Applied Mathematics Commons^™

Rigid Body Constrained Motion Optimization And Control On Lie Groups And Their Tangent Bundles, Brennan S. Mccann

Doctoral Dissertations and Master's Theses

Rigid body motion requires formulations where rotational and translational motion are accounted for appropriately. Two Lie groups, the special orthogonal group SO(3) and the space of quaternions H, are commonly used to represent attitude. When considering rigid body pose, that is spacecraft position and attitude, the special Euclidean group SE(3) and the space of dual quaternions DH are frequently utilized. All these groups are Lie groups and Riemannian manifolds, and these identifications have profound implications for dynamics and controls. The trajectory optimization and optimal control problem on Riemannian manifolds presents significant opportunities for theoretical development. Riemannian optimization is an attractive …

Impact Of Vaccine Supplies And Delays On Optimal Control Of The Covid-19 Pandemic: Mapping Interventions For The Philippines, Carlo Delfin S. Estadilla, Joshua Uyheng, Elvira P. De Lara-Tuprio, Timothy Robin Y. Teng, Jay Michael R. Macalalag, Ma. Regina Justina E. Estuar

Mathematics Faculty Publications

Background

Around the world, controlling the COVID-19 pandemic requires national coordination of multiple intervention strategies. As vaccinations are globally introduced into the repertoire of available interventions, it is important to consider how changes in the local supply of vaccines, including delays in administration, may be addressed through existing policy levers. This study aims to identify the optimal level of interventions for COVID-19 from 2021 to 2022 in the Philippines, which as a developing country is particularly vulnerable to shifting assumptions around vaccine availability. Furthermore, we explore optimal strategies in scenarios featuring delays in vaccine administration, expansions of vaccine supply, and …

A Novel Mathematical Model Of The Trojan Y-Chromosome Strategy With Optimal Control, Christopher Turner

Electronic Theses and Dissertations

Invasive species are a prevalent problem all over the world. Controlling and eradicating an invasive species is an even more diffcult problem. The Trojan Y Chromosome (TYC) eradication strategy is one control method. This method alters the female to male sex ratio by introducing sex reversed males called supermales. These sex reversed males can only produce male progeny. Mathematical models of this strategy have shown that a population can be driven to extinction with a continuous supply of these sex reversed males. There are many different mathematical models of this strategy, but most have serious flaws, such as negative solutions …

Relaxation And Linear Programs On A Hybrid Control Model, Héctor Jasso-Fuentes, Jose-Luis Menaldi

Mathematics Faculty Research Publications

Some optimality results for hybrid control problems are presented. The hybrid model under study consists of two subdynamics, one of a standard type governed by an ordinary differential equation, and the other of a special type having a discrete evolution. We focus on the case when the interaction between the subdynamics takes place only when the state of the system reaches a given fixed region of the state space. The controller is able to apply two controls, each applied to one of the two subdynamics, whereas the state follows a composite evolution, of continuous type and discrete type. By the …

Optimal Sampling Paths For Autonomous Vehicles In Uncertain Ocean Flows, Andrew J. De Stefan

Dissertations

Despite an extensive history of oceanic observation, researchers have only begun to build a complete picture of oceanic currents. Sparsity of instrumentation has created the need to maximize the information extracted from every source of data in building this picture. Within the last few decades, autonomous vehicles, or AVs, have been employed as tools to aid in this research initiative. Unmanned and self-propelled, AVs are capable of spending weeks, if not months, exploring and monitoring the oceans. However, the quality of data acquired by these vehicles is highly dependent on the paths along which they collect their observational data. The …

A Comparison Of The Trojan Y Chromosome Strategy To Harvesting Models For Eradication Of Non-Native Species, Jingjing Lyu, Pamela J. Schofield, Kristen M. Reaver, Matthew Beauregard, Rana D. Parshad

Faculty Publications

The Trojan Y Chromosome Strategy (TYC) is a promising eradication method for biological control of non-native species. The strategy works by manipulating the sex ratio of a population through the introduction of supermales that guarantee male offspring. In the current manuscript, we compare the TYC method with a pure harvesting strategy. We also analyze a hybrid harvesting model that mirrors the TYC strategy. The dynamic analysis leads to results on stability of solutions and bifurcations of the model. Several conclusions about the different strategies are established via optimal control methods. In particular, the results affirm that either a pure harvesting …

Analysis Of An Eco-Epidemiological Model Under Optimal Control Measures For Infected Prey, Alfred Hugo, Emanuel Simanjilo

Applications and Applied Mathematics: An International Journal (AAM)

This paper examines the analysis of an eco-epidemiological model with optimal control strategies for infected prey. A model is proposed and analyzed qualitatively using the stability theory of the differential equations. A local and global study of the model is performed around the disease-free equilibrium and the endemic equilibrium to analyze the global stability using the Lyapunov function. The time-dependent control is introduced into the system to determine the best strategy for controlling the disease. The results obtained suggested the separation of the infected population plays a vital role in disease elimination.

Numerical Simulations For Optimal Control Of A Cancer Cell Model With Delay, Jessica S. Lugo

Murray State Theses and Dissertations

Mathematical models are often created to analyze the complicated behavior of many physical systems. One such system is that of the interaction between cancer cells, the immune system, and various treatments such as chemotherapy, radiation, and immunotherapy. Using models that depict these relationships gives researchers insight on the dynamics of this complicated system and possibly ideas for improved treatment schedules.

The model presented here gives the relationship of cancer cells in development phases with immune cells and cycle-specific chemotherapy treatment. This model includes a constant delay term in the mitotic phase. Optimal control theory is used to minimize the cost …

Parameter Estimation And Optimal Control Of The Dynamics Of Transmission Of Tuberculosis With Application To Cameroon, A. Temgoua, Y. Malong, J. Mbang, S. Bowong

Applications and Applied Mathematics: An International Journal (AAM)

This paper deals with the problem of parameter estimation and optimal control of a tuberculosis (TB) model with seasonal fluctuations. We first present a uncontrolled TB model with seasonal fluctuations. We present the theoretical analysis of the uncontrolled TB model without seasonal fluctuations. After, we propose a numerical study to estimate the unknown parameters of the TB model with seasonal fluctuations according to demographic and epidemiological data from Cameroon. Simulation results are in good accordance with the seasonal variation of the new active reported cases of TB in Cameroon. Using this TB model with seasonality, the tuberculosis control is formulated …

Using A Coupled Bio-Economic Model To Find The Optimal Phosphorus Load In Lake Tainter, Wi, Mackenzie Jones

Williams Honors College, Honors Research Projects

In Dunn County, Wisconsin the lakes suffer from algae blooms due to excess phosphorus runoff. A coupled bio-economic model is studied with the intent of finding the optimal level of phosphorus that should be allowed into the lake depending on certain biologic and economic parameters. We model the algae and phosphorus concentration in the lake over time based off the phosphorus input. Community welfare is modeled by comparing the costs and benefits of phosphorus fertilizer. This model is proposed to find the phosphorus level that maximizes community welfare and then determine how certain environmental and social change initiatives will affect …

Assessing The Economic Tradeoffs Between Prevention And Suppression Of Forest Fires, Elizabeth Trulia Heines

Doctoral Dissertations

The number of large-scale, high-severity forest fires occurring in the United States is increasing, as is the cost to suppress these fires. These trends have prompted investigations into alternative fuels methods to help prevent these large wildfires. One of the key challenges in studying the costs and benefits of forest fire prevention management is the incorporation of risk and uncertainty surrounding management decisions. We use a technique developed by William Reed to incorporate the stochasticity of the time of a forest fire into our optimal control problems. The goal of these problems is to determine the optimal fire prevention management …

Optimal Control And Its Application To The Life-Cycle Savings Problem, Tracy A. Taylor

Theses and Dissertations

Throughout the course of this thesis, we give an introduction to optimal control theory and its necessary conditions, prove Pontryagin's Maximum Principle, and present the life-cycle saving under uncertain lifetime optimal control problem. We present a very involved sensitivity analysis that determines how a change in the initial wealth, discount factor, or relative risk aversion coefficient may affect the model the terminal depletion of wealth time, optimal consumption path, and optimal accumulation of wealth path. Through simulation of the life-cycle saving under uncertain lifetime model, we are not only able to present the model dynamics through time, but also to …

Investigating Advection Control In Competitive Pde Systems And Environmental Transmission In Johne's Disease Ode Models, Kokum Rekha De Silva

Doctoral Dissertations

We extend the work on optimal control of advective direction in a reaction-diffusion population model to a system representing two competing populations. We investigate the choice of movement direction to benefit a population. First, the advective direction in one of the populations in a competition model is the control. Next, we extend the work by taking the advective directions of both populations as controls. In both these cases the objective is to maximize a weighted combination of the two populations while minimizing the cost involved in the species movement. Mathematical analysis is completed to derive the optimality system and numerical …

Population Modeling For Resource Allocation And Antimicrobial Stewardship, Jason Bintz

Doctoral Dissertations

This dissertation contains two types of population models with applications in conservation biology and epidemiology. In particular, it considers models for resource allocation and antimicrobial stewardship.

In a population model with a parabolic differential equation and density dependent growth, we study the problem of allocating resources to maximize the net benefit in the conservation of a single species while the cost of the resource allocation is minimized. The net benefit is measured in terms of maximizing population abundance and the goal of maximizing abundance is divided between the goal of maximizing the overall abundance across space and time and the …

Mathematical Modeling And Optimal Control Of Alternative Pest Management For Alfalfa Agroecosystems, Cara Sulyok

Mathematics Honors Papers

This project develops mathematical models and computer simulations for cost-effective and environmentally-safe strategies to minimize plant damage from pests with optimal biodiversity levels. The desired goals are to identify tradeoffs between costs, impacts, and outcomes using the enemies hypothesis and polyculture in farming. A mathematical model including twelve size- and time-dependent parameters was created using a system of non-linear differential equations. It was shown to accurately fit results from open-field experiments and thus predict outcomes for scenarios not covered by these experiments.

The focus is on the application to alfalfa agroecosystems where field experiments and data were conducted and provided …

Mathematical Modeling Of Immune Responses To Hepatitis C Virus Infection, Ivan Ramirez

Electronic Theses and Dissertations

An existing mathematical model of ordinary differential equations was studied to better understand the interactions between hepatitis C virus (HCV) and the immune system cells in the human body. Three possible qualitative scenarios were explored: dominant CTL response, dominant antibody response, and coexistence. Additionally, a sensitivity analysis was carried out to rank model parameters for each of these scenarios. Therapy was addressed as an optimal control problem. Numerical solutions of optimal controls were computed using a forward-backward sweep scheme for each scenario. Model parameters were estimated using ordinary least squares fitting from longitudinal data (serum HCV RNA measurements) given in …

Optimal Control For Management In Gypsy Moth Models, Marco Vinisio Martinez

Doctoral Dissertations

The gypsy moth, Lymantria dispar (L.), is an invasive species and the most destructive forest defoliator in North America. Gypsy moth outbreaks are spatially synchronized over areas across hundreds of kilometers. Outbreaks can result in loss of timber and other forestry products. Greater losses tend to occur to the ecosystem services that forests provide, such as wildlife habitat, carbon sequestration, and nutrient cycling. The United States can be divided in three different areas: a generally infested area (populations established), an uninfested area (populations not established), and a transition zone between the two. There are different management programs matching these different …

Optimal Control Modeling And Simulation, With Application To Cholera Dynamics, Chairat Modnak

Mathematics & Statistics Theses & Dissertations

The theory of optimal control, a modern extension of the calculus of variations. has found many applications in a wide range of scientific fields, particularly in epidemiology with respect to disease prevention and intervention. In this dissertation. we conduct optimal control modeling, simulation and analysis to cholera dynamics. Cholera is a severe intestinal infectious disease that remains a serious public health threat in developing countries. Transmission of cholera involves complex interactions between the human host, the pathogen, and the environment. The worldwide cholera outbreaks and their increasing severity, frequency and duration in recent years underscore the gap between the complex …

Optimal Control For A Class Of Age Structured Dynamic Models, Ameneh Mccullough

Summer Research

The mathematical theory of optimal control plays an important role in natural resource conservation efforts. In many applications, the underlying models are simple and deterministic. While scalar models can be used effectively on many problems, age-structured models can provide a more nuanced modeling tool. However, the theory and application becomes more complicated in this setting. This work examines a class of age-structured dynamic models with potential applications to age-targeted harvesting, motivated by the case of Shearwater harvesting management. We tailored several pre-existing styles of models to our problem. The models are created, but further analysis needs to be done.

Use Of Optimal Control Models To Predict Treatment Time For Managing Tick-Borne Disease, Holly D. Gaff, Elsa Schaefer, Suzanne Lenhart

Biological Sciences Faculty Publications

Tick-borne diseases have been on the rise recently, and correspondingly, there is an increased interest in implementing control measures to decrease the risk. Optimal control provides an ideal tool to identify the best method for reducing risk while accounting for the associated costs. Using a previously published model, a variety of frameworks are assessed to identify the key factors influencing mitigation strategies. The level and duration of tick-reducing efforts are key metrics for understanding the successful reduction in tick-borne disease incidence. The results show that the punctuated nature of the tick's life history plays a critical role in reducing risk …

Optimal Theory Applied In Integrodifference Equation Models And In A Cholera Differential Equation Model, Peng Zhong

Doctoral Dissertations

Integrodifference equations are discrete in time and continuous in space, and are used to model the spread of populations that are growing in discrete generations, or at discrete times, and dispersing spatially. We investigate optimal harvesting strategies, in order to maximize the profit and minimize the cost of harvesting. Theoretical results on the existence, uniqueness and characterization, as well as numerical results of optimized harvesting rates are obtained. The order of how the three events, growth, dispersal and harvesting, are arranged also affects the harvesting behavior.

Cholera remains a public health threat in many parts of the world and improved …

On The Lqg Theory With Bounded Control, D. V. Iourtchenko, J. L. Menaldi, A. S. Bratus

Mathematics Faculty Research Publications

We consider a stochastic optimal control problem in the whole space, where the corresponding HJB equation is degenerate, with a quadratic running cost and coeffcients with linear growth. In this paper we provide a full mathematical details on the key estimate relating the asymptotic behavior of the solution as the space variable goes to infinite.

Modelling And Optimal Control For Nonlinear Multistage Dynamical System Of Microbial Fed-Batch Culture, Chongyang Liu, Zhaohua Gong, Enmin Feng, Hongchao Yin

Chongyang Liu

In this paper, we propose a new controlled multistage system to formulate the fed-batch culture process of glycerol bio-dissimilation to 1,3-propanediol (1,3-PD) by regarding the feeding rate of glycerol as a control function. Compared with the previous systems, this system doesn’t take the feeding process as an impulsive form, but a time-continuous process, which is much closer to the actual culture process. Some properties of the above dynamical system are then proved. To maximize the concentration of 1,3-PD at the terminal time, we develop an optimal control model subject to our proposed controlled multistage system and continuous state inequality constraints. …

Optimal Control For Nonlinear Dynamical System Of Microbial Fed-Batch Culture, Chongyang Liu

Chongyang Liu

In fed-batch culture of glycerol bio-dissimilation to 1, 3-propanediol (1, 3-PD), the aim of adding glycerol is to obtain as much 1, 3-PD as possible. So a proper feeding rate is required during the process. Taking the concentration of 1, 3-PD at the terminal time as the performance index and the feeding rate of glycerol as the control function, we propose an optimal control model subject to a nonlinear dynamical system and constraints of continuous state and non-stationary control. A computational approach is constructed to seek the solution of the above model in two aspects. On the one hand we …

Optimal Control Of Delay-Differential Inclusions With Multivalued Initial Conditions In Infinite Dimensions, Boris S. Mordukhovich, Dong Wang, Lianwen Wang

Mathematics Research Reports

This paper is devoted to the study of a general class of optimal control problems described by delay-differential inclusions with infinite-dimensional state spaces, endpoints constraints, and multivalued initial conditions. To the best of our knowledge, problems of this type have not been considered in the literature, except some particular cases when either the state space is finite-dimensional or there is no delay in the dynamics. We develop the method of discrete approximations to derive necessary optimality conditions in the extended Euler-Lagrange form by using advanced tools of variational analysis and generalized differentiation in infinite dimensions. This method consists of the …

Optimal Switching Control For Microbial Fed-Batch Culture, Chongyang Liu, Zhaohua Gong, Enmin Feng, Hongchao Yin

Chongyang Liu

In fed-batch culture of glycerol bio-dissimilation to 1,3-propanediol (1,3-PD), the aim of adding glycerol is to obtain as much 1,3-PD as possible. Hence, a proper feed strategy is required during the process. In this paper, we present an optimal switching control model based on our proposed controlled switching system. Some properties of the controlled switching system are obtained. Subsequently, we prove the existence of optimal control. In order to deduce the optimality conditions, we transcribe the optimal switching control model into an equivalent one with fixed switching instants and parameters. Finally, the optimality conditions of the equivalent problem are investigated …

Discrete Approximations, Relaxation, And Optimization Of One-Sided Lipschitzian Differential Inclusions In Hilbert Spaces, Tzanko Donchev, Elza Farkhi, Boris S. Mordukhovich

Mathematics Research Reports

We study discrete approximations of nonconvex differential inclusions in Hilbert spaces and dynamic optimization/optimal control problems involving such differential inclusions and their discrete approximations. The underlying feature of the problems under consideration is a modi- fied one-sided Lipschitz condition imposed on the right-hand side (i.e., on the velocity sets) of the differential inclusion, which is a significant improvement of the conventional Lipschitz continuity. Our main attention is paid to establishing efficient conditions that ensure the strong approximation (in the W^1,p-norm as p greater than or equal to 1) of feasible trajectories for the one-sided Lipschitzian differential inclusions under. consideration by …

Optimal Therapy Regimens For Treatment-Resistant Mutations Of Hiv, Weiqing Gu, Helen Moore

All HMC Faculty Publications and Research

In this paper, we use control theory to determine optimal treatment regimens for HIV patients, taking into account treatment-resistant mutations of the virus. We perform optimal control analysis on a model developed previously for the dynamics of HIV with strains of various resistance to treatment (Moore and Gu, 2005). This model incorporates three types of resistance to treatments: strains that are not responsive to protease inhibitors, strains not responsive to reverse transcriptase inhibitors, and strains not responsive to either of these treatments. We solve for the optimal treatment regimens analytically and numerically. We find parameter regimes for which optimal dosing …

Discrete Approximations Of Differential Inclusions In Infinite-Dimensional Spaces, Boris S. Mordukhovich

Mathematics Research Reports

In this paper we study discrete approximations of continuous-time evolution systems governed by differential inclusions with nonconvex compact values in infinite-dimensional spaces. Our crucial result ensures the possibility of a strong Sobolev space approximation of every feasible solution to the continuous-time inclusion by its discrete-time counterparts extended as Euler's "broken lines." This result allows us to establish the value and strong solution convergences of discrete approximations of the Bolza problem for constrained infinite-dimensional differential/evolution inclusions under natural assumptions on the initial data.

Optimal Control Of Semilinear Evolution Inclusions Via Discrete Approximations, Boris S. Mordukhovich, Dong Wang

Mathematics Research Reports

This paper studies a Mayer type optimal control problem with general endpoint constraints for semilinear unbounded evolution inclusions in reflexive and separable Banach spaces. First, we construct a sequence of discrete approximations to the original optimal control problem for evolution inclusions and prove that optimal solutions to discrete approximation problems uniformly converge to a given optimal solution for the original continuous-time problem. Then, based on advanced tools of generalized differentiation, we derive necessary optimality conditions for discrete-time problems under fairly general assumptions. Combining these results with recent achievements of variational analysis in infinite-dimensional spaces, we establish new necessary optimality conditions …