Physical Sciences and Mathematics Commons^™

Functional Effects Of Calcium Regulation Of Thin Filaments At Single Particle Resolution, Christopher Solis-Ocampo

Electronic Theses and Dissertations

Heart disease is the leading cause of death in the United States. Understanding heart function at the molecular level is critical for developing of more effective treatments. In the cardiac muscle, the thin filament is composed by troponin (Tn), tropomyosin (Tm), and F-actin. It provides Ca2+-dependent regulation of contraction by modulating myosin attachment and force generation in a cooperative scheme. However, this mechanism remains unclear. To understand thin filament activation, we studied the binding and functional properties of Tn and Tm to F-actin at single particle resolution by employing fluorescence image colocalization, in vitro motility assays, and Förster resonance energy …

Product Authentication Using Hash Chains And Printed Qr Codes, Harshith R. Keni

Electronic Theses and Dissertations

This thesis explores the usage of simple printed tags for authenticating products. Printed tags are a cheap alternative to RFID and other tag based systems and do not require specialized equipment. Due to the simplistic nature of such printed codes, many security issues like tag impersonation, server impersonation, reader impersonation, replay attacks and denial of service present in RFID based solutions need to be handled differently. An algorithm that utilizes hash chains to secure such simple tags while still keeping cost low is discussed. The security characteristics of this scheme as well as other product authentication schemes that use RFID …

Effect Of Oil And Natural Gas Development On Survival And Health Of White-Tailed Deer In The Western Dakotas, Katherine L. Moratz

Electronic Theses and Dissertations

Oil and gas development in North Dakota has resulted in the need for information regarding how increased activity has affected white-tailed deer (Odocoileus virginianus) populations. We evaluated white-tailed deer ecology in response to energy development and hypothesized that oil and gas development would negatively affect adult and neonate white-tailed deer due to increased vehicle traffic and human-related effects. We captured and radio-collared adult female and neonate white-tailed deer across three study areas: Dunn County, North Dakota, an area influenced by energy development, and Grant County, North Dakota, and Perkins County, South Dakota, areas not impacted by energy development at this …

The Woz Recognizer: A Tool For Understanding User Perceptions Of Sketch-Based Interfaces, Jared Bott

Electronic Theses and Dissertations

Sketch recognition has the potential to be an important input method for computers in the coming years; however, designing and building an accurate and sophisticated sketch recognition system is a time consuming and daunting task. Since sketch recognition is still at a level where mistakes are common, it is important to understand how users perceive and tolerate recognition errors and other user interface elements with these imperfect systems. A problem in performing this type of research is that we cannot easily control aspects of recognition in order to rigorously study the systems. We performed a study examining user perceptions of …

Towards Structural Determination Of Human Α1-Glycine Receptor Allostery, Rathna Jyothi Veeramachaneni

Electronic Theses and Dissertations

Recent advances in technology have led to the determination of numerous notable structures of membrane proteins. While they provide valuable information about the structure of membrane proteins these studies often provide static images with potentially limited dynamics, and structural determination often requires truncation of flexible regions, and often utilizes bacterial homologs given the need for stable, heterologous overexpression. In order to better understand allostery at a molecular level, state-dependent crosslinking studies coupled with multidimensional mass spectrometry (MS) were conducted on glycine receptor (GlyR) stabilized in different allosteric states. Predominant allosteric states were stabilized using wild type or mutated receptor in …

A Study Of Holistic Strategies For The Recognition Of Characters In Natural Scene Images, Muhammad Ali

Electronic Theses and Dissertations

Recognition and understanding of text in scene images is an important and challenging task. The importance can be seen in the context of tasks such as assisted navigation for the blind, providing directions to driverless cars, e.g. Google car, etc. Other applications include automated document archival services, mining text from images, and so on. The challenge comes from a variety of factors, like variable typefaces, uncontrolled imaging conditions, and various sources of noise corrupting the captured images. In this work, we study and address the fundamental problem of recognition of characters extracted from natural scene images, and contribute three holistic …

Gesture Assessment Of Teachers In An Immersive Rehearsal Environment, Roghayeh Barmaki

Electronic Theses and Dissertations

Interactive training environments typically include feedback mechanisms designed to help trainees improve their performance through either guided- or self-reflection. When the training system deals with human-to-human communications, as one would find in a teacher, counselor, enterprise culture or cross-cultural trainer, such feedback needs to focus on all aspects of human communication. This means that, in addition to verbal communication, nonverbal messages must be captured and analyzed for semantic meaning. The goal of this dissertation is to employ machine-learning algorithms that semi-automate and, where supported, automate event tagging in training systems developed to improve human-to-human interaction. The specific context in which …

Spatial And Temporal Modeling For Human Activity Recognition From Multimodal Sequential Data, Jun Ye

Electronic Theses and Dissertations

Human Activity Recognition (HAR) has been an intense research area for more than a decade. Different sensors, ranging from 2D and 3D cameras to accelerometers, gyroscopes, and magnetometers, have been employed to generate multimodal signals to detect various human activities. With the advancement of sensing technology and the popularity of mobile devices, depth cameras and wearable devices, such as Microsoft Kinect and smart wristbands, open a unprecedented opportunity to solve the challenging HAR problem by learning expressive representations from the multimodal signals recording huge amounts of daily activities which comprise a rich set of categories. Although competitive performance has been …

Saturn's Rings: Measuring Particle Size Distributions Using Cassini Uvis Occultation Data, Tracy Becker

Electronic Theses and Dissertations

Since its arrival to Saturn in 2004, the Cassini spacecraft has utilized its suite of sophisticated instruments to further our understanding of the Saturnian ring system. We analyze occultation data from Cassini's Ultraviolet Imaging Spectrograph (UVIS) in order to measure the particle size distribution and place limits on the minimum particle sizes in Saturn's rings. Throughout the ring system, particle accretion is countered by collisional and tidal disruption and Keplerian shear. Therefore, the particle size distribution of the rings is continually evolving. The presence of sub-centimeter particles, which have short lifetimes due to these processes, is indicative of ongoing dynamics …

Evaluating Floating Treatment Wetlands To Improve Nitrogen Removal In A Wet Detention Pond, Zachary Marimon

Electronic Theses and Dissertations

Wet detention ponds are used for stormwater treatment across the United States and reduce most pollutants by at least 60%, but only remove 30% of total nitrogen. Floating Treatment Wetlands (FTWs) are an emerging technology that uses aquatic plants suspended in the pelagic zone to remove nitrogen through vegetative assimilation and microbial denitrification. A before-after field experiment evaluated nitrogen removal in a an existing pond in Orlando, FL, retrofitted with BioHaven® FTWs planted with the aquatic macrophytes Juncus effusus (Soft Rush) and Pontederia cordata (Pickerelweed). Surface water samples were used to compare the nitrogen removal performance of the pond under …

Multidimensional Room-Temperature Fluorescence Microscopy For The Nondestructive Analysis Of Forensic Trace Textile Fibers, Nirvani Mujumdar

Electronic Theses and Dissertations

The purpose of this dissertation is to advance nondestructive methodology for forensic fiber examination. Non-destructive techniques that can either discriminate between similar fibers or match a known to a questioned fiber – and still preserve the physical integrity of the fibers for further court examination - are highly valuable in forensic science. A challenging aspect of forensic fiber examinations involves the comparison of fibers colored with visually indistinguishable dyestuffs. This is not an uncommon situation, as there are numerous indistinguishable fibers pre-dyed with commercial dyes of virtually identical colors. Minimal chemical structural variations are actually encouraged by the dye patent …

Quantitative Framework For Social Cultural Interactions, Taranjeet Singh Bhatia

Electronic Theses and Dissertations

For an autonomous robot or software agent to participate in the social life of humans, it must have a way to perform a calculus of social behavior. Such a calculus must have explanatory power (it must provide a coherent theory for why the humans act the way they do), and predictive power (it must provide some plausible events from the predicted future actions of the humans). This dissertation describes a series of contributions that would allow agents observing or interacting with humans to perform a calculus of social behavior taking into account cultural conventions and socially acceptable behavior models. We …

Impact Of Gamma-Irradiation On The Characteristics Of Iii-N/Gan Based High Electron Mobility Transistors, Anupama Yadav

Electronic Theses and Dissertations

In this study, the fundamental properties of AlGaN/GaN based High Electron Mobility Transistors (HEMTs) have been investigated in order to optimize their performance in radiation harsh environment. AlGaN/GaN HEMTs were irradiated with 60Co gamma-rays to doses up to 1000 Gy, and the effects of irradiation on the devices' transport and optical properties were analyzed. Understanding the radiation affects in HEMTs devices, on carrier transport, recombination rates and traps creation play a significant role in development and design of radiation resistant semiconductor components for different applications. Electrical testing combined with temperature dependent Electron Beam Induced Current (EBIC) that we used in …

Tryopenjml - A Verily Based Web Application For Learning About The Java Modeling Language, Tushar Deshpande

Electronic Theses and Dissertations

This thesis has a two-fold purpose. On the one hand, the web applications are an important part of life. On a day to day basis, from managing our heath care choices to banking, to connecting to a friend, almost everything is done through a web application. Development of these applications is also a very trend-driven domain. Numerous web frameworks are available today, but almost none has been created taking reliability into consideration. With the combination of application construction recipes and static analysis, the Verily framework was created to build more reliable web applications. On the other hand, the goal of …

Comparing The Variational Approximation And Exact Solutions Of The Straight Unstaggered And Twisted Staggered Discrete Solitons, Daniel Marulanda

Electronic Theses and Dissertations

Discrete nonlinear Schrödinger equations (DNSL) have been used to provide models of a variety of physical settings. An application of DNSL equations is provided by Bose-Einstein condensates which are trapped in deep optical-lattice potentials. These potentials effectively splits the condensate into a set of droplets held in local potential wells, which are linearly coupled across the potential barriers between them [3]. In previous works, DNLS systems have also been used for symmetric on-site-centered solitons [11]. A few works have constructed different discrete solitons via the variational approximation (VA) and have explored their regions for their solutions [11, 12]. Exact solutions …

Theoretical-Experimental Study Of The Two-Photon Circular Dichroism Of Helicenes And Aromatic Amino Acids In The Uv Region: From The Structure-Property Relationship To The Final Implementation, Yuly Katherine Vesga Prada

Electronic Theses and Dissertations

Two-photon circular dichroism (TPCD) has been recognized for its exceptional spectroscopic ability for the structural and conformational analysis of chiral systems due to its high sensitivity to small peptide structural distortions. In 2008, Hernandez and co-workers demonstrated TPCD experimentally by the development of the Double L-scan technique. Since then, we have been working on a systematic theoretical-experimental study of chiral molecules using TPCD. In this dissertation, I present my contribution to the continuation to the study of the structure-property relationship of TPCD in molecules with axial chirality in solution, as well as the implementation of the TPCD measurements in the …

Financial Investment Management For Forest Sustainability, Zarina Ismailova

Electronic Theses and Dissertations

This is paper is discussion about main problems of forest management, whether financial investment has a substantial impact on the long term perspective of forest landscape restoration and, more specifically, what strategy and what financial options are available to make the forest projects more sustainable. A few relevant questions to ask are: who are the main actors in the implementation of FLR projects; which steps have to be taken; and, which financial options would more suitable and would be feasible to implement. There are three main parts of this research to be investigated:

1. forest issues along with their respective solutions, …

Breast Cancer Classification Of Mammographic Masses Using Circularity Max Metric, A New Method, Tae Keun Heo

Electronic Theses and Dissertations

Breast cancer classification can be divided into two categories. The first category is a benign tumor, and the other is a malignant tumor. The main purpose of breast cancer classification is to classify abnormalities into benign or malignant classes and thus help physicians with further analysis by minimizing potential errors that can be made by fatigued or inexperienced physicians. This paper proposes a new shape metric based on the area ratio of a circle to classify mammographic images into benign and malignant class. Support Vector Machine is used as a machine learning tool for training and classification purposes. The improved …

Current Status Of Falcon Populations In Saudi Arabia, Albara M. Binothman

Electronic Theses and Dissertations

Falcons (Falco spp.) are widely used for falconry in the countries of the Middle East. During the 2015 breeding season, we surveyed historic and active nest sites of Barbary (Falco pelegrinoides pelegrinoides) and Lanner (F. biarmicus) Falcons in Saudi Arabia. Field and questionnaire surveys were conducted and personal contact with falconers was made to document the current distribution and price changes for Lanner Falcons, Barbary Falcons, Saker Falcons (F. cherrug), Peregrine Falcons (F. peregrinus), Gyrfalcons (F. rusticolus), and Hybrid Falcons in Saudi Arabia. We categorized our survey into three geographic groups; southwest (A), northwest (B), and central (C) regions of …

Use Of Photo-Identification And Mark-Recapture Techniques To Identify Characteristics Of The Stock Structure Of Coastal Bottlenose Dolphins (Tursiops Truncatus) Off Northern South Carolina, Daniela C. Silva

Electronic Theses and Dissertations

National Marine Fisheries Service (NMFS) stock assessment reports describe two coastal and two estuarine bottlenose dolphin stocks that utilize the waters of northern South Carolina (Waring et al. 2014), but coastal data from this area are lacking. Photo-ID mark-recapture surveys were conducted from 2013-2015 along two 50 km coastal transects centered on Murrells Inlet, SC; and from 2014-2015 along two 50 km transects covering both coastal and estuarine waters centered on Little River, SC. Capture histories of marked individuals were used to estimate abundance and, in conjunction with neighboring catalog comparisons, infer movements, residency patterns, and stock membership. Local abundance …

Optimizing Vehicle Usage Using Csp, Sat And Max-Sat, Raheem T. Al Rammahi

Electronic Theses and Dissertations

Most of the companies in Iraq spend significant amounts of time and money when transferring employees between home and work. In this thesis, we model the problem of the Dhi Qar Oil company (DQOC) transportations using three modeling languages from AI: Constraint Programing (CP), Boolean Satisfiability (SAT), and Maximum Satisfiability (MAX-SAT). We then use solvers to find optimal solutions to this problem.

We show which of these solvers is more efficient when finding optimal solutions. For this purpose, we create a test suite of 360 problems to test these solvers. All solvers are applied to these problems and the final …

Photoassisted Generation Of Complex N, O, S Polyheterocycles, Weston James Umstead

Electronic Theses and Dissertations

This research set out to continue the exploration and diversification of excited state o-azaxylylene cycloadditions, utilizing both pre-photochemical and post-photochemical modifications.

Pre-photochemical modifications came through the addition of heteroatoms, namely nitrogen and oxygen, to the tether that links the unsaturated photopendant to the photogenerated o-azaxylylene. Photochemistry resulted in the formation of new, interesting N, O, S polyheterocycles.

Post-photochemical modifications took place through several different cycloaddition reactions, including a [4+2] hetero-Diels Alder reaction, a [4+2] Povarov cyclization, a [3+2] nitrile oxide addition, and a [3+2] nitrone cyclization. These reactions were applied first to a model system, and then to …

Quinolines: Novel Synthesis And Derivatives Of Heterocyclic Bioactive Agents, Ginelle A. Ramann

Electronic Theses and Dissertations

Tuberculosis is a pulmonary disease that has ravaged the world throughout history. Even today, many developed and developing countries are experiencing this plight, made worse by the scourge of antibiotic-resistant bacteria.

Mycobacterium tuberculosis's class II fructose-1,6-bisphosphate aldolase presents an interesting target in the design of new therapies against this disease. Previous attempts to construct an inhibitor to this enzyme fell short due to poor selectivity or poor cellular uptake. However a new class of noncompetitive inhibitor based on 8-hydoxyquinoline-2-carboxylic acid presents a fresh approach. Preliminary studies indicate various modifications to this scaffold could be beneficial to its inhibitory efficacy.

Modifications …

Greenc5: An Adaptive, Energy-Aware Collection For Green Software Development, Junya Michanan

Electronic Theses and Dissertations

Dynamic data structures in software applications have been shown to have a large impact on system performance. In this paper, we explore energy saving opportunities of interface-based dynamic data structures. Our results suggest that savings opportunities exist in the C5 Collection between 16.95% and 97.50%. We propose a prototype and architecture for creating adaptive green data structures by applying machine learning tools to build a model for predicting energy efficient data structures based on the dynamic workload. Our neural network model can classify energy efficient data structures based on features such as the number of elements, frequency of operations, interface …

Implementing Agile Development At Scale: An Industry Case Study, Nikita Kataria

Electronic Theses and Dissertations

Agile software development methodologies are extremely popular. Their dynamic restructuring of the development process has been seen as the silver bullet for increasing the productivity of software development. A significant number of studies have analyzed the impact of implementing agile techniques. However these are mostly evaluated only in smaller team settings. There is very little reporting done on how agile development methods can be implemented at the team level and scaled up at the program/portfolio level in large software organizations.

We present the results of an empirical study conducted at Pearson Education. The study focuses on the penetration of agile …

Molecular Mechanisms Of Protein Thermal Stability, Lucas Sawle

Electronic Theses and Dissertations

Organisms that thrive under extreme conditions, such as high salt concentration, low pH, or high temperature, provide an opportunity to investigate the molecular and cellular strategies these organisms have adapted to survive in their harsh environments. Thermophilic proteins, those extracted from organisms that live at high temperature, maintain their structure and function at much higher temperatures compared to their mesophilic counterparts, found in organisms that live near room temperature. Thermophilic and mesophilic homolog protein pairs have identical functionality, and show a high degree of structural and sequential similarity, but differ significantly in their response to high temperature. Addressing the principles …

A Descriptive Study Of The Effect Of Payer Source On Multiple Longitudinal Outcome Measures Within The Tbi Model Systems National Database Using Longitudinal Hlm Analyses, Melissa Carole Hofmann

Electronic Theses and Dissertations

Using longitudinal data from the TBIMS ND, this study utilized a longitudinal hierarchical linear modeling approach to describe the effect of primary payer source on individual level change in outcomes including the FIM and DRS. To facilitate the use of parametric statistics, Rasch-transformed FIM and DRS scores were utilized; thus approaching an interval level of measurement. The FIM was separated into 3 separate cognitive, mobility, and self-care subscales. In this way, rehabilitation professionals including speech, physical, and occupational therapists for this TBI sample could reference results to inform current clinical practice.

Results indicated that FIM and DRS trajectories were best …

A Comparison Of Latent Class Analysis And The Mixture Rasch Model: A Cross-Cultural Comparison Of 8th Grade Mathematics Achievement In The Fourth International Mathematics And Science Study (Timss-2011), Turker Toker

Electronic Theses and Dissertations

This study provides a comparison of the results of latent class analysis (LCA) and mixture Rasch model (MRM) analysis using data from the Trends in International Mathematics and Science Study - 2011 (TIMSS-2011) with a focus on the 8th-grade mathematics section. The research study focuses on the comparison of LCA with Mplus version 7.31 and MRM with WinMira 2011 to determine if results obtained differ when the assumed psychometric model differs. Also, a log-linear analysis was conducted to understand the interactions between latent classes identified by LCA and MRM. The data set used in the study was from four diverse …

A Comparison Between Propensity Score Matching, Weighting, And Stratification In Multiple Treatment Groups: A Simulation Study, Priyalatha Govindasamy

Electronic Theses and Dissertations

The application of propensity score techniques (matching, stratification, and weighting) with multiple treatment levels are similar to those used in binary groups. However, given that the application of propensity scores in multiple treatment groups is new, factors affecting the performance of matching, stratification, and weighting in multiple treatment groups are less explored. Therefore, this study was conducted to determine the performance of different propensity score techniques with multiple treatment groups under various circumstances. Specifically, the study focused on examining how the three propensity score corrective techniques perform in estimating treatment effects under (1) overt and (2) hidden types of selection …

Relaxation Of Metals And Their Impact On Nitroxides, Priyanka Aggarwal

Electronic Theses and Dissertations

Pulsed and continuous wave electron spin resonance were used to characterize the relaxation rates of selected paramagnetic metals at 5 to 15 K or 80 K, measure the impact of these rapidly relaxing metals on the relaxation rates of nitroxide radicals in glassy mixtures and in discrete complexes, and characterize novel iron-sulfur proteins.

Spin echoes were observed at 5 to 7 K in 1:1 water:glycerol for Er(diethylenetriamine pentaacetic acid)^2- (Er(DTPA)^2-), Co(DTPA)^3- and aquo Co²⁺ with relaxation times that are strongly temperature dependent. Deep proton modulation was present on spin echo decays (Ch. 3). For Gd …