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Full-Text Articles in Translational Medical Research
Median Lethal Dose, Antimalarial Activity, Phytochemical Screening And Radical Scavenging Of Methanolic Languas Galanga Rhizome Extract, Hesham Al-Mekhlafi
Median Lethal Dose, Antimalarial Activity, Phytochemical Screening And Radical Scavenging Of Methanolic Languas Galanga Rhizome Extract, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
The methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes. The antimalarial activities during early and established infections, as well as the prophylactic activity were evaluated. Phytochemical screening and radical scavenging activity of the extract were also investigated to elucidate the possible mechanism of the antimalarial properties. The acute oral toxicity (LD(50)) of Languas galanga extract in mice was established to be 4,998 mg/kg. The extract of Languas galanga rhizomes demonstrated significant …
Opportunities And Obstacles To The Elimination Of Malaria From Peninsular Malaysia: Knowledge, Attitudes And Practices On Malaria Among Aboriginal And Rural Communities, Hesham Al-Mekhlafi
Opportunities And Obstacles To The Elimination Of Malaria From Peninsular Malaysia: Knowledge, Attitudes And Practices On Malaria Among Aboriginal And Rural Communities, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
Background: Despite continuous efforts by the government and private sectors, malaria is still a public health problem in rural Peninsular Malaysia. This study investigated household knowledge, attitude and practices (KAP) regarding malaria in two malaria endemic communities, forest-aboriginal and rural communities, in the Lipis district of Pahang state, Malaysia. Methods: A descriptive cross-sectional study with a semi-structured questionnaire was carried out among 100 and 123 households from forest-aboriginal and rural areas, respectively. Results: Knowledge about malaria and its transmission is significantly higher among the rural participants than the aborigines (86.2% vs 76%, p < 0.01). However, use of medicinal plants and beliefs in witchcraft and sorcery in treating febrile diseases were significantly higher among the aboriginal population (p < 0.01). There were no significant differences between the two communities in terms of the knowledge about malaria symptoms, attitudes towards its severity and practices in preventive measures against malaria by using mosquito bed nets. However, the knowledge and practice of different preventive measures to combat malaria, such as insecticide and the elimination of breeding areas, was significantly higher among the rural population than the aborigines (p < 0.001). Conclusions: Both communities were aware of malaria as a disease, but knowledge, attitudes and practices were inadequate. Providing efficient health education to people residing in malaria endemic areas would improve their understanding about malaria prevention in order to bring about the elimination of malaria from the country.
Ethnobotanical Study On Some Malaysian Anti-Malarial Plants: A Community Based Survey, Hesham Al-Mekhlafi
Ethnobotanical Study On Some Malaysian Anti-Malarial Plants: A Community Based Survey, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
Ethnopharmacological relevance: Various plants species are used in the traditional medicine for the treatment of malaria. This is the first community based ethnobotanical study in Peninsular Malaysia. Aim of the study: To investigate the plants traditionally used in the treatment of malaria in Malaysia. Materials and methods: An ethnobotanical survey was carried out among 233 Aboriginal and rural households, and traditional healers in malaria endemic areas in Peninsular Malaysia. Data were collected using a pre-tested questionnaire. Results: Nineteen species belonging to 17 families were identified. Twelve plant species have not previously been documented for the treatment of malaria in Malaysia. …
Intestinal Microsporidial Infections Among Orang Asli (Aborigine) Children From Malaysia, Hesham Al-Mekhlafi
Intestinal Microsporidial Infections Among Orang Asli (Aborigine) Children From Malaysia, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
No abstract provided.