Substance Abuse and Addiction Commons^™

Role Of Medial Prefrontal Cortical Group Ii Metabotropic Glutamate Receptor In The Development Of Cocaine Sensitization, Xiaohu Xie

Theses and Dissertations (ETD)

The current studies examined the role of medial prefrontal cortical (mPFC) group II metabotropic glutamate receptors (mGluR_2/3) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR_2/3 receptor agonist, APDC, dose-dependently reduced acute behavioral response to cocaine (0.015-15 nmol/side with significant effects starting at 1.5nmol/side). The effects of APDC were prevented by intra-mPFC co-injections of an mGluR_2/3 antagonist, LY341495 (1.5 nmol/side). Repeated intra-mPFC APDC (1.5 nmol/side) injections also prevented the initiation of behavioral and neurochemical sensitization, which is defined as enhanced nucleus accumbens (NAc) dopamine response to cocaine. Once sensitization was …

Treatment Of Co-Morbid Methamphetamine Substance Abuse And Borderline Personality Disorder Features Using Modified Dialectical Behavior Therapy, Jessica R. Schultz Fischer

Dissertations

The study investigated the effectiveness of a time-limited, skills-based treatment in a population of female substance abusers. This project implemented a pilot clinical trial to evaluate the effectiveness of a 12-session modified Dialectical Behavior Therapy (DBT) protocol among a small sample of women, with co-morbid borderline personality disorder features, receiving concurrent outpatient treatment for methamphetamine abuse. A non-concurrent multiple baseline design was used. In addition to on-going assessment conducted during baseline and weekly over the course of treatment, a comprehensive assessment battery was administered pre-, and post-treatment as well as at 1 and 3 months following treatment. Findings suggest that …

Neuroadaptive Changes In The Mesocortical Glutamatergic System During Nicotine Self-Administration And After Extinction In Rats, Fan Wang

Theses and Dissertations (ETD)

The mesocorticolimbic pathway is critical in almost all aspects of drug abuse, including nicotine. Though many of the neurochemical and molecular effects of nicotine have been well studied, nicotine’s long-term neuroadaptive effects, specifically within the mesocorticolimbic pathway, are largely undefined. Thus, in current study, we determined the neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration (SA), which emulates important aspects of nicotine intake by humans, and after extinction. In the initial study, after 18 days of nicotine SA, in the medial prefrontal cortex (mPFC), NMDA receptor subunit 2A (NR2A) and NR2B were increased by 67% and 83%, …

Adolescents And Marijuana Use: The Affects Of Peer And Parent Relationships And Substance Abuse Education., Samuel Joseph Cosimano

Electronic Theses and Dissertations

The purpose of this study was to analyze gender, race, substance abuse programs such as Drug Abuse Resistance Education (D.A.R.E.), parents, and peers and their ability to influence or predict adolescents and their decisions to use marijuana. All of the variables used for this study came from secondhand data collected by Esbensen and Osgood (1999), Gang Resistance Education and Training (G.R.E.A.T.). The analysis revealed that males are more likely to have ever used marijuana, that mixed race adolescents have a higher rate than other races to have ever used marijuana, that when adolescents complete the substance abuse program, D.A.R.E. have …

Does State Certification Or Licensure Influence Outpatient Substance Abuse Treatment Program Practices?, Jamie Chriqui, Yvonne Terry-Mcelrath, Duane C. Mcbride, S Eidson, Curtis Vanderwaal

Faculty Publications

In the United States, state governments legally authorize outpatient substance abuse treatment programs. In some states, programs are certified or accredited (ideal standards). Other states license programs (minimal standards). Additionally, some states authorize programs through "deemed status", which is afforded to programs attaining accreditation from a national accrediting body. Primary legal research and the National Survey of Substance Abuse Treatment Services' (N-SSATS) data were used to examine the relationships between state authorization type (certification/accreditation vs licensure with and without deemed status) and outpatient treatment program practices. Programs in certification/accreditation (vs licensure) states had significantly higher odds of offering wrap-around and …

Does State Certification Or Licensure Influence Outpatient Substance Abuse Treatment Program Practices?, Jamie Chriqui, Yvonne Terry-Mcelrath, Duane C. Mcbride, S Eidson, Curtis Vanderwaal

Duane McBride

In the United States, state governments legally authorize outpatient substance abuse treatment programs. In some states, programs are certified or accredited (ideal standards). Other states license programs (minimal standards). Additionally, some states authorize programs through "deemed status", which is afforded to programs attaining accreditation from a national accrediting body. Primary legal research and the National Survey of Substance Abuse Treatment Services' (N-SSATS) data were used to examine the relationships between state authorization type (certification/accreditation vs licensure with and without deemed status) and outpatient treatment program practices. Programs in certification/accreditation (vs licensure) states had significantly higher odds of offering wrap-around and …

Globalization And Drug And Alcohol Use In Rural Communities In Nigeria: A Case Study, Charles Fiki

The Journal of Sociology & Social Welfare

This paper presents an exploratory study of alcohol and drug use in two rural communities in Plateau State, Nigeria. The aim is to raise awareness of the rural alcohol and drug problem. The paper examines the patterns of alcohol consumption and drug use, and their perceived functions for substance use among rural farmers in Nigeria. The study shows the common use of marijuana and alcohol in addition to prescription drugs. There is also evidence of multiple or combinational drug use. Pleasure and relaxation emerged as the major reasons for drug and alcohol use. Factors influencing alcohol and drug use are …

Assimilation Into A Therapeutic Community For Substance-Abusing Women, Joni Furlong

Masters Theses & Specialist Projects

Therapeutic communities provide structure, support and a safe living environment for individuals attempting to recover from addiction. Using peer influence, counseling, education, self-help groups, and case management, they assist residents in conforming to social norms and developing effective coping mechanisms while remaining drug-free. Prior studies have consistently demonstrated the effectiveness of these programs. But, why are they effective for some and not others? This study explored the residents1 backgrounds and the methods employed by them to assimilate into the therapeutic community, the recovering community, and then society at large. The data confirmed my suspicion that the women's ability to conform …

Examining Smoking And Cessation During Pregnancy Among An Appalachian Sample: A Preliminary View, Lesley Cottrell, Mark Gibson, Carole Harris, Alia Rai, Sabera Sobhan, Traci Berry, Bonita Stanton

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Several transitions that a woman experiences prenatally may influence her desire or ability to discontinue smoking. This study explores the role of smoking for young, Appalachian, nulliparous pregnant women and their plans for smoking during their pregnancies.

Results

The reports of women and their male partners were taken from baseline interviews conducted during the first trimester of pregnancy. Cigarette smoking appeared to be more than an isolated addictive activity; rather, smoking was interwoven in women's social and personal realms, often changing as their perceptions of self changed. Women and their partners who continued to smoke appeared to be …

Risk Markers Associated With Physical And Psychological Abuse By Intimate Partners Against Women In Substance Abuse Treatment, Scott J. Buchanan

Seton Hall University Dissertations and Theses (ETDs)

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The Substance Of Quality Treatment With Coexisting Problems (Book Review), Kristina M. Kays

Faculty Publications - Psychology Department

Reviews the book, "Clinical handbook of co-existing mental health and drug and alcohol problems" by Amanda Baker and Richard Velleman (see record 2007-01081-000). The text editors, Baker and Velleman, propose to present "practical descriptions of assessments and interventions for coexisting problems, with a view to enhancing motivation, confidence and competence to do so". Not only do the chapters succinctly address expert views on assessment, but they also thoughtfully explain intervention approaches with coexisting issues, specific populations, and further training and supervision needs in the treatment of coexisting disorders. The editors use European spelling and an approach that is a "symptom-focused …

Social Workers' Knowledge Of Substance Abuse, Mirta Escobedo Johnson

Theses Digitization Project

This study was designed to determine how knowledgeable child welfare social workers are of substance abuse when working with substance abusing clients. The results indicated that social workers within San Bernardino County have competent levels of knowledge in substance abuse which allow them to provide appropriate services to the community members they serve.

Uncovering The Methadone Counseling Process Among Recovering And Non Recovering Chemical Dependency Counselors, Sara-Amanda Mccarthy, Jennifer Ann Palmersheim

Theses Digitization Project

The purpose of this study was to uncover the methadone counseling process among recovering and non-recovering chemical dependency counselors by examining the concepts and techniques utilized throughout the counseling process. This study examined whether the recovery status of a counselor affected the counselor's theoretical addiction model and the concepts and techniques that were utilized throughout the counseling process.

Teaching Parenting Skills In A Methadone Treatment Setting, Randy R. Gainey, Kevin P. Haggerty, Charles B. Fleming, Richard F. Catalano

Sociology & Criminal Justice Faculty Publications

Family factors significantly affect children’s risk of substance abuse, delinquency, and other problem behaviors (Arthur, Hawkins, Pollard, Catalano, & Baglioni, 2002). Children of substance abusers represent a particularly high-risk population. Prenatal exposure to addictive substances and the medical complications that may arise are important factors that, from conception, place this population at high risk of drug abuse and other problem behaviors (Griffith, Azuma, & Chasnoff, 1994). As children of substance abusers mature, their lives are characterized by exposure to continued drug and alcohol abuse by family members, recurrent or chronic illnesses, frequent moves, financial troubles, legal conflicts, family disorganization, and …

Impact Of Extra-Curricular Activities On Adolescents' Connectedness And Cigarette Smoking: Final Report, Margaret Hall, Greg Hamilton, Therese Shaw, Donna Cross, Tommy Cordin, Leanne Lester, Stacey Waters

Research outputs pre 2011

In Australia, cigarette smoking is still the leading cause of preventable death and yet in the past 10 years, despite efforts that have been made in the classroom and through the media, there have been limited reductions in adolescent smoking. The Extra-curricular Project builds on the work of two other projects conducted by researchers from the Child Health Promotion Research Centre (CHPRC). The Smoking Cessation for Youth Project (SCYP), conducted by the Western Australian Centre for Health Promotion Research, led to the identification of connectedness as a key mediator of cigarette smoking. The role of extra-curricular activities in mediating school …

Optimising School Nurse Involvement In Youth Based Tobacco Control Programs: Presented To The Western Australian Health Promotion Foundation, Child Health Promotion Research Unit, Edith Cowan University

Research outputs pre 2011

A significant proportion of youth smoke regularly, placing them at risk of addiction to cigarette smoking. It is known that adolescence is a critical period for the establishment of adult drug use behaviours. The key focus for this research program is the investigation of interventions addressing adolescent smoking cessation, with a particular emphasis on School Nurse involvement.

The research program aims to provide capacity building benefits at three levels: to secondary school nurses, to two post-graduate students, as well as school health promotion /smoking prevention/cessation practitioners and researchers. Ultimately this project may add previously underused but well trained, highly credible …

Alcohol-Induced Suppression Of Gluconeogenesis Is Greater In Ethanol Fed Female Rat Hepatocytes Than Males, Ken D. Sumida, Alma A. Cogger, Aleksey V. Matveyenko

Physical Therapy Faculty Articles and Research

The impact of alcohol-induced suppression on hepatic gluconeogenesis (HGN) after chronic ethanol consumption between males and females is unknown. To determine the effects of chronic alcohol consumption (8 weeks) on HGN, the isolated hepatocyte technique was used on 24 h fasted male and female Wistar rats. Livers were initially perfused with collagenase and the hepatocytes were isolated. Aliquots of the cell suspension were placed in Krebs-Henseleit buffer and incubated for 30 min with lactate, [U-C-14]lactate, and nine different concentrations of ethanol (EtOH). Dose-effect curves were generated for the determination of maximal and half-maximal alcohol-induced inhibition on HGN. There was no …

Why It Is Important To Look At Long-Term Abstinence From Heroin Use: A Review Life Beyond Heroin: An Exploration Of The Motivations For Long-Term Heroin Abstinence, Lucy Dann

Theses : Honours

The phenomenon of achieving long-term abstinence from drug use remains to be thoroughly understood in the alcohol and other drug (AOD) community, particularly in the area of heroin use. This review assesses research in the field of long-term abstinence from drug use and highlights the need to examine long-term abstinence from heroin use. Prochaska and DiClemente's (1986) Stages of Change model of behaviour change is examined as well as literature examining its importance in the AOD field. Studies examining long-term abstinence from alcohol, tobacco, cocaine and heroin use are reviewed from a psychological perspective, focusing on cognitive-behavioural constructs. Findings revealed …

Developing Healthy Kids In Healthy Communities: Eight Evidence-Based Strategies For Preventing High-Risk Behaviour., Gary L. Hopkins, Duane Mcbride, Helen H. Marshak, Kiti Freier, John V. Stevens, Wendi Kannenberg, James B. Weaver, Stephanie L. Sargent Weaver, Peter N. Landless, Jonathan Duffy

Faculty Publications

Australian youth engage in behaviour that threatens their health and wellbeing. National surveys report that about a third of young Australians have tried an illicit drug. High rates of substance use and risky sexual behaviour among young Australians suggest that effective prevention efforts based on empirical evidence need to be expanded. Church-associated organisations are an untapped resource that could be used to improve the health and welfare of young people. We describe eight evidence-based elements to consider in designing strategies to prevent high-risk behaviour in young people.

Injecting Drug Users In India: Understanding Sexual Behaviours And Sexual Networks To Design Effective Behaviour Change Strategies, Avina Sarna, Waimar Tun, Aruna Bhattacharya, Vaishali Sharma Mahendra, Neville Selhore, Arjun Singh, Louis Apicella

HIV and AIDS

The practice of injecting drug use has been spreading to different parts of India since the early 1980s and is associated with an increase in HIV prevalence rates. Injecting drug users (IDUs) engage in both risky injection and sexual practices that increase the risk for HIV transmission. While risky injection practices are well understood, there is limited understanding of IDUs’ sexual behaviors and social networks. The Population Council conducted a cross-sectional study to explore patterns of risky sexual behaviors, sexual network characteristics, and drivers of high-risk behaviors of IDUs in Delhi and Imphal. The contrasting settings were selected to allow …

Best Practices In Intercultural Health; Five Case Studies In Latin America, J. Mignone, J. Bartlett, J. O'Nwil, Treena Orchard

Dr. Treena Orchard

The practice of integrating western and traditional indigenous medicine is fast becoming an accepted and more widely used approach in health care systems throughout the world. However, debates about intercultural health approaches have raised significant concerns. This paper reports findings of five case studies on intercultural health in Chile, Colombia, Ecuador, Guatemala, and Suriname. It presents summary information on each case study, comparatively analyzes the initiatives following four main analytical themes, and examines the case studies against a series of the best practice criteria.

Consent Or Coercion? Referral To Alcoholics Anonymous, Louis Charland

Louis C. Charland

No abstract provided.

Does Borderline Personality Disorder Exist?, Louis Charland

Louis C. Charland

No abstract provided.

In This Life: The Impact Of Gender And Tradition On Sexuality And Relationships For Devadasi Sex Workers In Rural India, Treena Orchard

Dr. Treena Orchard

In the popular imagination and certain academic fields, sex workers' experiences of sexuality and intimate relationships are often "naturalized," to the point where they are assumed to be deviant or completely different than those of women in mainstream society. Researchers and sex worker organizations are challenging these reified constructions by examining more diverse and representative models of sexuality and relationships. However, the experiences of women selling sex in the "third world" are consistently portrayed as violent, non-pleasurable, and oppressive, characteristics often applied universally to "third world women". Using data from ethnographic fieldwork with girls and women who belong to the …

Girl, Woman, Lover, Mother: Towards A New Understanding Of Child Prostitution Among Young Devadasi Sex Workers In Rural Karnataka, India, Treena Orchard

Dr. Treena Orchard

The emotive issue of child prostitution is at the heart of international debates over ‘trafficking’ in women and girls, the “new slave trade”, and how these phenomena are linked with globalization, sex tourism, and expanding transnational economies. However, young sex workers, particularly those in the ‘third world’, are often represented through tropes of victimization, poverty, and “backwards” cultural traditions, constructions that rarely capture the complexity of the girls’ experiences and the role that prostitution plays in their lives. Based on ethnographic fieldwork with girls and young women who are part of the Devadasi (servant/slave of the God) system of sex …

Anorexia And The Maccat-T Test For Mental Competence: Validity, Value, Emotion. Commentary On Jacinta Tan’S Competence To Make Treatment Decisions In Anorexia Nervosa: Thinking Processes And Values, Louis Charland

Louis C. Charland

No abstract provided.

Affective Neuroscience And Addiction, Louis Charland

Louis C. Charland

No abstract provided.

Cognitive Modularity Of Emotion, Louis Charland

Louis C. Charland

No abstract provided.

Benevolent Theory: Moral Treatment At The York Retreat, Louis Charland

Louis C. Charland

No abstract provided.

Brief Report: Impact Of Classroom Presentations About Health And Help Seeking On Rural Australian Adolescents’ Intentions To Consult Health Care Professionals., Coralie J. Wilson

Frank Deane

Building Bridges-GP-Team (Building Bridges-Team; Wilson et al., 2004c) is a variation of the Building Bridges to General Practice: GPs in Schools program (Building Bridges-GP; Wilson et al., 2004a), which promotes consultation with health care professionals who are local and available for rural and regional adolescent’ consultation. The first major component of Building Bridges-GP-Team involves structured health professional training that provides knowledge in three basic areas: (1) adolescents’ help seeking barriers and ways to address barriers in primary health care; (2) developmental issues relevant to adolescent’ help seeking; and (3) classroom management, presentation strategies, and elementary teaching skills. Training is based …