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Medical Cell Biology

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Full-Text Articles in Sports Medicine

Satellite Cells In Human Skeletal Muscle Plasticity, Tim Snijders, Joshua P. Nederveen, Bryon R. Mckay, Sophie Joanisse, Lex B. Verdijk, Luc J. C. Van Loon, Gianni Parise Jan 2015

Satellite Cells In Human Skeletal Muscle Plasticity, Tim Snijders, Joshua P. Nederveen, Bryon R. Mckay, Sophie Joanisse, Lex B. Verdijk, Luc J. C. Van Loon, Gianni Parise

Faculty of Health Sciences Publications

Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber maintenance, repair and remodeling. Our knowledge of the role of satellite cells in muscle fiber adaptation has traditionally relied on in vitro cell and in vivo animal models. Over the past decade, a genuine effort has been made to translate these results to humans under physiological conditions. Findings from in vivo human studies suggest that satellite cells play a key role in skeletal muscle fiber repair/remodeling in response to exercise. Mounting evidence indicates that aging has a profound impact on the regulation of satellite cells ...