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Full-Text Articles in Nanotechnology
Surface Engineering For Controlled Growth And Deposition Of Nanomaterials - Assembly And Design At The Nano-Microscale, David Fox
Electronic Theses and Dissertations, 2020-
Materials with nanoscale dimensions offer several important benefits over bulk materials (e.g. increased surface area, low-cost, deviation from bulk properties, etc.). Such materials are critical components for next-generation energy storage materials, optoelectronic devices, and catalyst systems. However, these materials are often processed in liquid media, and their diminutive structures are fragile in the presence of capillary forces. As such, preparing uniform and stable nanomaterial coatings is a significant challenge. Herein, we discuss an approach where the substrate itself is factored into the assembly and growth of these materials. First, nanoporous surfaces were utilized to achieve a uniform deposition of one-dimensional …
How Small Organic Osmolytes Modulate Actin Filament Assembly Kinetics And Mechanics, Pavlo Kravchuk
How Small Organic Osmolytes Modulate Actin Filament Assembly Kinetics And Mechanics, Pavlo Kravchuk
Electronic Theses and Dissertations, 2020-
Actin filament assembly and mechanics are crucial for muscle contraction, maintenance of cell structure, motility, and division. Actin filament assembly occurs in a crowded intracellular environment consisting of various types of molecules, including small organic molecules known as osmolytes. Ample evidence highlights the protective functions of osmolytes such as trimethylamine-N-oxide (TMAO), including their effects on protein stability and their ability to counteract cellular osmotic stress. Recently, TMAO has been shown to counteract the denaturing effects of urea on actin filament assembly based on bulk fluorescence assays. Yet, how TMAO affects individual actin filament assembly dynamics and mechanics is not well …
From Dna Logic Gates To Dna Nanorobots, Tatiana Molden
From Dna Logic Gates To Dna Nanorobots, Tatiana Molden
Electronic Theses and Dissertations, 2020-
Due to their biocompatibility and parallel data processing, DNA computational devices are highly desired for applications in diagnosis and treatment of cancer, infectious and genetic diseases. Much like in modern electronic devices, DNA computation is based on the logic gates - by directly interacting with DNA or RNA input molecules, they produce a specific output depending on their embedded logic function. This work is devoted to the development of functional parts of a future DNA nanorobot for biomedical applications. Specifically, we used DNA nanotechnology and the concept of multicomponent DNA probes to develop three parts of the DNA nanorobot: computing, …
Interactions Between Gold Nanoparticles And Immunoglobulin Isotypes, Rick Hassan
Interactions Between Gold Nanoparticles And Immunoglobulin Isotypes, Rick Hassan
Electronic Theses and Dissertations, 2020-
Gold Nanoparticles have piqued interest for use in a wide range of diagnostic and therapeutic applications including biosensors, assays, vaccine development, drug delivery, and photothermal therapy. While extensive research has been conducted, the applications of gold nanoparticles have yet to see the same level of commercial success as well-established methods such as ELISA and lateral flow immunoassays. Studies analyzing the efficacy of gold nanoparticle technologies in vivo and in vitro provide seemingly conflicting results that reflect a further need for investigation into the biological response of gold nanoparticles. A large factor in the variation is the nature of the interaction …
Chitosan-Gallium Nanocomposite: Synthesis, Characterization And Antibacterial Activity, Samjhana Bhandari
Chitosan-Gallium Nanocomposite: Synthesis, Characterization And Antibacterial Activity, Samjhana Bhandari
Electronic Theses and Dissertations, 2020-
The emergence of multidrug-resistant (MDR) strains of bacteria and the lack of a novel class of antibiotics has become a global health concern. Pseudomonas aeruginosa is one common MDR bacteria responsible for nosocomial infections and related mortality worldwide. It has developed resistance against commonly available antibiotics and is in the WHO's priority list of bacteria for which new antibiotics are desperately needed. Currently there is a growing interest in developing metal and non-metal-based nanoparticles to target multidrug-resistant bacteria. The objective of this study is to evaluate the efficacy of a novel nanocomposite of two non-traditional antimicrobials: a metal (Ga-III) and …
Development And Characterization Of A Novel Serum Free Human Ipsc Motoneuron-Primary Human Schwann Cell Model Of Myelination, Aakash Patel
Development And Characterization Of A Novel Serum Free Human Ipsc Motoneuron-Primary Human Schwann Cell Model Of Myelination, Aakash Patel
Electronic Theses and Dissertations, 2020-
Myelination and node of Ranvier formation play an important role in saltatory conduction of axonal action potentials in the peripheral nervous system (PNS). Degeneration or damage of this myelin can lead to impairment in the conduction of signals by the axons, and cause deficits in sensory and motor function. Currently, animal-based models are the primary method used to study myelination; however, data generated in animal models generally translate poorly to humans, especially as applied to drug discovery. In order to accurately study myelination in humans without having to rely on human testing, an engineered in vitro model of myelination could …