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- Anitbiotic (1)
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- Coalescence Kick Method (1)
- Des-methyl laulimalide (1)
- Doped Clusters (1)
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- Electronics Structure (1)
- Geometry (1)
- HIV (1)
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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
Geometry And Electronic Structure Of Doped Clusters Via The Coalescence Kick Method, Boris Averkiev
Geometry And Electronic Structure Of Doped Clusters Via The Coalescence Kick Method, Boris Averkiev
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Developing chemical bonding models in clusters is one of the most challenging tasks of modern theoretical chemistry. There are two reasons for this. The first one is that clusters are relatively new objects in chemistry and have been extensively studied since the middle of the 20th century. The second reason is that clusters require high-level quantum-chemical calculations; while for many classical molecules their geometry and properties can be reasonably predicted by simpler methods.
The aim of this dissertation was to study doped clusters and explain their chemical bonding. The research was focused on three classes of compounds: aluminum clusters doped …
Carbohydrate Derivatives In Antibiotics Research, Yi Liang
Carbohydrate Derivatives In Antibiotics Research, Yi Liang
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
In this study, we investigated the potential applications of carbohydrates in the development of new antibiotics. To tackle the problem of multidrug-resistant variants of M. tuberculosis (MDR-TB), we investigated the biosynthesis pathways of trehalose, which has contributed to significant drug resistance. Some new methods were developed for the synthesis of potential inhibitors (6-azido-trehalose and 6,6'-diazido-trehalose) that have been designed to imitate the intermediate molecule (trehalose 6-phosphate, TPP) of OtsA-OtsB pathway. At the same time, some new antibacterial agents based on trehalose have been synthesized. Members of the 1,2,3-triazole family have shown interesting biological properties. Steroid derivatives have been developed in …
Detecting Organic Molecules On The Surface Of Inorganic Dust Particles Using Aerosol Mass Spectrometry, Sileola B. Akinsiku
Detecting Organic Molecules On The Surface Of Inorganic Dust Particles Using Aerosol Mass Spectrometry, Sileola B. Akinsiku
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Detection of organic molecules present on the surface of dust particles is important in homeland security, agriculture, and several other applications. The research presented reports the ability of the aerosol mass spectrometer (AMS) to detect molecules on the surface of dust particles without detecting the particle core.
Experiments were carried out to detect semi-volatile organic compounds adsorbed onto the surface of particulates without interference from the dust particle core. Methyl salicylate, oleic acid, and organophosphorus pesticides such as Malathion were detected on the surface of particles representative of dust-type materials. Zeolite powders were used as aerosol support, representative of a …
Synthetic Studies Of Laulimalide Analogues, Ian Addison Mcalexander
Synthetic Studies Of Laulimalide Analogues, Ian Addison Mcalexander
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Chapter 1 provides some background information on the disease area of cancer and current modes of treatment. Chemotherapy treatment is discussed with a focus on the major cellular targets for these drugs: DNA and microtubules. For each target, classes of active compounds are described along with their mode of action. The microtubule stabilizing agent laulimalide is introduced and a case is made for analogue synthesis.
Chapter 2 describes our first generation efforts toward synthesis of des-methyl laulimalide. The target compound is divided into a northern and southern fragment with the synthesis of each fragment described. The preparation of landmark intermediates …
A Comparative Study Of The Structural Features And Kinetic Properties Of The Mofe And Vfe Proteins From Azotobacter Vinelandii, Miguel Alejandro Pabon Sanclemente
A Comparative Study Of The Structural Features And Kinetic Properties Of The Mofe And Vfe Proteins From Azotobacter Vinelandii, Miguel Alejandro Pabon Sanclemente
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Biological nitrogen fixation is accomplished in the bacterium Azotobacter vinelandii by means of three metalloenzymes: The molybdenum, vanadium, and iron-only nitrogenase. The knowledge regarding biological nitrogen fixation has come from studies on the Mo-dependent reaction. However, the V- and Fe-only-dependent reduction of nitrogen remains largely unknown.
By using homology modeling techniques, the protein folds that contain the metal cluster active sites for the V- and Fe-only nitrogenases were constructed. The models uncovered similarities and differences existing among the nitrogenases regarding the identity of the amino acid residues lining pivotal structural features for the correct functioning of the proteins. These differences, …
Sonication Assisted Synthesis Of Oligomannosides, Christabel Tomla Tanifum
Sonication Assisted Synthesis Of Oligomannosides, Christabel Tomla Tanifum
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Oligomannosides prevalently exist as cell surface antigens. They play important roles in diseases such as viral infection and cancer, and they have been shown to be useful as candidates for vaccines. HIV, one of the most devastating modern diseases, has a high content of mannose sugars on its envelope glycoprotein gp120. Oligomannosides of the HIV virus, also called Man9, which are found on the glycoprotein gp120, have been shown to play a protective role for the HIV virus, shielding highly conserved protein domains of gp120 from proteolytic attacks. Thus gp120 plays an important role in HIV infection of cells, being …