Physical Sciences and Mathematics Commons^™

Integrated Analysis Of Content And Construct Validity, Byron Gajewski, Larry Price, Valorie Coffland, Diane Boyle, Marjorie Bott

Diane Kay Boyle PhD, RN, FAAN

Establishing adequacy of psychometric properties of an instrument involves acquisition and evaluation of evidence based on item content and internal structure. Content validity evidence consists of subject matter experts providing quantitative ratings of the extent to which items are a representative sample of targeted domain. Evidence of internal structure includes factor analytic studies and examination of item interrelationships based on item responses from participants. Although subject matter expert ratings and participant response data are traditionally analyzed separately, each serves to inform the other in important ways. We propose integrating subject matter experts’ and participants’ data seamlessly to establish a unified …

Risk, Odds, And Their Ratios, Joseph Hilbe

Joseph M Hilbe

A brief monograph explaining the meaning of the terms, risk, risk ratio, odds, and odds ratio and how to calculate each, together with standard errors and confidence intervals. Stata code is provided showing how all of the terms can be calculated by hand, as well as by using logistic and Poisson models.

Identification And Efficient Estimation Of The Natural Direct Effect Among The Untreated, Samuel D. Lendle, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

The natural direct effect (NDE), or the effect of an exposure on an outcome if an intermediate variable was set to the level it would have been in the absence of the exposure, is often of interest to investigators. In general, the statistical parameter associated with the NDE is difficult to estimate in the non-parametric model, particularly when the intermediate variable is continuous or high dimensional. In this paper we introduce a new causal parameter called the natural direct effect among the untreated, discus identifiability assumptions, and show that this new parameter is equivalent to the NDE in a randomized …

Flexible Distributed Lag Models Using Random Functions With Application To Estimating Mortality Displacement From Heat-Related Deaths, Roger D. Peng

Johns Hopkins University, Dept. of Biostatistics Working Papers

No abstract provided.

Adjusting Medicare Capitation Payments Using Prior Hospitalization Data, Arlene Ash, Frank Porell, Leonard Gruenberg, Eric Sawitz, Alexa Beiser

Frank Porell

The diagnostic cost group approach to a reimbursement model for health maintenance organizations is presented. Diagnostic information about previous hospitalizations is used to create empirically determined risk groups, using only diagnoses involving little or no discretion in the decision to hospitalize. Diagnostic cost group and other models (including Medicare's current formula and other prior-use models) are tested for their ability to predict future costs, using R2 values and new measures of predictive performance. The diagnostic cost group models perform relatively well with respect to a range of criteria, including administrative feasibility, resistance to provider manipulation, and statistical accuracy.

Modeling Criminal Careers As Departures From A Unimodal Population Age-Crime Curve: The Case Of Marijuana Use, Donatello Telesca, Elena Erosheva, Derek Kreager, Ross Matsueda

COBRA Preprint Series

A major aim of longitudinal analyses of life course data is to describe the within- and between-individual variability in a behavioral outcome, such as crime. Statistical analyses of such data typically draw on mixture and mixed-effects growth models. In this work, we present a functional analytic point of view and develop an alternative method that models individual crime trajectories as departures from a population age-crime curve. Drawing on empirical and theoretical claims in criminology, we assume a unimodal population age-crime curve and allow individual expected crime trajectories to differ by their levels of offending and patterns of temporal misalignment. We …

Toxicity Profiling Of Engineered Nanomaterials Via Multivariate Dose Response Surface Modeling, Trina Patel, Donatello Telesca, Saji George, Andre Nel

COBRA Preprint Series

New generation in-vitro high throughput screening (HTS) assays for the assessment of engineered nanomaterials provide an opportunity to learn how these particles interact at the cellular level, particularly in relation to injury pathways. These types of assays are often characterized by small sample sizes, high measurement error and high dimensionality as multiple cytotoxicity outcomes are measured across an array of doses and durations of exposure. In this article we propose a probability model for toxicity profiling of engineered nanomaterials. A hierarchical framework is used to account for the multivariate nature of the data by modeling dependence between outcomes and thereby …

Screening Designs That Minimize Model Dependence, Kenneth P. Fairchild

Theses and Dissertations

When approaching a new research problem, we often use screening designs to determine which factors are worth exploring in more detail. Before exploring a problem, we don't know which factors are important. When examining a large number of factors, it is likely that only a handful are significant and that even fewer two-factor interactions will be significant. If there are important interactions, it is likely that they are connected with the handful of significant main effects. Since we don't know beforehand which factors are significant, we want to choose a design that gives us the highest probability a priori of …

Studying The Handling Of Heat Stressed Cattle Using The Additive Bi-Logistic Model To Fit Body Temperature, Fan Yang

Department of Statistics: Dissertations, Theses, and Student Work

Daily activities consume the energy of heifers, subsequently causing an elevation of body temperature, depending on the ambient conditions. A better understanding of the dynamics of body temperature (Tb) would be helpful when deciding how to process and handle heifers. It would also lead to specific recommendations on moving heifers under different ambient conditions, especially during the summer. In this study, a bi-logistic mixed model is used to describe the dynamics of Tb during the moving event. Data were taken from heifers in pens located at different distances from the heifer work station on four separate summer days under hot …

If And How Many 'Races'? The Application Of Mixture Modeling To World-Wide Human Craniometric Variation, Bridget Frances Beatrice Algee-Hewitt

Doctoral Dissertations

Studies in human cranial variation are extensive and widely discussed. While skeletal biologists continue to focus on questions of biological distance and population history, group-specific knowledge is being increasingly used for human identification in medico-legal contexts. The importance of this research has been often overshadowed by both philosophic and methodological concerns. Many analyses have been constrained in their scope by the limited availability of representative samples and readily criticized for adopting statistical techniques that require user-guidance and a priori information. A multi-part project is presented here that implements model-based clustering as an alternative approach for population studies using craniometric traits. …

Geographic Disparities Associated With Stroke And Myocardial Infarction In East Tennessee, Ashley Pedigo Golden

Doctoral Dissertations

Stroke and myocardial infarction (MI) are serious conditions whose burdens vary by socio-demographic and geographic factors. Although several studies have investigated and identified disparities in burdens of these conditions at the county and state levels, little is known regarding their geographic epidemiology at the neighborhood level. Both conditions require emergency treatments and therefore timely geographic accessibility to appropriate care is critical. Investigation of disparities in geographic accessibility to stroke and MI care and the role of Emergency Medical Services (EMS) in reducing treatment delays are vital in improving health outcomes. Therefore, the objectives of this work were to: (i) classify …

Energy Functional For Nuclear Masses, Michael Giovanni Bertolli

Doctoral Dissertations

An energy functional is formulated for mass calculations of nuclei across the nuclear chart with major-shell occupations as the relevant degrees of freedom. The functional is based on Hohenberg-Kohn theory. Motivation for its form comes from both phenomenology and relevant microscopic systems, such as the three-level Lipkin Model. A global fit of the 17-parameter functional to nuclear masses yields a root- mean-square deviation of χ[chi] = 1.31 MeV, on the order of other mass models. The construction of the energy functional includes the development of a systematic method for selecting and testing possible functional terms. Nuclear radii are computed within …

An Analysis Of Breast Cancer Metastasis, Jennifer Lee Gildner

Statistics

The main objective of this paper is to evaluate possible socio-economic status, clinical, and treatment associations with the occurrence of distant metastasis in Stage I – III breast cancer patients. After analysis in a logistic regression model, four variables were found to be significant with occurrence of distant metastases. These variables were: education, disease group (Triple-negative, Her2Neu-positive and Luminal A), stage at diagnosis, and concordance to chemotherapy based on the NCCN guidelines. Patients without a college degree were found to be more likely to develop distant metastasis than those with a college degree (OR = 2.46 95% CI 1.44 – …

Time-Dependent Cortical Activation In Voluntary Muscle Contraction, Qi Yang, Xiao-Feng Wang, Yin Fang, Vlodek Siemionow, Wanxiang Yao, Guang H. Yue

Xiaofeng Wang

This study was to characterize dynamic source strength changes estimated from high-density scalp electroencephalogram (EEG) at different phases of a submaximal voluntary muscle contraction. Eight healthy volunteers performed isometric handgrip contractions of the right arm at 20% maximal intensity. Signals of the handgrip force, electromyography (EMG) from the finger flexor and extensor muscles and 64-channel EEG were acquired simultaneously. Sources of the EEG were analyzed at 19 time points across preparation, execution and sustaining phases of the handgrip. A 3-layer boundary element model (BEM) based on the MNI (Montréal Neurological Institute) brain MRI was used to overlay the sources. A …

Reliable A-Posteriori Error Estimators For Hp-Adaptive Finite Element Approximations Of Eigenvalue/Leigenvector Problems, Stefano Giani, Luka Grubisic, Jeffrey S. Ovall

Mathematics and Statistics Faculty Publications and Presentations

We present reliable a-posteriori error estimates for hp-adaptive finite element approxima- tions of eigenvalue/eigenvector problems. Starting from our earlier work on h adaptive finite element approximations we show a way to obtain reliable and efficient a-posteriori estimates in the hp-setting. At the core of our analysis is the reduction of the problem on the analysis of the associated boundary value problem. We start from the analysis of Wohlmuth and Melenk and combine this with our a-posteriori estimation framework to obtain eigenvalue/eigenvector approximation bounds.

Design And Implementation Of An Open Framework For Ubiquitous Carbon Footprint Calculator Applications, Farzana Rahman, Casey O'Brien, Sheikh Iqbal Ahamed, He Zhang, Lin Liu

Mathematics, Statistics and Computer Science Faculty Research and Publications

As climate change is becoming an important global issue, more and more people are beginning to pay attention to reducing greenhouse gas emissions. To measure personal or household carbon dioxide emission, there are already plenty of carbon footprint calculators available on the web. Most of these calculators use quantitative models to estimate carbon emission caused by a user's activities. Although these calculators can promote public awareness regarding carbon emission due to an individual's behavior, there are concerns about the consistency and transparency of these existing CO₂ calculators. Apart from a small group of smart phone based carbon footprint calculator …

The Role Of Cell Sterilization In Population Based Studies Of Radiogenic Second Cancers Following Radiation Therapy, Annelise Giebeler

Dissertations & Theses (Open Access)

Advances in radiotherapy have generated increased interest in comparative studies of treatment techniques and their effectiveness. In this respect, pediatric patients are of specific interest because of their sensitivity to radiation induced second cancers. However, due to the rarity of childhood cancers and the long latency of second cancers, large sample sizes are unavailable for the epidemiological study of contemporary radiotherapy treatments. Additionally, when specific treatments are considered, such as proton therapy, sample sizes are further reduced due to the rareness of such treatments. We propose a method to improve statistical power in micro clinical trials. Specifically, we use a …

Development Of A Bayesian Joint Logistic Model To Better Study The Association Between Haplotypes And Disease, Anthony M. D'Amelio Jr

Dissertations & Theses (Open Access)

In 2011, there will be an estimated 1,596,670 new cancer cases and 571,950 cancer-related deaths in the US. With the ever-increasing applications of cancer genetics in epidemiology, there is great potential to identify genetic risk factors that would help identify individuals with increased genetic susceptibility to cancer, which could be used to develop interventions or targeted therapies that could hopefully reduce cancer risk and mortality.

In this dissertation, I propose to develop a new statistical method to evaluate the role of haplotypes in cancer susceptibility and development. This model will be flexible enough to handle not only haplotypes of any …

A Stochastic Version Of The Em Algorithm To Analyze Multivariate Skew-Normal Data With Missing Responses, M. Khounsiavash, M. Ganjali, T. Baghfalaki

Applications and Applied Mathematics: An International Journal (AAM)

In this paper an algorithm called SEM, which is a stochastic version of the EM algorithm, is used to analyze multivariate skew-normal data with intermittent missing values. Also, a multivariate selection model framework for modeling of both missing and response mechanisms is formulated. By the SEM algorithm missing values of responses are inputed by the conditional distribution of missing values given observed data and then the log-likelihood of the pseudocomplete data is maximized. The algorithm is iterated until convergence of parameter estimates. Results of an application are also reported where a Bootstrap approach is used to compute the standard error …

A Group Acceptance Sampling Plans For Lifetimes Following A Marshall-Olkin Extended Exponential Distribution, G. S. Rao

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, a group acceptance sampling plan is developed for a truncated life test when the lifetime of an item follows the Marshall-Olkin extended exponential distribution. The minimum number of groups required for a given group size and the acceptance number is determined when the consumer’s risk and the test termination time are specified. The operating characteristic values, according to various quality levels, are found and the minimum ratios of the true average life to the specified life at the specified producer’s risk are obtained. The results are explained with examples.

Applying Gmdh-Type Neural Network And Genetic Algorithm For Stock Price Prediction Of Iranian Cement Sector, Saeed Fallahi, Meysam Shaverdi, Vahab Bashiri

Applications and Applied Mathematics: An International Journal (AAM)

The cement industry is one of the most important and profitable industries in Iran and great content of financial resources are investing in this sector yearly. In this paper a GMDH-type neural network and genetic algorithm is developed for stock price prediction of cement sector. For stocks price prediction by GMDH type-neural network, we are using earnings per share (EPS), Prediction Earnings Per Share (PEPS), Dividend per share (DPS), Price-earnings ratio (P/E), Earnings-price ratio (E/P) as input data and stock price as output data. For this work, data of ten cement companies is gathering from Tehran stock exchange (TSE) in …

Water Quality Models For Stormwater Runoff In Two Lincoln, Nebraska Urban Watersheds, Jake Fisher

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Water quality monitoring was conducted in two urban watersheds (Colonial Hills and Taylor Park) located in southeast Lincoln, NE over a three year period spanning from October 2008 through September 2011. In-line probes continuously measured for turbidity, conductivity, dissolved oxygen, and water temperature while other water quality constituents were analyzed for discrete water samples collected using grab and automatic sampling techniques. The water quality data was used to calculate event mean concentrations (EMCs) for sixteen storm events sampled over the duration of the project period. Three types of stormwater quality multiple linear regression models were developed for the estimation of …

Spatial Analysis Of Fatal Automobile Crashes In Kentucky, William Nathan Oris

Masters Theses & Specialist Projects

Fatal automobile crashes have claimed the lives of over 33,000 people each year in the United States since 1995. As in any point event, fatal crash events do not occur randomly in time or space. The objectives of this study were to identify spatial patterns and hot spots in FARS (Fatal Analysis Reporting System) fatal crash events based on temporal and demographic characteristics. The methods employed included 1) rate calculation using FARS points and average daily traffic flow; 2) planar kernel density estimation of FARS crash events based on temporal and demographic attributes within the data; and 3) two case …

A General Family Of Dual To Ratio-Cum-Product Estimator In Sample Surveys, Florentin Smarandache, Rajesh Singh, Mukesh Kumar, Pankaj Chauhan, Nirmala Sawan

Branch Mathematics and Statistics Faculty and Staff Publications

This paper presents a family of dual to ratio-cum-product estimators for the finite population mean. Under simple random sampling without replacement (SRSWOR) scheme, expressions of the bias and mean-squared error (MSE) up to the first order of approximation are derived. We show that the proposed family is more efficient than usual unbiased estimator, ratio estimator, product estimator, Singh estimator (1967), Srivenkataramana (1980) and Bandyopadhyaya estimator (1980) and Singh et al. (2005) estimator. An empirical study is carried out to illustrate the performance of the constructed estimator over others.

Automating Construction And Selection Of A Neural Network Using Stochastic Optimization, Jason Lee Hurt

UNLV Theses, Dissertations, Professional Papers, and Capstones

An artificial neural network can be used to solve various statistical problems by approximating a function that provides a mapping from input to output data. No universal method exists for architecting an optimal neural network. Training one with a low error rate is often a manual process requiring the programmer to have specialized knowledge of the domain for the problem at hand.

A distributed architecture is proposed and implemented for generating a neural network capable of solving a particular problem without specialized knowledge of the problem domain. The only knowledge the application needs is a training set that the network …

Moderate Deviation Of Intersection Of Ranges Of Random Walks In The Stable Case, Justin Anthony Grieves

Doctoral Dissertations

Given p independent, symmetric random walks on d-dimensional integer lattice that are the domain of attraction for a stable distribution, we calculate the moderate deviation of the intersection of ranges of the random walks in the case where the walks intersect infinitely often as time goes to infinity. That is to say, we establish a weak law convergence of intersection of ranges to intersection local time of stable processes and use this convergence as a link to establish deviation results.

Testing For Improvement In Prediction Model Performance, Margaret S. Pepe Phd, Kathleen F. Kerr Phd, Gary Longton, Zheyu Wang Phd

Margaret S Pepe PhD

New methodology has been proposed in recent years for evaluating the improvement in prediction performance gained by adding a new predictor, Y, to a risk model containing a set of baseline predictors, X, for a binary outcome D. We prove theoretically that null hypotheses concerning no improvement in performance are equivalent to the simple null hypothesis that the coefficient for Y is zero in the risk model, P(D=1|X,Y). Therefore, testing for improvement in prediction performance is redundant if Y has already been shown to be a risk factor. We investigate properties of tests through simulation studies, focusing on the change …

Exploration And Comparison Of Methods For Combining Population- And Family-Based Genetic Association Using The Genetic Analysis Workshop 17 Mini-Exome, David W. Fardo, Anthony R. Druen, Jinze Liu, Lucia Mirea, Claire Infante-Rivard, Patrick Breheny

Biostatistics Faculty Publications

We examine the performance of various methods for combining family- and population-based genetic association data. Several approaches have been proposed for situations in which information is collected from both a subset of unrelated subjects and a subset of family members. Analyzing these samples separately is known to be inefficient, and it is important to determine the scenarios for which differing methods perform well. Others have investigated this question; however, no extensive simulations have been conducted, nor have these methods been applied to mini-exome-style data such as that provided by Genetic Analysis Workshop 17. We quantify the empirical power and false-positive …

Real Options Models In Real Estate, Jin Won Choi

Electronic Thesis and Dissertation Repository

Our aim in this thesis is to investigate the usefulness of real options analysis, taking case studies of problems in real estate. In the realm of real estate, we consider the following three problems. First, we consider the valuation and usefulness of presale contracts of condominiums, which can be viewed as similar to call options on condominiums. Secondly, we consider the valuation of farm land from the perspective of land developers, who may think of farm land as being similar to call options on subdivision lots. Third, we consider the valuation of opportunities to install solar panels on properties, in …

Generalized Exponential Models With Applications, Iman Mabrouk

Electronic Thesis and Dissertation Repository

We introduce a generalized exponential model whose exact moments and normalizing constant are obtained in terms of Meijer’s generalized hypergeometric G-function. Actually, several widely utilized statistical distributions such as the gamma, Weibull and half-normal constitute particular cases thereof. The generalized inverse Gaussian distribution, which was popularized in the late seventies by Ole Barndor_Neilsen, is also extended by incorporating an additional parameter in its density function, the moments of the resulting distribution being expressed in terms of Bessel functions. A number of data sets were then fitted with diverse exponential-type models for comparison purposes. Additionally, it is shown that the …