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- 129S1/SvImJ mouse; ABCC6 gene; animal cell; animal experiment; animal model; animal tissue; article; C3H/He mouse; controlled study; DBA 2 mouse; diet; gene; gene mutation; genetic variability; histopathology; inbred mouse strain; KK/HlJ mouse; liver; magnesium blood level; mineralization; mouse; nonhuman; phosphate blood level; protein expression; pseudoxanthoma elasticum; single nucleotide polymorphism (1)
- 19th Century (1)
- 3' untranslated region; animal experiment; animal model; animal tissue; artery calcification; Article; asj 2J mouse; asj mouse; autosomal recessive disorder; Bagg albino mouse; controlled study; dietary intake; Enpp1 gene; female; gait disorder; gene; generalized arterial calcification of infancy; genetic complementation; genome size; histopathology; indel mutation; intron; joint stiffness; large scale production; micro-computed tomography; missense mutation; molecular pathology; mouse; mouse model; mutant mouse strain; mutational analysis; nonhuman; phenotype; polymerase chain reaction; protein blood level; strain difference; vibrissa (1)
- Adenocarcinoma in situ;; aggressive digital papillary adenocarcinoma;; apocrine gland;; eccrine gland;; papillary eccrine adenoma (1)
- Adipose-derived stem cells (1)
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- Congenital muscular dystrophies (CMD) (1)
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Articles 1 - 20 of 20
Full-Text Articles in Dermatology
Spontaneous Asj-2j Mutant Mouse As A Model For Generalized Arterial Calcification Of Infancy: A Large Deletion/Insertion Mutation In The Enpp1 Gene., Qiaoli Li, C Herbert Pratt, Louise A Dionne, Heather Fairfield, Son Yong Karst, John P Sundberg, Jouni Uitto, Yin Tintut
Spontaneous Asj-2j Mutant Mouse As A Model For Generalized Arterial Calcification Of Infancy: A Large Deletion/Insertion Mutation In The Enpp1 Gene., Qiaoli Li, C Herbert Pratt, Louise A Dionne, Heather Fairfield, Son Yong Karst, John P Sundberg, Jouni Uitto, Yin Tintut
Department of Dermatology and Cutaneous Biology Faculty Papers
Generalized arterial calcification of infancy (GACI), an autosomal recessive disorder caused by mutations in the ENPP1 gene, manifests with extensive mineralization of the cardiovascular system. The affected individuals in most cases die within the first year of life, and there is currently no effective treatment for this disorder. In this study, we characterized a spontaneous mutant mouse, asj-2J, as a model for GACI. These mice were identified as part of a phenotypic deviant search in a large-scale production colony of BALB/cJ mice at The Jackson Laboratory. They demonstrated a characteristic gait due to stiffening of the joints, with phenotypic similarity …
Jewish Dermatologists In Nazi Germany., Walter H.C. Burgdorf, Lawrence Charles Parish
Jewish Dermatologists In Nazi Germany., Walter H.C. Burgdorf, Lawrence Charles Parish
Department of Dermatology and Cutaneous Biology Faculty Papers
With the development of medical specialties beginning in the 1860’s, physicians could devote their time to the study of specific organ systems or surgical approaches. Although Jews had been given full rights in the new Germany by 1871, prejudice and other restrictions often precluded hospital and university appointments. Major specialities like internal medicine and surgery were almost closed to Jews, as were obstetrics and gynecology. Dermatology with its heavy emphasis on sexually transmitted diseases evolved into a suitable domain for Jewish physicians almost by default. Even those Jews who converted to Christianity were not spared from discrimination. Paul Gerson Unna …
Steatocystoma Multiplex: Those Little Tumours., Ellen H. De Moll, W. Clark Lambert, Lawrence Charles Parish
Steatocystoma Multiplex: Those Little Tumours., Ellen H. De Moll, W. Clark Lambert, Lawrence Charles Parish
Department of Dermatology and Cutaneous Biology Faculty Papers
No abstract provided.
Tumour-Stroma Crosstalk In The Development Of Squamous Cell Carcinoma., Yok Zuan Lim, Andrew P South
Tumour-Stroma Crosstalk In The Development Of Squamous Cell Carcinoma., Yok Zuan Lim, Andrew P South
Department of Dermatology and Cutaneous Biology Faculty Papers
Squamous cell carcinoma (SCC) represents one of the most frequently diagnosed tumours and contributes significant mortality worldwide. Recent deep sequencing of cancer genomes has identified common mutations in SCC arising across different tissues highlighting perturbation of squamous differentiation as a key event. At the same time significant data have been accumulating to show that common tumour-stroma interactions capable of driving disease progression are also evident when comparing SCC arising in different tissues. We and others have shown altered matrix composition surrounding SCC can promote tumour development. This review focuses on some of the emerging data with particular emphasis on SCC …
Subacute Cutaneous Lupus Erythematosus With Erythema Multiforme-Like Lesions: Consideration For Rowell Syndrome, Kelly L. Reed Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do
Subacute Cutaneous Lupus Erythematosus With Erythema Multiforme-Like Lesions: Consideration For Rowell Syndrome, Kelly L. Reed Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Eosinophilic Pustular Folliculitis, Ryan Owen Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Eosinophilic Pustular Folliculitis, Ryan Owen Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Herpes Zoster Duplex Bilateralis, Sean Branch Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Herpes Zoster Duplex Bilateralis, Sean Branch Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Darkening And Eruptive Nevi During Treatment With Erlotinib (Poster), Stephen Hemperly Do, Tanya Ermolovich Do, Nektarios I. Lountzis Md
Darkening And Eruptive Nevi During Treatment With Erlotinib (Poster), Stephen Hemperly Do, Tanya Ermolovich Do, Nektarios I. Lountzis Md
Department of Medicine
No abstract provided.
Mouse Models For Pseudoxanthoma Elasticum: Genetic And Dietary Modulation Of The Ectopic Mineralization Phenotypes., Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, Jouni Uitto
Mouse Models For Pseudoxanthoma Elasticum: Genetic And Dietary Modulation Of The Ectopic Mineralization Phenotypes., Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, Jouni Uitto
Department of Dermatology and Cutaneous Biology Faculty Papers
Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene. Null mice (Abcc6(-/-) ) recapitulate the genetic, histopathologic and ultrastructural features of PXE, and they demonstrate early and progressive mineralization of vibrissae dermal sheath, which serves as a biomarker of the overall mineralization process. Recently, as part of a mouse aging study at The Jackson Laboratory, 31 inbred mouse strains were necropsied, and two of them, KK/HlJ and 129S1/SvImJ, were noted to have vibrissae dermal mineralization similar to Abcc6(-/-) mice. These two strains were shown to harbor a single nucleotide polymorphism (rs32756904) in the …
Human Adipose-Derived Stem Cell Transplantation As A Potential Therapy For Collagen Vi-Related Congenital Muscular Dystrophy., Vitali Alexeev, Machiko Arita, Adele Donahue, Paolo Bonaldo, Daniel A. Monti, Olga Igoucheva
Human Adipose-Derived Stem Cell Transplantation As A Potential Therapy For Collagen Vi-Related Congenital Muscular Dystrophy., Vitali Alexeev, Machiko Arita, Adele Donahue, Paolo Bonaldo, Daniel A. Monti, Olga Igoucheva
Department of Dermatology and Cutaneous Biology Faculty Papers
INTRODUCTION: Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness within the first two years of life. Collagen VI-related muscle disorders have recently emerged as one of the most common types of CMD. COL6 CMD is caused by deficiency and/or dysfunction of extracellular matrix (ECM) protein collagen VI. Currently, there is no specific treatment for this disabling and life-threatening disease. The primary cellular targets for collagen VI CMD therapy are fibroblasts in muscle, tendon and skin, as opposed to muscle cells for other types of muscular dystrophies. However, recent advances in …
Language Barriers To Informed Consent For Dermatologic Interventions., Jordan Wang, Matthew Keller
Language Barriers To Informed Consent For Dermatologic Interventions., Jordan Wang, Matthew Keller
Department of Dermatology and Cutaneous Biology Faculty Papers
CASE SCENARIO
A 39-year-old Spanish-speaking woman with limited English-language proficiency presents with her 13-year-old son to your private dermatology practice. Through her son, you learn the patient is worried about a mole that has significantly grown in size over the past 3 months. After examination, you recommend the nevus be biopsied to better evaluate it. However, you are barely able to communicate with the patient, and you suspect that her son is not interpreting everything you say based on his especially brief communications with her. To proceed with the biopsy, you must first obtain informed consent.
As the dermatologist, you …
Blockade Of Mast Cell Activation Reduces Cutaneous Scar Formation, Lin Chen, Megan Schrementi, Matthew J. Ranzer, Traci A. Wilgus, Luisa A. Dipietro
Blockade Of Mast Cell Activation Reduces Cutaneous Scar Formation, Lin Chen, Megan Schrementi, Matthew J. Ranzer, Traci A. Wilgus, Luisa A. Dipietro
Faculty Publications & Research
Damage to the skin initiates a cascade of well-orchestrated events that ultimately leads to repair of the wound. The inflammatory response is key to wound healing both through preventing infection and stimulating proliferation and remodeling of the skin. Mast cells within the tissue are one of the first immune cells to respond to trauma, and upon activation they release pro-inflammatory molecules to initiate recruitment of leukocytes and promote a vascular response in the tissue. Additionally, mast cells stimulate collagen synthesis by dermal fibroblasts, suggesting they may also influence scar formation. To examine the contribution of mast cells in tissue repair, …
Images In Clinical Medicine. Rumpel-Leede Sign., Krystle Wang, Jason Lee
Images In Clinical Medicine. Rumpel-Leede Sign., Krystle Wang, Jason Lee
Department of Dermatology and Cutaneous Biology Faculty Papers
No abstract provided.
Is Aggressive Digital Papillary Adenocarcinoma Really Aggressive Digital Papillary Adenocarcinoma?, S. Chen, M. Asgari
Is Aggressive Digital Papillary Adenocarcinoma Really Aggressive Digital Papillary Adenocarcinoma?, S. Chen, M. Asgari
Journal Articles
No abstract provided.
Papillary Adenocarcinoma In Situ Of The Skin: Report Of Four Cases, S. Chen, M. Asgari
Papillary Adenocarcinoma In Situ Of The Skin: Report Of Four Cases, S. Chen, M. Asgari
Journal Articles
Although rare isolated cases of adenocarcinoma in situ of skin have been reported in the literature, adenocarcinoma in situ of skin as a concept and as a diagnostic category has not been established in the field of dermatopathology. In this work, four cases of papillary adenocarcinoma in situ of the skin are presented. In addition, the notion that lesions previously reported in the medical literature under the term of "papillary eccrine adenoma" are actually adenocarcinoma in situ is discussed.
Mediastinal Synovial Sarcoma., Niaz Hussain Soomro, Sanaullah Junejo, Aneeqa Ahsan Zafar, Shirin Siddiqi, Ghulam H
Mediastinal Synovial Sarcoma., Niaz Hussain Soomro, Sanaullah Junejo, Aneeqa Ahsan Zafar, Shirin Siddiqi, Ghulam H
Department of Medicine
The mediastinum is an uncommon site of synovial sarcoma which is a rare soft tissue malignancy. An 18 year old boy was admitted for right sided chest pain since one year. Based on the CT scan chest findings, tru-cut biopsy of the mass was performed and histopathology initially reported as neurofibroma. The tumor was excised via posterolateral thoracotomy and excisional biopsy established the diagnosis of primary synovial sarcoma arising from the mediastinum. Patient was started on adjuvant chemotherapy at the oncologist tumor board’s recommendation and he received 6 cycles of adriamycin and ifosfamide. At last follow up he is free …
Making Facelifts Obsolete?, Shevanti Jegasothy
Making Facelifts Obsolete?, Shevanti Jegasothy
S. Manjula Jegasothy, MD
No abstract provided.
Cosmetic Controversies, Shevanti Jegasothy
Cosmetic Controversies, Shevanti Jegasothy
S. Manjula Jegasothy, MD
No abstract provided.
Top 10 Cosmeceuticals 2014, Shevanti Jegasothy
Top 10 Cosmeceuticals 2014, Shevanti Jegasothy
S. Manjula Jegasothy, MD
No abstract provided.
Innovative Solutions For Difficult Cosmetic Problems, Shevanti Jegasothy
Innovative Solutions For Difficult Cosmetic Problems, Shevanti Jegasothy
S. Manjula Jegasothy, MD
No abstract provided.