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Articles 1 - 16 of 16
Full-Text Articles in Physical Sciences and Mathematics
Attempted Synthesis & Antibacterial Properties Of Apt-6k Against Ndm-1 K. Pneumoniae, Alec Bofetiado
Attempted Synthesis & Antibacterial Properties Of Apt-6k Against Ndm-1 K. Pneumoniae, Alec Bofetiado
Honors Theses
NDM-1 K. pneumoniae is a highly resistant bacterial organism that is capable of causing debilitating nosocomial infections in immunocompromised patients. Only "last-resort" antibiotics--such as colistin--work against this organism. Therefore, new antibiotics are needed to help fight against these types of infections. APT-6K is a novel compound that was demonstrated to be effective against MRSA with nanomolar concentrations in a prior study. Novel methods of APT-6K synthesis and its testing for antibiotic effects against NDM-1 K. pneumoniae were attempted in this research. APT-6K synthesis was unsuccessful. Commercially-prepared APT-6K also did not demonstrate growth inhibition against NDM-1 K. pneumoniae nor against a …
Determination Of Metals And Microplastics In Sediment From Oyster Reefs In The Mississippi Sound, Shelby Goza
Determination Of Metals And Microplastics In Sediment From Oyster Reefs In The Mississippi Sound, Shelby Goza
Honors Theses
This research centers on the determination of metals (Cd, Pb, V, Cr, Mn, Fe, Co, Ni, Cu) and microplastics (MPs) in marine sediment from oyster reefs in the Mississippi Sound Estuary. Oysters (Crassostrea virginica) are a vital part of the Gulf Coast economy, but their population has dramatically declined in recent years due to multiple stressors, including oil spills and fluctuations in salinity from flooding. Increasingly frequent flooding events also introduce high loads of MPs and sediments containing heavy metals from the Mississippi River. These pollutants can have deleterious effects on oyster biology; however, they have not been adequately …
Lc-Ms/Ms Method Development And Analysis Of Tricyclic Antidepressants In Human Plasma, Shahbaz Gul
Lc-Ms/Ms Method Development And Analysis Of Tricyclic Antidepressants In Human Plasma, Shahbaz Gul
Honors Theses
Depression has become one of the most prominent problems in society, disrupting both personal and social lives. Tricyclic antidepressants (TCAs) were first developed in the 1950’s and became some of the leading anti-depressant medications on the market later that decade. Today, newer anti-depressants have risen to the forefront, being safer and having a lower side-effect probability. Nonetheless, TCAs continue to be prescribed for severe depression, especially in cases where the newer anti-depressants have failed. However, TCAs are still highly potent, the toxicity associated with these compounds cannot be ignored. They have considerable cardiovascular and neurological toxicity, and in the event …
Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly
Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly
Honors Theses
Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration …
A Systematic Investigation Of The Effects Of Chain Length And Ionic Head Group On Perfluoroalkyl Acid Binding To Human Serum Albumin, Jake Ulrich
Honors Theses
Perfluoroalkyl acids (PFAAs) are industrial chemicals used in everyday products ranging from non-stick coatings to fire-fighting foam. PFAAs are contaminants of emerging concern (CECs) and are bioaccumulative, persistent and toxic. Unlike other CECs, PFAAs bioaccumulate in areas of high protein concentration, such as the kidneys, liver and blood; therefore, it is vital to study PFAA-protein interactions. Human Serum Albumin (HSA) is the model protein used for PFAA-protein studies because it is the most abundant protein in the human body and it binds and transports endogenous and exogenous ligands. Previously, researchers have investigated PFAA-HSA binding, but most of these studies have …
The United States, China, And Climate Change: An Analysis Of The Us-China Climate Pact And Its Implications For International Climate Negotiations, Joesph Fiorile
Honors Theses
Climate change increasingly is becoming a major issue for the international community. It is contributing to rising global temperatures, rising sea levels, drought, natural disaster intensification, and ecological damage, amongst other things. A scientific consensus has emerged over recent years that implicates greenhouse gases, chief amongst them carbon dioxide, for causing global warming. Climate scientists overwhelmingly agree that the greenhouse gas effect has been caused in large part by the spike of human emissions since the dawn of the Industrial Revolution. To reverse the problem, the density of greenhouse gases in Earth’s atmosphere, especially carbon dioxide, has to be reduced. …
Polychlorinated Biphenyl (Pcb) Pollution Of The Hudson River: Social Policy And Health Considerations, Laura Schad
Polychlorinated Biphenyl (Pcb) Pollution Of The Hudson River: Social Policy And Health Considerations, Laura Schad
Honors Theses
The purpose of this paper is to examine pollution in the Hudson River and the role General Electric has had in creating this problem. The focus will be on social issues and problems that have emerged as a result of the environmental damage from pollution. Until recently, there was little research done on the health and environmental justice issues that impact the New York communities where GE’s factories were located. This paper examines the material collected and studies that were done which document Hudson River pollution and the contributions as well as cleanup efforts of General Electric. The overall problems …
Sustainable Agriculture: How France Promotes Sustainability, Jordan Pulling
Sustainable Agriculture: How France Promotes Sustainability, Jordan Pulling
Honors Theses
High consumption lifestyles led to a rapid decline in natural resources. The daily gestures of the people of the world use a quantity massive resource and energy that cannot be replaced. Decision makers of the world are invited to consider what changes will be needed to focus about sustainable and sustainable practices if we want to continue living in the way which we have become accustomed to. The development of renewable energies was a first step towards total sustainable development. Recently, however, we have seen a new way to reduce negative impacts on the rights of the Earth: changes in …
Kinetic Modeling Of Catalytic Aerogels, Yi Cao
Kinetic Modeling Of Catalytic Aerogels, Yi Cao
Honors Theses
As pollution becomes an increasing concern globally, strict regulations have been set on vehicle pollutant emissions. The three-way catalytic converter is capable of converting toxic emissions such as carbon monoxide, unburned hydrocarbons and nitrogen oxides to less hazardous waste such as carbon dioxide, water, and nitrogen. Current catalysts employ platinum group metals, which are expensive and environmentally damaging to mine. Catalytically-active aerogels such as Co-Al, Cu-Al and V-Al aerogels have shown promise as alternatives to these metals. The work presented here adapts and extends a global kinetic model which predicts the conversion of hydrocarbons and carbon monoxide on platinum catalyst …
Sem-Edx Analysis Of Aerosol Samples, Xuanhan Zhao
Sem-Edx Analysis Of Aerosol Samples, Xuanhan Zhao
Honors Theses
One of the important environmental issues in upstate New York is the acid rain problem in the Adirondack Mountains, which is associated with atmospheric aerosols. As a part of a systematic study to understand the transport, transformation, and effects of airborne pollutants in the Adirondack Mountains, we are performing an analysis of atmospheric aerosols collected at Piseco Lake. In previous work, we used proton induced X-ray emission (PIXE) [1] spectrometry to measure the concentrations of elements in aerosol samples as a function of the size of the particulate matter. The results of the PIXE analysis indicate significant concentrations of sulfur …
A Comparative Study Of Gupix And Geopixe Software In The Analysis Of Pixe Spectra Of Aerosol Samples, Sean Collison
A Comparative Study Of Gupix And Geopixe Software In The Analysis Of Pixe Spectra Of Aerosol Samples, Sean Collison
Honors Theses
Proton-induced X-ray emission (PIXE) spectroscopy is a powerful tool used in the Union College Ion-Beam Analysis Laboratory for the elemental analysis of environmental pollution. Samples are bombarded with proton beams from the 1.1‐MV Pelletron accelerator and characteristic X-rays emitted from the samples are detected, resulting in X-ray energy spectra. These spectra are analyzed using software packages that fit the data and calculate the concentrations of elements in the samples. I have performed a comparative study of two of the most popular software packages, GUPIX and GeoPIXE, in the analysis of atmospheric aerosol samples to assess the strengths and weaknesses of …
Proton Induced X-Ray Emission Spectrometry Of Atmospheric Aerosols At Piseco Lake, Adam Margulies
Proton Induced X-Ray Emission Spectrometry Of Atmospheric Aerosols At Piseco Lake, Adam Margulies
Honors Theses
Chemical studies of lakes and aerosols in the Adirondack region of New York State have found evidence of environmental pollution resulting in acid rain. We obtained air samples for July and September 2012 from Piseco Lake and analyzed particulate depositions with Proton Induced X-ray Emission (PIXE) spectrometry. We detected an array of light elements, including sulfur particulates in the 0.25 - 8 μm range, possibly stemming from coal combustion in the Appalachians and Mid-West of the United States. We also found systematic errors with the accelerator charge integration system due to beam spreading after the beam passes through the target. …
My Experience Exploring The Effects Of Lead (Pb +2) Toxicity In Drosophila Melanogaster Using Sociability Interaction Testing And Microarrays At The University Of Puerto Rico-Rio Piedras In San Juan, Puerto Rico, Charlton Diaz
Honors Theses
Lead is an environmental contaminant widely dispersed throughout the world. Exposure to lead causes neurological damage in humans and may be linked to neurodevelopmental pathologies such as attention deficit hyperactivity disorder, antisocial behavior, and autistic spectrum disorders (ASD). Drosophila melanogaster (fruit flies) have been used to understand the behavioral, synaptic, and molecular changes that occur after developmental exposure to lead and to study ASD-associated pathology. Flies were exposed through the mother and until eclosion to either a lead-laced medium or a control corn-based medium and were isolated until the beginning for the behavioral studies. Sociability testing was done using a …
Documenting The Anthropogenic Impact On Ballston Lake New York From A Short Core Using Stable Isotopes Of Carbon And Nitrogen And Trace Metals, Taylor S. Labrecque
Documenting The Anthropogenic Impact On Ballston Lake New York From A Short Core Using Stable Isotopes Of Carbon And Nitrogen And Trace Metals, Taylor S. Labrecque
Honors Theses
Ballston Lake occupies a portion of an avulsed channel of the Mohawk River between Schenectady and Saratoga Springs, New York. The lake is about 5 km long, generally less than 200m wide, ~8-15m deep, dimictic, with a catchment basin area of ~22km2. Long cores (>8 m) indicate that the lake formed ~13,000 cal yr BP. This study was undertaken to document recent environmental change recorded in the upper portion of sediment in Ballston Lake. Three sediment cores ~40 cm long were acquired from ~8 m water depth at the north end of Ballston Lake (42°57.101’N, 73°51.066’W), and were analyzed …
The History Of Mining In Cerro De Pasco And Heavy Metal Deposition In Lake Junin Peru, Erin M. Delman
The History Of Mining In Cerro De Pasco And Heavy Metal Deposition In Lake Junin Peru, Erin M. Delman
Honors Theses
Lake Junín covers 530-km2 and is located at 4,430-m in an intermontane basin between the eastern and western cordillera of the central Peruvian Andes. The lake sits between the large sulfide mining districts of La Oroya and Cerro de Pasco. Designated a National Reserve in 1974, Lake Junín drains northward to the Río San Juan, which joins the Río Mantaro within several kilometers of the lake. Dam construction by the Cerro de Pasco Copper Corporation on the Río Mantaro in 1932 caused the Río San Juan, the principal river draining Cerro de Pasco, to back up into the lake. Using …
Old Father Hudson: The Three Stages Of Environmental Activism In The Hudson River Valley, Gregory P. Cannillo
Old Father Hudson: The Three Stages Of Environmental Activism In The Hudson River Valley, Gregory P. Cannillo
Honors Theses
Consequences of development have threatened the health of the Hudson River for decades. These have included the prospect of destroying scenic value of the Hudson River Valley with the a hydroelectric power plant on Storm King Mountain, as well as the pollution of the river itself by a variety of industrial sources. Since the 1960s, a long lineage of environmental activism in the Hudson River Valley has emerged to address those issues. The example of the Hudson River supplies an excellent case study of how environmental issues began to be addressed in the later half of the 20th century. I …