Physical Sciences and Mathematics Commons^™

Nonhematopoietic Erythropoietin: A Study Of Signaling, Structure, And Behavior, Nicholas John Pekas

Dissertations and Theses

Erythropoietin (EPO) is a cytokine hormone known for initiating red blood cell proliferation by binding to its homodimer receptor (EPOR)2 in the bone marrow. Recent progress in neurobiology has shown that EPO also exerts robust neurotrophic and neuroprotective activity in the CNS. It is widely thought that EPO’s neurotrophic activity is centrally involved in its antidepressant and cognitive enhancing effects. However, EPO’s potent erythropoietic effects prevent it from being used in the clinic to treat psychiatric disorders. A chemically engineered non-erythropoietic derivative of EPO, carbamoylated EPO (CEPO), produces psychoactive effects without activating hematopoiesis. However, CEPO is expensive to produce and …

Deep Features To Analyze Pulmonary Abnormalities In Chest X-Rays Due To Covid-19, Supriti Ghosh

Dissertations and Theses

Artificial Intelligence (AI) has contributed a lot since the beginning. Healthcare is no exception. Detecting anomaly/abnormality in (bio)medical image is crucial. In this thesis, we aim at detecting/screening pulmonary abnormalities due to Covid-19 in chest X-rays using deep features. We study CheXNet, DenseNet169, ResNet50 and VggNet16 to analyze CXRs to detect the evidence of Covid-19 in this research. CheXNet was primarily designed for radiologist-level pneumonia detection in Chest X-rays (CXRs). We created a benchmark dataset size of 4,716 CXRs (2,358 Covid-19 positive cases and 2,358 non-Covid cases (Healthy and Pneumonia cases)) and with k(=5) fold cross-validation technique, using the DenseNet, …

Graph Realizability And Factor Properties Based On Degree Sequence, Daniel John

Electronic Theses and Dissertations

A graph is a structure consisting of a set of vertices and edges. Graph construction has been a focus of research for a long time, and generating graphs has proven helpful in complex networks and artificial intelligence.

A significant problem that has been a focus of research is whether a given sequence of integers is graphical. Havel and Hakimi stated necessary and sufficient conditions for a degree sequence to be graphic with different properties. In our work, we have proved the sufficiency of the requirements by generating algorithms and providing constructive proof.

Given a degree sequence, one crucial problem is …

The Design And Testing Of Fluorescence-Based Sensors For Phosphate And Phosphonate, Sara Hassanzadehroknabadi

Electronic Theses and Dissertations

Inorganic phosphate (Pi) is an essential compound for all living things, as it serves as a component of nucleic acids and ATP, which are required for plant growth and proliferation. However, when excess Pi enters the aquatic environment, it has severe detrimental effects through the induction of harmful algal blooms (HAB), which negatively impact aquatic life, the quality of drinking water as well as recreational activities. It is therefore critical to have fast, sensitive, and inexpensive sensors for Pi that quickly and quantitively measure its concentration in a field setting.

Phosphonates or organophosphorus compounds are phosphoric acids possessing alkyl or …

Influence Of Ceramide On Lipid Domain Stability Studied With Small-Angle Neutron Scattering: The Role Of Acyl Chain Length And Unsaturation, Mitchell Dipasquale, Tye G. Deering, Dhimant Desai, Arun K. Sharma, Shantu Amin, Todd E. Fox, Mark Kester, John Katsaras, Drew Marquardt, Frederick A. Heberle

Chemistry and Biochemistry Publications

Ceramides and diacylglycerols are groups of lipids capable of nucleating and stabilizing ordered lipid domains, structures that have been implicated in a range of biological processes. Previous studies have used fluorescence reporter molecules to explore the influence of ceramide acyl chain structure on sphingolipid-rich ordered phases. Here, we use small-angle neutron scattering (SANS) to examine the ability of ceramides and diacylglycerols to promote lipid domain formation in the well-characterized domain- forming mixture DPPC/DOPC/cholesterol. SANS is a powerful, probe-free technique for interrogating membrane heterogeneity, as it is differentially sensitive to hydrogen's stable isotopes protium and deuterium. Specifcally, neutron contrast is generated …

Reinforcement Learning Applied To The Shoals Marine Laboratory Smart Grid, Daniel C. Mattson

Honors Theses and Capstones

Reinforcement learning (RL) techniques have been applied to smart grids with a variety of applications. The most common objective is to optimize profit for one actor in the system. The goal of this work is to apply different RL models to the smart grid at the Shoals Marine Laboratory (SML) located on Appledore Island, Maine in an effort to reduce costs and minimize the amount of nonrenewable energy consumed on the island. The RL models implemented resulted in more sustainable practices in simulations, with a linear spline model outperforming the naive policy the SML currently uses. Future work includes extending …

Generally Covariant Theory Of Multipole Moment Conserving Quasiparticles, Gavin Eric Riley

Honors Theses and Capstones

This report represents the creation of a field theory which is capable of describing quasiparticle excitations that preserve 2^k -pole moments. These quasiparticles exhibit certain ’semidynamic’ properties such as individual particle immobility but free movement of bound 2^L-tuples. We provide a review of work done on dipole conserving fractons and their dynamics [1] and expand upon it to describe higher moment conserving systems with global quadratic (and higher) phase symmetry. This requires the selection of the temporal and spatial directions. The selection of a temporal direction is done with a foliation defined by an anisotropic scaling of space and time, …

Comparing Twins Ion Temperature Maps With Mms, Ampere, And Themis Observations During July 26, 2017 Reconnection Event, Isabella M. Householder

Honors Theses and Capstones

The solar wind releases a constant stream of ionized particles into space which causes complex behaviors to occur within Earth’s magnetosphere. These disruptions can initiate magnetic reconnection and cause flow reversal of ions in the magnetotail. Two flow reversal events were locally detected by the Magnetospheric Multiscale Mission (MMS) on July 26, 2017 at 0700 UT and 0730 UT. The Two Wide-Angle Imaging Neutral-Atom Spectrometers (TWINS) provide a global measurement of heated signatures of the magnetic field and detected an increase in ion temperature during these reconnection events without the presence of a geomagnetic storm. Active Magnetosphere and Planetary Electrodynamics …

Development Of A Fluxgate Magnetometer Model, Eleonora Olsmats

Honors Theses and Capstones

As a part of the UNH SWFO-L1 mission to monitor space weather and the sun’s behavior, the fluxgate magnetometer is an important component to measure external magnetic fields. The basic principle of a fluxgate magnetometer is to detect changes in the ambient magnetic field by inducing a magnetic field in a ferromagnetic material via a drive winding. Each magnetometer is unique due to the ferromagnetic properties of the core material which can be seen in the hysteresis loop which is a relationship between the magnetic field strength (H) and the induced magnetic field (B). Measuring the hysteresis of a fluxgate …

Constraining The Star Formation Histories Of Galaxies In The Swift/Uvot + Manga (Swim) Value-Added Catalog, Nikhil Ajgaonkar

Theses and Dissertations--Physics and Astronomy

Although our understanding about galaxy evolution has improved in the past few
decades, we still do not understand how galaxies suddenly stop forming stars and move towards a quiescent phase. In order to do that, we must derive the Star Formation Histories (SFHs) of galaxies, that trace the change in Star Formation (SF) inside the galaxy over the cosmic timescale. This is achieved by using a set of spatially resolved near-ultraviolet (NUV) and optical spectroscopic images of the galaxies. We generate the Swift/UVOT + MaNGA value added catalog (SwiM VAC; Molina et al., 2020b) which comprises 150 galaxies having a …

Biofabrication Of Magnetic Nanoparticles And Their Use As Carriers For Pectinase And Xylanase, Shady S. Hassan, Brendan Duffy, Gwilym A. Williams, Amit Jaiswal

Articles

In this study, superparamagnetic iron oxide nanoparticles (MNPs) were synthesized via exposure of fungal cell filtrate from Aspergillus flavus to aqueous iron ions. The extracellular synthesis of MNPs was monitored by UV–Vis spectrophotometry and showed an absorption peak at 310 nm. The morphology of MNPs was found to be flake-like, as confirmed by Field Emission Scanning Electron Microscopy (FESEM), while the average crystallite size was ∼16 nm, as determined by X-ray diffraction (XRD). Energy dispersive X-ray (EDX) analysis was performed to confirm the presence of elemental Fe in the sample. Pectinase and xylanase were covalently immobilized on MNPs with efficiencies …

A Modified Spectroscopic Approach For The Real-Time Detection Of Pollen And Fungal Spores At A Semi-Urban Site Using The Wibs-4+, Part I, Emma Markey, Jerry Hourihane Clancy, Moisés Martínez-Bracero, Finnian Neeson, Roland Sarda-Estève, Dominique Baisnée, Eoin Mcgillicuddy, Gavin Sewell, David J. O’Connor

Articles

The real-time monitoring of primary biological aerosol particles (PBAP) such as pollen and fungal spores has receivedmuch attention in recent years as a result of their health and climatic effects. In this study, theWideband Integrated Bioaerosol Sensor (WIBS) 4+ model was evaluated for its ability to sample and detect ambient fungal spore and pollen concentrations, compared to the traditional Hirst volumetric method. Although the determination of total pollen and fungal spore ambient concentrations are of interest, the selective detection of individual pollen/fungal spore types are often of greater allergenic/agricultural concern. To aid in this endeavour, modifications were made to the …

Thermalization And Quantum Information In Conformal Field Theory, Ashish Kakkar

Theses and Dissertations--Physics and Astronomy

The consequences of the constraints of conformal symmetry are far-reaching within
theoretical physics. In this dissertation we address a series of questions in conformal
field theory: 1) We calculate the spectrum of qKdV charges in a large central charge
expansion. 2) We determine the corrections to bulk information geometry from 1/N
contributions to holographic correlators. 3) We study the higher genus partitions
functions of CFTs associated with classical and quantum error-correcting codes.

High Performance Data Acquisition And Analysis Routines For The Nab Experiment, David Mathews

Theses and Dissertations--Physics and Astronomy

Probes of the Standard Model of particle physics are pushing further and further into the so-called “precision frontier”. In order to reach the precision goals of these experiments, a combination of elegant experimental design and robust data acquisition and analysis is required. Two experiments that embody this philosophy are the Nab and Calcium-45 experiments. These experiments are probing the understanding of the weak interaction by examining the beta decay of the free neutron and Calcium-45 respectively. They both aim to measure correlation parameters in the neutron beta decay alphabet, a and b. The parameter a, the electron-neutrino correlation coefficient, is …

Understanding The Degradation Mechanism In Methyl Ammonium Lead Halide Perovskite And Black Phosphorene Via Electrical Transport Study, Huda Saleh Aljeailan

Theses and Dissertations--Physics and Astronomy

This work seeks to understand the degradation mechanism of technically important material systems such as black phosphorene (BP), arsenic phosphorene (AsP) and Methyl ammonium lead iodide (CH₃NH₃PbI₃) perovskite. Degradation studies were conducted by studying the in-situ electrical transport properties (resistance and thermoelectric power (TEP)) of these materials in vacuum (under annealed condition) and after exposure to the ambient air.

BP and both exhibited p-type semiconducting (positive TEP) behavior under annealed conditions and the changes in their transport properties upon exposure to ambient air can be explained as due to the charge transfer between the …

Data Acquisition, Analysis And Simulations For The Fermilab Muon G−2 Experiment, Fang Han

Theses and Dissertations--Physics and Astronomy

The goal of the new Muon g-2 E989 experiment at Fermi National Accelerator Laboratory (FNAL) is a precise measurement of the muon anomalous magnetic moment, a_μ ≡ (g-2)/2. The previous BNL experiment measured the anomaly a_μ(BNL) with an uncertainty of 0.54 parts per million (ppm). The discrepancy between the current standard model calculation of the a_μ(SM) and the previous measurement a_μ(BNL) is over 3σ. The FNAL Muon g-2 experiment aims at increasing the precision to 140 parts per billion (ppb) to resolve the discrepancy between the theoretical …

The Synthesis And Biocatalytic Reduction Of Beta-Keto Alkynes, Rhema M. Francis

Electronic Theses and Dissertations

The preparation of enantiopure homopropargyl alcohols (but-3-yn-ols) is of high importance to the scientific community. They are employed as valuable pharmaceutical intermediates and are opportune to generate antiviral nucleoside analogues. Chiral inducement of these molecules thus far has been poor (low ee) and has constituted a key challenge for asymmetric synthesis in the last few decades. Enzyme-catalyzed enantioselective reductions of ketones have become popular to produce thus-prepared synthons on an industrial scale. Among them, biocatalysts (dehydrogenases, reductases) emerge as a biodegradable option for chemical transformations, in comparison to chiral catalysts that employ highly toxic metals. This research investigates the catalytic …

The Application Of Deep Learning And Cloud Technologies To Data Science, Ian A. Trawinski

Electronic Theses and Dissertations

Machine Learning and Cloud Computing have become a staple to businesses and educational institutions over the recent years. The two forefronts of big data solutions have garnered technology giants to race for the superior implementation of both Machine Learning and Cloud Computing. The objective of this thesis is to test and utilize AWS SageMaker in three different applications: time-series forecasting with sentiment analysis, automated Machine Learning (AutoML), and finally anomaly detection. The first study covered is a sentiment-based LSTM for stock price prediction. The LSTM was created with two methods, the first being SQL Server Data Tools, and the second …

Neuromatch Academy: A 3-Week, Online Summer School In Computational Neuroscience, Bernard Marius 'T Hart, Titipat Achakulvisut, Ayoade Adeyemi, Athena Akrami, Bradly Alicea, Alicia Alonso-Andres, Diego Alzate-Correa, Arash Ash, Jesus J. Ballesteros, Aishwarya Balwani, Eleanor Batty, Ulrik Beierholm, Ari S. Benjamin, Upinder Bhalla, Gunnar Blohm, Joachim C. H. Blohm, Kathryn Bonnen, Marco Brigham, Bingni W. Brunton, John Butler, Brandon Caie, N Alex Cayco Gajic, Sharbatanu Chatterjee, Spyridon Chavlis, Ruidong Chen, You Cheng, H. M. Chow, Raymond Chua, Yunwei Dai, Isaac David, Eric E. J. Dewitt, Julien Denis, Alish Dipani, Arianna Dorschel, Jan Drugowitsch, Kshitij Dwivedi, Sean Escola, Haoxue Fan, Roozbeh Farhoodi, Yicheng Fei, Pierre-Étienne Fiquet, Lorenzo Fontolan, Jeremy Forest, Yuki Fujishima, Byron V. Galbraith, Mario Galdamez, Richard Gao, Julijana Gjorgjieva, Alexander Gonzalez, Qinglong Gu, Yueqi Guo, Ziyi Guo, Pankaj K. Gupta, Busra Tugce Gurbuz, Caroline Haimerl, Jordan B. Harrod, Alexandre Hyafil, Martin Irani, Daniel Jacobson, Michelle Johnson, Ilenna Simone Jones, Gili Karni, Robert E. Kass, Hyosub Edward Kim, Andreas M. Kist, Randal Koene, Konrad Kording, Matthew R. Krause, Arvind Kumar, Norma K. Kühn, Ray Lc, Matthew L. Laporte, Junseok Lee, Songting Li, Sikun Lin, Yang Lin, Shuze Liu, Tony Liu, Jesse A. Livezey, Linlin Lu, Jakob H. Macke, Kelly Mahaffy, A. Lucas Martins, Nicolás Martorell, Manolo Martínez, Marcelo G. Mattar, Jorge Aurelio Menendez, Kenneth D. Miller, Patrick J. Mineault, Nosratullah Mohammadi, Yalda Mohsenzadeh, Elenor Morgenroth, Taha Morshedzadeh, Alice Claudia Mosberger, Madhuvanthi Muliya, Marieke Mur, John D. Murray, Yashas Nd, Richard Naud, Prakriti Nayak, Anushka Oak, Itzel Olivos Castillo, Seyedmehdi Orouji, Jorge Otero-Millan, Marius Pachitariu, Biraj Pandey, Renato Paredes, Jesse Parent, Il Memming Park, Megan A. K. Peters, Xaq Pitkow, Panayiota Poirazi, Haroon Popal, Sandhya Prabhakaran, Tian Qiu, Srinidhi Ragunathan, Raul Rodriguez-Cruces, David Rolnick, Ashish Kumar Sahoo, Saeed Salehinajafabadi, Cristina Savin, Shreya Saxena, Paul Schrater, Karen Schroeder, Alice C. Schwarze, Madineh Sedigh-Sarvestani, K. Yuvaraj Sekhar, Reza Shadmehr, Maryam M. Shanechi, Siddhant Sharma, Eric Shea-Brown, Krishna V. Shenoy, Carolina L. Shimabukuro, Sergey Shuvaev, Man Ching Alison Sin, Maurice Smith, Nicholas A. Steinmetz, Karolina Stosio, Elizabeth Straley, Gabrielle Strandquist, Carsen Stringer, Rimjhim Tomar, Ngoc Tran, Sofia Triantafillou, Lawrence Udeigwe, Davide Valeriani, Vincent Valton, Maryam Vaziri-Pashkam, Peter Vincent, Gal Vishne, Pascal Wallisch, Peiyuan Wang, Claire Ward, Michael Waskom, Kunlin Wei, Anqi Wu, Zhengwei Wu, Brad Wyble, Lei Zhang, Daniel Zysman, Federico D’Oleire Uquillas, Tara Van Viegen

Articles

No abstract provided.

The Effects Of Channel Incision And Land Use On Surface-Water/Groundwater Interactions In The Teanaway River Basin, Washington, Usa, Joseph Petralia

All Master's Theses

The Teanaway River basin, a major tributary to the Yakima River, is host to several restoration projects with the intention of returning the river channel to a more natural state and improving riparian habitat. These projects may also increase aquifer storage and potentially increase summertime streamflows. This study of the Teanaway Valley Family Farm, an 88-hectare parcel on the main-stem Teanaway River that was recently purchased by Washington Department of Fish and Wildlife, provides hydrogeologic data that will inform these restoration projects. Following the purchase of this land, ten wells were installed within and slightly above the floodplain in order …

Satellite Evidence Of Canopy-Height Dependence Of Forest Drought Resistance In Southwestern China, Peipei Xu, Wei Fang, Tao Zhou, Hu Li, Xiang Zhao, Spencer Berman, Ting Zhang, Chuixiang Yi

Publications and Research

The frequency and intensity of drought events are increasing with warming climate, which has resulted in worldwide forest mortality. Previous studies have reached a general consensus on the size-dependency of forest resistance to drought, but further understanding at a local scale remains ambiguous with conflicting evidence. In this study, we assessed the impact of canopy height on forest drought resistance in the broadleaf deciduous forest of southwestern China for the 2010 extreme drought event using linear regression and a random forest (RF) model. Drought condition was quantified with standardized precipitation evapotranspiration index (SPEI) and drought resistance was measured with the …

Automatic Cephalometric Landmark Detection On X-Ray Images Using Object Detection, Cheng-Ho King, Yin-Lin Wang, Chia-Ling Tsai

Publications and Research

We propose a new deep convolutional cephalometric landmark detection framework for orthodontic treatment. Our proposed method consists of two major steps: landmark detection using a deep neural network for object detection, and landmark repair to ensure one instance per landmark class. For landmark detection, we modify the loss function of the backbone network YOLOv3 to eliminate the constrains on the bounding box and incorporate attention mechanism to improve the detection accuracy. For landmark repair, a triangle mesh is generated from the average face to eliminate superfluous instances, followed by estimation of missing landmarks from the detected ones using Laplacian Mesh. …

Fixed Points Of Functions Below The Line Y = X, Grace Fryling, Harrison Rouse

Undergraduate Mathematics Day: Past Content

This paper concerns fixed points of functions whose graphs lie on or below the line y = x. Using the Monotone Convergence Theorem, we show that positive fixed points of such functions are “attracting on the right” so long as we include a couple of further assumptions about these functions near their fixed points. As an illustrative example, we confirm that this is the case for the function y = x sin x; the positive fixed points of this function “attract on the right” and “repel on the left.” Further, we generalize by showing that differentiability is in fact not …

Finding An Effective Shape Parameter Strategy To Obtain The Optimal Shape Parameter Of The Oscillatory Radial Basis Function Collocation In 3d, Quinnlan Aiken, Annika Murray, Ar Lamichhane

Undergraduate Mathematics Day: Past Content

Recent research into using the Method of Approximate Particular Solutions to numerically solve partial differential equations, has shown promising results. High levels of accuracy can be obtained when implementing this method, however the success of this collocation method is dependent on a shape parameter that is found in nearly all radial basis functions. If the shape parameter is not appropriately chosen, then it can provide an unacceptable result. Two shape parameter strategies are considered, a random variable shape parameter strategy and a leave-one-out cross validation strategy. The main objective of this work is to assess the viability of using these …

Evolution Of Drought And Low Temperature Responses In Temperate Pooideae Grasses: Timings, Determinants, And Intersections, Aayudh Das

Graduate College Dissertations and Theses

Anthropogenically-mediated rises in atmospheric CO2 and global average temperatures is leading to increasingly severe drought and extreme weather events, the latter including unseasonal bouts of low and high temperatures. In order for plant breeders and conservation biologists to predict future responses to global warming, they must understand the ecological and evolutionary processes that shaped plant tolerance to stressful environments in the past. This is particularly true for grasses (Poaceae) that dominate approximately one-third of the Earth's vegetative cover, live in some of the world's harshest terrestrial environments, and are tremendously important, both ecologically and economically. One of the largest subfamily …

Resonant Trojan Emris With Lisa, Vanessa Myhaver

Graduate College Dissertations and Theses

Extreme--mass--ratio inspirals (EMRI) are prospective sources for the detection of observational signals with the Laser Interferometer Space Antenna (LISA) mission, built to accurately detect and measure gravitational waves -- ripples in the curvature, and fabric of space--time. EMRIs are typically comprised of a supermassive black hole (SMBH) one million times more massive than our Sun, and a stellar--origin black hole several orders of magnitude smaller. As the smaller black hole spirals into the supermassive black hole, thousands of cycles of the gravitational waveform serve as a precision probe for the extreme space-time curvature of the system. The goal of this …

Gauge Against The Machine: Improving Representations Within Sociotechnical Instruments To Enrich Context And Identify Biases, Joshua Minot

Graduate College Dissertations and Theses

The proliferation of digital data across all areas of society has transformed our ability to hypothesize, study, and understand social systems.From this richness of data we have seen the development of innovative instruments to study---and make decisions with---the digital artifacts of the modern day. These developments build on advancements in computation, connectivity, analytical methodologies, and sociological theories. The sociotechnical instruments we have developed have been revolutionary to how we understand society and how we conduct business, but with these broad leaps comes ample room (and need) for more nuanced advancements. As with the development of any field, as the digital …

The Impact Of Prior Exposure To Physics On Students' Transition To Flipped Classrooms With Active Learning, Johnny Gonzalez

Graduate College Dissertations and Theses

The pedagogical approach of the flipped classroom with an active learning model shows great benefit for all students in many disciplines. This study explored the possibility that certain subsets of students may have varying benefits from this model. In this study, we used survey questions to categorize students and analysis of the Forced Concept Inventory (FCI) scores, including normalized gain (NG), to measure learning improvement. In particular, we used a questionnaire with two questions that were used to partition each sub-group. The first group consisted of students that have varying levels of physics knowledge and the second group consisted of …

On The Use Of Allen’S Interval Algebra In The Coordination Of Resource Consumption By Transactional Business Processes, Zakaria Maamar, Fadwa Yahya, Lassaad Ben Ammar

All Works

This paper presents an approach to coordinate the consumption of resources by transactional business processes. Resources are associated with consumption properties known as unlimited, limited, limited-but-extensible, shareable, and non-shareable restricting their availabilities at consumption-time. And, processes are associated with transactional properties known as pivot, retriable, and compensatable restricting their execution outcomes in term of either success or failure. To consider the intrinsic characteristics of both consumption properties and transactional properties when coordinating resource consumption by processes, the approach adopts Allen’s interval algebra through different time-interval relations like before, overlaps, and during to set up the coordination, which should lead to …

Using Circle Packings To Approximate Harmonic Measure Distribution Functions, Ella Wilson

Undergraduate Mathematics Day: Past Content

Harmonic measure distribution functions, h-functions, encode information about the geometry of domains in the plane. Specifically, given a domain and a basepoint in the domain, for a fixed radius, r, the value h(r) is the probability that a Brownian particle first exits the domain within distance r of the basepoint. There are many domains for which we can compute h-functions, such as the disk and the inside and outside of a wedge. However, exact computation is often difficult or impossible for more complicated domains, so we need methods to approximate these h-functions. In this paper, we develop two methods for …