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Articles 1 - 30 of 1627

Full-Text Articles in Translational Medical Research

A Comparison Efficacy Study Of Commercial Nasopharyngeal Swabs Versus A Novel 3d Printed Swab For The Detection Of Sars-Cov-2, Forest W. Arnold, Gerald Grant, Phillip F. Bressoud, Stephen P. Furmanek, Donghoon Chung, Nadine Sbaih, Dipan Karmali, Meredith Cahill, George Pantalos Jul 2020

A Comparison Efficacy Study Of Commercial Nasopharyngeal Swabs Versus A Novel 3d Printed Swab For The Detection Of Sars-Cov-2, Forest W. Arnold, Gerald Grant, Phillip F. Bressoud, Stephen P. Furmanek, Donghoon Chung, Nadine Sbaih, Dipan Karmali, Meredith Cahill, George Pantalos

The University of Louisville Journal of Respiratory Infections

The large volume of diagnostic tests required by the response to the pandemic of COVID-19 pandemic resulted in a shortage of commercial nasopharyngeal swabs. In an effort to alleviate the shortage, swabs created by 3D printing may be a solution. We designed and produced 3D printed swabs and sought to compare their ability to detect SARS-CoV-2 in patients admitted for COVID-19 or who were suspected of having COVID-19. A total of 30 patients were swabbed with a commercial and printed 3D swab. Results matched in 28 of 31 patients (90%). Two patients were discordant with a positive commercial swab and ...


Treatment-Associated Improvements In Self-Regulation And Mood As Theory-Based Correlates Of Increased Self-Efficacy For Weight-Management Behaviors, James J. Annesi Jun 2020

Treatment-Associated Improvements In Self-Regulation And Mood As Theory-Based Correlates Of Increased Self-Efficacy For Weight-Management Behaviors, James J. Annesi

Health Behavior Research

Expanded understanding of the psychosocial dynamics of weight-loss treatment processes is required to improve consistently poor results. Women with obesity of ages 40–59 years participated in self-regulation-based (n = 41) and information-based (n = 46) treatments. Improvements in self-regulation and self-efficacy related to exercise and eating, mood, exercise, intake of fruits/vegetables and sweets, and weight were significant, and generally greater in the self-regulation group. Exercise- and eating-behavior changes significantly mediated the prediction of self-efficacy changes by changes in self-regulation, with mood change significantly adding to the prediction strength. Findings suggested the value in supporting exercise for its psychosocial benefits within ...


Stroke Management In The Time Of Covid, Marwa Elnazeir, Siddharth Narayanan, Kerri Remmel Jun 2020

Stroke Management In The Time Of Covid, Marwa Elnazeir, Siddharth Narayanan, Kerri Remmel

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Covid-19 Radiological Library, Forest W. Arnold, Tracy Vanmeter, Lachlan Smith, Danny Mcgrath, Matthew Grassman, Nishant Patel, William Mattingly Jun 2020

Covid-19 Radiological Library, Forest W. Arnold, Tracy Vanmeter, Lachlan Smith, Danny Mcgrath, Matthew Grassman, Nishant Patel, William Mattingly

The University of Louisville Journal of Respiratory Infections

No abstract provided.


A Patient With Escherichia Coli Bacteremia And Covid-19 Co-Infection: A Case Report For The Louisville Covid-19 Epidemiology Study, Sarah E. Moore Pharmd, Ashley M. Wilde Pharmd, Bcps-Aqid, Matthew Song Pharmd, Bcidp, Brian C. Bohn Pharmd, Clayton J. Patross Pharmd, Bcps, Bryan Denham Md, Paul Schulz, Julio A. Ramirez Jun 2020

A Patient With Escherichia Coli Bacteremia And Covid-19 Co-Infection: A Case Report For The Louisville Covid-19 Epidemiology Study, Sarah E. Moore Pharmd, Ashley M. Wilde Pharmd, Bcps-Aqid, Matthew Song Pharmd, Bcidp, Brian C. Bohn Pharmd, Clayton J. Patross Pharmd, Bcps, Bryan Denham Md, Paul Schulz, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

Patients with COVID-19 may have co-infections with other microorganisms. Here we report a case of a patient with an E. coli bacteremia secondary to a urinary tract infection, who experienced fevers while on active antimicrobial therapy. The patient was eventually tested for COVID-19 and found to be positive. This case emphasizes the need to suspect COVID-19 even in patients with documented bacterial infection.


Sars-Cov-2 And Bacterial Co-Infection, Rodrigo Cavallazzi Jun 2020

Sars-Cov-2 And Bacterial Co-Infection, Rodrigo Cavallazzi

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Life In The Time Of Covid, Julio A. Ramirez Jun 2020

Life In The Time Of Covid, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Healthcare Workers In The Time Of Covid, Julio A. Ramirez, Ruth Carrico Jun 2020

Healthcare Workers In The Time Of Covid, Julio A. Ramirez, Ruth Carrico

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Abo Blood Group Type And Susceptibility To Covid-19 Infection, G. Rafael Fernandez-Botran May 2020

Abo Blood Group Type And Susceptibility To Covid-19 Infection, G. Rafael Fernandez-Botran

The University of Louisville Journal of Respiratory Infections

Since December 2019, the SARS-CoV2 (COVID-19) pandemic has continued to extend over most of the world, infecting over four million people and causing well over 300,000 deaths so far (https://coronavirus.jhu.edu/map.html, accessed on May 14, 2020). A significant percentage of infected patients develop severe symptoms and life-threatening conditions. While COVID-19 infection can affect all ages, available evidence points to older age and pre-existing comorbidities such as hypertension, diabetes and coronary heart disease, as important risk factors related to increased mortality rates. [1-3] Moreover, recent reports from China and the U.S. have suggested that the ...


Causes Of Challenges In Implementing Computer-Based Knowledge Management Systems In Healthcare Institutions: A Case Study Of Private Hospitals In Johannesburg, South Africa, George Maramba, Alfred Coleman, Felix F. Ntawanga May 2020

Causes Of Challenges In Implementing Computer-Based Knowledge Management Systems In Healthcare Institutions: A Case Study Of Private Hospitals In Johannesburg, South Africa, George Maramba, Alfred Coleman, Felix F. Ntawanga

The African Journal of Information Systems

The advent of computer-based knowledge management systems has changed the world, especially in the way businesses operate, making them an integral aspect to modern economies and the drivers of success. Studies show that the implementation of computer-based knowledge management systems is challenging, particularly in healthcare institutions. This paper presents a study that was undertaken to identify the causes of challenges encountered when implementing computer-based knowledge management systems in healthcare institutions. A case was used as this study’s research methodology in which three private hospitals based in Johannesburg, South Africa, were utilized. Six participants, two from each private hospital, were ...


Implementation Of The Louisville Covid-19 Surveillance Protocol: Experiences From The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, Dawn Balcom, William Johnson, Amr Aboelnasr, Mutasem Abuhalaweh, Stephen Furmanek, Montray Smith, Amanda Lasnik, Donghoon Chung, Julio A. Ramirez May 2020

Implementation Of The Louisville Covid-19 Surveillance Protocol: Experiences From The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, Dawn Balcom, William Johnson, Amr Aboelnasr, Mutasem Abuhalaweh, Stephen Furmanek, Montray Smith, Amanda Lasnik, Donghoon Chung, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

The lack of available testing for SARS-CoV-2 has been one of the primary challenges in the development and implementation of a comprehensive approach to infection prevention and transmission in the United States (US). In response to the need for increased testing capacities and capabilities, the University of Louisville (UofL) Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID) initiated the Louisville Coronavirus Surveillance Program, a comprehensive approach to surveillance and testing of patients and healthcare workers. The first specimens were accepted on March 12, 2020 and parallel testing was done using a high-capacity testing process and ...


An Eye On The Dog As The Scientist’S Best Friend For Translational Research In Ophthalmology: Focus On The Ocular Surface, Lionel Sebbag, Jonathan P. Mochel May 2020

An Eye On The Dog As The Scientist’S Best Friend For Translational Research In Ophthalmology: Focus On The Ocular Surface, Lionel Sebbag, Jonathan P. Mochel

Biomedical Sciences Publications

Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (ie., rabbits, mice and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help ...


Variability In Naltrexone Biotransformation, Stephani L. Stancil May 2020

Variability In Naltrexone Biotransformation, Stephani L. Stancil

Research Days

No abstract provided.


Composite Quantitative Knee Structure Metrics Predict The Development Of Accelerated Knee Osteoarthritis: Data From The Osteoarthritis Initiative, Matthew S. Harkey, Julie E. Davis, Lori Lyn. Price, Robert J. Ward, James W. Mackay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Bing Lu, Timothy E. Mcalindon, Jeffrey B. Driban May 2020

Composite Quantitative Knee Structure Metrics Predict The Development Of Accelerated Knee Osteoarthritis: Data From The Osteoarthritis Initiative, Matthew S. Harkey, Julie E. Davis, Lori Lyn. Price, Robert J. Ward, James W. Mackay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Bing Lu, Timothy E. Mcalindon, Jeffrey B. Driban

UMass Center for Clinical and Translational Science Supported Publications

BACKGROUND: We aimed to determine if composite structural measures of knee osteoarthritis (KOA) progression on magnetic resonance (MR) imaging can predict the radiographic onset of accelerated knee osteoarthritis.

METHODS: We used data from a nested case-control study among participants from the Osteoarthritis Initiative without radiographic KOA at baseline. Participants were separated into three groups based on radiographic disease progression over 4 years: 1) accelerated (Kellgren-Lawrence grades [KL] 0/1 to 3/4), 2) typical (increase in KL, excluding accelerated osteoarthritis), or 3) no KOA (no change in KL). We assessed tibiofemoral cartilage damage (four regions: medial/lateral tibia/femur), bone ...


A Call For Grounding Implicit Bias Training In Clinical And Translational Frameworks, Nao Hagiwara, Frederick W. Kron, Mark W. Scerbo, Ginger S. Watson May 2020

A Call For Grounding Implicit Bias Training In Clinical And Translational Frameworks, Nao Hagiwara, Frederick W. Kron, Mark W. Scerbo, Ginger S. Watson

Psychology Faculty Publications

Since the publication of Unequal Treatment in 2003,1 the number of studies investigating the implicit bias of health-care providers and its troubling consequences has increased exponentially. Bias can occur in all three psychological components: affects (ie, prejudice), cognition (ie, stereotypes), and behaviour (ie, discrimination). Implicit bias refers to prejudicial attitudes towards and stereotypical beliefs about a particular social group or members therein. These prejudicial attitudes and stereotypical beliefs are activated spontaneously and effortlessly, which often result in discriminatory behaviours.2 This definition is consistent with how implicit bias is defined in psychology3 and in literature on health disparities ...


Umccts Newsletter, May 2020, Umass Center For Clinical And Translational Science May 2020

Umccts Newsletter, May 2020, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the May 2020 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


Possible Role Of Tetracyclines On Covid-19: Recycling Well-Known Old Drugs From The Shelf, Martin Gnoni, Raul Vasquez-Gararatti, Angel Mena May 2020

Possible Role Of Tetracyclines On Covid-19: Recycling Well-Known Old Drugs From The Shelf, Martin Gnoni, Raul Vasquez-Gararatti, Angel Mena

The University of Louisville Journal of Respiratory Infections

We are in the midst of a pandemic due to the novel coronavirus SARS-CoV-2. Innovative therapies are in the lookup around the world. Recently, chloroquine and hydroxychloroquine in addition to Azithromycin were proposed to be used in patients with severe disease even though strong evidence is lacking. We propose the use of tetracyclines in addition to anti-virals early in the curse of the disease in order to prevent the Cytokine Storm Syndrome associated with COVID-19 and prevent ARDS. The proposed mechanisms of tetracyclines are: 1) anti-apoptotic properties; 2) decrease the Myeloperoxidase and ROS releaser from immune cells; 3) decrease neutrophil ...


Rna Therapeutics: Informational Drugs As A Pandemic Response Tool, Anastasia Khvorova Apr 2020

Rna Therapeutics: Informational Drugs As A Pandemic Response Tool, Anastasia Khvorova

UMass Center for Clinical and Translational Science Seminars

This presentation, hosted by the Community Engagement and Research Section, University of Massachusetts Medical School Center for Clinical and Translational Science, describes the development of siRNA-based approaches for modulation of COVID-19 in the lung in a three-month time frame.

This talk was the second in the COVID-19 Research Community Forum webinar series, a collaboration of the four federally-funded Clinical and Translational Science Awardees (CTSA) in Massachusetts, that provided an opportunity for community members, institutions and other organizations to be part of the discussions surrounding the COVID-19 pandemic. The MA CTSAs, consisting of the UMass Center for Clinical and Translational Science ...


The Symbiome Project: An Exploratory Investigation Of The Biological, Psychological, And Social Mechanisms That Contribute To The Transition From Acute To Chronic Musculoskeletal Pain, Joshua Y. Lee Apr 2020

The Symbiome Project: An Exploratory Investigation Of The Biological, Psychological, And Social Mechanisms That Contribute To The Transition From Acute To Chronic Musculoskeletal Pain, Joshua Y. Lee

Electronic Thesis and Dissertation Repository

This dissertation presents the initial findings of the SYMBIOME project; which attempts to combine the objective and subjective aspects of musculoskeletal pain to develop a prognostic clinical phenotype. Chapter 2 presents a moderator analysis of functional outcomes (pain interference and pain severity). Psychosocial moderators can affect the relationship between biomarkers and pain. For pain severity, TNF-α, TGF-β1, and CRP were moderated by employment status, pre-existing psychopathology, and sex. For pain interference, IL-1β, cortisol, TGF-β1, CRP, and IL-6 were moderated by pre-existing pain, peri-traumatic fear, region of injury, and peri-traumatic stress. Chapter 3 presents a latent growth curve analysis in determining ...


How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi K. Kamepalli Md,Fidsa,Cwsp Apr 2020

How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi K. Kamepalli Md,Fidsa,Cwsp

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Covid-19, Colleagues, Confusion, And Conversations, Nathanael R. Sanchez M.D., Katherine S. Lee , M.D., Karen Weaver M.D. Apr 2020

Covid-19, Colleagues, Confusion, And Conversations, Nathanael R. Sanchez M.D., Katherine S. Lee , M.D., Karen Weaver M.D.

Clinical Research in Practice: The Journal of Team Hippocrates

During the COVID-19 pandemic, doctors in a community hospital reflect on their decision-making regarding treatment options for COVID-19. Whether to use hydroxychloroquine is the treatment discussed in most detail.


When Rationing Becomes Part Of Clinical Decision-Making, Christopher A. Hopper, Mitra Bahaee Apr 2020

When Rationing Becomes Part Of Clinical Decision-Making, Christopher A. Hopper, Mitra Bahaee

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical practice-based reflection on Noack DP, Newton G. Compared to maximal current management standards, oscillating positive expiratory pressure devices have not been shown to improve clinically relevant outcomes in COPD patients with acute exacerbation. Clin. Res. Prac. 2017;3(2):eP1516. doi: 10.22237/crp/149886732.


Clinical Decision Science Suggests Different Research Questions Need To Be Asked Related To Informed Consent, John K. Geddes Apr 2020

Clinical Decision Science Suggests Different Research Questions Need To Be Asked Related To Informed Consent, John K. Geddes

Clinical Research in Practice: The Journal of Team Hippocrates

The author examines the literature relating to informed consent for early cardiac catheterization to treat Non-ST-segment elevation acute coronary syndrome, and considers whether Clinical Decision Science might provide new directions for applying the clinical research literature.


Valbenazine Has A Small But Meaningful Benefit For Tardive Dyskinesia, Joseph Friedli, Ryan Quick, Reem Sobh, Samantha Cowing Apr 2020

Valbenazine Has A Small But Meaningful Benefit For Tardive Dyskinesia, Joseph Friedli, Ryan Quick, Reem Sobh, Samantha Cowing

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of

Hauser RA, Factor SA, Marder SR, et al. KINECT 3: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Valbenazine for Tardive Dyskinesia. Am J Psychiatry. 2017;174(5):476-484. https://doi.org/10.1176/appi.ajp.2017.16091037

and

Factor SA, Remington G, Comella CL, et al. The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study. J Clin Psychiatry. 2017;78(9):1344-1350. https://doi.org/10.4088/JCP.17m11777

exploring the efficacy of a newer therapy for tardive dyskinesia, and describing recommendations for a ...


From The Editor: Defining The Scholarship Of Clinical Decision Science, James Peter Meza Apr 2020

From The Editor: Defining The Scholarship Of Clinical Decision Science, James Peter Meza

Clinical Research in Practice: The Journal of Team Hippocrates

The Editor refines the focus of the journal to a new area of scholarship, Clinical Decision Science, exploring how the complex interacting aspects of clinical care are described, understood, shared, and explained in the context of the doctor-patient relationship.


Recapitulation Of The Accessible Interface Of Biopsy-Derived Canine Intestinal Organoids To Study Epithelial-Luminal Interactions, Yoko M. Ambrosini, Yejin Park, Albert E. Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C. Borcherding, Jinah Jang, Karin Allenspach, Jonathan P. Mochel, Hyun Jung Kim Apr 2020

Recapitulation Of The Accessible Interface Of Biopsy-Derived Canine Intestinal Organoids To Study Epithelial-Luminal Interactions, Yoko M. Ambrosini, Yejin Park, Albert E. Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C. Borcherding, Jinah Jang, Karin Allenspach, Jonathan P. Mochel, Hyun Jung Kim

Biomedical Sciences Publications

Recent advances in canine intestinal organoids have expanded the option for building a better in vitro model to investigate translational science of intestinal physiology and pathology between humans and animals. However, the three-dimensional geometry and the enclosed lumen of canine intestinal organoids considerably hinder the access to the apical side of epithelium for investigating the nutrient and drug absorption, host-microbiome crosstalk, and pharmaceutical toxicity testing. Thus, the creation of a polarized epithelial interface accessible from apical or basolateral side is critical. Here, we demonstrated the generation of an intestinal epithelial monolayer using canine biopsy-derived colonic organoids (colonoids). We optimized the ...


Translating Research Into Practice: Protocol For A Community-Engaged, Stepped Wedge Randomized Trial To Reduce Disparities In Breast Cancer Treatment Through A Regional Patient Navigation Collaborative, Tracy A. Battaglia, Karen M. Freund, Jennifer S. Haas, Nicole Casanova, Sharon Bak, Howard Cabral, Rachel A. Freedman, Karen Burns. White, Stephenie C. Lemon Apr 2020

Translating Research Into Practice: Protocol For A Community-Engaged, Stepped Wedge Randomized Trial To Reduce Disparities In Breast Cancer Treatment Through A Regional Patient Navigation Collaborative, Tracy A. Battaglia, Karen M. Freund, Jennifer S. Haas, Nicole Casanova, Sharon Bak, Howard Cabral, Rachel A. Freedman, Karen Burns. White, Stephenie C. Lemon

Open Access Articles

BACKGROUND: Racial and socioeconomic disparities in breast cancer mortality persist. In Boston, MA, Black, Non-Hispanic women and Medicaid-insured individuals are 2-3 times more likely to have delays in treatment compared to White or privately insured women. While evidence-based care coordination strategies for reducing delays exist, they are not systematically implemented across healthcare settings.

METHODS: Translating Research Into Practice (TRIP) utilizes community engaged research methods to address breast cancer care delivery disparities. Four Massachusetts Clinical and Translational Science Institute (CTSI) hubs collaborated with the Boston Breast Cancer Equity Coalition (The Coalition) to implement an evidence-based care coordination intervention for Boston residents ...


Copd Exacerbation Caused By Sars-Cov-2: A Case Report From The Louisville Covid-19 Surveillance Program, Forest W. Arnold, Kamran Mahmood, Angeline Prabhu, Darmaan Aden, Anupama Raghuram, Mark Burns, Leslie A. Beavin, Donghoon Chung, Kenneth E. Palmer, Julio A. Ramirez Apr 2020

Copd Exacerbation Caused By Sars-Cov-2: A Case Report From The Louisville Covid-19 Surveillance Program, Forest W. Arnold, Kamran Mahmood, Angeline Prabhu, Darmaan Aden, Anupama Raghuram, Mark Burns, Leslie A. Beavin, Donghoon Chung, Kenneth E. Palmer, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

A 53-year-old male with a history of chronic obstructive pulmonary disease (COPD) on home oxygen presented to the hospital with worsening shortness of breath plus cough. He was admitted to the intensive care unit for COPD exacerbation and respiratory failure. A routine evaluation was performed including a nasopharyngeal swab for a respiratory viral panel, which was negative. His symptoms improved over 48 hours at which time a surveillance test for SARS-CoV-2 returned as positive. After clinical improvement, he was discharged to home isolation.


How To Prevent Covid-19 In Nurses And Physicians In The Hospital Setting: Universal Test-And-Isolate For All Patients Admitted To Hospitals, Julio A. Ramirez, Ruth Carrico, Forest W. Arnold, Paul Schulz Apr 2020

How To Prevent Covid-19 In Nurses And Physicians In The Hospital Setting: Universal Test-And-Isolate For All Patients Admitted To Hospitals, Julio A. Ramirez, Ruth Carrico, Forest W. Arnold, Paul Schulz

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Umccts Newsletter, April 2020, Umass Center For Clinical And Translational Science Apr 2020

Umccts Newsletter, April 2020, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the April 2020 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.