bromide, respectively, followed by oxidation and pyrolysis. Exclusively the (E)-extemal halovinyl isomer and the internal halovinyl isomer are observed. The amino protecting group is a critical determinant of the reaction course (alkene addition vs. 5-exo-trig-like cyclization).
Highly Reactive Form Of Copper And Reagents Thereof, Reuben D. Rieke
Highly Reactive Form Of Copper And Reagents Thereof, Reuben D. Rieke
Chemistry Department: Faculty Publications
A novel Zerovalent copper species and an organocopper reagent are disclosed. The Zerovalent copper species is directly produced by reaction of a reducing agent with a combination of copper(I) cyanide or halide and an alkali metal halide salt. The organocopper reagent resulting from the reaction of the zerovalent copper species and an organic compound having one or more stable anionic leaving groups is a stable reagent that will not significantly homocouple and under controlled conditions tolerates the presence of nitrile, epoxide, imine, enone, ketone, ester, allyl and benzyl groups within the organo radical. The reagent can be controlled so that …
Highly Reactive Zerovalent Metals From Metal Cyanides, Reuben D. Rieke
Highly Reactive Zerovalent Metals From Metal Cyanides, Reuben D. Rieke
Chemistry Department: Faculty Publications
Novel zerovalent metal species and organometallic reagents are disclosed. The zerovalent metal species are directly produced by reaction of a reducing agent on a metal cyanide salt. Preferably, the zerovalent metal species are directly produced by reaction of an alkali metal reducing agent with a metal cyanide salt. The organometallic reagent results from the reaction of the zerovalent metal species and an organic compound having one or more stable anionic leaving groups.