Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Chemistry (124)
- Organic Chemistry (66)
- Education (9)
- Life Sciences (8)
- Biochemistry (6)
-
- Biochemistry, Biophysics, and Structural Biology (6)
- Materials Chemistry (5)
- Medicinal-Pharmaceutical Chemistry (5)
- Science and Mathematics Education (5)
- Medicine and Health Sciences (4)
- Polymer Chemistry (4)
- Analytical Chemistry (3)
- Inorganic Chemistry (3)
- American Studies (2)
- Arts and Humanities (2)
- Environmental Chemistry (2)
- Higher Education (2)
- Pharmacy and Pharmaceutical Sciences (2)
- Artificial Intelligence and Robotics (1)
- Atmospheric Sciences (1)
- Biophysics (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Chemicals and Drugs (1)
- Computational Chemistry (1)
- Computer Sciences (1)
- Curriculum and Instruction (1)
- Earth Sciences (1)
- Educational Assessment, Evaluation, and Research (1)
- Institution
-
- University of the Pacific (22)
- Louisiana State University (20)
- Selected Works (9)
- GALILEO, University System of Georgia (5)
- Illinois Wesleyan University (5)
-
- Portland State University (5)
- University of Denver (4)
- University of South Carolina (4)
- University of Mississippi (3)
- University of Richmond (3)
- Butler University (2)
- Colby College (2)
- Duquesne University (2)
- Marquette University (2)
- Old Dominion University (2)
- Sacred Heart University (2)
- University of Minnesota Morris Digital Well (2)
- University of Missouri, St. Louis (2)
- University of Puget Sound (2)
- University of South Florida (2)
- Utah State University (2)
- Ateneo de Manila University (1)
- Chapman University (1)
- Connecticut College (1)
- Georgia Southern University (1)
- Kennesaw State University (1)
- Liberty University (1)
- Merrimack College (1)
- Parkland College (1)
- Purdue University (1)
- Publication Year
- Publication
-
- University of the Pacific Theses and Dissertations (22)
- LSU Historical Dissertations and Theses (18)
- Electronic Theses and Dissertations (8)
- Ram S. Mohan (5)
- Scholarship (5)
-
- Theses and Dissertations (5)
- Chemistry Faculty Publications (4)
- Honors Theses (4)
- Chemistry Grants Collections (3)
- Dissertations (3)
- Chemistry & Biochemistry Faculty Publications (2)
- Chemistry & Physics Faculty Publications (2)
- Chemistry Ancillary Materials (2)
- Chemistry Publications (2)
- Chemistry and Biochemistry Faculty Publications (2)
- Dissertations and Theses (2)
- Jeffrey H. Glans (2)
- LSU Doctoral Dissertations (2)
- Master's Theses (2009 -) (2)
- Summer Research (2)
- USF Tampa Graduate Theses and Dissertations (2)
- Undergraduate Honors Thesis Collection (2)
- Anton Geiler (1)
- Chancellor’s Honors Program Projects (1)
- Chemistry Faculty Publications and Presentations (1)
- Chemistry Faculty Research (1)
- Chemistry: Faculty Publications (1)
- Conference papers (1)
- Graduate Theses and Dissertations (1)
- Health Sciences Student Work (1)
- Publication Type
Articles 1 - 30 of 125
Full-Text Articles in Physical Sciences and Mathematics
An Efficient And Chemoselective Method To Generate Arynes, Bryan Metze, Riley A. Roberts, Aleksandra Nilova, David R. Stuart
An Efficient And Chemoselective Method To Generate Arynes, Bryan Metze, Riley A. Roberts, Aleksandra Nilova, David R. Stuart
Chemistry Faculty Publications and Presentations
Arynes hold immense potential as reactive intermediates in organic synthesis as they engage in a diverse range of mechanistically distinct chemical reactions. However, the poor functional group compatibility of generating arynes or their precursors has stymied their widespread use. Here, we show that generating arynes by deprotonation of an arene and elimination of an “onium” leaving group is mild, efficient and broad in scope. This is achieved by using aryl(TMP)iodonium salts (TMP = 2,4,6-trimethoxyphenyl) as the aryne precursor and potassium phosphate as the base, and a range of arynophiles are compatible. Additionally, we have performed the first quantitative analysis of …
Molecular Devices For Measuring Weak Solvophobic Interactions And The Development Of Pedagogical Tools For Organic Chemistry Students, Alexander N. Manzewitsch
Molecular Devices For Measuring Weak Solvophobic Interactions And The Development Of Pedagogical Tools For Organic Chemistry Students, Alexander N. Manzewitsch
Theses and Dissertations
The main topics of this dissertation are: 1) the development and discussion of a new molecular balance for measuring alkyl-alkyl interactions in a wide array of organic solvents, 2) the development of linear solvation energy relationships between solvent interaction parameters and solvent accessible surface area (SASA) in CH-arene interactions, and 3) the development of online resources for helping undergraduate students perform organic chemistry mechanisms problems well.
The solvophobic effect, that is the forced association between two solutes due to intermolecular attraction of the solvent molecules, is ubiquitous in organic chemistry and responsible for many significant phenomena thereof. However, there is …
Ferrocenium Salt Aided Substitution Reactions And Synthesis Of Glycosylated Curcumin Derivatives, Deva Saroja Talasila
Ferrocenium Salt Aided Substitution Reactions And Synthesis Of Glycosylated Curcumin Derivatives, Deva Saroja Talasila
Dissertations
Organic synthesis has been significantly advanced with the employment of transition metal complexes. The discovery of transition metal catalysts provided the synthetic community with powerful tools for accelerating reactions and making them more selective and efficient. Many chemical reactions do not happen without a catalyst.
Iron-based catalysts have several advantages for the chemical industry because it is a non-toxic and ecologically friendly metal. Our group previously found that ferrocenium cations with a 3+ oxidation state of iron-catalyzed propargylic substitution reactions at low temperatures. The sandwich structure of ferrocenes allows substituents to be introduced on the cyclopentadienyl rings, which allows for …
Theory Of Aqueous Solvation: Uninterrupted, Cyclic Hydrogen-Bonding Essential For Accurate Keto-Enol Energies And Grotthuss Tautomerism Of Acetone, Mark Recznik
Electronic Theses and Dissertations
Keto-enol tautomerization (KET) is a fundamental process impacting a range of molecular phenomena in organic and biochemistry. However, the accurate computation of solution-phase KET energies remains a challenge, even for prototypical acetone.
In Part I, keto-enol tautomers of acetone were incorporated into solvent clusters that interact via uninterrupted, cyclic hydrogen-bonding (UCHB) networks. An empirical model was created to predict accurate KET energies, Etaut, of simple carbonyl compounds. Based on the availability of experimental data and structural simplicity, acetone was selected as a prototype. A discrete-continuum strategy was employed – accounting simultaneously for local noncovalent interactions and bulk-phase effects …
Simple Arenes As Aryne Synthetic Equivalents Via Sulfonium Salt Intermediates, Riley A. Roberts
Simple Arenes As Aryne Synthetic Equivalents Via Sulfonium Salt Intermediates, Riley A. Roberts
Student Research Symposium
Arynes are ephemeral molecules that are yet to be fully exploited in synthetic strategy because they are often challenging to access. These reactive intermediates participate in a myriad of reactions that conventional chemistry is incapable of, making them extremely useful for the synthesis of important molecules like pharmaceuticals and agrochemicals. While classical approaches for synthesizing arynes employ cheap starting material, extremely harsh reagents are necessary to generate the aryne. In contrast, methods that do not require harsh reaction conditions do require starting material that is exceedingly difficult to synthesize. To access arynes quickly and efficiently, the work described herein aims …
Visual Demonstration Of Substituent Effects For Chromium(Vi) Alcohol Oxidation, Biyu (Chelsea) Zhao
Visual Demonstration Of Substituent Effects For Chromium(Vi) Alcohol Oxidation, Biyu (Chelsea) Zhao
Student Scholar Symposium Abstracts and Posters
This research visualized the effect of different substituents, which could be either activators or deactivators on an aromatic ring for alcohol oxidants using Chromium(VI). The color of chromic acid changes from orange to blue gradually, providing a method to visualize the rate. Rate constants were used as a quantitative method to evaluate the rate.
Synthesis Of Β,Β-Disubstituted Styrenes Via Trimethylsilyl Trifluoromethanesulfonate-Promoted Aldehyde-Aldehyde Aldol Addition-Deformylative Elimination., Grant J. Dixon, Michael R. Rodriguez, Tyler G. Chong, Kevin Y. Kim, C. Wade Downey
Synthesis Of Β,Β-Disubstituted Styrenes Via Trimethylsilyl Trifluoromethanesulfonate-Promoted Aldehyde-Aldehyde Aldol Addition-Deformylative Elimination., Grant J. Dixon, Michael R. Rodriguez, Tyler G. Chong, Kevin Y. Kim, C. Wade Downey
Chemistry Faculty Publications
In the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and 2,6-lutidine, α,α-disubstituted aldehydes condense with electron-rich aromatic aldehydes to yield β, β- disubstituted styrenes. More electron-rich aromatic aldehydes react more rapidly and in higher yield. Preliminary results suggest that the reaction may proceed via the ionization and formal deformylation of an aldol intermediate.
Lipophilic Probes For Cellular Ethylene Detection, Morgan R. Brown
Lipophilic Probes For Cellular Ethylene Detection, Morgan R. Brown
Electronic Theses and Dissertations
The structure of ethylene is simple, yet its biological effects are significant. When considering its role in biology it is almost exclusively regarded as a plant hormone. Research on ethylene from plants was progressed by several advancements in analytical instrumentation, from its discovery to elucidation of its signaling pathway. There is currently limited understanding of ethylene’s role in mammals, but evidence suggests that it may be a biomarker for oxidative stress! Additional tools and technology are crucial to study this surprising and important signaling role in mammals. Our group has developed molecular ethylene probes as a strategy to detect ethylene …
Design, Synthesis, And Catalytic Application Of Crystalline Porous Nanomaterials, Zainab Abdullah Almansaf
Design, Synthesis, And Catalytic Application Of Crystalline Porous Nanomaterials, Zainab Abdullah Almansaf
Graduate Theses and Dissertations
Chapter 1: COFs (covalent organic frameworks) are a new type of microporous crystalline polymer connected by organic units via strong covalent bonds. Due to their well-defined crystalline structures and excellent chemical and thermal stabilities, COF materials are considered promising candidates in applications such as gas adsorption, catalysis, and energy storage.Chapter 2: A new covalent organic framework (COF) based on imine bonds was assembled from 2-(4-formylphenyl)-5-formylpyridine and 1,3,6,8-tetrakis(4-aminophenyl)pyrene, which showed an interesting dual-pore structure with high crystallinity. Postmetallation of the COF with Pt occurred selectively at the N donor (imine and pyridyl) in the larger pores. The metalated COF served as …
Developing Covalent-Organic Frameworks For Protecting Against Radiation, Megan J. Francis
Developing Covalent-Organic Frameworks For Protecting Against Radiation, Megan J. Francis
Senior Theses
This research focuses on the development of lightweight, thermostable dual-function materials for secondary radiation protection and sensing by the integration of hydrogen-rich aliphatic chains inside the porous matrix of covalent-organic frameworks (COFs). The main aims of this project are the synthesis of organic linkers for forming a robust porous COF, synthesizing the porous COF through a condensation reaction, the development of hydrogen-rich aliphatic chains, and integration of aliphatic chains into COFs through click chemistry. This manuscript outlines the methodology and development of a novel self-assembled crystalline, porous material engineered to combine the functions of a shield and sensitive dosimeter. The …
End Group Modification Of Linear Dendritic Block Copolymers (Ldbcs), Chinwe Udemgba
End Group Modification Of Linear Dendritic Block Copolymers (Ldbcs), Chinwe Udemgba
Honors Theses
Linear dendritic block copolymers are amphiphilic molecules that consist of a dendritic hydrophilic portion and a linear hydrophobic portion. Its unique ability to self-assemble into spherical nanoaggregates while having the potential to uptake and transport both hydrophilic and hydrophobic drugs makes these polymers an item of interest in regard to the drug delivery field. The synthesis of polyamidoamine-polylactide linear dendritic block copolymers was designed to address the common issues in drug delivery systems, including problems in permeability, solubility, stability, specificity, and retention. Though this linear dendritic block copolymer has previously been synthesized in our lab with cationic amine surface functionalities, …
Synthesis Of A Dd-Π-Aa Organic Dye For Dye-Sensitized Solar Cells, Hope Lovell
Synthesis Of A Dd-Π-Aa Organic Dye For Dye-Sensitized Solar Cells, Hope Lovell
Honors Theses
This project investigates the synthesis of a DD-π-AA (dual donor/dual acceptor) organic dye as a potential sensitizer for dye-sensitized solar cells (DSCs). The design of this dye was based off previous research that found dual donor/dual acceptor dyes exhibited promising results when used in a DSC. The donor groups, acceptor groups, and π-bridge were chosen for their stability, ability to absorb in the near-infrared (NIR) region, and intramolecular charge transfer (ICT) abilities.
While many components of the dye were synthesized, the final stages of the synthetic scheme were not completed due to the loss of time from COVID-19. Had the …
Photoassisted Synthesis Of Complex Polyheterocycles Via Rational Design Of Tailored Photoprecursors, Tina Alanna Holt
Photoassisted Synthesis Of Complex Polyheterocycles Via Rational Design Of Tailored Photoprecursors, Tina Alanna Holt
Electronic Theses and Dissertations
Natural products remain the most common source for drug leads, although diversity-oriented synthesis of unnatural complex molecules is gaining momentum. Our lab has been developing experimentally simple and straightforward approaches to complex molecular architectures via photochemical reactions involving a minimal number of experimental steps. In order to achieve this, photoprecursors were assembled via high yielding reactions. Next, we deployed photoinduced cycloadditions to create complex 3-dimentional structures. Lastly, with this obtained primary photoproduct, post-photochemical transformations were used to further grow its scaffold complexity.
One method to increase scaffold complexity is the [4+2] intramolecular cycloadditions of azaxylylenes, which are developed through standard …
The Application Of Machine Learning In Analyzing Organic Compounds From Nmr Spectral Data, Nicole Maia Powell
The Application Of Machine Learning In Analyzing Organic Compounds From Nmr Spectral Data, Nicole Maia Powell
Senior Independent Study Theses
Nuclear magnetic resonance (NMR) is used in organic chemistry to identify unknown organic compounds. The data obtained from an NMR spectrometer are typically shown in the form of a spectrum, which is then analyzed by an analytical chemist. The action of analyzing a spectrum, especially one of a large and complex molecule, is a long and tedious process. In this project, Python is used to implement hierarchical clustering on NMR data obtained from an NMR spectrometer at the College of Wooster to explore its application in NMR analysis. MATLAB is used to build a decision tree from the same data, …
Total Synthesis Of Cytotoxic Mansouramycins From Amino Acids, Beatriz Gamez
Total Synthesis Of Cytotoxic Mansouramycins From Amino Acids, Beatriz Gamez
Theses and Dissertations
Natural products produced by plants, animals, and microorganisms are of significant importance in chemistry for being major sources of molecular scaffolds essential for new drug discovery. Mansouramycins are cytotoxic bioactive compounds containing isoquinoline skeletons with substituents on the quinone and pyridine rings that may be difficult to synthesize. Synthetic processes exist for compounds B and D, however, there exists an absence of simple synthetic approaches to all four alkaloids.
This project aims to provide a general total synthetic pathway to Mansouramycins A—D from amino acids for possible use in cancer treatment via these isoquinolinequinones. Preliminary experimentation suggests there may be …
Aryne-Guided C-H Functionalization Of Benzenoid Rings Using Diaryliodonium Salts, Aleksandra Nilova
Aryne-Guided C-H Functionalization Of Benzenoid Rings Using Diaryliodonium Salts, Aleksandra Nilova
Dissertations and Theses
The benzenoid core is a frequent and irreplaceable component of biologically active molecules. Structure function relationship of these compounds has been broadly analyzed and presented in numerous literature reports. Herein, we augmented existing knowledge by a broad analysis of the benzenoid substitution patterns in small molecule active pharmaceutical ingredients approved by the FDA. Our findings reveal a strong correlation that the most represented substitution patterns are those achieved via SEAr. Despite the rapid development of methods to functionalize benzenoid rings, the lack of synthetic methodologies to access sterically and electronically unfavorable positions is highlighted. We sought to establish …
Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria, Keren Solomon
Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria, Keren Solomon
Electronic Theses and Dissertations
This thesis describes the isolation, structure elucidation, and synthesis of natural products from marine cyanobacteria. A crude extract from a cyanobacterium collected in Curacao showed selective affinity for the dopamine D5 receptor in a screen against a panel of CNS receptors. Due to the high similarity of the D5 and D1 receptor, to date there are no known ligands that differentiate them. Attempts to purify the compound responsible for this affinity led to the isolation of the known compound caylobolide A. A second extract from a cyanobacterium collected in Panama underwent bioassay-guided fractionation and yielded the novel …
Teaching College Chemistry In The Time Of Covid-19 Pandemic: A Personal Account Of Teaching In The Old Normal Vs. The New Normal, Armando M. Guidote Jr
Teaching College Chemistry In The Time Of Covid-19 Pandemic: A Personal Account Of Teaching In The Old Normal Vs. The New Normal, Armando M. Guidote Jr
Chemistry Faculty Publications
The SARS CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2), cause of COVID-19 (CoronaVirus Disease 2019) has afflicted close to 10 million people all over the world resulting to almost half a million deaths. This disease is severely contagious and necessitates social or physical distancing between persons. As such, traditional face-to-face learning is not advised and teachers need to shift to online teaching. There are challenges to online teaching and learning for students, teachers, and the higher education institute, e.g. hardware, bandwidth, and software issues. These will be difficult but these can be overcome eventually. This work is a personal account …
First-Semester Organic Chemistry During Covid-19: Prioritizing Group Work, Flexibility, And Student Engagement, Leslie A. Nickerson, Kevin M. Shea
First-Semester Organic Chemistry During Covid-19: Prioritizing Group Work, Flexibility, And Student Engagement, Leslie A. Nickerson, Kevin M. Shea
Chemistry: Faculty Publications
Our first-semester organic chemistry class focused on structured group work to enable active learning in class. When Smith College switched to online learning after spring break, the class was adapted to fit into an online learning model while retaining active learning. Using feedback from students, we implemented two tracks, one focused on independent work and one focused on group work. Using Zoom’s breakout rooms, we were able to simulate the full class and small group experiences of our in-person class with the help of student learning assistants to facilitate group learning. Slack was introduced for class questions and communications. Student …
Development Towards An Ethylene Sensing Artificial Metalloenzyme, Mitchell Lee Ellinwood
Development Towards An Ethylene Sensing Artificial Metalloenzyme, Mitchell Lee Ellinwood
Electronic Theses and Dissertations
Ethylene (ethene) is the essential ripening hormone for climacteric plants, and consequently its detection and quantification is of considerable interest to the horticulture industry. Its detection however is a non-trivial pursuit, traditionally requiring expensive and inaccessible instrumentation that fail to provide in vivo information about ethylene. A ruthenium based fluorescent probe for the selective detection of ethylene has recently been developed, and it was envisioned that this probe could be made biocompatible by encasing it within a protein scaffold making it an artificial metalloenzyme. To this end biotinylated N-heterocyclic carbenes (NHCs) were synthesized, which can be appended onto the ruthenium …
Studies On The Size And Non-Planarity Of Aromatic Stacking Moiety On Conformation Selectivity And Thermal Stabilization Of G-Quadruplexes, Mandeep Singh
University of the Pacific Theses and Dissertations
Targeting DNA has the advantage over proteins for cancer remediation because of the fewer copies of the ligands required for the desired therapeutic effect. Traditionally, covalent DNA binders like alkylating agents have been used to induce genetic instability through the formation of DNA lesions and strand breaks, leading to cellular apoptosis. The primary drawback of this treatment is the non-specific binding that affects both cancerous and non-cancerous cells. G-quadruplexes are the DNA secondary structures that are present in abundance near the promoter regions of the oncogenes and are involved in the regulation of their activities. A ligand-mediated stabilization of G-quadruplexes …
Thioenamide Synthesis Inspired By Peptide Macrocycles, Joshua Allen Lutz
Thioenamide Synthesis Inspired By Peptide Macrocycles, Joshua Allen Lutz
LSU Doctoral Dissertations
Despite advances in medicine, antibiotic resistance threatens to return once preventable diseases to the human population. The microbisporicins are 24-amino acid antibiotic peptides belonging to the lantibiotic class, which pathogens have been slow to develop resistance. The uncommon post-translational modification S-[(Z)-2-aminovinyl]-D-cysteine (AviCys) is likely crucial to their activity, and appears in a small number of other peptides with compelling biological activities. Total synthesis of an AviCys-containing peptide has eluded the chemical community.
The primary challenge of AviCys synthesis is the construction of a thioenamide functional group. We demonstrate that acid-promoted reactions between an amide and …
Organic Chemistry Ii Lab Manual, Caitlyn Bailey
Organic Chemistry Ii Lab Manual, Caitlyn Bailey
Senior Honors Theses
This project aims to supply a full lab manual and grading key for Organic Chemistry II, a class often taken by sophomores in Liberty University’s science degree programs. Properly applied laboratory experiments create a beneficial learning environment for science students by using hands-on procedures to transform intangible lecture concepts into concrete demonstrations. Lab work also fosters the development of problem-solving and critical-thinking skills that students need in research and the workplace. Thus, having a comprehensive lab manual is critical to students’ success and understanding in this upper-level class. This project adds to the experiments of Organic Chemistry II lab through …
Use Of Pope Engagement Index To Measure Cognitive Load Of Physical Modeling Activities In Organic Chemistry, Jenifer Calvert
Use Of Pope Engagement Index To Measure Cognitive Load Of Physical Modeling Activities In Organic Chemistry, Jenifer Calvert
Master of Science in Chemical Sciences Theses
Understanding how students learn and process information is critical to developing physical modeling activities that facilitate student learning by decreasing cognitive load in the working memory. Optimizing cognitive load during physical modeling activities in organic chemistry is the key to effective and efficient learning. Using EEG (electroencephalogram) and eye tracking technologies, researchers measured and recorded the cognitive processing of participants while they completed a chiral physical modeling activity. Analysis of the data using the Engagement Index developed by Pope et al provided information necessary to develop curriculum that does not undermine student learning due to excessive cognitive load.
Organic Chemistry With A Biological Emphasis Volume Ii, Timothy Soderberg
Organic Chemistry With A Biological Emphasis Volume Ii, Timothy Soderberg
Chemistry Publications
The traditional approach to teaching Organic Chemistry, taken by most of the textbooks that are currently available, is to focus primarily on the reactions of laboratory synthesis, with much less discussion - in the central chapters, at least - of biological molecules and reactions. This is despite the fact that, in many classrooms, a majority of students are majoring in Biology or Health Sciences rather than in Chemistry, and are presumably taking the course in order to learn about the chemistry that takes place in living things.
In an effort to address this disconnect, I have developed a textbook for …
Organic Chemistry With A Biological Emphasis Volume I, Timothy Soderberg
Organic Chemistry With A Biological Emphasis Volume I, Timothy Soderberg
Chemistry Publications
The traditional approach to teaching Organic Chemistry, taken by most of the textbooks that are currently available, is to focus primarily on the reactions of laboratory synthesis, with much less discussion - in the central chapters, at least - of biological molecules and reactions. This is despite the fact that, in many classrooms, a majority of students are majoring in Biology or Health Sciences rather than in Chemistry, and are presumably taking the course in order to learn about the chemistry that takes place in living things.
In an effort to address this disconnect, I have developed a textbook for …
Application Of The Picoloyl Substituent In Carbohydrate Chemistry, Michael Mannino, Alexei V. Demchenko
Application Of The Picoloyl Substituent In Carbohydrate Chemistry, Michael Mannino, Alexei V. Demchenko
Michael Mannino
Lewis Base Promoted Annulations Of Allenoates With 1,4-Naphthoquinones, Nicole Marie Shoup
Lewis Base Promoted Annulations Of Allenoates With 1,4-Naphthoquinones, Nicole Marie Shoup
Electronic Theses and Dissertations
Lewis base promoted cyclization of allenoates with electron deficient olefins open up the possibility to generate more complex organic structures. By generating more complex molecules, we are able to produce new compounds for biomedical and material applications. Both phosphine and amine Lewis bases offer interesting annulations with allenoates resulting in Lu or Morita–Baylis–Hillman type reactions. Once the Lewis base engages with the allenoate there can be several modes of nucleophilic reactivity that allows for the allenic ester to act as a two or three carbon synthon. The allenoate can then react with varying electron deficient olefins generating more complex molecules …
Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez
Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez
University of the Pacific Theses and Dissertations
In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switches in various trans-2-aminocyclohexanol derivatives. By changing the groups on the amine nitrogen, these models provided a wide pH range in which a switch can occur. The pH-induced switch of conformation was monitored by 1H-NMR spectroscopy. The models were also incorporated into the bilayer membrane of liposome structures and tested for their ability to disrupt their membrane upon their conformational flip induced by a decrease in pH.
In this work, the amide bond has been studied as a molecular switch and various amide derivatives have been tested for …
Recent Trends In Stratospheric Chlorine From Very Short‐Lived Substances, Ryan Hossaini, Elliot Atlas, Sandip S. Dhomse, Martyn P. Chipperfield, Peter F. Bernath, Anton M. Fernando, Jens Mühle, Amber A. Leeson, Stephen A. Montzka, Wuhu Feng
Recent Trends In Stratospheric Chlorine From Very Short‐Lived Substances, Ryan Hossaini, Elliot Atlas, Sandip S. Dhomse, Martyn P. Chipperfield, Peter F. Bernath, Anton M. Fernando, Jens Mühle, Amber A. Leeson, Stephen A. Montzka, Wuhu Feng
Chemistry & Biochemistry Faculty Publications
Very short‐lived substances (VSLS), including dichloromethane (CH2Cl2), chloroform (CHCl3), perchloroethylene (C2Cl4), and 1,2‐dichloroethane (C2H4Cl2), are a stratospheric chlorine source and therefore contribute to ozone depletion. We quantify stratospheric chlorine trends from these VSLS (VSLCltot) using a chemical transport model and atmospheric measurements, including novel high‐altitude aircraft data from the NASA VIRGAS (2015) and POSIDON (2016) missions. We estimate VSLCltot increased from 69 (±14) parts per trillion (ppt) Cl in 2000 to 111 (±22) ppt Cl in 2017, with >80% delivered to …