Physical Sciences and Mathematics Commons^™

Journal Usage By Subject For Fiscal Year 2010, Michael A. Cerbo Ii

Technical Services Reports and Statistics

Journal holdings for the University Libraries are listed alphabetically by subject than authority title. Usage statistics for the fiscal year are included along with a cost per use where available. The information is taken from each vendor and incorporated in Serials Solutions 360 Counter.

The Perfect Spill: Solutions For Averting The Next Deepwater Horizon, Robert Costanza, David Batker, John W. Day, Rusty A. Feagin, M. Luisa Martinez, Joe Roman

Institute for Sustainable Solutions Publications and Presentations

In this article the authors comment on the oil spill incident from the Deepwater Horizon, particularly on its economic and ecological damages. The authors highlighted the disaster as an event wherein much is needed to be learned so that future oil spills can be avoided. One lesson refers to the valuability of natural capital assets and other public entities that are at risks due to private interests and that better regulations and incentives are needed to protect these assets against risks.

Role Of Surface Charge Density In Nanoparticle-Templated Assembly Of Bromovirus Protein Cages, Mc Daniel, Ib Tsvetkova, Zt Quinkert, A Murali, M De, Vm Rotello, Cc Kao, B Dragnea

Vincent Rotello

Self-assembling icosahedral protein cages have potencially useful physical and chemical characteristics for a variety of nanotechnology applications, ranging from therapeutic or diagnostic vectors to building blocks for hierarchical materials. For application-specific functional control of protein cage assemblies, a deeper understanding of the interaction between the protein cage and its payload is necessary. Protein-cage encapsulated nanoparticles, with their well-defined surface chemistry, allow for systematic control over key parameters of encapsulation such as the surface charge, hydrophobicity, and size. Independent control over these variables allows experimental testing of different assembly mechanism models. Previous studies done with Brome mosaic virus capsids and negatively …

Effect Of Nanoparticle Surface Charge At The Plasma Membrane And Beyond, Rr Arvizo, Or Miranda, Ma Thompson, Cm Pabelick, R Bhattacharya, Jd Robertson, Vm Rotello, Ys Prakash, P Mukherjee

Vincent Rotello

Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

Gold Nanoparticle Self-Assembly Promoted By A Non-Covalent, Charge-Complemented Coiled-Coil Peptide, D Ernenwein, P Ghosh, V Rotello, J Chmielewski

Vincent Rotello

Non-covalent interactions between cationic gold nanoparticles and an anionic coiled-coil peptide were harnessed for coiled-coil mediated self-assembly of gold nanoparticles (GNPs)

Slides: Celebrating Flpma: Land Use Planning At The Blm, Marcilynn Burke

The Past, Present, and Future of Our Public Lands: Celebrating the 40th Anniversary of the Public Land Law Review Commission’s Report, One Third of the Nation’s Land (Martz Summer Conference, June 2-4)

Presenter: Marcilynn Burke, BLM Deputy Director - Programs and Policy, U.S. Dept. of the Interior, (Washington, D.C.)

30 slides

Enzyme-Amplified Array Sensing Of Proteins In Solution And In Biofluids, Or Miranda, Ht Chen, Cc You, De Mortenson, Xc Yang, Uhf Bunz, Vm Rotello

Vincent Rotello

We have developed an enzyme−nanoparticle sensor array where the sensitivity is amplified through enzymatic catalysis. In this approach cationic gold nanoparticles are electrostatically bound to an enzyme (β-galactosidase, β-Gal), inhibiting enzyme activity. Analyte proteins release the β-Gal, restoring activity and providing an amplified readout of the binding event. Using this strategy we have been able to identify proteins in buffer at a concentration of 1 nM, substantially lower than current strategies for array-based protein sensing. Moreover, we have obtained identical sensitivity in studies where the proteins are spiked into the complex protein matrix provided by desalted human urine (1.5 μM …

Recognition Mediated Encapsulation And Isolation Of Flavin-Polymer Conjugates Using Dendritic Guest Moieties, C Subramani, G Yesilbag, Bj Jordan, Xn Li, A Khorasani, G Cooke, A Sanyal, Vm Rotello

Vincent Rotello

Diaminopyridine dendritic scaffolds encapsulate polymeric flavin via non-covalent interactions and demonstrate isolation of the redox moiety.

Chemically Directed Immobilization Of Nanoparticles Onto Gold Substrates For Orthogonal Assembly Using Dithiocarbamate Bond Formation, Mh Park, Xx Duan, Y Ofir, B Creran, D Patra, Xy Ling, J Huskens, Vm Rotello

Vincent Rotello

Dithiocarbamate-mediated bond formation combined with soft lithography was used for the selective immobilization of amine-functionalized silica nanoparticles on gold substrates. The available amine groups on the upper surface of the immobilized silica nanoparticles were further utilized for postdeposition of additional materials including particles, dyes, and biomolecules. The robustness of dithiocarbamate-mediated immobilization enables orthogonal assembly on surfaces via selective removal of the masking thiol ligands using iodine vapor etching followed by further functionalization.

Hyperbranched Conjugated Polymers: Postfunctionalization, C Kub, J Tolosa, Aj Zucchero, Pl Mcgrier, C Subramani, A Khorasani, Vm Rotello, Uhf Bunz

Vincent Rotello

Out on a limb: Sonogashira coupling of a suitable AB(2) monomer containing two iodine and one alkyne group forms a hyperbranched conjugated polymer that is studded with iodine end groups (see picture: I purple). These iodine groups are a perfect handle for convenient, efficient, and high-yielding post-functionalization to access hyperbranched, fluorescent poly(phenyleneethynylene)s.

Intracellular Delivery Of A Membrane-Impermeable Enzyme In Active Form Using Functionalized Gold Nanoparticles, P Ghosh, Xc Yang, R Arvizo, Zj Zhu, Ss Agasti, Zh Mo, Vm Rotello

Vincent Rotello

Gold nanoparticles were coated with a short peptide to promote intracellular delivery of membrane-impermeable proteins. Through microscopy and enzyme assays, we demonstrated the particles were able to transport functional enzymes into a variety of cell lines. Significantly, the transported proteins were able to escape from endosomes. Moreover, these particles showed no apparent cytotoxicity.

Theoretical Description Of A Dna-Linked Nanoparticle Self-Assembly, Chia Wei Hsu, Francesco Sciortino, Francis Starr

Francis Starr

No abstract provided.

Rapid Transport Of Water Via A Carbon Nanotube Syringe, Jose Rivera, Francis Starr

Francis Starr

No abstract provided.

Morphology And Transport Properties Of Two-Dimensional Sheet Polymers, Scott Knauert, Jack Douglas, Francis Starr

Francis Starr

Whereas there has been extensive theoretical and experimental investigation of the properties of linear polymer chains in solution, there has been far less work on sheet-like polymers having 2D connectivity and 3D crumpled or collapsed shapes caused by thermal fluctuations, attractive self-interactions, or both. Sheet-like polymers arise in a variety of contexts ranging from self-assembled biological membranes (e.g., the spectrin network of red blood cells, microtubules, etc.) to nanocomposite additives to polymers (carbon nanotubes, graphene, and clay sheets) and polymerized monolayers. We investigate the equilibrium properties of this broad class of polymers using a simple model of a sheet polymer …

Current Issues In Research On Structure-Property Relationships In Polymer Nanocomposites, J. Jancar, J. Douglas, Francis Starr, S. Kumar, P. Cassagnau, A. Lesser, S. Sternstein, M. Buehler

Francis Starr

No abstract provided.

Array-Based Sensing Of Normal, Cancerous, And Metastatic Cells Using Conjugated Fluorescent Polymers, A Bajaj, Or Miranda, R Phillips, Ib Kim, Dj Jerry, Uhf Bunz, Vm Rotello

Vincent Rotello

A family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface features. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of the cell type as well differentiating between normal, cancerous, and metastatic isogenic cell types with high accuracy.

An Integrated Collection Of Tools For Continuously Improving The Processes By Which Health Care Is Delivered: A Tool Report, Lj Osterweil, La Clarke, Gs Avrunin

Leon Osterweil

With the availability of powerful computational and commu- nication systems, scientists now readily access large, complicated derived datasets and build on those results to produce, through further processing, yet other derived datasets of interest. The scientific processes used to create such datasets must be clearly documented so that scientists can evaluate their soundness, reproduce the results, and build upon them in responsible and appropriate ways. Here, we present the concept of an analytic web, which defines the scientific processes employed and details the exact appli- cation of those processes in creating derived datasets. The work described here is similar to …

Scholars Day Program Of Events 2010, Carl Goodson Honors Program

Scholars Day

No abstract provided.

Nebraska Statewide Groundwater-Level Monitoring Report 2010, J. T. Korus, M. E. Burbach, L. M. Howard, R. M. Joeckel

Conservation and Survey Division

No abstract provided.

Universal Two-Step Crystallization Of Dna-Functionalized Nanoparticles, Wei Dai, Sanat K. Kumar, Francis W. Starr

Francis Starr

No abstract provided.

Valency Dependence Of Polymorphism And Polyamorphism In Dna-Functionalized Nanoparticles, Wei Dai, Chia Wei Hsu, Francesco Sciortino, Francis W. Starr

Francis Starr

Nanoparticles (NP) functionalized with single-stranded DNA (ssDNA) offer a route to custom-designed, self- assembled nanomaterials with potentially unusual properties. The bonding selectivity of DNA guarantees one-to-one binding to form double-stranded DNA (dsDNA), and an appropriate base sequence results in head-to-tail binding linking NP into networks. We explore the phase behavior and structure of a model for NP functionalized with between 3 and 6 short ssDNA through simulations of a coarse-grained molecular model, allowing us to examine both the role of the number of attached strands (valency) and their relative orientations. The NP assemble into networks where the number of NP …