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Articles 1 - 23 of 23
Full-Text Articles in Obstetrics and Gynecology
A Mechanism For Synergy With Combined Mtor And Pi3 Kinase Inhibitors, S. Yang, X. Xiao, Xiangbing Meng, Kimberly Leslie
A Mechanism For Synergy With Combined Mtor And Pi3 Kinase Inhibitors, S. Yang, X. Xiao, Xiangbing Meng, Kimberly Leslie
Xiangbing Meng
Dysregulation of the mammalian target of rapamycin (mTOR) signaling has been found in many human cancers, particularly those with loss of the tumor suppressor PTEN. However, mTORC1 inhibitors such as temsirolimus have only modest activity when used alone and may induce acquired resistance by activating upstream mTORC2 and Akt. Other tumors that do not depend upon PI3K/Akt/mTOR signaling for survival are primarily resistant. This study tested the hypothesis that the limited clinical efficacy of temsirolimus is due to a compensatory increase in survival signaling pathways downstream of Akt as well as an incomplete block of 4E-BP1-controlled proliferative processes downstream of …
Amifostine Enhancement Of The Anti-Cancer Effects Of Paclitaxel In Endometrial Cancer Is Tp53-Dependent, W. Luo, F. Wu, R. Elmaoued, B. Beck, E. Fischer, Xiangbing Meng, Kimberly Leslie, Donghai Dai
Amifostine Enhancement Of The Anti-Cancer Effects Of Paclitaxel In Endometrial Cancer Is Tp53-Dependent, W. Luo, F. Wu, R. Elmaoued, B. Beck, E. Fischer, Xiangbing Meng, Kimberly Leslie, Donghai Dai
Xiangbing Meng
Endometrial cancer (ECa) is the fourth most common malignancy in women. Currently, there is no effective therapy for advanced and recurrent cancer. Among the poor-outcome endometrial cancers, there is a high frequency of TP53 mutations. We have previously reported that amifostine has a direct anti-cancer effect and has a significant synergistic effect with paclitaxel when used in endometrial cancer cell and xenograft models. In this report, using a cell line with knock-down p53 expression through siRNA, we found that amifostine enhancement of paclitaxel's anticancer effect is p53 status-dependent. Amifostine promotes entry into the G2-M phase through regulation of cyclin-dependent kinase-1 …
Cytoplasmic Metadherin (Mtdh) Provides Survival Advantage Under Conditions Of Stress By Acting As Rna-Binding Protein, Xiangbing Meng, Danlin Zhu, Shujie Yang, Xinjun Wang, Zhi Xiong, Yuping Zhang, Pavla Brachova, Kimberly Leslie
Cytoplasmic Metadherin (Mtdh) Provides Survival Advantage Under Conditions Of Stress By Acting As Rna-Binding Protein, Xiangbing Meng, Danlin Zhu, Shujie Yang, Xinjun Wang, Zhi Xiong, Yuping Zhang, Pavla Brachova, Kimberly Leslie
Xiangbing Meng
Overexpression of metadherin (MTDH) has been documented in many solid tumors and is implicated in metastasis and chemoresistance. MTDH has been detected at the plasma membrane as well as in the cytoplasm and nucleus, and the function of MTDH in these locales remains under investigation. In the nucleus, MTDH acts as a transcription co-factor to induce expression of chemoresistance-associated genes. However, MTDH is predominantly cytoplasmic in prostate tumors, and this localization correlates with poor prognosis. Herein, we used endometrial cancer cells as a model system to define a new role for MTDH in the cytoplasm. First, MTDH was primarily localized …
The Brca2-Interacting Protein Bccip Functions In Rad51 And Brca2 Focus Formation And Homologous Recombinational Repair, H. Lu, X. Guo, Xiangbing Meng, J. Liu, C. Allen, J. Wray, J. Nickoloff, Z. Shen
The Brca2-Interacting Protein Bccip Functions In Rad51 And Brca2 Focus Formation And Homologous Recombinational Repair, H. Lu, X. Guo, Xiangbing Meng, J. Liu, C. Allen, J. Wray, J. Nickoloff, Z. Shen
Xiangbing Meng
Homologous recombinational repair (HRR) of DNA damage is critical for maintaining genome stability and tumor suppression. RAD51 and BRCA2 colocalization in nuclear foci is a hallmark of HRR. BRCA2 has important roles in RAD51 focus formation and HRR of DNA double-strand breaks (DSBs). We previously reported that 13CCIPalpha interacts with BRCA2. We show that a second isoform, BCCIPP, also interacts with BRCA2 and that this interaction occurs in a region shared by BCCIPot and BCCIPP. We further show that chromatin-bound BRCA2 colocalizes with BCCIP nuclear foci and that most radiation-induced RAD51 foci colocalize with BCCIP. Reducing BCCIPalpha by 90% or …
Rice Gene Osnac19 Encodes A Novel Nac-Domain Transcription Factor And Responds To Infection By Magnaporthe Grisea, Ruiming Lin, Wensheng Zhao, Xiangbing Meng, Min Wang, Youliang Peng
Rice Gene Osnac19 Encodes A Novel Nac-Domain Transcription Factor And Responds To Infection By Magnaporthe Grisea, Ruiming Lin, Wensheng Zhao, Xiangbing Meng, Min Wang, Youliang Peng
Xiangbing Meng
The plant-specific NAC-domain proteins have been identified to play important roles in plant responses to stresses or in plant development regulation. In this research, a full-length cDNA clone OsNAC19 (Oryza sativa NAC19), encoding a novel NAC-domain protein, was isolated from a cDNA library prepared with rice leaves infected by incompatible race 131 of blast fungus (Magnaporthe grisea). The similarity between OsNAC 19 and the members of OsNAC3 subgroup is from 65.87 to 51.53%. One plant-specific NAC domain is located in the N-terminus of OsNAC19. The protein OsNAC19 was localized in the nucleus of onion epidemical cells. The fusion protein of …
Genomic Structure Of The Human Bccip Gene And Its Expression In Cancer, Xiangbing Meng, J. Liu, Z. Shen
Genomic Structure Of The Human Bccip Gene And Its Expression In Cancer, Xiangbing Meng, J. Liu, Z. Shen
Xiangbing Meng
Human BCCIPalpha (Tok-1alpha) is a BRCA2 and CDKN1A (Cip1, p21) interacting protein. Our previous studies have showed that overexpression of BCCIPalpha inhibits the growth of certain tumor cells [Oncogene 20 (2001) 336]. In this study, we report the genomic structure of the human BCCIP gene, which contains nine exons. Alternative splicing of the 3-terminal exons produces two isoforms of BCCIP transcripts, BCCIPalpha and BCCIPbeta. The BCCIP gene is flanked by two genes that are transcribed in the opposite orientation of the BCCIP gene. It lies head-to-head and shares a bi-directional promoter with the uroporphyrinogen III synthase (UROS) gene. The last …
Select Gamma-Secretase Inhibitors Induce Apoptosis In Pre-B All Cells And Disrupt The Balance Between Constitutive Notch Signaling And Repression., Bridget Wilson, Xiangbing Meng, Tomas Mazel, Cheryl Willman, Susan Atlas, Richard Harvey, I.-Ming Chen, Stephen Hunger, Janet Oliver, Stuart Winter
Select Gamma-Secretase Inhibitors Induce Apoptosis In Pre-B All Cells And Disrupt The Balance Between Constitutive Notch Signaling And Repression., Bridget Wilson, Xiangbing Meng, Tomas Mazel, Cheryl Willman, Susan Atlas, Richard Harvey, I.-Ming Chen, Stephen Hunger, Janet Oliver, Stuart Winter
Xiangbing Meng
No abstract provided.
Short Panicle1 Encodes A Putative Ptr Family Transporter And Determines Rice Panicle Size, Shengben Li, Qian Qian, Zhiming Fu, Dali Zeng, Xiangbing Meng, Junko Kyozuka, Masahiko Maekawa, Xudong Zhu, Jian Zhang, Jiayang Li, Yonghong Wang
Short Panicle1 Encodes A Putative Ptr Family Transporter And Determines Rice Panicle Size, Shengben Li, Qian Qian, Zhiming Fu, Dali Zeng, Xiangbing Meng, Junko Kyozuka, Masahiko Maekawa, Xudong Zhu, Jian Zhang, Jiayang Li, Yonghong Wang
Xiangbing Meng
The architecture of the rice inflorescence, which is determined mainly by the number and length of primary and secondary inflorescence branches, is of importance in both agronomy and developmental biology. The position and number of primary branches are established during the phase transition from vegetative to reproductive growth, and several of the genes identified as participating in this process do so by regulating the meristemic activities of inflorescence. However, little is known about the molecular mechanism that controls inflorescence branch elongation. Here, we report on a novel rice mutant, short panicle1 (sp1), which is defective in rice panicle elongation, and …
Degradation Of Monoculm 1 By Apc/C-Tad1 Regulates Rice Tillering, Cao Xu, Yonghong Wang, Yanchun Yu, Jingbo Duan, Zhigang Liao, Guosheng Xiong, Xiangbing Meng, Guifu Liu, Qian Qian, Jiayang Li
Degradation Of Monoculm 1 By Apc/C-Tad1 Regulates Rice Tillering, Cao Xu, Yonghong Wang, Yanchun Yu, Jingbo Duan, Zhigang Liao, Guosheng Xiong, Xiangbing Meng, Guifu Liu, Qian Qian, Jiayang Li
Xiangbing Meng
A rice tiller is a specialized grain-bearing branch that contributes greatly to grain yield. The MONOCULM 1 (MOC1) gene is the first identified key regulator controlling rice tiller number; however, the underlying mechanism remains to be elucidated. Here we report a novel rice gene, Tillering and Dwarf 1 (TAD1), which encodes a co-activator of the anaphase-promoting complex (APC/C), a multi-subunit E3 ligase. Although the elucidation of co-activators and individual subunits of plant APC/C involved in regulating plant development have emerged recently, the understanding of whether and how this large cell-cycle machinery controls plant development is still very limited. Our study …
Association Of Human Rad52 Protein With Transcription Factors, J. Liu, Xiangbing Meng, Z. Shen
Association Of Human Rad52 Protein With Transcription Factors, J. Liu, Xiangbing Meng, Z. Shen
Xiangbing Meng
The human RAD52 protein has been implicated in DNA homologous recombination. Four major functional domains have been identified: a DNA binding domain (amino acids 1-85), a self-association and UBC9-interacting domain (amino acids 85-159), an RPA-interacting domain (amino acids 221-280), and a RAD51-interacting domain (amino acids 287-330). However, it is uncertain about the functional roles of the C-terminal region of RAD52 protein. In this report, we demonstrate an association of a C-terminal domain of human RAD52 (amino acids 302-418) with the XPB and XPD subunits of transcription factor TFIIH and RNA polymerase II (RNAPII). Using a Gal-4 binding based transcription assay, …
Ikk Inhibitor Bay 11-7082 Induces Necroptotic Cell Death In Precursor-B Acute Lymphoblastic Leukaemic Blasts, Xiangbing Meng, Marina Martinez, Mary Raymond-Stintz, Stuart Winter, Bridget Wilson
Ikk Inhibitor Bay 11-7082 Induces Necroptotic Cell Death In Precursor-B Acute Lymphoblastic Leukaemic Blasts, Xiangbing Meng, Marina Martinez, Mary Raymond-Stintz, Stuart Winter, Bridget Wilson
Xiangbing Meng
No abstract provided.
Induction Of Mitotic Cell Death By Overriding G2/M Checkpoint In Endometrial Cancer Cells With Non-Functional P53, Xiangbing Meng, Laura Laidler, Elizabeth Kosmacek, Shujie Yang, Zhi Xiong, Danlin Zhu, Xinjun Wang, Donghai Dai, Yuping Zhang, Xiaofang Wang, Pavia Brachova, Lina Albitar, Dawei Liu, Florenza Ianzini, Michael Mackey, Kimberly Leslie
Induction Of Mitotic Cell Death By Overriding G2/M Checkpoint In Endometrial Cancer Cells With Non-Functional P53, Xiangbing Meng, Laura Laidler, Elizabeth Kosmacek, Shujie Yang, Zhi Xiong, Danlin Zhu, Xinjun Wang, Donghai Dai, Yuping Zhang, Xiaofang Wang, Pavia Brachova, Lina Albitar, Dawei Liu, Florenza Ianzini, Michael Mackey, Kimberly Leslie
Xiangbing Meng
OBJECTIVE: Endometrial tumors with non-functional p53, such as serous uterine endometrial carcinomas, are aggressive malignancies with a poor outcome, yet they have an Achilles' heel: due to loss of p53 function, these tumors may be sensitive to treatments which abrogate the G2/M checkpoint. Our objective was to exploit this weakness to induce mitotic cell death using two strategies: (1) EGFR inhibitor gefitinib combined with paclitaxel to arrest cells at mitosis, or (2) BI2536, an inhibitor of polo-like kinase 1 (PLK1), to block PLK1 activity. METHODS: We examined the impact of combining gefitinib and paclitaxel or PLK1 inhibitor on expression of …
Cloning And Characterization Of The Dhdps Gene Encoding The Lysine Biosynthetic Enzyme Dihydrodipocolinate Synthase From Zizania Latifolia (Griseb), Fanna Kong, Shaomei Jiang, Xiangbing Meng, Chengli Song, Jinfeng Shi, Demin Jin, Shaolin Jiang, Bin Wang
Cloning And Characterization Of The Dhdps Gene Encoding The Lysine Biosynthetic Enzyme Dihydrodipocolinate Synthase From Zizania Latifolia (Griseb), Fanna Kong, Shaomei Jiang, Xiangbing Meng, Chengli Song, Jinfeng Shi, Demin Jin, Shaolin Jiang, Bin Wang
Xiangbing Meng
Dihydrodipicolinate synthase (DHDPS) is the main enzyme of a specific branch of the aspartate pathway leading to lysine biosynthesis in higher plants. We have cloned and characterized the DHDPS gene from Zizania latifolia Griseb, which was named ZlDHDPS. Sequence analysis indicates that it contains an ORF of 954 bp interrupted by two exons and one intron encoding a polypeptide of 317 amino acids lacking a plastid transit peptide and a stop codon. The sequence of ZlDHDPS has high identity with known plant DHDPS in GenBank. Southern blotting analysis indicates that there are two copies of Z. latifolia DHDPS (ZlDHDPS) gene …
Differential Expression Of Ikaros Isoforms In Monozygotic Twins With Mll-Rearranged Precursor-B Acute Lymphoblastic Leukemia, Thomas Russell, Janet Oliver, Bridget Wilson, Christy Tarleton, Stuart Winter, Xiangbing Meng
Differential Expression Of Ikaros Isoforms In Monozygotic Twins With Mll-Rearranged Precursor-B Acute Lymphoblastic Leukemia, Thomas Russell, Janet Oliver, Bridget Wilson, Christy Tarleton, Stuart Winter, Xiangbing Meng
Xiangbing Meng
Infant leukemia associated with rearrangement of the MLL gene typically presents with high-risk clinical features. Relapse is common despite aggressive therapy and perturbations in signaling pathways may contribute to disease resistance. We evaluated twin 4-month-old monozygotic baby boys who presented with MLL-rearranged precursor-B acute lymphoblastic leukemia. Two different MLL/AF4 variants were found in both the twins, the first involving MLL intron 8 and AF4 intron 3 and the second stemming from translocations of MLL exon 10 and AF4 exon 4. We detected expression of the DNA-binding Ikaros isoforms, Ik1, Ikx +, Ik2 and the dominant-negative 114 Ikaros isoform in both …
Abrogation Of The Transactivation Activity Of P53 By Bccip Down-Regulation, Xiangbing Meng, Jingyin Yue, Zhihe Liu, Zhiyuan Shen
Abrogation Of The Transactivation Activity Of P53 By Bccip Down-Regulation, Xiangbing Meng, Jingyin Yue, Zhihe Liu, Zhiyuan Shen
Xiangbing Meng
The tumor suppression function of p53 is mostly conferred by its transactivation activity, which is inactivated by p53 mutations in similar to 50% of human cancers. In cancers harboring wild type p53, the p53 transactivation activity may be compromised by other mechanisms. Identifying the mechanisms by which wild type p53 transactivation activity can be abrogated may provide insights into the molecular etiology of cancers harboring wild type p53. In this report, we show that BCCIP, a BRCA2 and CDKN1A- interacting protein, is required for the transactivation activity of wild type p53. In p53 wild type cells, BCCIP knock down by …
Dwarf27, An Iron-Containing Protein Required For The Biosynthesis Of Strigolactones, Regulates Rice Tiller Bud Outgrowth, Hao Lin, Renxiao Wang, Qian Qian, Meixian Yan, Xiangbing Meng, Zhiming Fu, Cunyu Yan, Biao Jiang, Zhen Su, Jiayang Li, Yonghong Wang
Dwarf27, An Iron-Containing Protein Required For The Biosynthesis Of Strigolactones, Regulates Rice Tiller Bud Outgrowth, Hao Lin, Renxiao Wang, Qian Qian, Meixian Yan, Xiangbing Meng, Zhiming Fu, Cunyu Yan, Biao Jiang, Zhen Su, Jiayang Li, Yonghong Wang
Xiangbing Meng
Tillering in rice (Oryza sativa) is one of the most important agronomic traits that determine grain yields. Previous studies on rice tillering mutants have shown that the outgrowth of tiller buds in rice is regulated by a carotenoid-derived MAX/RMS/D (more axillary branching) pathway, which may be conserved in higher plants. Strigolactones, a group of terpenoid lactones, have been recently identified as products of the MAX/RMS/D pathway that inhibits axillary bud outgrowth. We report here the molecular genetic characterization of d27, a classic rice mutant exhibiting increased tillers and reduced plant height. D27 encodes a novel iron-containing protein that localizes in …
Recovery From Dna Damage-Induced G(2) Arrest Requires Actin-Binding Protein Filamin-A/Actin-Binding Protein 280, Xiangbing Meng, Y. Yuan, A. Maestas, Z. Shen
Recovery From Dna Damage-Induced G(2) Arrest Requires Actin-Binding Protein Filamin-A/Actin-Binding Protein 280, Xiangbing Meng, Y. Yuan, A. Maestas, Z. Shen
Xiangbing Meng
Filamin-A (filamin-1) is an actin-binding protein involved in the organization of actin networks. Our previous study shows that filamin-A interacts with BRCA2, and lack of filamin-A expression results in increased cellular sensitivity to several DNA damaging agents in melanoma cells (Yuan, Y., and Shen, Z. (2001) J. Biol. Chem. 276, 48318-48324), suggesting a role of filamin-A in DNA damage response. In this report, we demonstrated that deficiency of filamin-A results in an 8-h delay in the recovery from G(2) arrest in response to ionizing radiation. However, filamin-A deficiency does not affect the initial activation of the G(2)/M checkpoint. We also …
Bccip Functions Through P53 To Regulate The Expression Of P21(Waf1/Cip1), Xiangbing Meng, H. Lu, Z. Shen
Bccip Functions Through P53 To Regulate The Expression Of P21(Waf1/Cip1), Xiangbing Meng, H. Lu, Z. Shen
Xiangbing Meng
The BCCIP protein is a BRCA2 and CDKN1A (p21(Waf1/Cip1)) Interacting Protein, which binds to a highly conserved domain of BRCA2, and a C-terminal domain of the CDK-inhibitor p21. We have previously reported that overexpression of BCCIP increases p21 mRNA and protein levels, and inhibits G(1) to S progression. In this report, we show that a partial shutdown of BCCIP expression by RNA interference reduces p21 levels and impairs G(1)/S checkpoint activation in response to ionizing radiation in HT1080 cells. We further show that the regulation of p21 expression by BCCIP is dependent on p53, and BCCIP regulates p53 transcription activity. …
Molecular Cloning And Characterization Of A Rice Gene Encoding Ap2/Erebp-Type Transcription Factor And Its Expression In Response To Infection With Blast Fungus And Abiotic Stresses, Running Lin, Wensheng Zhao, Xiangbing Meng, You-Liang Peng
Molecular Cloning And Characterization Of A Rice Gene Encoding Ap2/Erebp-Type Transcription Factor And Its Expression In Response To Infection With Blast Fungus And Abiotic Stresses, Running Lin, Wensheng Zhao, Xiangbing Meng, You-Liang Peng
Xiangbing Meng
The AP2/EREBP domain-containing transcription factors play various functions in developmental processes and stress-related responses in plants. In present study, a full-length cDNA OsEBP2 (Oryza sativa ethylene-responsive-element binding protein2), encoding a 396-amino-acid protein containing one AP2/EREBP domain, was isolated from a cDNA library prepared with japonica rice leaves infected by blast fungus Magnaporthe grisea, which is identity to the locus OsO9g26420 and has been isolated from the japonica variety before. OsEBP2 is a member of Group VII of ERF family and is orthologous to OsBIERF1 in indica variety. OsEBP2 transcripts were detected at a similar level in the leaf, sheath and …
Bccip Regulates Homologous Recombination By Distinct Domains And Suppresses Spontaneous Dna Damage, Huimei Lu, Jingyin Yue, Xiangbing Meng, Jac Nickoloff, Zhiyuan Shen
Bccip Regulates Homologous Recombination By Distinct Domains And Suppresses Spontaneous Dna Damage, Huimei Lu, Jingyin Yue, Xiangbing Meng, Jac Nickoloff, Zhiyuan Shen
Xiangbing Meng
Homologous recombination (HR) is critical for maintaining genome stability through precise repair of DNA double-strand breaks (DSBs) and restarting stalled or collapsed DNA replication forks. HR is regulated by many proteins through distinct mechanisms. Some proteins have direct enzymatic roles in HR reactions, while others act as accessory factors that regulate HR enzymatic activity or coordinate HR with other cellular processes such as the cell cycle. The breast cancer susceptibility gene BRCA2 encodes a critical accessory protein that interacts with the RAD51 recombinase and this interaction fluctuates during the cell cycle. We previously showed that a BRCA2- and p21-interacting protein, …
Combination Therapy With Mtor And Pi3 Kinase Inhibitors Is Broadly Synergistic In A Wide Variety Of Endometrial Cancer Cells, Shujie Yang, Xue Xiao, Xiangbing Meng, Kimberly K. Leslie
Combination Therapy With Mtor And Pi3 Kinase Inhibitors Is Broadly Synergistic In A Wide Variety Of Endometrial Cancer Cells, Shujie Yang, Xue Xiao, Xiangbing Meng, Kimberly K. Leslie
Xiangbing Meng
Dysregulation of mammalian target of rapamycin (mTOR) signaling has been found in many human tumors, including endometrial cancer, and mTOR inhibitors have been utilized in clinical trials as targeted therapies with only limited success. Herein we identify a viable treatment alternative that overcomes temsirolimus-induced AKT phosphorylation in endometrial cancer. Our data suggest temsirolimus and BEZ235 inhibit different components of the AKT/mTOR signaling pathway to accomplish synergistic pathway inhibition, which is necessary for therapeutic efficacy to abrogate the increased signaling through AKT that occurs with mTOR inhibition alone
Knockdown Of Mtdh Increases Drug Sensitivity To Hdac Inhibitor And Trail Combination Treatment In Endometrial Cancer Cells, Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, Kimberly Leslie
Knockdown Of Mtdh Increases Drug Sensitivity To Hdac Inhibitor And Trail Combination Treatment In Endometrial Cancer Cells, Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, Kimberly Leslie
Xiangbing Meng
Understanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy.
The Combination Of Paclitaxel And Gefitinib Inhibits Endometrial Cancer Cells By Inducing Mitotic Catastrophe: Proof Of Principle For Dual Therapy In Endometrial Cancer, Xiangbing Meng, Laura Laidler, Lina Albitar, Anna Holmes, Donghai Dai, Thomas Buekers, David Bender, Kimberly Leslie
The Combination Of Paclitaxel And Gefitinib Inhibits Endometrial Cancer Cells By Inducing Mitotic Catastrophe: Proof Of Principle For Dual Therapy In Endometrial Cancer, Xiangbing Meng, Laura Laidler, Lina Albitar, Anna Holmes, Donghai Dai, Thomas Buekers, David Bender, Kimberly Leslie
Xiangbing Meng
Serous uterine endometrial cancer is a lethal disease for which new therapeutic regimens are urgently needed. Combinations of chemotherapeutic agents and small molecule growth factor inhibitors have demonstrated activity in cancers from other sites. Our objective was to determine whether such a combination using Paclitaxel and Gefitinib could be active in serous endometrial cancer cells.