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Full-Text Articles in Sports Medicine
Differential Gene Expression Of Foxo1, Id1, And Id3 Between Young And Older Men And Associations With Muscle Mass And Function, Thomas W. Buford, Matthew B. Cooke, Brian D. Shelmadine, Geoffrey M. Hudson, Liz L. Redd, Darryn S. Willoughby
Differential Gene Expression Of Foxo1, Id1, And Id3 Between Young And Older Men And Associations With Muscle Mass And Function, Thomas W. Buford, Matthew B. Cooke, Brian D. Shelmadine, Geoffrey M. Hudson, Liz L. Redd, Darryn S. Willoughby
Faculty Publications
Background and aims: Aging is associated with significant losses of skeletal muscle mass and function. Numerous biochemical molecules have been implicated in the development of these age-related changes, however evidence from human models is sparse. Assessment of transcript expression is useful as it requires minimal tissue and may potentially be used in clinical trials. This study aimed to compare mRNA expression of proteolytic genes in skeletal muscle of young (18–35 yrs) and older (55–75 yrs) men.
Methods: Muscle tissue was obtained from young (n=14, 21.35±01.03 yrs) and older (n=13, 63.85±1.83 yrs) men using percutaneous biopsy, and transcript expression was quantified …