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Cleveland State University

2016

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Articles 1 - 30 of 96

Full-Text Articles in Physical Sciences and Mathematics

The Chemistry Of The Flint Water Crisis, Ernest M. Oleksy Dec 2016

The Chemistry Of The Flint Water Crisis, Ernest M. Oleksy

The Downtown Review

Politics and science do not always go hand-in-hand. Nowhere was this more clear than in the Flint Water Crisis. Negligence towards growing levels of lead poisoning in drinking water led to incredibly deleterious effects on Flint's citizens. The chemistry of equilibrium and the shortcomings of local leaders led to Flint's water becoming a crisis.

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What Determines The Fate Of Rising Parcels In A Heterogeneous Environment?, Maren Brast, Roel A.J. Neggers, Thijs Heus Dec 2016

What Determines The Fate Of Rising Parcels In A Heterogeneous Environment?, Maren Brast, Roel A.J. Neggers, Thijs Heus

Physics Faculty Publications

© 2016. The Authors. We investigate the potential impact of the local environment on rising parcels in a convective boundary layer. To this end, we use data from an LES simulation of a shallow convective cloud field to feed a parcel model with a range of different local environments, representative of the heterogeneous environment inside a shallow cumulus cloud layer. With this method we can study the statistics of an ensemble of rising parcels, but also the behavior of individual parcels. Through the use of a heterogeneous environment, the interactions between different parcels are indirectly represented. The method, despite its …

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Glutathione Species And Metabolomic Prints In Subjects With Liver Disease As Biological Markers For The Detection Of Hepatocellular Carcinoma, Juan R. Sanabria, Rajan S. Kombu, Guo Fang Zhang, Yana Sandlers, Jizhou Ai, Rafael A. Ibarra, Rime Abbas, Kush Goyal, Henri Brunengraber Dec 2016

Glutathione Species And Metabolomic Prints In Subjects With Liver Disease As Biological Markers For The Detection Of Hepatocellular Carcinoma, Juan R. Sanabria, Rajan S. Kombu, Guo Fang Zhang, Yana Sandlers, Jizhou Ai, Rafael A. Ibarra, Rime Abbas, Kush Goyal, Henri Brunengraber

Chemistry Faculty Publications

© 2016 The Authors Background The incidence of liver disease is increasing in USA. Animal models had shown glutathione species in plasma reflects liver glutathione state and it could be a surrogate for the detection of hepatocellular carcinoma (HCC). Methods The present study aimed to translate methods to the human and to explore the role of glutathione/metabolic prints in the progression of liver dysfunction and in the detection of HCC. Treated plasma from healthy subjects (n = 20), patients with liver disease (ESLD, n = 99) and patients after transplantation (LTx, n = 7) were analyzed by GC- or LC/MS. …

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Bezout Inequality For Mixed Volumes, Ivan Soprunov, Artem Zvavitch Dec 2016

Bezout Inequality For Mixed Volumes, Ivan Soprunov, Artem Zvavitch

Mathematics and Statistics Faculty Publications

In this paper we consider the following analog of Bezout inequality for mixed volumes: V(P1,…,Pr,Δn−r)Vn(Δ)r−1≤∏i=1rV(Pi,Δn−1) for 2≤r≤n. We show that the above inequality is true when Δ is an n-dimensional simplex and P1,…,Pr are convex bodies in Rn. We conjecture that if the above inequality is true for all convex bodies P1,…,Pr, then Δ must be an n-dimensional simplex. We prove that if the above inequality is true for all convex bodies P1,…,Pr, then Δ must be indecomposable (i.e. cannot be written as the Minkowski sum of two convex bodies which are not homothetic to Δ), which confirms the conjecture …

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Cgils Phase 2 Les Intercomparison Of Response Of Subtropical Marine Low Cloud Regimes To Co2 Quadrupling And A Cmip3 Composite Forcing Change, Peter N. Blossey, Christopher S. Bretherton, Anning Cheng, Satoshi Endo, Thijs Heus, Adrian P. Lock, Johan J. Van Der Dussen Dec 2016

Cgils Phase 2 Les Intercomparison Of Response Of Subtropical Marine Low Cloud Regimes To Co2 Quadrupling And A Cmip3 Composite Forcing Change, Peter N. Blossey, Christopher S. Bretherton, Anning Cheng, Satoshi Endo, Thijs Heus, Adrian P. Lock, Johan J. Van Der Dussen

Physics Faculty Publications

© 2016. The Authors. Phase 1 of the CGILS large-eddy simulation (LES) intercomparison is extended to understand if subtropical marine boundary-layer clouds respond to idealized climate perturbations consistently in six LES models. Here the responses to quadrupled carbon dioxide (“fast adjustment”) and to a composite climate perturbation representative of CMIP3 multimodel mean 2×CO2 near-equilibrium conditions are analyzed. As in Phase 1, the LES is run to equilibrium using specified steady summertime forcings representative of three locations in the Northeast Pacific Ocean in shallow well-mixed stratocumulus, decoupled stratocumulus, and shallow cumulus cloud regimes. The results are generally consistent with a single-LES …

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Overseas Chinese Environmental Engineers And Scientists Association (Oceesa) Report, Dec 2016., Yung-Tse Hung, Wen-Chi Ku, Lawrence K. Wang Dec 2016

Overseas Chinese Environmental Engineers And Scientists Association (Oceesa) Report, Dec 2016., Yung-Tse Hung, Wen-Chi Ku, Lawrence K. Wang

Civil and Environmental Engineering Faculty Publications

This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is 2016 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2016/33D1, December 2016, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung …

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Eventual Quasi-Linearity Of The Minkowski Length, Ivan Soprunov, Jenya Soprunova Nov 2016

Eventual Quasi-Linearity Of The Minkowski Length, Ivan Soprunov, Jenya Soprunova

Mathematics and Statistics Faculty Publications

The Minkowski length of a lattice polytope PP is a natural generalization of the lattice diameter of PP. It can be defined as the largest number of lattice segments whose Minkowski sum is contained in PP. The famous Ehrhart theorem states that the number of lattice points in the positive integer dilates tPtP of a lattice polytope PP behaves polynomially in t∈Nt∈N. In this paper we prove that for any lattice polytope PP, the Minkowski length of tPtP for t∈Nt∈N is eventually a quasi-polynomial with linear constituents. We also give a formula for the Minkowski length of coordinates boxes, degree …

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Hif Stabilization Weakens Primary Cilia, Andrew Resnick Nov 2016

Hif Stabilization Weakens Primary Cilia, Andrew Resnick

Physics Faculty Publications

© 2016 Andrew Resnick. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Although solitary or sensory cilia are present in most cells of the body and their existence has been known since the sixties, very little is known about their functions. One suspected function is fluid flow sensing-physical bending of cilia produces an influx of Ca++, which can then result in a variety of activated signaling pathways. Defective cilia and ciliary-associated proteins have been …

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Trimethylamine N-Oxide And Mortality Risk In Patients With Peripheral Artery Disease, Vichai Senthong, Zeneng Wang, Yiying Fan, Yuping Wu, Stanley L. Hazen, W.H. Wilson Tang Oct 2016

Trimethylamine N-Oxide And Mortality Risk In Patients With Peripheral Artery Disease, Vichai Senthong, Zeneng Wang, Yiying Fan, Yuping Wu, Stanley L. Hazen, W.H. Wilson Tang

Mathematics and Statistics Faculty Publications

Background: Production of the proatherogenic metabolite, trimethylamine N-oxide (TMAO), from dietary nutrients by intestinal microbiota enhances atherosclerosis development in animal models and is associated with atherosclerotic coronary artery disease in humans. The utility of studying plasma levels of TMAO to risk stratify in patients with peripheral artery disease (PAD) has not been reported. Methods and Results: We examined the relationship between fasting plasma TMAO and all-cause mortality (5-year), stratified by subtypes of PAD and presence of coronary artery disease in 935 patients with PAD who underwent elective angiography for cardiac evaluation at a tertiary care hospital. Median plasma TMAO was …

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On The Geometry Of The Rotating Liquid Drop, Ivailo M. Mladenov, John Oprea Sep 2016

On The Geometry Of The Rotating Liquid Drop, Ivailo M. Mladenov, John Oprea

Mathematics and Statistics Faculty Publications

Here we consider the problem of a fluid body rotating with a constant angular velocity and subjected to surface tension. Determining the equilibrium configuration of this system turns out to be equivalent to the geometrical problem of determining the surface of revolution with a prescribed mean curvature. In the simply connected case, the equilibrium surface can be parameterized explicitly via elliptic integrals of the first and second kind. Here, we present two such parameterizations of the drops and we use the second of them to study finer details of the drop surfaces such as the existence of closed geodesics.

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Factors Controlling Stratocumulus Cloud Lifetime Over Coastal Land, Mohamed S. Ghonima, Thijs Heus, Joel R. Norris, Jan Kleissl Aug 2016

Factors Controlling Stratocumulus Cloud Lifetime Over Coastal Land, Mohamed S. Ghonima, Thijs Heus, Joel R. Norris, Jan Kleissl

Physics Faculty Publications

The breakup of stratocumulus clouds over coastal land areas is studied using a combination of large-eddy simulations (LESs) and mixed-layer models (MLMs) with a focus on mechanisms regulating the timing of the breakup. In contrast with stratocumulus over ocean, strong sensible heat flux over land prevents the cloud layer from decoupling during day. As the cloud thins during day, turbulence generated by surface flux becomes larger than turbulence generated by longwave cooling across the cloud layer. To capture this shift in turbulence generation in the MLM, an existing entrainment parameterization is extended. The MLM is able to mimic cloud evolution …

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Realizing Spaces As Classifying Spaces, Gregory Lupton, Samuel Bruce Smith Aug 2016

Realizing Spaces As Classifying Spaces, Gregory Lupton, Samuel Bruce Smith

Mathematics and Statistics Faculty Publications

Which spaces occur as a classifying space for fibrations with a given fibre? We address this question in the context of rational homotopy theory. We construct an infinite family of finite complexes realized (up to rational homotopy) as classifying spaces. We also give several non-realization results, including the following: the rational homotopy types of and are not realized as the classifying space of any simply connected, rational space with finite-dimensional homotopy groups.

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Share Notify.Pptx, Theresa M. Nawalaniec Jul 2016

Share Notify.Pptx, Theresa M. Nawalaniec

Michael Schwartz Library Publications

Sharing science research

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Anomalous Fluctuations In The Orientation And Velocity Of Swarming Bacteria, Shawn D. Ryan, Gil Ariel, Avraham Be’Er Jul 2016

Anomalous Fluctuations In The Orientation And Velocity Of Swarming Bacteria, Shawn D. Ryan, Gil Ariel, Avraham Be’Er

Mathematics and Statistics Faculty Publications

Simultaneous acquisition of phase-contrast light microscopy and fluorescently labeled bacteria, moving within a dense swarm, reveals the intricate interactions between cells and the collective flow around them. By comparing wild-type and immotile cells embedded in a dense wild-type swarm, the effect of the active thrust generated by the flagella can be singled out. It is shown that while the distribution of angles among cell velocity, cell orientation, and the local flow around it is Gaussian-like for immotile bacteria, wild-type cells exhibit anomalous non-Gaussian deviations and are able to move in trajectories perpendicular to the collective flow. Thus, cells can maneuver …

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Consequences Of The Angular Spectrum Decomposition Of A Focused Beam, Including Slower Than C Beam Propagation, Gérard Gouesbet, James A. Lock Jul 2016

Consequences Of The Angular Spectrum Decomposition Of A Focused Beam, Including Slower Than C Beam Propagation, Gérard Gouesbet, James A. Lock

Physics Faculty Publications

When dealing with light scattering and propagation of an electromagnetic beam, there are essentially two kinds of expansions which have been used to describe the incident beam (i) a discrete expansion involving beam shape coefficients and (ii) a continuous expansion in terms of an angular spectrum of plane waves. In this paper, we demonstrate that the angular spectrum decomposition readily leads to two important consequences, (i) laser light beams travel in free space with an effective velocity that is smaller than the speed of light c, and (ii) the optical theorem does not hold for arbitrary shaped beams, both …

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Design And Validation For Fpga Trust Under Hardware Trojan Attacks, Sanchita Mal-Sarkar, Robert Karam, Seetharam Narasimhan, Anandaroop Ghosh, Aswin Krishna, Swarup Bhunia Jun 2016

Design And Validation For Fpga Trust Under Hardware Trojan Attacks, Sanchita Mal-Sarkar, Robert Karam, Seetharam Narasimhan, Anandaroop Ghosh, Aswin Krishna, Swarup Bhunia

Electrical and Computer Engineering Faculty Publications

Field programmable gate arrays (FPGAs) are being increasingly used in a wide range of critical applications, including industrial, automotive, medical, and military systems. Since FPGA vendors are typically fabless, it is more economical to outsource device production to off-shore facilities. This introduces many opportunities for the insertion of malicious alterations of FPGA devices in the foundry, referred to as hardware Trojan attacks, that can cause logical and physical malfunctions during field operation. The vulnerability of these devices to hardware attacks raises serious security concerns regarding hardware and design assurance. In this paper, we present a taxonomy of FPGA-specific hardware Trojan …

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Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide And 5-Year Mortality Risk In Stable Coronary Artery Disease: The Contributory Role Of Intestinal Microbiota In A Courage-Like Patient Cohort, Vichai Senthong, Zeneng Wang, Xinmin S. Li, Yiying Fan, Yuping Wu, W. H. Wilson Tang, Stanley L. Hazen Jun 2016

Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide And 5-Year Mortality Risk In Stable Coronary Artery Disease: The Contributory Role Of Intestinal Microbiota In A Courage-Like Patient Cohort, Vichai Senthong, Zeneng Wang, Xinmin S. Li, Yiying Fan, Yuping Wu, W. H. Wilson Tang, Stanley L. Hazen

Mathematics and Statistics Faculty Publications

Background: Trimethylamine-N-oxide (TMAO), a metabolite derived from gut microbes and dietary phosphatidylcholine, is linked to both coronary artery disease pathogenesis and increased cardiovascular risks. The ability of plasma TMAO to predict 5-year mortality risk in patients with stable coronary artery disease has not been reported. This study examined the clinical prognostic value of TMAO in patients with stable coronary artery disease who met eligibility criteria for a patient cohort similar to that of the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial. Methods and Results: We examined the relationship between fasting plasma TMAO and all-cause mortality over 5-year …

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Characterization Of Simplices Via The Bezout Inequality For Mixed Volumes, Christos Saroglou, Ivan Soprunov, Arten Zvavitch Jun 2016

Characterization Of Simplices Via The Bezout Inequality For Mixed Volumes, Christos Saroglou, Ivan Soprunov, Arten Zvavitch

Mathematics and Statistics Faculty Publications

We consider the following Bezout inequality for mixed volumes: V (K1, . . . ,Kr, Δ[n − r])Vn(Δ)r−1 ≤ r i=1 V (Ki, Δ[n − 1]) for 2 ≤ r ≤ n. It was shown previously that the inequality is true for any -dimensional simplex and any convex bodies in . It was conjectured that simplices are the only convex bodies for which the inequality holds for arbitrary bodies in . In this paper we prove that this is indeed the case if we assume that is a convex polytope. Thus the Bezout inequality characterizes simplices in the class of …

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Plasma Trimethylamine N-Oxide, A Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden, Vichai Senthong, Xinmin S. Li, Timothy Hudec, John Coughlin, Yuping Wu, Bruce Levison, Zeneng Wang, Stanley L. Hazen, W.H. Wilson Tang Jun 2016

Plasma Trimethylamine N-Oxide, A Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden, Vichai Senthong, Xinmin S. Li, Timothy Hudec, John Coughlin, Yuping Wu, Bruce Levison, Zeneng Wang, Stanley L. Hazen, W.H. Wilson Tang

Mathematics and Statistics Faculty Publications

Background: Trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, has mechanistic links to atherosclerotic coronary artery disease (CAD) pathogenesis and is associated with adverse outcomes. Objectives: This study sought to examine the relationship between plasma TMAO levels and the complexity and burden of CAD and degree of subclinical myonecrosis. Methods: We studied 353 consecutive stable patients with evidence of atherosclerotic CAD detected by elective coronary angiography between 2012 and 2014. Their high-sensitivity cardiac troponin T (hs-cTnT) levels were measured. SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) scores and lesion characteristics were used to quantify …

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Oncogenic Pik3ca Mutations Reprogram Glutamine Metabolism In Colorectal Cancer, Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, Yan Xu Jun 2016

Oncogenic Pik3ca Mutations Reprogram Glutamine Metabolism In Colorectal Cancer, Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, Yan Xu

Chemistry Faculty Publications

Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by upregulating glutamate pyruvate transaminase 2 (GPT2) in colorectal cancer (CRC) cells, making them more dependent on glutamine. Compared with isogenic wild-type (WT) cells, PIK3CA mutant CRCs convert substantially more glutamine to alpha-ketoglutarate to replenish the tricarboxylic acid cycle and generate ATP. Mutant p110 alpha upregulates GPT2 gene expression through an AKT-independent, PDK1-RSK2-ATF4 signalling axis. Moreover, aminooxyacetate, which inhibits the enzymatic activity of aminotransferases including GPT2, suppresses xenograft tumour growth of CRCs with PIK3CA mutations, but not …

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Novel Protein Disulfide Isomerase Inhibitor With Anticancer Activity In Multiple Myeloma, Sergei Vatolin, James G. Phillips, Babal K. Jha, Shravya Govindgari, Jennifer Hu, Dale Grabowski, Yvonne Parker, Daniel J. Lindner, Fei Zhong, Clark W. Distelhorst, Mitchell R. Smith, Claudiu Cotta, Yan Xu, Sujatha Chilakala, Rebecca R. Kuang, Samantha Tall, Frederic J. Reu Jun 2016

Novel Protein Disulfide Isomerase Inhibitor With Anticancer Activity In Multiple Myeloma, Sergei Vatolin, James G. Phillips, Babal K. Jha, Shravya Govindgari, Jennifer Hu, Dale Grabowski, Yvonne Parker, Daniel J. Lindner, Fei Zhong, Clark W. Distelhorst, Mitchell R. Smith, Claudiu Cotta, Yan Xu, Sujatha Chilakala, Rebecca R. Kuang, Samantha Tall, Frederic J. Reu

Chemistry Faculty Publications

Multiple myeloma cells secrete more disulfide bond–rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should increase ER stress beyond repair in this incurable cancer. Here, we report the mechanistically unbiased discovery of a novel PDI-inhibiting compound with antimyeloma activity. We screened a 30,355 small-molecule library using a multilayered multiple myeloma cell–based cytotoxicity assay that modeled disease niche, normal liver, kidney, and bone marrow. CCF642, a bone marrow–sparing compound, exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. An active biotinylated analog …

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The Ecological Impacts Of Non-Native Species On River Otter Populations, Nadia Swit May 2016

The Ecological Impacts Of Non-Native Species On River Otter Populations, Nadia Swit

The Downtown Review

Most nonindigenous species invasions can have negative consequences on an environment. Trophic systems may become altered as prey sources are depleted, which can have further implications on community and habitat structure. However, some species invasions can be positive as it can provide another food source for key stone species. The effects of invasive species are reviewed in the following paper for the North American river otter (Lontra canadensis) and the Eurasian otter (Lutra lutra). In the case of the North American river, the introduction of the lake trout (Salvelinus namaycush) has negatively impacted otter …

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Early Growth And Development Impairments In Patients With Ganglioside Gm3 Synthase Deficiency, H. Wang, A. Wang, Dan Wang, A. Bright, V. Sency, Aimin Zhou, B. Xin May 2016

Early Growth And Development Impairments In Patients With Ganglioside Gm3 Synthase Deficiency, H. Wang, A. Wang, Dan Wang, A. Bright, V. Sency, Aimin Zhou, B. Xin

Chemistry Faculty Publications

Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GSD) causes a complete absence of GM3 and all downstream biosynthetic derivatives. The individuals affected by this disorder manifest severe irritability, intractable seizures and profound intellectual disability. However, we have found that most newborns seem symptom-free for a period of time after birth. In order to further understand the onset of the disease, we investigated the early growth and development of patients with this condition through this study. We compared 37 affected individuals with their normal siblings and revealed that all children with GSD …

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A Model For Collective Dynamics In Ant Raids, Shawn D. Ryan May 2016

A Model For Collective Dynamics In Ant Raids, Shawn D. Ryan

Mathematics and Statistics Faculty Publications

Ant raiding, the process of identifying and returning food to the nest or bivouac, is a fascinating example of collective motion in nature. During such raids ants lay pheromones to form trails for others to find a food source. In this work a coupled PDE/ODE model is introduced to study ant dynamics and pheromone concentration. The key idea is the introduction of two forms of ant dynamics: foraging and returning, each governed by different environmental and social cues. The model accounts for all aspects of the raiding cycle including local collisional interactions, the laying of pheromone along a trail, and …

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Water Resilient Cities: Climate Change, Infrastructure, Economies And Governance In The Great Lakes Basin, Wendy A. Kellogg Apr 2016

Water Resilient Cities: Climate Change, Infrastructure, Economies And Governance In The Great Lakes Basin, Wendy A. Kellogg

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

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Usefulness Of Relative Hypochromia In Risk Stratification For Nonanemic Patients With Chronic Heart Failure, Muhammad Hammadah, Marie Luise Brennan, Yuping Wu, Stanley L. Hazen, W.H. Wilson Tang Apr 2016

Usefulness Of Relative Hypochromia In Risk Stratification For Nonanemic Patients With Chronic Heart Failure, Muhammad Hammadah, Marie Luise Brennan, Yuping Wu, Stanley L. Hazen, W.H. Wilson Tang

Mathematics and Statistics Faculty Publications

The purpose of this study is to investigate the impact of a reduction of hemoglobin (Hb) content in the erythrocytes as estimated by mean corpuscular hemoglobin concentration (MCHC) on long-term clinical outcomes in nonanemic patients with heart failure (HF). We prospectively enrolled 1,579 subjects with HF who underwent coronary angiography enrolled in the GeneBank study with 5-year follow-up of all-cause mortality. Levels of Hb and MCHC were assessed at enrollment and after 6 months of follow-up. Anemia was defined as Hb levels <13 g/dl in men and <12 g/dl in women. In our nonanemic cohort (n = 785, 49.7%), mean Hb and median MCHC were 13.8 ± 1.1 g/dl and 34.3 g/dL (interquartile range 33.6 to 35), respectively. Nonanemic patients with heart failure with lower MCHC had higher mortality risk (quartiles 1 vs 4, hazard ratio = 2.1, 95% confidence interval 1.4 to 3.3, p = 0.001). In a subset of nonanemic patients with persistent normal Hb on follow-up (n = 206), the mean time between baseline and follow-up MCHC levels was 169.3 ± 41.6 days. In comparison with patients with levels of MCHC more than the first quartile (≥33.6 g/dl) on baseline and follow-up, patients with persistently low MCHC (<33.6 g/dl) had a significantly increased mortality risk (log rank <0.001). All models remained significant even after adjusting for traditional cardiac risk factors, left ventricular ejection fraction, baseline Hb levels, and mean corpuscular volume. In conclusion, relative hypochromia is an independent predictor of increased mortality risk in patients with HF, even in the setting of normal Hb levels.

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Climate Change, Infrastructure, Economies, And Governance In The Great Lakes Basin, Wendy A. Kellogg Apr 2016

Climate Change, Infrastructure, Economies, And Governance In The Great Lakes Basin, Wendy A. Kellogg

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

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Metabolomics Reveals New Mechanisms For Pathogenesis In Barth Syndrome And Introduces Novel Roles For Cardiolipin In Cellular Function, Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan Mcritchie, Susan Sumner, Hilary J. Vernon Mar 2016

Metabolomics Reveals New Mechanisms For Pathogenesis In Barth Syndrome And Introduces Novel Roles For Cardiolipin In Cellular Function, Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan Mcritchie, Susan Sumner, Hilary J. Vernon

Chemistry Faculty Publications

Barth Syndrome is the only known Mendelian disorder of cardiolipin remodeling, with characteristic clinical features of cardiomyopathy, skeletal myopathy, and neutropenia. While the primary biochemical defects of reduced mature cardiolipin and increased monolysocardiolipin are well-described, much of the downstream biochemical dysregulation has not been uncovered, and biomarkers are limited. In order to further expand upon the knowledge of the biochemical abnormalities in Barth Syndrome, we analyzed metabolite profiles in plasma from a cohort of individuals with Barth Syndrome compared to age-matched controls via 1H nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry. A clear distinction between metabolite profiles of …

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Gut Microbial Metabolite Tmao Enhances Platelet Hyperreactivity And Thrombosis Risk, Weifei Zhu, Jill C. Gregory, Elin Org, Jennifer A. Buffa, Nilaksh Gupta, Zeneng Wang, Lin Li, Xiaoming Fu, Yuping Wu, Margarete Mehrabian, R. Balfour Sartor, Thomas M. Mcintyre, Roy L. Silverstein, W.H. Wilson Tang, Joseph A. Didonato, J. Mark Brown, Aldons J. Lusis, Stanley L. Hazen Mar 2016

Gut Microbial Metabolite Tmao Enhances Platelet Hyperreactivity And Thrombosis Risk, Weifei Zhu, Jill C. Gregory, Elin Org, Jennifer A. Buffa, Nilaksh Gupta, Zeneng Wang, Lin Li, Xiaoming Fu, Yuping Wu, Margarete Mehrabian, R. Balfour Sartor, Thomas M. Mcintyre, Roy L. Silverstein, W.H. Wilson Tang, Joseph A. Didonato, J. Mark Brown, Aldons J. Lusis, Stanley L. Hazen

Mathematics and Statistics Faculty Publications

Normal platelet function is critical to blood hemostasis and maintenance of a closed circulatory system. Heightened platelet reactivity, however, is associated with cardiometabolic diseases and enhanced potential for thrombotic events. We now show gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential. Plasma TMAO levels in subjects (n > 4,000) independently predicted incident (3 years) thrombosis (heart attack, stroke) risk. Direct exposure of platelets to TMAO enhanced sub-maximal stimulus-dependent platelet activation from multiple agonists through augmented Ca2+ release from intracellular stores. Animal model studies employing dietary choline or TMAO, germ-free mice, and microbial …

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A Systematic Investigation Of Structure/Function Requirements For The Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop Of High-Density Lipoprotein, Xiaodong Gu, Zhiping Wu, Ying Huang, Matthew A. Wagner, Camelia Baleanu Gogonea, Ryan A. Mehl, Jennifer A. Buffa, Anthony J. Didonato, Leah B. Hazen, Paul L. Fox, Valentin Gogonea, John S. Parks, Joseph A. Didonato, Stanley L. Hazen Mar 2016

A Systematic Investigation Of Structure/Function Requirements For The Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop Of High-Density Lipoprotein, Xiaodong Gu, Zhiping Wu, Ying Huang, Matthew A. Wagner, Camelia Baleanu Gogonea, Ryan A. Mehl, Jennifer A. Buffa, Anthony J. Didonato, Leah B. Hazen, Paul L. Fox, Valentin Gogonea, John S. Parks, Joseph A. Didonato, Stanley L. Hazen

Chemistry Faculty Publications

The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I) plays a critical role in high-density lipoprotein (HDL) maturation. We previously identified a highly solvent-exposed apoA-I loop domain (Leu159–Leu170) in nascent HDL, the so-called “solar flare” (SF) region, and proposed that it serves as an LCAT docking site (Wu, Z., Wagner, M. A., Zheng, L., Parks, J. S., Shy, J. M., 3rd, Smith, J. D., Gogonea, V., and Hazen, S. L. (2007) Nat. Struct. Mol. Biol. 14, 861–868). The stability and role of the SF domain of apoA-I in supporting HDL binding and activation of LCAT are debated. Here we …

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