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Articles 1 - 20 of 20
Full-Text Articles in Physical Sciences and Mathematics
Investigating The Structure Of The Papain-Inhibitor Complex Using Spr And Nmr, Margaret Sara Thomasson
Investigating The Structure Of The Papain-Inhibitor Complex Using Spr And Nmr, Margaret Sara Thomasson
LSU Doctoral Dissertations
Cysteine proteases (CPs) are enzymes with a nucleophilic thiol in their active sites. Inhibitors of cysteine proteases (ICPs) occur naturally in bacterial pathogens and some protozoa. In parasites, ICPs are often virulence factors, contributing to the formation and survival of amastigotes within host cells. These amastigotes have higher CP activity, therefore making both ICPs and CPs potential drug targets. Despite great genetic variability, ICPs contain highly conserved structural features, including a series of defined loops that play a significant role in binding CPs. Papain, a CP from Carica papaya, complexes with ICP from Leishmania mexicana. Although the individual 3-D structures …
Fundamental Studies Of Humic Acid's Influence On Pollutant Toxicity To Aquatic Organisms, Rachel Dawn Deese
Fundamental Studies Of Humic Acid's Influence On Pollutant Toxicity To Aquatic Organisms, Rachel Dawn Deese
LSU Doctoral Dissertations
The main purpose of the research presented in this dissertation was to further understand the intricate and convoluted interactions between natural organic material, biological entities, and pollutants. This was achieved by utilizing humic acids (HAs) from differing sources, chemically modified humic acid, two biological entities (model biomembranes and Artemia Franciscana), and three types of pollutants (cations, surfactants, and carbon nanotubes). Fluorescence spectroscopy and model biomembranes were used to measure the change in HA’s ability to interact with the biomembranes in the presence of cations. Three differently sourced HAs, chemical modified HAs, and a range of cations were studied to elucidate …
Microelectrophoresis System Utilizing Conductivity Detection Analyzing Biological Molecues, Michelle Galloway
Microelectrophoresis System Utilizing Conductivity Detection Analyzing Biological Molecues, Michelle Galloway
LSU Doctoral Dissertations
Microfabrication technology has proven to be a valuable tool for creating polymer-based devices utilized in chemical and biochemical assays. Although, reducing the size of the device allows for short analysis times and reduces the reagent demand to ultrasmall volumes (< 1 nanoliter), a resulting consequence is the constraint placed on the limits of detection associated with the detector hardware required for readout. To overcome such constraints, laser-induced fluorescence (LIF) is often employed as a detection method as it provides low detection limits, which approach the single molecule level. Unfortunately, most LIF systems do not offer the benefits of miniaturization, with the detector components (i.e. laser, optics, filters) often times requiring a much larger footprint compared to the device. Another readout strategy that has shown promise for these devices is conductivity detection. Detection can be accomplished using either conventional-size or microfabricated electrodes, which can be integrated on the device. Although conductivity has been commonly used to detect inorganic or small organic species, the potential for detection of biological species has received little attention. In this work, an integrated conductivity detector was developed for the analysis of amino acids, peptides, proteins, and oligonucleotides (double-stranded DNA). Using the detector, mass detection sensitivities in the range of 10-18 - 10-21 moles were achieved. To increase the throughput of the system a state-of-the-art, multichannel device with a conductivity array detector was devised. This device, which consists of a 16-channel fluidic network and a printed circuit board, is geared toward automating three-processing steps onto a single fluidic platform including purification, preconcentration and detection for downstream parallel processing.
Chromatographic Studies., Richard Thomas Moravek
Chromatographic Studies., Richard Thomas Moravek
LSU Historical Dissertations and Theses
No abstract provided.
A Study Of Line-Width Photographic Photometry For Use In Spectrochemical Analysis., John A. Perry
A Study Of Line-Width Photographic Photometry For Use In Spectrochemical Analysis., John A. Perry
LSU Historical Dissertations and Theses
No abstract provided.
Analytical Studies Of Some Acyloin-Oximes., Hans A. Suter
Analytical Studies Of Some Acyloin-Oximes., Hans A. Suter
LSU Historical Dissertations and Theses
No abstract provided.
A Study Of The Factors Which Influence Selectivity In Liquid Extraction., Robert Christie Binning
A Study Of The Factors Which Influence Selectivity In Liquid Extraction., Robert Christie Binning
LSU Historical Dissertations and Theses
No abstract provided.
A Study Of Temperature Effect On Adsorption Chromatography., Lie Tien Chang
A Study Of Temperature Effect On Adsorption Chromatography., Lie Tien Chang
LSU Historical Dissertations and Theses
No abstract provided.
Chromatography With Aqueous And Polar Solvents., Mary Veronica Drawe
Chromatography With Aqueous And Polar Solvents., Mary Veronica Drawe
LSU Historical Dissertations and Theses
No abstract provided.
A Study Of Some Factors Affecting Chromatographic Adsorption., Patterson B. Moseley
A Study Of Some Factors Affecting Chromatographic Adsorption., Patterson B. Moseley
LSU Historical Dissertations and Theses
No abstract provided.
Studies In Analytical Chemistry: I. New Methods For The Determination Of Ash In Petroleum Crudes. Ii. Studies In Oscillographic Polarography., Gerald Perkins
Studies In Analytical Chemistry: I. New Methods For The Determination Of Ash In Petroleum Crudes. Ii. Studies In Oscillographic Polarography., Gerald Perkins
LSU Historical Dissertations and Theses
No abstract provided.
The Detection And Determination Of Antimony By Means Of Rhodamine B., William Cornelius Hamilton
The Detection And Determination Of Antimony By Means Of Rhodamine B., William Cornelius Hamilton
LSU Historical Dissertations and Theses
No abstract provided.
Chromatographic Studies., Patrick Henry Monaghan
Chromatographic Studies., Patrick Henry Monaghan
LSU Historical Dissertations and Theses
No abstract provided.
Some Applications Of Chromatography To Specific Problems., Marvin Lee Owens
Some Applications Of Chromatography To Specific Problems., Marvin Lee Owens
LSU Historical Dissertations and Theses
No abstract provided.
The Application Of High Frequency Oscillations To Chemical Analysis., Thomas Shepherd Burkhalter
The Application Of High Frequency Oscillations To Chemical Analysis., Thomas Shepherd Burkhalter
LSU Historical Dissertations and Theses
No abstract provided.
Studies In The Application Of Extraction Methods To Analytical Chemistry., Jack Kenneth Carlton
Studies In The Application Of Extraction Methods To Analytical Chemistry., Jack Kenneth Carlton
LSU Historical Dissertations and Theses
No abstract provided.
A Spectrophotometric Study Of Some Deuterium Substituted Toluenes--Infrared Region., Olen Alvin Nance
A Spectrophotometric Study Of Some Deuterium Substituted Toluenes--Infrared Region., Olen Alvin Nance
LSU Historical Dissertations and Theses
No abstract provided.
A Spectral Study Of Some Deuterated Toluenes., Charles Hooper Smith
A Spectral Study Of Some Deuterated Toluenes., Charles Hooper Smith
LSU Historical Dissertations and Theses
No abstract provided.
The Preparation And Properties Of Some 1-Alkyl-Cyclopentanols And Their Derivatives., Crawford Reid Mclellan
The Preparation And Properties Of Some 1-Alkyl-Cyclopentanols And Their Derivatives., Crawford Reid Mclellan
LSU Historical Dissertations and Theses
No abstract provided.
A Kinetic Study Of A Homogeneous, Unimolecular Gaseous Decomposition Reaction., Harold Arthur Frediani
A Kinetic Study Of A Homogeneous, Unimolecular Gaseous Decomposition Reaction., Harold Arthur Frediani
LSU Historical Dissertations and Theses
No abstract provided.