Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Investigating The Impacts Of Crash Prediction Models On Quantifying Safety Effectiveness Of Adaptive Signal Control Systems, Weimin Jin, Mashrur Chowdhury, Sakib Mahmud Khan, Patrick Gerard
Investigating The Impacts Of Crash Prediction Models On Quantifying Safety Effectiveness Of Adaptive Signal Control Systems, Weimin Jin, Mashrur Chowdhury, Sakib Mahmud Khan, Patrick Gerard
Publications
Introduction: Adaptive Signal Control System (ASCS) can improve both operational and safety benefits at signalized corridors. Methods: This paper develops a series of models accounting for model forms and possible predictors and implements these models in Empirical Bayes (EB) and Fully Bayesian (FB) frameworks for ASCS safety evaluation studies. Different models are validated in terms of the ability to reduce the potential bias and variance of prediction and improve the safety effectiveness estimation accuracy using real-world crash data from non-ASCS sites. This paper then develops the safety effectiveness of ASCS at six different corridors with a total of 65 signalized …
Forces And Disease: Electrostatic Force Differences Caused By Mutations In Kinesin Motor Domains Can Distinguish Between Disease-Causing And Non-Disease-Causing Mutations, Lin Li, Yunhui Peng, Subash Godar, Ivan Getov, Shaolei Teng, Joshua Alper, Emil Alexov
Forces And Disease: Electrostatic Force Differences Caused By Mutations In Kinesin Motor Domains Can Distinguish Between Disease-Causing And Non-Disease-Causing Mutations, Lin Li, Yunhui Peng, Subash Godar, Ivan Getov, Shaolei Teng, Joshua Alper, Emil Alexov
Publications
The ability to predict if a given mutation is disease-causing or not has enormous potential to impact human health. Typically, these predictions are made by assessing the effects of mutation on macromolecular stability and amino acid conservation. Here we report a novel feature: the electrostatic component of the force acting between a kinesin motor domain and tubulin. We demonstrate that changes in the electrostatic component of the binding force are able to discriminate between disease-causing and non-disease-causing mutations found in human kinesin motor domains using the receiver operating characteristic (ROC). Because diseases may originate from multiple effects not related to …