Physical Sciences and Mathematics Commons^™

Simultaneous Determination Of Multiple Actinide Elements In A Variety Of Soils Utilizing A Standardized Sequential Extraction Protocol, Sherry Alina Faye

UNLV Theses, Dissertations, Professional Papers, and Capstones

To obtain a better understanding of the mobility of actinide element contaminants in the environment, the association of the contaminants with specific host phases of soils and sediments must be investigated. This investigation is most commonly conducted using sequential extraction techniques that employ the selective dissolution of soil phases with increasingly aggressive chemical treatment. Though several sequential extraction studies exist in literature, conclusions cannot be made by direct comparison of data due to the lack of uniformity in the protocols used. This work aims to continue development of a standard sequential extraction protocol and expanding its capabilities to include the …

Development Of Quantitative Bioanalytical Methods For The Pharmacological Studies Of Anti-Cancer Drugs, Ye Feng

ETD Archive

In the anticancer drug discovery and therapy development, it is essential to understand the pharmacological properties of the drugs. Today, pharmaceutical analysis is employed throughout the whole drug discovery and development process. Pharmacokinetic-pharmacodynamic relationships are playing an increasingly important role in decisions on the rational development and use of new drugs and they can provide a detailed knowledge of the mechanism of the drug and a better understanding of the molecular targets on which they act. Due to the significance of pharmacological analysis, sensitive analytical methods are critically needed for pharmacological studies. Therefore, our long-term goal is to provide guidelines …

Development Of Lc-Ms/Ms Methods For Quantitative Analysis Of Plant-Derived Anticancer Agent And Synthetic Estrogen In Complex Matrices, Simuli Lindah Wabuyele

ETD Archive

No abstract provided.

Design And Synthesis Of Antithrombotic Liposomal Protein Conjugate, Hailong Zhang

ETD Archive

Recent advances in the molecular bases of haemostasis have highlighted that endothelial thrombomodulin (TM) plays a critical role in local haemostasis by binding thrombin and subsequently converting protein C to its active form (APC). In addition, the binding of thrombin to TM drastically alters the thrombin's procoagulant activities to anticoagulant activities. The lipid bilayer in which it resides serves as an essential 'cofactor', locally concentrating and coordinating the appropriate alignment of reacting cofactors and substrates for protein C activation. On the other hand, liposomes have been extensively studied as cell membrane model as well as carrier for delivering certain vaccines, …

Development And Applications Of Ionic Liquids And Near-Infrared Multispectral Imaging Techniques, Irena Mejac

Dissertations (1934 -)

In this work, we explore novel analytical applications of Ionic Liquids and Near-infrared multispectral imaging microscopy.

Ionic liquids (ILs) belong to a group of organic salts that are liquid at room temperature and can be, due to their unique chemical and physical properties, successfully used for a variety of applications. The main goal of this study was to explore the synergistic use of ILs in chemical separations. Specifically, chiral ILs were used as novel chiral selectors for Capillary Electrophoresis and as solvents for stationary phase in Gas Chromatography. As chiral selectors IL provides baseline-separation as well as enantiomeric separation of …

Study Of Drug Delivery Behavior Through Biomembranes Using Thermal And Bioanalytical Techniques, Hareesha Reddy Venumuddala

ETD Archive

This Master of Science thesis encompasses two projects in chemical pharmaceuticals. The first is a study of excipients and the added new information collected beyond Thermal Gravimetric Analysis and Differential Scanning Calorimetry from Dielectric Analysis. These new properties enhance our global knowledge of excipients by thermal analytical methods. Excipients, the inactive ingredients in formulated drugs, aid different functions of the active pharmacy ingredient, the drugs. Low temperature transitions, by DEA including melting of frozen solvents, e.g. water, are more definitive than observed by low temperature DSC. Millions of dollars are expended annually on pharmaceutical testing to qualify excipients for fully …

Fabricating New Miniaturized Biosensors For The Detection Of Dna Damage And Dna Mismatches, N. Indika Perera

ETD Archive

A large number of genetic diseases and genetic disorders are simply caused by base alterations in the genome. Therefore, developing efficient and cost effective techniques for routine detection of these alterations is of great importance. Different methods involving gel electrophoresis and Polymerase Chain Reaction have been widely employed, but majority of these methods are costly, time consuming, and lack throughput, creating a fundamental gap between the current state-of-the-art and desired characteristics of low-cost, high-speed, simplicity, versatility, and potential for miniaturization. In this study, we attempt to bridge this gap by developing new sensing platforms to detect DNA base mismatches and …

High Pressure Spectral Chemistry Of Selected Organic Compounds, Frank William Linsley

Theses and Dissertations

The series of compounds indicated by the formular C_6H_5-(CH=CH)n-C_6H_5 change in color from white (colorless) to yellow to orange to red to deep red as n increases from 1 to 12. Stilbene is the first compound of this series (n=1). Under pressure, exerted by a diamond anvil press, stilbene can be seen to change color from white to yellow to red as increasing pressure is applied. Similar color changes are observed for the compounds where n=2,3, and 4 when subjected to similar pressure. This study records and reports the spectra versus pressure for these compounds.

The Determination Of Ethanol In Aqueous Solution By Gas-Liquid Partition Chromatography, Robert L. Morrison

University of the Pacific Theses and Dissertations

The present chemical and physical methods for the determination of ethyl alcohol are all subject to systematic errors derived from any of a number of interfacing substances usually present in solution with the ethanol. Some of the most popular methods are slow and tedious and require a good deal of skill and technique to perform. The dichromate (2), pycnometer and refractometer methods are three such methods. The interfering substances most often present in industrial and food products are fusel oils and acetaldehyde. These substances interfere in the three methods just mentioned. It is of course possible to analyze for these …

A Study Of Chromatographic Adsorption Analysis And Its Application To Inorganic Qualitative Analysis, Sidney Marion Beck

Theses and Dissertations

This work is a study of the analytical applications of the chromatographic method, particularly as applied to inorganic qualitative analysis. It is divided into four parts as follows: (a) The main part of the work is a search of the common laboratory reagents, likely to be found in any beginning qualitative analysis laboratory, with the purpose of finding the best reagents for developing an invisible chromatogram on an adsoption column of activated alumina. For the most part, only inorganic reagents were used, but in special cases, a few of the more common orgaic reagents were used. (b) An evaluation of …