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Full-Text Articles in Kinesiotherapy
Long-Term High Salt Intake Involves Reduced Sk Currents And Increased Excitability Of Pvn Neurons With Projections To The Rostral Ventrolateral Medulla In Rats, Andrew D. Chapp, Renjun Wang, Zixi Cheng, Zhiying Shan, Qing-Hui Chen
Long-Term High Salt Intake Involves Reduced Sk Currents And Increased Excitability Of Pvn Neurons With Projections To The Rostral Ventrolateral Medulla In Rats, Andrew D. Chapp, Renjun Wang, Zixi Cheng, Zhiying Shan, Qing-Hui Chen
Department of Kinesiology and Integrative Physiology Publications
Evidence indicates that high salt (HS) intake activates presympathetic paraventricular nucleus (PVN) neurons, which contributes to sympathoexcitation of salt-sensitive hypertension. The present study determined whether 5 weeks of HS (2% NaCl) intake alters the small conductance Ca2+-activated potassium channel (SK) current in presympathetic PVN neurons and whether this change affects the neuronal excitability. In whole-cell voltage-clamp recordings, HS-treated rats had significantly decreased SK currents compared to rats with normal salt (NS, 0.4% NaCl) intake in PVN neurons. The sensitivity of PVN neuronal excitability in response to current injections was greater in HS group compared to NS controls. The …
High Salt Intake Augments Excitability Of Pvn Neurons In Rats: Role Of The Endoplasmic Reticulum Ca2+ Store, Robert A. Larsen, Andrew D. Chapp, Le Gui, Michael J. Huber, Zixi Jack Cheng, Zhiying Shan, Qing-Hui Chen
High Salt Intake Augments Excitability Of Pvn Neurons In Rats: Role Of The Endoplasmic Reticulum Ca2+ Store, Robert A. Larsen, Andrew D. Chapp, Le Gui, Michael J. Huber, Zixi Jack Cheng, Zhiying Shan, Qing-Hui Chen
Department of Kinesiology and Integrative Physiology Publications
High salt (HS) intake sensitizes central autonomic circuitry leading to sympathoexcitation. However, its underlying mechanisms are not fully understood. We hypothesized that inhibition of PVN endoplasmic reticulum (ER) Ca2+ store function would augment PVN neuronal excitability and sympathetic nerve activity (SNA). We further hypothesized that a 2% (NaCl) HS diet for 5 weeks would reduce ER Ca2+ store function and increase excitability of PVN neurons with axon projections to the rostral ventrolateral medulla (PVN-RVLM) identified by retrograde label. PVN microinjection of the ER Ca2+ ATPase inhibitor thapsigargin (TG) increased SNA and mean arterial pressure (MAP) in a …
Direct Pro-Inflammatory Effects Of Prorenin On Microglia, Peng Shi, Justin L. Grobe, Fiona A. Desland, Guannan Zhou, Xiao Z. Shen, Zhiying Shan, Et. Al.
Direct Pro-Inflammatory Effects Of Prorenin On Microglia, Peng Shi, Justin L. Grobe, Fiona A. Desland, Guannan Zhou, Xiao Z. Shen, Zhiying Shan, Et. Al.
Department of Kinesiology and Integrative Physiology Publications
Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the brain during hypertension, especially in high blood pressure that is associated with chronic activation of the renin-angiotensin-system. In addition, we determined whether prorenin, an essential component of the renin-angiotensin-system, exerts direct pro-inflammatory effects on these microglia. Our data indicate that two rodent models which display neurogenic hypertension and over activation of the renin-angiotensin-system in the brain (sRA mice and spontaneously hypertensive rats) exhibit microglial …