Physical Sciences and Mathematics Commons^™

A Novel Nonparametric Test For Heterogeneity Detection And Assessment Of Fluid Removal Among Crrt Patients In Icu, Shaowli Kabir

Theses and Dissertations--Epidemiology and Biostatistics

Over the past decade acute kidney injury (AKI) has been occurring among 20%-50% of patients admitted to the intensive care unit (ICU) in United States. Continuous renal replacement therapy (CRRT) has become a popular treatment method among these critically ill patients. But there are multiple complications in implementing this treatment, including discrepancies in practiced and prescribed fluid removal, possibly related to the heterogeneity among these patients. With mixture modeling there have been several techniques in detecting heterogeneity with their specific limitations. In this dissertation a novel nonparametric ‘d test’ will be used to detect heterogeneity among CRRT patients in ICU. …

Distribution Of Particulate Organic Carbon – Fluxes And Inventories – In Growth-Faulted Coastal Wetlands, Samuel Joel Whitehead

Theses and Dissertations--Earth and Environmental Sciences

Coastal wetlands along the Northern Gulf of Mexico (NGOMx) are critically important but threatened environments which provide significant and diverse economic, social, and environmental value. These environments are essential components to the global carbon cycle, serving as one of the most efficient terrestrial carbon sinks. Since onset of the Industrial Revolution increasing rates of coastal wetland loss have been documented due to a variety of anthropogenic activities, neotectonic processes, subsidence, and rising sea-levels. This research utilized an array of methods and sedimentological analyses to test the hypothesis that growth-fault induced changes at Earth’s surface affects the delivery to, and storage …

The Revised Systematics And Paleoecology Of The Devonian Stemless Crinoid Genus Edriocrinus Hall, 1858, Catherine E. Herbert

Theses and Dissertations--Earth and Environmental Sciences

New morphological observations of Edriocrinus Hall, 1858, enable a modern, holistic view of this unusual crinoid genus, previously included in the Superorder Flexibilia (Zittel, 1895) Wright et al., 2017. Re-analysis of Edriocrinus suggests that the genus should now be assigned to the Order ‘Dendrocrinida’ within the Magnorder Eucladida Wright, 2017 based on the five infrabasals, single radianal in the cup, absent anal sac, and non-pinnulate arms with rectangular uniserial brachials. Moreover, examination of the slight variations separating the current 14 Edriocrinus species indicates that these “species” are likely ecophenotypes. The current Edriocrinus species are revised based on firmly bound calyx …

The Performance Optimization Of Asp Solving Based On Encoding Rewriting And Encoding Selection, Liu Liu

Theses and Dissertations--Computer Science

Answer set programming (ASP) has long been used for modeling and solving hard search problems. These problems are modeled in ASP as encodings, a collection of rules that declaratively describe the logic of the problem without explicitly listing how to solve it. It is common that the same problem has several different but equivalent encodings in ASP. Experience shows that the performance of these ASP encodings may vary greatly from instance to instance when processed by current state-of-the-art ASP grounder/solver systems. In particular, it is rarely the case that one encoding outperforms all others. Moreover, running an ASP system on …

Investigating The Uncertainties In Ct Non-Small Cell Lung Cancer Radiomics, Gary Ge

Theses and Dissertations--Radiation Medicine

Radiomics is a technique that extracts quantitative features, termed radiomic features, from medical images using data-characterization algorithms. These radiomic features can be used to identify tissue characteristics and radiologic phenotyping that are not observable by clinicians in a non-invasive, low-cost manner, potentially generating image biomarkers for clinical decision. To date, there are still many uncertainties involved in radiomics which limit its clinical implementation. Herein, we propose to explore the impact of each component in the radiomics pipeline on predicting clinical outcomes. In Chapter II, we conduct a thorough review of CT lung cancer radiomics studies to examine the typical feature …

Bat Activity On West Virginia Mined Lands Restored Via The Forestry Reclamation Approach, Briana C. Snyder

Theses and Dissertations--Forestry and Natural Resources

The Forestry Reclamation Approach (FRA) is a practical guide to reforesting surface mined lands. Bats, as a unique group of species with declining populations, could benefit from this reforestation. In order to determine if the FRA is providing suitable bat foraging habitat, I surveyed bat activity at created depressional wetlands on 1-year old and 8-year old FRA restored lands (FRA1; FRA8), as well as at naturally formed wetlands in regenerating forest on traditionally reclaimed mined land (~40 years old; REGEN) and wetlands in mature forest not previously mined (MAT). I passively recorded echolocation calls for 12 nights across sixteen sites …

Influence Of Bedrock Erodibility On Orogen Evolution In Collisional Systems And Implications For Geodynamic Models, Stephanie Ann Sparks

Theses and Dissertations--Earth and Environmental Sciences

Theoretical and numerical geodynamic models of continental collisional systems often involve, either explicitly or implicitly, a necessary yet complicated dependence between tectonics and erosion; however, the exact nature of these relationships remains elusive and controversial. In such models for the Himalayan-Tibetan (H-T) collisional orogen, surface processes are theorized or in some cases required to play an essential role in modulating critical processes active in the evolution of that system. To investigate, at least to first order. these interactions between climate and tectonics, we generate a simplified landscape evolution model of an actively uplifting orogenic wedge acted upon by surface processes. …

Syn- To Post-Orogenic Evolution Of Collisional Mountain Systems: Investigating The Potential For Crustal Flow Using Thermochronology And Numerical Models, Brandon Spencer

Theses and Dissertations--Earth and Environmental Sciences

This dissertation is composed of three distinct manuscripts which collectively investigate processes that contribute to the late evolution of collisional mountain systems —specifically, the ancient Appalachian-Caledonian system. In the first paper, ⁴⁰Ar/³⁹Ar thermochronological data are used to constrain the timing of exhumation of the Scandian orogenic wedge of northern Scotland. Muscovite and amphibole samples yield dates of ca. 420-411 Ma, consistent with cooling after peak orogenesis. During this cooling phase, dates from both systems in individual thrust sheets show an increase in cooling rate in the later stage of exhumation; in the orogenic core, the cooling rate …

Deformation Of Wall Rocks And Overburden Sequences Proximal To Salt Diapirs In Salt Valley, Utah: Implications For Predicting Subseismic Damage In Salt Tectonic Systems, William Swanger

Theses and Dissertations--Earth and Environmental Sciences

Although deformation related to salt tectonics is generally considered to be an ancillary field of structural geology, owing to its relatively limited occurrence in the geologic record, the preponderance of salt-involved systems in multiple hydrocarbon-rich basins around the world (e.g., Gulf of Mexico, Atlantic passive margins, Iran, etc.) creates a necessity for understanding salt-related deformation. Traditionally, salt was considered to be relatively weak and thus was mostly unable to drive deformation of adjacent wall rocks and cover sequences. However, a number of recent numerical modeling studies have shown that mobilized and pressurized salt may have the ability to actively pierce …

Evaluating Restoration Outcomes: Red Spruce Reforestation In The West Virginia Highlands, Benjamin Rhodes

Theses and Dissertations--Forestry and Natural Resources

Red spruce (Picea rubens) is the keystone species of the red spruce-northern hardwood forest, a unique high-elevation plant community that supports hundreds of animal species in the Central Appalachians. These forests were devastated by the Industrial Logging Era of the late 1800s and early 1900s, and they remain in a degraded and fragmented state. Current restoration efforts include red spruce plantings on old field sites and reclaimed coal mines. This project seeks to aid those efforts by evaluating restoration outcomes for vegetation and soils along a ten-year chronosequence. Specifically, the study aims to determine whether restoration site soils …

Opioid Use Disorder Treatment With Buprenorphine: Analysis Of Treatment Utilization And Associated Outcomes In Kentucky, Feitong Lei

Theses and Dissertations--Epidemiology and Biostatistics

Opioid use disorder (OUD) is chronic opioid use that results in clinically significant suffering, impairment, or even death. The opioid epidemic in the United States has become a public health and economic crisis, affecting patients' well-being and the nation's overall health and welfare. Eastern Kentucky was among the first regions affected by the opioid crisis, and Kentucky has historically ranked among the top five states for age-adjusted drug overdose mortality rate.

There are three medications (buprenorphine, methadone, naltrexone) approved by the U.S. Food and Drug Administration to treat OUD. As a partial opioid agonist, buprenorphine is a safe medication for …

Learning A Scalable Algorithm For Improving Betweenness In The Lightning Network, Vincent Davis

Theses and Dissertations--Computer Science

This paper presents a scalable algorithm for solving the Maximum Betweenness Improvement Problem as it occurs in the Bitcoin Lightning Network. In this approach, each node is embedded with a feature vector whereby an Advantage Actor-Critic model identifies key nodes in the network that a joining node should open channels with to maximize its own expected routing opportunities. This model is trained using a custom built environment, lightning-gym, which can randomly generate small scale-free networks or import snapshots of the Lightning Network. After 100 training episodes on networks with 128 nodes, this A2C agent can recommend channels in the Lightning …

Gene Silencing Provides Insights Into Bark Beetle Biology And Creates Potential For Broad Scale Forest Protection, Beth R. Kyre

Theses and Dissertations--Entomology

Dendroctonus bark beetles are among the most economically and ecologically significant forest pests in North America and play a critical role in the overall health of conifer forest ecosystems. Dendroctonus bark beetles influence ecosystem benefits and biodiversity and drive forest succession, and adversely affect timber production, forest management, and recreation. As temperatures surge and climatic fluctuations become more extreme, catastrophic bark beetle outbreaks are increasing in frequency, escalating pressures on highly vulnerable conifer forests already compromised by heat and drought. Eruptive outbreaks of Dendroctonus beetles are largely unhindered by traditional silvicultural management; these practices further disrupt forest ecosystem services, including …

Tryptophan-Like Fluorescence And Non-Point Source Pollution In Karst Basins, Inner Bluegrass Region, Kentucky, Ryan Dapkus

Theses and Dissertations--Earth and Environmental Sciences

Typically, the degree of fecal contamination of water is assessed by the concentration of thermotolerant coliforms, like E. coli. This method is time-consuming, taking > 18 hours between the start of incubation and subsequent enumeration. The current study examines the utility of monitoring tryptophan-like fluorescence (TLF) using in-situ fluorometers as a proxy for fecal contamination, particularly E. coli. Relative timing of discharge peaks and TLF peaks is considered, as well as differences in E. coli concentrations and major anion concentrations between two different basins that were monitored weekly. Results indicate that TLF is somewhat useful in the prediction of …

A Study Of The Analysis Of Hemp-Derived Oil Products: Development Of A Method For The Analysis Of Phytocannabinoids In Medicinal Products, Erin Johnson

Theses and Dissertations--Pharmacology and Nutritional Sciences

Human interactions with cannabis have a history spanning millennia as a source of fiber, food, and medicine. The plant came across Asia, Europe, and Africa with the movements of people and travelers eventually coming to the Americas with European explorers. In colonizing North America, cannabis fiber was key to the production of canvas and ropes for ships. Although fiber was the driver for cannabis production in the United States, medicinal uses were prevalent and propelled the eventual regulations. The Pure Food and Drug Act of 1906 mandated accurate labeling on drugs such as cannabis followed by the Marihuana Tax Act …

Smart Decision-Making Via Edge Intelligence For Smart Cities, Nathaniel Hudson

Theses and Dissertations--Computer Science

Smart cities are an ambitious vision for future urban environments. The ultimate aim of smart cities is to use modern technology to optimize city resources and operations while improving overall quality-of-life of its citizens. Realizing this ambitious vision will require embracing advancements in information communication technology, data analysis, and other technologies. Because smart cities naturally produce vast amounts of data, recent artificial intelligence (AI) techniques are of interest due to their ability to transform raw data into insightful knowledge to inform decisions (e.g., using live road traffic data to control traffic lights based on current traffic conditions). However, training and …

Multivariate Statistical Modeling For Radio-Genomics Study, Tiantian Zeng

Theses and Dissertations--Statistics

Radiogenomics is a new direction in cancer research that focuses on the associations among radiomics, genomics and clinical outcome. Currently, the major challenge for Radiogenomics lies in the effective integration of genomics and imaging data for promising clinical outcome prediction. Herein, we propose a multivariate joint model that can integrate imaging and genomic data for better predicting the clinical outcome. Specifically, we jointly consider two multivariate group lasso models, one regresses imaging features on genomic features, and the other regresses patient’s clinical outcome on genomic features. An L1 penalty term is introduced for each variable, and weight in the penalty …

Geometric Properties Of Weighted Projective Space Simplices, Derek Hanely

Theses and Dissertations--Mathematics

A long-standing conjecture in geometric combinatorics entails the interplay between three properties of lattice polytopes: reflexivity, the integer decomposition property (IDP), and the unimodality of Ehrhart h*-vectors. Motivated by this conjecture, this dissertation explores geometric properties of weighted projective space simplices, a class of lattice simplices related to weighted projective spaces.

In the first part of this dissertation, we are interested in which IDP reflexive lattice polytopes admit regular unimodular triangulations. Let Delta_(1,q)denote the simplex corresponding to the associated weighted projective space whose weights are given by the vector (1,q). Focusing on the case where Delta …

The V1-Periodic Region In Complex Motivic Ext And A Real Motivic V1-Selfmap, Ang Li

Theses and Dissertations--Mathematics

My thesis work consists of two main projects with some connections. In the first project we establish a v₁ periodicity theorem in Ext over the complex motivic Steenrod algebra. The element h₁ of Ext, which detects the homotopy class \eta in the motivic Adams spectral sequence, is non-nilpotent and therefore generates h₁-towers. Our result is that, apart from these h₁-towers, v₁ periodicity operators give isomorphisms in a range near the top of the Adams chart. This result generalizes well-known classical behavior.

In the second project we consider a nontrivial action of C_{2 …}

Elastic And Inelastic Compton Scattering From Deuterium At 61 Mev, Danula Godagama

Theses and Dissertations--Physics and Astronomy

A Compton scattering experiment using deuteron as target nuclei was carried out at the HIγS free electron laser facility at Durham, NC, with the goal of extracting the electromagnetic scalar polarizabilities of the neutron, α_n and β_n. A beam of 61~MeV gamma photons with a narrow energy spread was incident on a liquid deuterium target. The scattered gamma rays were detected at three scattering angles, 55^o, 115^o and 150^o. Backward-scattered gamma rays were detected using two large-volume NaI spectrometers with energy resolution (σ_E/E) better than 2%. The combined effect of …

Understanding The Physics Of Galaxy Clusters Out To Their Virial Radii And Beyond, Arnab Sarkar

Theses and Dissertations--Physics and Astronomy

In the hierarchical structure formation model, galaxy clusters grow and evolve via mergers and accretion from the surrounding cosmic web, leaving distinctive marks in the gas properties, metallicity, and dynamical state at the outskirts of clusters, which needs to be probed to better understand the growth of a cluster. I probed the gas properties of four nearby galaxy groups MKW4, Antlia, RXJ1159, and ESO3060170 out to their virial radii using deep Suzaku and mostly snapshot Chandra observations. I found the gas entropy profiles of MKW4 follow a power-law at its outskirts - as expected from purely gravitational structure formation model. …

Studies Of Time Variations Of The Magnetic Field In The Nedm@Sns Experiment, Mojtaba Behzadipour

Theses and Dissertations--Physics and Astronomy

It is thought that equal quantities of matter and antimatter were generated at the moment of the Big Bang. However, observations of the Universe show that there is a significant excess of matter over antimatter. The matter-antimatter asymmetry in the Universe (baryon to photon ratio) is observed to be of the order of 10^-10 [1]. Baryogenesis is a possible explanation for the matter-antimatter asymmetry of the universe. In 1967, Sakharov proposed three criteria necessary for Baryogenesis. The three conditions are: 1) baryon number violation, 2) C and CP violation and 3) departure from thermal equilibrium. However, the Standard Model's …

Angular Distribution Of Electron-Helium Scattering In The Presence Of A 1.17 Ev Laser Field, Brian N. Kim

Theses and Dissertations--Physics and Astronomy

We have measured relative differential cross sections for 350 eV electrons scattered by a helium target in the presence of 1.17 eV photons from an Nd:YAG laser. We report an angular distribution of free-free electrons that were scattered elastically at angles between 15^o and 80^o and of free-free electrons that underwent the process of electron-impact excitation of helium to its unresolved (1s2s)¹S and (1s2p)¹P excited states at angles between 1^o and 80^o. Our experiments test the momentum transfer dependence and the relationship between elastic and inelastic scattering in the Kroll-Watson approximation. …

Neutron Spectroscopy Of The Parity-Violating 0.734 Ev Neutron Resonance In Lanthanum-139 In Preparation For The Noptrex Time Reversal Violation Experiment, Danielle Schaper

Theses and Dissertations--Physics and Astronomy

One of the most outstanding questions in physics is the matter-antimatter asymmetry of the Universe, resulting from excess baryogenesis processes during the early moments of the formation of the Universe. At present, the types of processes needed to explain this matter excess, so-called `CP-violating processes' are known to exist within the present framework of the Standard Model of particle physics. However, decades of research has shown that our understanding of the origin of these processes is incomplete, as we do not presently know of enough sources of CP-violating processes to account for the large baryon asymmetry that we observe. The …

Milky Way Morphology Probed By 6d Astrometric Data From The Gaia Space Telescope, Joshua Taylor Harry

Theses and Dissertations--Physics and Astronomy

At varying height above and below the plane of the Milky Way, I have used astrometric methods to classify stars of different galactic components of the Milky Way - the thin disk, thick disk, and stellar halo. This work complements prior study of Milky Way sub-structure - notably involving number density and/or pairwise correlations - which demonstrate non-steady state effects in the galaxy, such as axial/north-south symmetry breaking or more complex phenomena like the Gaia snail. This has motivated my exploration of stellar population changes with height about the Milky Way mid-plane, and the study of symmetry in such changes …

First Steps In The Small-Scale Structure Formation In The Universe: The Emergence Of Galaxies, Da Bi

Theses and Dissertations--Physics and Astronomy

Galactic morphology in the contemporary universe results from the convergence of a long list of physical processes, not all of them yet fully understood and quantified. The universe exhibits a hierarchical structure: galaxies grow being immersed in dark matter (DM) halos, which in turn are fed by diffuse and filamentary accretion. I use a suite of very high-resolution zoom-in cosmological simulations of galaxies in order to study the assembly of galaxies at high redshifts, z ≥ 2, to quantify the role of environment and of the parent DM halos in this procss. My models have been chosen to lie within …

An Energy-Integrated Analysis For Measuring The Anomalous Precession Frequency For The Muon G − 2 Experiment At Fermilab, Laura Kelton

Theses and Dissertations--Physics and Astronomy

In the search for physics beyond the Standard Model, the Muon g − 2 Experiment at Fermilab (E989) will make the most precise measurement of the anomalous magnetic moment of the muon, a_μ. Improvements in precision come from both increased statistics and new techniques to significantly reduce previous systematic uncertainties. The muon a_μ is determined by extracting both the anomalous spin precession frequency, ω_a, and the average magnetic field sampled by the muons, B. Traditionally an energy threshold analysis method which requires reconstruction of decay positrons from the muon decay, μ⁺ → e^{+ …}

Matrix Interpretations And Tools For Investigating Even Functionals, Benjamin Stringer

Theses and Dissertations--Computer Science

Even functionals are a set of polynomials evaluated on the terms of hollow symmetric matrices. Their properties lend themselves to applications such as counting subgraph embeddings in generic (weighted or unweighted) host graphs and computing moments of binary quadratic forms, which occur in combinatorial optimization. This research focuses primarily on counting subgraph embeddings, which is traditionally accomplished with brute-force algorithms or algorithms curated for special types of graphs. Even functionals provide a method for counting subgraphs algebraically in time proportional to matrix multiplication and is not restricted to particular graph types. Counting subgraph embeddings can be accomplished by evaluating a …

Supporting Stylized Language Models Using Multi-Modality Features, Chengxi Li

Theses and Dissertations--Computer Science

As AI and machine learning systems become more common in our everyday lives, there is an increased desire to construct systems that are able to seamlessly interact and communicate with humans. This typically means creating systems that are able to communicate with humans via natural language. Given the variance of natural language, this can be a very challenging task. In this thesis, I explored the topic of humanlike language generation in the context of stylized language generation. Stylized language generation involves producing some text that exhibits a specific, desired style. In this dissertation, I specifically explored the use of multi-modality …

Don't Give Me That Story! -- A Human-Centered Framework For Usable Narrative Planning, Rachelyn Farrell

Theses and Dissertations--Computer Science

Interactive or branching stories are engaging and can be embedded into digital systems for a variety of purposes, but their size and complexity makes it difficult and time-consuming for humans to author them. Narrative planning algorithms can automatically generate large branching stories with guaranteed causal consistency, using a hand-authored library of story content pieces. The usability of such a system depends on both the quality of the narrative model upon which it is built and the ability of the user to create the story content library.

Current narrative planning algorithms use either a limited or no model of character belief, …