Substance Abuse and Addiction Commons^™

Molecular Mechanisms Of Opioid Use Disorder In Human Brain Models, Emily Mendez

Dissertations & Theses (Open Access)

Opioid use disorder (OUD) is a national and global public health crisis with no end in sight. While studies from animal models hint at widespread epigenetic and transcriptomic alterations of opioid drugs, the molecular consequences of long-term exposure to opioid drugs in human brain is still unclear, and human-centered translational models are necessary to discern the human cell type-specific effects of OUD.

Using postmortem brain Brodmann area 9 (BA9) from the UTHealth Brain Collection for Research on Psychiatric Disorders, I identified angiogenic gene networks perturbed in the RNA and protein of OUD subjects, as well as downregulation of many neuron-correlated …

Understanding The Perspectives And Attitudes Of 12-Step Participants Towards Medication-Assisted Treatment, Christopher Scott

Electronic Theses, Projects, and Dissertations

Background: The effects of living with a substance use disorder (SUD) are vast. Medication-assisted treatment (MAT) has grown increasingly popular as a recovery tool among substance users but does not align with the popular 12-step model, which demands complete abstinence from narcotics and mind-altering substances. Objective: The primary aim of this phenomenology study was to explore the perspectives and attitudes towards MAT among 12-step participants. The secondary aim was to compare the responses of treatment and non-treatment professionals. Methods: This study used non-probability sampling methods to recruit participants who reported regular participation in a 12-step program. Semi-structured …

The Co-Occurrence Of Past Year Major Depressive Episodes And Marijuana Use And Its Relation To Mental Health Resource Utilization, Suicidal Ideation And Planning, Rachel Miranda

Honors Program Theses and Research Projects

Depression is a mental health disorder found worldwide affecting all demographics and is a major cause of global disability. For youth, depression can be very serious as it is a leading contributor to suicide, a top three cause of adolescent death. When we examine the onset of depression in adolescence, we also must acknowledge that youth access and usage of mental health resources and interactions with their communities may influence their outlook. We set out to examine how the co-occurrence of past year marijuana use and major depressive episodes (MDE), the variable we use to measure youth depression in this …

Methamphetamine-Induced Dna Double-Stranded Breaks: The Impact Of The Dopamine Transporter And Insights Into The Mechanisms Of Dna Damage In Mouse Neuro 2a Cells, Lizette Couto

Dissertations, Theses, and Capstone Projects

Methamphetamine (METH) abuse remains a global health concern, with emerging evidence highlighting its genotoxic potential. In the central nervous system METH enters dopaminergic cells primarily through the dopamine transporter (DAT), which controls the dynamics of dopamine (DA) neurotransmission by driving the reuptake of extracellular DA into the presynaptic neuronal cell. Additional effects of METH on the storage of DA in synaptic vesicles lead to the dysregulated cytosolic accumulation of DA. Previous studies have shown that after METH disrupts intracellular vesicular stores of DA, the excess DA in the cytosol is rapidly oxidized. This generates an abundance of reactive oxygen species …

Lived Experiences Of People With Substance Use Disorder As Healthcare Education To Develop Empathy For This Population, Whitney Bynum

Nursing | Senior Theses

The negative attitudes and feelings of healthcare workers towards patients with substance use disorder are well documented. These include, but are not limited to, believing a person with this disease is “drug seeking”, “violent”, and “unmotivated”. While this population has challenging issues to address, these beliefs can decrease the quality of care provided and results in less people seeking out needed treatment. Reducing stigmas through alternative education methods, like learning the life story of a patient, can help health care workers develop feelings of empathy and compassion. Subsequently, this education can result in better care and outcomes for these patients. …

Empowering Providers To Empower Their Patients: One Model To Expand Knowledge, Competency, And Awareness For The Perinatal Substance Use Workforce, Jacqueline Jacobs

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Perinatal substance use (PSU) is a serious and growing public health concern. It is associated with a variety of adverse health outcomes for both mother and child and has been shown to negatively impact the parent-child relationship. Despite the growing prevalence of PSU, there are notable deficits in provider knowledge regarding, and comfortability with, PSU. Moreover, providers report feelings of judgment, resentment, fear, and hesitancy related to their work with women with PSU. Subsequently, women with PSU struggle to find appropriate, compassionate, and effective treatment for their substance misuse. Widespread and accessible training is needed to bolster provider knowledge base, …

Design Guidelines For Homeless Shelter And Resource Center Site Plans, Samuel Johnson

All Graduate Reports and Creative Projects, Fall 2023 to Present

Homelessness is one of the most pressing humanitarian issues facing the country today. Lack of affordable housing, among many other complicating factors, have led to many cities scrambling to find both short-, middle-, and long-term solutions to the issue. The Covid-19 pandemic added a disruption in services, critical record-keeping, and data-gathering, which has further confounded experts looking for an effective path forward. As it stands, there is a significant gap in academic research addressing best practices for shelter site design, particularly as it relates to landscape. The role of landscape and greenspace within and around a shelter is not well …

Improving Minors' Access To Treatment For Opioid Use Disorder: A Policy Analysis, Sara Jane Hamilton

Master's Projects and Capstones

As the opioid epidemic continues to have devastating effects on our communities, medications to treat opioid use disorder (MOUDs) are severely underutilized especially for adolescents. Unlike adults, minors need parental approval before obtaining MOUDs presenting a key barrier to timely treatment. Being able to treat adolescents as soon as they are ready is critically important for people with OUD, and while cost and other barriers have been addressed in the literature, there is a paucity on how parental consent affects the accessibility of treatment. This paper aims to explore a potential policy in California that addresses the lack of access …

Enhancing Long-Term Outcomes: Implementing Community Engaged Research To Augment Substance Use Disorder Treatment, Kevin M. Quinn

Masters Theses

The Universal Evaluation Tool is an intuitive self-assessment instrument to enhance long-term treatment outcomes for Guiding Light’s residential addiction rehabilitation program. Designed as a versatile method for collecting primary data, the Universal Evaluation Tool can be administered to clients at any point during the recovery program (i.e., intake to discharge). The data collected from the survey can be used as a framework to guide treatment decisions, develop personalized care plans, offer insight into a client’s progress, and collect baseline data (e.g., sociodemographic characteristics) on a treatment population for use in grant applications.

A pilot study to generate preliminary data was …

Introduction Of A Policy Adherence Plan In An Outpatient Buprenorphine Treatment Clinic., Stacie Switzer Cheney

Doctor of Nursing Practice Papers

Abstract

Background: Medication-Assisted Treatment (MAT) is one of the most effective pharmacological therapies for opioid dependence. Regular urine drug screening to include random urine drug screens at least once a month is a key factor in improving quality care for those receiving treatment in an outpatient MAT clinic.

Problem: A rural outpatient MAT clinic has a current random urine policy that is not being utilized when treating clients with Opioid Use Disorder (OUD). This increases the risk of diversion and misuse of buprenorphine/naloxone (Suboxone), thus increasing the risk of overdose and death for OUD patients.

Environment: This project was implemented …

Effects Of A Self-Forgiveness Intervention On Recovery From Substance Use Disorders, Michael Saltzman

Dissertations

Previous research has highlighted the relationship between shame, guilt, and problematic substance use (Gueta, 2013; Luoma et al., 2019; McGaffin et al., 2013; Rahim & Patton, 2015). Self-forgiveness has been associated with positive outcomes for individuals in recovery with substance use disorders (SUDs), though only one prior study has explored the effects of a selfforgiveness intervention for individuals in treatment (Scherer et al., 2011). This study examines the effects of a self-forgiveness intervention on state shame and guilt, state self-forgiveness, and drug avoidance self-efficacy, and it is the first intervention study to focus on self-forgiveness for individuals with SUDs receiving …

Side-Stepping God: How The Nonreligious Find Success In Alcoholics Anonymous, Caitlin Trombley

Dissertations

This dissertation utilized mixed methods research to examine how nonreligious individuals with substance use disorders navigate recovery within—or in spite of—Alcoholics Anonymous (AA). Both the 12-step program itself and Alcoholics Anonymous have long been criticized for being religious and/or spiritual in nature, and some studies have shown that this is particularly challenging for nonreligious individuals seeking recovery. The purpose of this research was to (a) identify differences in recovery resources (recovery capital) between the religious, the nonreligious, those in AA, and those who have adopted alternative forms of recovery; (b) identify barriers that the nonreligious face as they navigate recovery …

Evidence-Based Practices And Self-Efficacy: A Quantitative Study Of Mental Health Counselors Treating Clients With Substance Use Disorder, Carl Bastien

Dissertations

Substance use disorder affects a substantial number of individuals in the United States. The specific problem of this research is that it was not known to what extent their use of evidence-based practices is driven by their sense of self-efficacy. The purpose of this quantitative correlational research was to examine to what extent the use of evidence-based practices covary with a sense of self-efficacy for mental health counselors treating individuals diagnosed with a substance use disorder. The study population was 121 mental health counselors who specialized in substance use disorder treatment who completed a digital survey. The study findings did …

Implementation Of Clinical Institute Withdrawal Assessment: Alcohol Revised (Ciwa-Ar) Education Program In A Crisis Stabilization Unit, Amanda Dehart

Doctor of Nursing Practice Final Manuscripts

Background: At this time the crisis stabilization Units do not currently utilize the Clinical Institute Withdrawal Assessment: Alcohol Revised tool with patients who may experience Alcohol Withdrawal Syndrome. Patients with alcohol use disorders have a high comorbidity rate with psychiatric disorders (Butterfield, et al, 2020). The Clinical Institute Withdrawal Assessment: Alcohol Revised or CIWA-Ar is currently the most widely used assessment tool in the psychiatric setting when assessing patients who may be experiencing Alcohol Withdrawal Syndrome (Pribék, et al, 2021) .

Purpose of Project: The purpose of this project is to measure pre and post -education knowledge of the registered …

A Literature Review Exploring The Effectiveness Of Dance/Movement Therapy As A Treatment Modality For Adults With Dual-Diagnosis In Recovery, Helen Turnbull

Expressive Therapies Capstone Theses

Abstract

The following literature review is an investigation of the current state of the literature regarding the use of dance/movement therapy as a treatment modality for adults with dual diagnosis in recovery. The theories explored in this paper present the primary and conventional modes that are currently being used to treat substance use and comorbid mental health disorders, such as the 12-Step program model of Alcoholics Anonymous, as well as introducing alternative methods of treatment, which include the use of dance/movement therapy, body-oriented psychotherapy, and the somatic work of the Alexander Technique, which offer a more holistic approach to healing …

Therapeutic Gardening For Addiction Recovery, Hugo A. Rivera Lopez

Master's Projects and Capstones

Problem: The use of evidence-based alternative forms of therapy like horticulture therapy and therapeutic gardening is underutilized in substance use recovery programs in the United States. As the country continues to struggle with addiction, it is important that recovery programs look to and incorporate these alternative therapies into official curricula. Currently, 46.3 million individuals living in the United States are living with a substance use disorder (U.S Department of Health and Human Services’ Substance Abuse and Mental Health Services Administration, 2022).

Context: The intervention was implemented at an all-male substance use treatment facility in San Jose, CA that houses up …

Therapeutic Gardening For Mental Health In Substance Use Recovery, Stephanie E. Schafer

Master's Projects and Capstones

Abstract

As the clinical nurse leader (CNL) in this project, I used the “[CNL]

Essential 1: Background for Practice from Sciences and Humanities” (Competencies and Curricular Expectations for Clinical Nurse Leader Education and Practice, 2013) and its competencies to focus on designing nursing care for a clinical or community-focused population based on biopsychosocial, public health, nursing, and organizational sciences and to synthesize evidence for practice to determine appropriate application of interventions across diverse populations. With the help of the CNL competencies and collaboration with the healthcare team, we created and implemented a therapeutic garden for residents in a substance use …

Prescription Drug Misuse Among Graduate Students: Prevalence And Links To Mental Health And Academic Burnout, Madison De Gruiter

Honors Theses

The aims of this study are to examine the prevalence of prescription drug misuse (PDM) among doctoral students and assess associations between PDM and anxiety and burnout in this population. Additional analyses analyzed differential associations by doctoral degree type (i.e., research versus professional programs). A sample of doctoral students (n=131) affiliated with the University of Mississippi participated in an anonymous survey to assess research aims.

Mind The Gap: Revealing The Association Between Depression, Marijuana Use, And Mental Health Care Utilization, Zachary Kobs

Honors Program Theses and Research Projects

Depression is a widespread mental health condition affecting millions worldwide, with young adults being particularly vulnerable. The concurrent use of marijuana has become an increasingly relevant factor in treating depression, especially in this population. However, recent literature reviews have highlighted a significant gap in knowledge regarding treatment outcomes in adolescents who utilize both mental health treatments, including antidepressants (AD), and marijuana. This research seeks to better understand the relationship between mental health treatment utilization and marijuana together by exploring the association between depression, marijuana use, and mental health care utilization. Our findings suggest that depression and marijuana use tend to …

Art And Rehabilitation: An Analysis Of Art In The Treatment Of Individuals Recovering From Substance Use Disorders, Cheyenne Weis

Theses/Capstones/Creative Projects

Substance use has been a huge problem in the United States for a long time. Typically, techniques such as behavioral therapies or 12-Step Programs are used regarding treatment for those trying to recover from substance use disorders. While these treatment options are useful for many people, it is also important to look at nonnormative options for treatment to help the greatest number of people. One of these treatment options is the use of art, either as art therapy or as therapeutic art-making. Previous research on art therapy and people with substance use disorders demonstrates that there are many benefits of …

Rural Appalachia And The Opioid Epidemic: Overcoming Current Barriers With New Solutions, Olivia Croft

Undergraduate Theses and Capstone Projects

The opioid epidemic has damaged the lives of many Americans since the early 2000’s. As America continues to look for ways to fight the opioid epidemic and save this country, the idea of providing the rescue drug, naloxone, to the general public has been discussed and implemented in some areas. An overdose from opioids causes a person to have respiratory depression and eventually stop breathing. Without intervention, this quickly leads to death. Although the opioid epidemic is nationwide, some of the most significantly affected populations are the rural communities tucked away in the Appalachian Mountains. In rural areas of America, …

Rural Appalachia And The Opioid Epidemic: Overcoming Current Barriers With New Solutions, Olivia Croft

Graduate Dissertations and Theses

The opioid epidemic has damaged the lives of many Americans since the early 2000’s. As America continues to look for ways to fight the opioid epidemic and save this country, the idea of providing the rescue drug, naloxone, to the general public has been discussed and implemented in some areas. An overdose from opioids causes a person to have respiratory depression and eventually stop breathing. Without intervention, this quickly leads to death. Although the opioid epidemic is nationwide, some of the most significantly affected populations are the rural communities tucked away in the Appalachian Mountains. In rural areas of America, …

Reducing Medical Errors For Patients With Substance Use Disorders With A Medical Information Card, Michael V. Hughes

Doctoral Dissertations

Background

Approximately 98,000 Americans perish annually due to medical errors and adverse events associated with the limited access to or incomplete pertinent patient health information (Centers for Disease Control and Prevention [CDC], 2022; Obrien et al., 2021). Pertinent patient health information includes patients’ allergies, current medications, current medical diagnosis, blood type, insurance, and emergency contact. The purpose of this project was to examine the efficacy in using File of Life cards in reducing medical errors among patients with substance use disorders (SUDs), and the perception of patients and healthcare providers ease of use, satisfaction of using the File of Life …

County Characteristics And Opioid Mortality Rates In The United States, Baksun Sung

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Opioid overdose deaths are not equally distributed across the United States. While some areas have a less severe problem with opioid abuse, others face serious challenges, which are affected by various social factors. To address that question, in Chapter 1, I investigate how opioid mortality trends differ according to opioid types, race, and region to identify susceptible populations and areas. In Chapter 1, I contend that synthetic opioid is a main trigger for the current opioid epidemic and that the epidemic is concentrated among blacks and in the Eastern United States. Next, the following studies examine how varying social vulnerabilities …

Designing A Work-Life Balance Learning Module For Cal Poly Construction Management Department, Alex Jones

Construction Management

The construction industry is known to create a highly stressful work environment given its unpredictability and mental/time demanding nature, which creates challenges for professionals to maintain a healthy work-life balance. This senior project aims to research and identify the key areas that foster this stress and propose a learning module for the Cal Poly Construction Management Department to implement into class curriculum. Having this learning module taught to students will raise awareness of the topic for future industry professionals and equip them with the tools to maintain a healthy equilibrium between their work demands and personal life. The learning module …

Surviving The Stigma: Incorporating Mental Health Literacy To Increase Help-Seeking In California First Responders, Yvonne C. Newson

Master's Projects and Capstones

First responders are at risk of developing mental health problems due to repeated exposure to traumatic incidents, increasing their chance of developing Post Traumatic Stress Disorder, substance abuse, suicidal ideation, and suicide. Unfortunately, first responders do not recognize that they may have a mental illness and are reluctant to seek help. This paper will discuss the prevalence of mental health problems among first responders and the barriers to their help-seeking. These barriers include the stigma around mental illness within the culture, the assessability of professional help, and the lack of mental health literacy regarding their well-being. Further discussion will focus …

Support For Social Workers Treating Adolescent Substance Abusers, Monica Delucia, Kethura Solano

Electronic Theses, Projects, and Dissertations

This study examines the barriers social workers experience when working with adolescent substance users. Research has not fully explored if intervention techniques are effective or suggest other approaches that may support substance use disorder professionals including supervisor support, training, and intervention. The purpose of this study was to evaluate if social workers who provide interventions to adolescent substance users have the adequate resources to be successful in their field. The literature review provides a better understanding of the common themes social workers experience when working with adolescent substance users.

This study used a qualitative design and interviewed 8 professional social …

Mental Health In M*A*S*H: An Analysis Of The Changing Portrayal Of Mental Health Topics In The 1970s And Early 1980s, Lyndsey Clark

Student Research Submissions

This paper studies all eleven seasons of the hit television show M*A*S*H (1972-1973) and examines how the portrayal of mental health changed in the show’s plotlines in response to changing guidelines and mental health policy in the 1970s and early 1980s. This study focuses on the association of mental illness with homosexuality, the changes made to the American Psychological Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM) in the 1970s and early 1980s, the rise and fall of mental health policies from the Kennedy Administration to the Reagan Administration, and the portrayal of several pertinent mental conditions, such as …

Assessing The Involvement Of Projections From The Prelimbic Prefrontal Cortex To The Paraventricular Nucleus Of The Thalamus In Cocaine Withdrawal-Induced Anxiety, Clinton Coelho

MUSC Theses and Dissertations

Withdrawal from cocaine induces an immediate and powerful negative affective state which is characterized by feelings of agitation and anxiety in humans and anxiety-like behaviors in rodents. It has been hypothesized that the anxiogenic effects associated with cocaine withdrawal play a major role in continued cocaine use and drive relapse to cocaine seeking. The prelimbic (PL) medial prefrontal cortex is not only involved in the processing and regulation of negative emotions such as anxiety but also mediates relapse to cocaine-seeking. Subcortical hubs of the reward system that receive projections from the PL neurons are known to be dysregulated during different …

How The United States Can Improve The Prevention And Treatment Of Substance Abuse Disorders, Kimberly E. Combs

Classical Conversations

Over thirty million people worldwide suffer from diagnosed drug-use disorders. In the United States alone, the Substance Abuse and Mental Health Services Administration found in the 2020 National Survey of Drug Use and Health (NSDUH) that of people aged 12 or older, over 40 million reported struggling with substance abuse at some point in their life. Alarming statistics suggest that rates of drug abuse continue to rise worldwide. Drug use is a recognized epidemic in the United States, and it is far from a recent issue. Health professionals, government officials, and researchers have been trying to solve the problem for …