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Specific And Non-Specific Binding Of Proteins And Nucleic Acids On Chemically Modified Reticulated Vitreous Carbon Electrodes, Hemangi Shedge

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Proteins and nucleic acids play major roles in many important biological processes. Specific and rapid detection of these biomolecules is important for early and precise diagnosis of various genetic diseases and other medical conditions. However, accurate and inexpensive detection of proteins and nucleic acids has always been a challenge. One of the obstacles is their non-specific adsorption on the sensor surface which leads to the conformational changes in the proteins, sometimes causing their denaturation. The non-specific adsorption on the surface also leads to sensor fouling which induces changes in the availability of active sensor surface for detection of analytes and …