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Articles 1 - 30 of 1879

Full-Text Articles in Physical Sciences and Mathematics

Approaches Towards The Synthesis Of Ketamine Metabolites, Ann K. Patrick May 2020

Approaches Towards The Synthesis Of Ketamine Metabolites, Ann K. Patrick

Honors Theses

Major Depressive disorder (MDD) plagues society and stands at the forefront of research as MDD affects approximately 16% of the population. Pharmaceutical drugs, including the selective serotonin reuptake inhibitors (SSRIs), have been used for MDD treatment and remain a popular option today. However, current antidepressant treatments have proven to be ineffective in just less than half of the patients. Research continues with the goal to better understand the mechanisms of the pathology of depression and to search for other treatment options. For example, the stress-neurogenesis hypothesis investigates the role of stress and decreased neuroplasticity within MDD.

Supporting the stress-neurogenesis hypothesis ...


Nasa L'Space Mission Concept Academy, Anaily Lorenzo May 2020

Nasa L'Space Mission Concept Academy, Anaily Lorenzo

Research Day

NASA L'Space Mission Concept Academy is a virtual academy in which we had to complete a 12-week team mission concept. Our mission objective was to design a small mission concept that characterized the polar water ice on Earth's moon. Our mission had to fit within the mission concept constraints (mass, volume, and budget). Our spacecraft design and scientific payload had to reflect what can be afforded within these constraints. To complete this mission concept, our team relied heavily on math, engineering, geology, and chemistry.


Surface-Enhanced Raman Spectroscopy For Cocaine Detection, Kiersten Jo Mead May 2020

Surface-Enhanced Raman Spectroscopy For Cocaine Detection, Kiersten Jo Mead

Chemistry

The detection of drugs of abuse using Raman spectroscopy is of particular interest to forensic researchers at the moment. Raman spectroscopy is highly specific, fast, non-destructive, and can be adapted for in-situ measurements, making it the ideal forensic technique. Researchers working under the guidance of Doctor Igor Lednev have been able to use UV resonance Raman spectroscopy to detect cocaine in oral fluid without the need for sample pretreatment. They were however unable to detect the cocaine at forensically relevant levels. To overcome this limitation, surface-enhanced Raman spectroscopy (SERS) was used in this proof of concept study for the detection ...


Research And Review Of Polymethyl-Methacrylate Copolymers In The Development Of Enhanced Pharmaceutical Delivery Systems, Jake Dyess Apr 2020

Research And Review Of Polymethyl-Methacrylate Copolymers In The Development Of Enhanced Pharmaceutical Delivery Systems, Jake Dyess

Senior Honors Theses

The following thesis shall primarily explore the current research regarding the implementation of modifiable microscopic and nanoscopic polymer particles as novel pharmaceutical delivery systems. Polymethacrylate-based copolymers, such as EudragitTM, are sensitive to alterations in pH levels, becoming increasingly more soluble in response to an increase in pH. The selective solubility and modifiable nature of these polymers allows for greater flexibility of treatment options for patients (Patra et al., 2017). The wide range of functionality of polymethacrylate (PMA) may provide solutions to challenges relating to the current treatment and therapy of certain conditions. Research indicates that PMA based micro- and ...


Periodic Table Club, Makayla Gill, Kailynn Jensen Apr 2020

Periodic Table Club, Makayla Gill, Kailynn Jensen

Honors Expanded Learning Clubs

This club is dedicated to teaching the generation of future scientists the periodic table. This is designed to be a unique take on a STEM club that uses the periodic table as a backbone for a solid foundation in chemistry.


Chemistry In Medicine, Olivia Visaggio, Alyssa Bondi, Matthew Gillingham, Hailey Loughlin Jan 2020

Chemistry In Medicine, Olivia Visaggio, Alyssa Bondi, Matthew Gillingham, Hailey Loughlin

Student Research Poster Presentations 2020

The chemistry behind medicine is important and necessary to study many different drugs and their effects. In this project, we focused on the chemical composition and mechanisms of various drugs. The drugs we focused on include Opioids, NSAIDs, and other medications, such as Benzodiazepines and antibiotics. For each drug, we provided its structure as well as the functional groups, which include a part of a molecule that is recognized based on its arrangement of atoms. Organic Chemistry provides individuals with an understanding of various organic compounds, and this field of study is important as it explains the ways in which ...


Green Chemistry: The Oxidation Of Benzaldehyde Using Atmospheric Oxygen And N-Heterocyclic Carbenes As Catalysts, Alex Brody, John Morgan Jan 2020

Green Chemistry: The Oxidation Of Benzaldehyde Using Atmospheric Oxygen And N-Heterocyclic Carbenes As Catalysts, Alex Brody, John Morgan

Student Research Poster Presentations 2020

Oxidation is a vital process in organic and biochemical reactions. In particular, the oxidation of aromatic aldehydes to carboxylic acids and esters is a vital process used in many different environments. Benzaldehyde is one common subject of this type of reaction, used in the synthesis of benzoic acid and benzoate derivatives. Unfortunately, the industrial synthesis of these compounds uses harmful heavy metal oxidants such as Chromium(VI) and Manganese(VII), which are very harmful to the environment. We proposed to eliminate these pollutants by using atmospheric oxygen and an organic catalyst in a solvent free reaction. This reaction would then ...


Synthesis Of Bio-Based Polymer Products, Joshua Sukie Jan 2020

Synthesis Of Bio-Based Polymer Products, Joshua Sukie

Williams Honors College, Honors Research Projects

The project covers the synthesis of two bio-based polymers. One aspect of the research investigates the synthesis of materials for use in vegetable oil-based UV-curable coating, and the subsequent polymerization of the materials into a coating film. The second aspect of the research follows the synthesis of a functionalized cellulose material for use as a reinforcer in a vegetable oil-based composite. Both products are subsequently analyzed by various methods.


A Model Experiment To Investigate The Possibility Of Glyphosate Contamination In St. Kitts And Nevis, Winston Fu Jan 2020

A Model Experiment To Investigate The Possibility Of Glyphosate Contamination In St. Kitts And Nevis, Winston Fu

Honors Undergraduate Theses

Glyphosate is a broad-spectrum herbicide that is used globally to combat the spread of weeds among crops. Not all countries around the world have been using the herbicide. For example, island countries such as Dominica and St. Kitts and Nevis do not use the herbicide on their crops. However, St. Kitts and Nevis imports food and other agricultural products from around the world, leading to the hypothesis that glyphosate is contaminating the soil through those imported products. The aim of this research project was to determine if glyphosate is present in the island country of St. Kitts and Nevis. A ...


An Investigation Into The History, Science, And Future Of Dental Filling Materials, Natalia Kaczor Jan 2020

An Investigation Into The History, Science, And Future Of Dental Filling Materials, Natalia Kaczor

Honors Theses

No abstract provided.


Electrolytic Oxidative Coupling Of Alcohols With Aldehydes To Form Esters, Katherine L. Verboom Jan 2020

Electrolytic Oxidative Coupling Of Alcohols With Aldehydes To Form Esters, Katherine L. Verboom

University Honors Program Theses

There are copious amounts of naturally occurring and synthetic esters known that have a wide range of applications in industry to produce fine chemicals. Traditional methods of ester synthesis involve a reaction between a carboxylic acid and an alcohol in the presence of a Bronsted acid catalyst. The primary objective of this research project was to carry out the ester synthesis using the electrochemical coupling of aldehydes with alcohols instead of with a Bronsted acid catalyst because the electrochemical coupling would be an all-around better alternative of ester synthesis than the traditional method of using the catalyst. Electrochemistry has long ...


Characterization Of O-Linked Glycosylated Neuropeptides In The American Lobster (Homarus Americanus): The Use Of Peptide Labeling Following Beta Elimination, Edward Myron Bull Jan 2020

Characterization Of O-Linked Glycosylated Neuropeptides In The American Lobster (Homarus Americanus): The Use Of Peptide Labeling Following Beta Elimination, Edward Myron Bull

Honors Projects

Neuropeptides are a class of small peptides that govern various neurological functions, and the American lobster (Homarus americanus) provides a model system for their characterization. Neuropeptides are commonly post-translationally modified (PTM), and one common PTM is glycosylation. Past research in the Stemmler lab has found glycosylated neuropeptides in H. americanus; however, the extent and biological role of this modification has not been well characterized. This study was undertaken to determine the number of glycosylated peptides in the sinus glands of H. americanus and to develop an approach to tag the site of glycosylation using beta-elimination chemistry. LC-MS paired with high ...


Development Of A Computer Algorithm For Generation Of Primers For Nucleic Acid Sequence Based Amplification (Nasba), Rohit Karnati Jan 2020

Development Of A Computer Algorithm For Generation Of Primers For Nucleic Acid Sequence Based Amplification (Nasba), Rohit Karnati

Honors Undergraduate Theses

Nucleic acid sequence based amplification (NASBA) is a primer based isothermal method of RNA/DNA amplification. Currently, primer design for NASBA has been restricted to hand creating sequences of oligonucleotides that must follow a set of rules to be compatible for the amplification process. This process of hand-creating primers is prone to error and time intensive. The detection of mutants, post amplification, also offers a benefit in point of care scenarios and the design of hybridization probes for sequences in the region of amplification is also an erroneous and time intensive process. By creating a program to design primers and ...


Evaluation Of The Mechanisms And Effectiveness Of Nano-Hydroxides, Wood And Dairy Manure-Derived Biochars To Remove Fluoride And Heavy Metals From Water, Anna Rose Wallace, Wenjie Sun Dr, Chunming Su Dr Dec 2019

Evaluation Of The Mechanisms And Effectiveness Of Nano-Hydroxides, Wood And Dairy Manure-Derived Biochars To Remove Fluoride And Heavy Metals From Water, Anna Rose Wallace, Wenjie Sun Dr, Chunming Su Dr

Civil and Environmental Engineering Theses and Dissertations

The development of effective treatment processes for the removal contaminants, such as fluoride and heavy metals, from polluted water have been urgently needed due to serious environmental health and safety concerns. In this dissertation, a variety of materials including various (hydro)oxide nanomaterials, biochars and surface modified biochar were studied to evaluate their effectiveness and mechanism on removing fluoride or mixed heavy metals from water.

In the Chapter 2, this study investigated the adsorptive removal of fluoride from water using various (hydro)oxide nanomaterials, focusing on ferrihydrite, hydroxyapatite (HAP) and brucite, which have the potential to be used as sorbents ...


Hypervalent Iodine Compounds With Carboxylate And Tetrazolate Ligands, Avichal Vaish Dec 2019

Hypervalent Iodine Compounds With Carboxylate And Tetrazolate Ligands, Avichal Vaish

Chemistry Theses and Dissertations

In modern organic chemistry, hypervalent (HV) iodine(III) compounds are frequently used as oxidizing agents but application of λ3-iodanes in polymer and material chemistry is still underexplored. This dissertation describes the preparation of dynamic and self-healing materials by employing ligand exchange reactions involving HV iodine(III) compounds of the type ArIL2 (Ar = Aryl, L = ligand, e.g., carboxylate or (pseudo)halide). These compounds can undergo ligand exchange reactions in presence of nucleophiles (Nu-) to form ArINu2. Diacetoxyiodo benzene was successfully employed as a crosslinker to prepare dynamic and self-healing gels derived from carboxylate-containing polymers. Furthermore, advantage ...


The Purposeful Position Of Phet Simulations In A 5e Model: A Rationale For Phet Integration In The Explore (Introduction), Explain (Core Instruction) And Elaborate (Assessment) Phases Of Nys Chemistry Units, Zackary D. Waild Oct 2019

The Purposeful Position Of Phet Simulations In A 5e Model: A Rationale For Phet Integration In The Explore (Introduction), Explain (Core Instruction) And Elaborate (Assessment) Phases Of Nys Chemistry Units, Zackary D. Waild

Education and Human Development Master's Theses

Often, students become disengaged and unmotivated by chemistry and struggle with the content. Due to the abstract nature of chemistry, students already struggle to visualize what is happening and, combined with the relatively high levels of disengagement, student learning is lacking. Simulations can help students and teachers alike overcome these issues in learning chemistry by providing actual visualizations of the chemistry phenomena for students to see. Simulations can also help students create connections between the chemistry content and its associated real-world phenomena, a link that can be difficult or even impossible for students to make. This compilation and guide of ...


Practice Problem Worksheets For Freshman Chemistry I (Openstax Chemistry 2nd Edition), Suzanne Ellenberger, Wenjian Du, Sara Blankenship, Ana West, Rupa Gokal, Joel Caughran Oct 2019

Practice Problem Worksheets For Freshman Chemistry I (Openstax Chemistry 2nd Edition), Suzanne Ellenberger, Wenjian Du, Sara Blankenship, Ana West, Rupa Gokal, Joel Caughran

Chemistry Ancillary Materials

This set of practice problem worksheets for Freshman Chemistry I was created under a Round Thirteen Mini-Grant for Ancillary Materials Creation and Revision. These materials are made to supplement OpenStax Chemistry (https://openstax.org/details/books/chemistry-2e).

Topics covered include:

  • Atoms, Molecules, and Ions;
  • Gases;
  • Compounds;
  • Solutions and Colloids;
  • Stoichiometry


9th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association Sep 2019

9th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association

MD Anderson Cancer Center Postdoctoral Association Annual Postdoctoral Science Symposium Abstracts

The mission of the Annual Postdoctoral Science Symposium (APSS) is to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience. The MD Anderson Postdoctoral Association convened its inaugural Annual Postdoctoral Science Symposium (APSS) on August 4, 2011.

The APSS provides a professional venue for postdoctoral scientists to develop, clarify, and refine their research as a result of formal reviews and critiques of faculty and other postdoctoral scientists. Additionally, attendees discuss current research on a broad range of subjects while promoting academic interactions and enrichment and developing new collaborations.


Printing 3d Models For Chemistry: A Step-By-Step Open-Source Guide For Hobbyists, Corporate Professionals, And Educators And Students In K-12 And Higher Education, Elisabeth Grace Billman-Benveniste, Jacob Franz, Loredana Valenzano-Slough Sep 2019

Printing 3d Models For Chemistry: A Step-By-Step Open-Source Guide For Hobbyists, Corporate Professionals, And Educators And Students In K-12 And Higher Education, Elisabeth Grace Billman-Benveniste, Jacob Franz, Loredana Valenzano-Slough

Open Access Books

3D-printing is a relatively inexpensive additive manufacturing method used to create tangible objects. As a relatively new technology, the true capability of 3D-printing has not yet been fully exploited, especially in academic and research/teaching settings. Through this work, 3D-printing in a classroom and research environment is employed as a tool for creation of fully customizable, three-dimensional molecular models and for the visualization of theoretical abstract concepts.


Trophic Upgrading And Mobilization Of Wax Esters In Microzooplankton, Keyana Roohani, Brad A. Haubrich, Kai-Lou Yue, Nigel D'Souza, Amanda Mantalbano, Tatiana Rynearson, Susanne Menden-Deuer, Christopher Reid Aug 2019

Trophic Upgrading And Mobilization Of Wax Esters In Microzooplankton, Keyana Roohani, Brad A. Haubrich, Kai-Lou Yue, Nigel D'Souza, Amanda Mantalbano, Tatiana Rynearson, Susanne Menden-Deuer, Christopher Reid

Science and Technology Faculty Journal Articles

Heterotrophic protists play pivotal roles in aquatic ecosystems by transferring matter and energy, including lipids, from primary producers to higher trophic predators. Using Oxyrrhis marina as a model organism, changes to the non-saponifiable protist lipids were investigated under satiation and starvation conditions. During active feeding on the alga Cryptomonas sp., the O. marina hexane soluble non-saponifiable fraction lipid profile reflected its food source with the observed presence of long chain mono-unsaturated fatty alcohols up to C25:1. Evidence of trophic upgrading in O. marina was observed with long chain mono-unsaturated fatty alcohol accumulation of up to C35:1. To the ...


The Roundtable Of Scientific Communication: From Classroom To Course Creation, Back To Classroom And Beyond, Sean P. Hickey Aug 2019

The Roundtable Of Scientific Communication: From Classroom To Course Creation, Back To Classroom And Beyond, Sean P. Hickey

University of New Orleans Theses and Dissertations

This research encompasses many aspects of chemical education research including curriculum and pedagogical changes to the freshman and sophomore courses. Curriculum changes included the addition of recitations to the general chemistry and organic chemistry lectures and the creation of four new classes, CHEM 1001, 1002, 3091, and 3092. The addition of recitations was not limited to but was focused on improving DFW rates for these courses.

CHEM 3091 and 3092 are chemistry internship and undergraduate teaching assistant classes. These courses were necessary to offer outside internship opportunities and training for undergraduate teaching assistants, respectively. CHEM 1001 and 1002 are chemistry ...


Copper And Barium As Dietary Discriminants: The Effects Of Diagenesis, J B. Lambert, S V. Simpson, Carole B. Szpunar, J E. Buikstra Jul 2019

Copper And Barium As Dietary Discriminants: The Effects Of Diagenesis, J B. Lambert, S V. Simpson, Carole B. Szpunar, J E. Buikstra

Carole Szpunar

No abstract provided.


Design And Synthesis Of Tlr2 And Tlr6 Heterodimer Ligands, A Triply Functionalized Α-Galcer Derivative For Identifying Proteins Involved In Glycolipid Trafficking, And The Disaccharide Of Staphylococcus Aureus Cp8 Towards A Self-Adjuvanting Vaccine, Sara Mayeth Mata Jul 2019

Design And Synthesis Of Tlr2 And Tlr6 Heterodimer Ligands, A Triply Functionalized Α-Galcer Derivative For Identifying Proteins Involved In Glycolipid Trafficking, And The Disaccharide Of Staphylococcus Aureus Cp8 Towards A Self-Adjuvanting Vaccine, Sara Mayeth Mata

Theses and Dissertations

Toll like receptors (TLRs) are found on B cells, macrophages, monocytes, and dendritic cells, and these cells belong to the innate immune system that recognizes antigens and induces multiple cell responses through the release of cytokines. TLR1, TLR2 and TLR6 function as heterodimers, either as TLR1/TLR2 or TLR2/TLR6 to recognize lipopeptides. TLR1/2 dimer activation releases inflammatory cytokines, while TLR2/TLR6 dimer activation releases immunomodulatory cytokines. Based on the size of the binding pocket between TLR2 and TLR6, it was hypothesized that lipopeptides, such as FSL1, could be simplified while keeping overall activity. FSL1 is a lipopeptide first ...


Periodic Table Of Elements, Mendeleev's Periodic Table: History, Achievements And Problems, Boris Oksengendler, Kamil Mukimov, Renat Letfullin, Nigora Turaeva, Gulmurza Abdurakhmanov, Shavkat Yuldashev Jun 2019

Periodic Table Of Elements, Mendeleev's Periodic Table: History, Achievements And Problems, Boris Oksengendler, Kamil Mukimov, Renat Letfullin, Nigora Turaeva, Gulmurza Abdurakhmanov, Shavkat Yuldashev

Bulletin of National University of Uzbekistan: Mathematics and Natural Sciences

This paper, devoted to the yubilee of Mendeleev's table, deals with a set of historical and physico-chemical problems related it. Basing on the evolutional approach to the development of the concept of “elements and structure” and up to the appearance of the notion “complexity” we discuss the applicability of Mendeleev's table to the understanding of modern aspects of science such as “nano”, “fractals”, “synergetics” and “hirality”. The problems which are open for further research are revealed and the particular importance of their development for the condensed matter science of living and nonliving matter is pointed out.


Mineralogy And Chemistry Of Rare Earth Elements In Alkaline Ultramafic Rocks And Fluorite In The Western Kentucky Fluorspar District, Warren H. Anderson Jun 2019

Mineralogy And Chemistry Of Rare Earth Elements In Alkaline Ultramafic Rocks And Fluorite In The Western Kentucky Fluorspar District, Warren H. Anderson

Kentucky Geological Survey Report of Investigations

Rare earth elements, or REE, are used in modern society in televisions, computers, cellphones, military equipment, and smart weapons systems. These metals are also used by the medical industry in magnetic resonance imaging and in medical products.

The igneous rocks in the Western Kentucky Fluorspar District of the New Madrid Rift System are considered alkaline ultramafic rocks that are slightly enriched in REE. These rocks are rare and only occur in several hundred locations in the world. They have a complex history of emplacement, fractionation, metasomatism, and alteration, and are overprinted with Mississippi Valley-type mineralization. They are classified as lamprophyres ...


Chem 339-011: Analytical Physical Chemistry For Chemical Engineers, Elena Avzianova Jun 2019

Chem 339-011: Analytical Physical Chemistry For Chemical Engineers, Elena Avzianova

Chemistry and Environmental Science Syllabi

No abstract provided.


Chem 126-141: General Chemistry Ii, David Fisher Jun 2019

Chem 126-141: General Chemistry Ii, David Fisher

Chemistry and Environmental Science Syllabi

No abstract provided.


Chem 244-043: Organic Chemistry Ii, Andrew B. Naughton Jun 2019

Chem 244-043: Organic Chemistry Ii, Andrew B. Naughton

Chemistry and Environmental Science Syllabi

No abstract provided.


Chem 126-041: General Chemistry Ii, David Fisher Jun 2019

Chem 126-041: General Chemistry Ii, David Fisher

Chemistry and Environmental Science Syllabi

No abstract provided.


Peppytides, Dave Zwicky May 2019

Peppytides, Dave Zwicky

2019 Symposium on Electronic Theses and Dissertations

Lightning talk for Symposium on Electronic Theses and Dissertations (ETD) at Purdue University on May 23, 2019.