Cardiology Commons^™

Development And Validation Of A Preprocedural Risk Score To Predict Access Site Complications After Peripheral Vascular Interventions Based On The Vascular Quality Initiative Database, Daniel Ortiz, Maharaj Singh, Arshad Jahangir, Suhail Allaqaband, Anjan Gupta, Tanvir Bajwa, Mark W. Mewissen

Arshad Jahangir, MD

Purpose

Access site complications following peripheral vascular intervention (PVI) are associated with prolonged hospitalization and increased mortality. Prediction of access site complication risk may optimize PVI care; however, there is no tool designed for this. We aimed to create a clinical scoring tool to stratify patients according to their risk of developing access site complications after PVI.

Methods

The Society for Vascular Surgery’s Vascular Quality Initiative database yielded 27,997 patients who had undergone PVI at 131 North American centers. Clinically and statistically significant preprocedural risk factors associated with in-hospital, post-PVI access site complications were included in a multivariate logistic regression …

A Meta-Analysis Of Incidence And Risk Factors Of Trastuzumab-Induced Cardiotoxicity In Breast Cancer, Zeeshan Ali Jawa, Ruth Perez, Lydia Garlie, Maharaj Singh, Rubina Qamar, Bijoy Khandheria, Arshad Jahangir, Yang Shi

Arshad Jahangir, MD

Background: A monoclonal antibody, trastuzumab targets the human epidermal growth factor receptor 2 (HER2) oncogene that is overexpressed in 25–30% of breast cancers. In combination with first-line therapy, trastuzumab resulted in significant improvement in survival outcomes for those with HER2-positive metastatic breast cancer. Due to its improvement in outcome and prolonged survival, trastuzumab has been established as standard of care in both adjuvant and metastatic settings. However, along with common adverse events, trastuzumab has been found to be associated with cardiotoxicity. An estimated 1–4% of patients treated with trastuzumab will develop heart failure and ~10% of patients will experience a …

Trans-Catheter Aortic Valve Replacement: The Future Is Here, Raymond Singer, J Kleaveland

Raymond L Singer MD

No abstract provided.

Relation Of Reduced Preclinical Left Ventricular Diastolic Function And Cardiac Remodeling In Overweight Youth To Insulin Resistance And Inflammation, Rachana Dahiya, Sarah Schultz, Arun Dahiya, Jinlin Fu, Christopher Flatley, Danusia Duncan, John Cardinal, Karam Kostner, Nuala Byrne, Andrew Hills, Mark Harris, Louise Conwell, Gary Leong

Nuala Byrne

Insulin resistance (IR) and inflammation are associated with an increased risk of cardiovascular disease and may contribute to obesity cardiomyopathy. The earliest sign of obesity cardiomyopathy is impaired left ventricular (LV) diastolic function, which may be evident in obese children and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and obese (OW) youth and to assess the relative individual contributions of adiposity, IR, and inflammation to alterations in cardiac structure and function. We studied …

Nainesh C Patel MD

No abstract provided.

Rapid Door To Balloon Time In The Treatment Of Acute St- Elevation Myocardial Infarction Meaningfully Reduces Overall Hospital Stay, Amit N. Nanavati Md, Nainesh Patel Md, Bruce Feldman Do, J Patrick Kleaveland Md, Orlando E. Rivera Rn, David A. Cox Md

Nainesh C Patel MD

No abstract provided.

Choosing Radial Vs. Femoral Cardiac Catheterization: Does Operator Seniority Matter? A Single Center Experience, Nitin Verma Md, Amit N. Nanavati Md, Justin Roberts Do, Nainesh C. Patel Md

Nainesh C Patel MD

No abstract provided.

Cardiac: Study Of Access Site For Enhancement Of Pci For Women (Safe-Pci For Women), Nainesh Patel

Nainesh C Patel MD

Description Multicenter, randomized, open-label, active-controlled study in which women undergoing an urgent or elective medical procedure to open a blood vessel in the heart (PCI) will be randomized to either transradial (through the arm) or transfemoral (through the leg) access site

Eligibility Inclusion Criteria-including but may not be limited to:
o Must be older than 18 years of age
o Must be female
o Undergoing urgent or elective PCI
o Appropriate performance scores

Purpose The primary study purpose is to assess the success and complication rates of the transradial approach to PCI in women compared with the transfermoral approach.

Door To Balloon Times Less Than 30 Minutes: The Lehigh Valley Health Network (Lvhn) Experience, M Sarkees, Matthew Martinez, Bruce Feldman, J Kleaveland, Orlando Rivera, Michael Rossi, William Combs, David Cox, Ronald Freudenberger, Nainesh Patel

Nainesh C Patel MD

No abstract provided.

Cardiopulmonary Resuscitation Prescription Program: A Pilot Randomized Comparator Trial (Poster), Marna R. Greenberg Do, Mph, Facep, Gavin C. Barr Jr. Md, Valerie Rupp Rn, Bsn, Nainesh Patel Md, Kevin Weaver Do, Kimberly Hamilton Ba, James Reed Iii, Phd

Nainesh C Patel MD

No abstract provided.

Stress Echo Doppler In Patients With Aortic Valve Stenosis, Bruce Feldman

Bruce A. Feldman DO

No abstract provided.

Dietary Habits Are Related To Outcomes In Patients With Advanced Heart Failure Awaiting Heart Transplantation, Heike Spaderna, Daniela Zahn, Johanna Pretsch, Sonja Connor, Armin Zitterman, Stefanie Schleithoff, Katrina Bramstedt, Jacqueline Smits, Gerdi Weiner

Katrina A. Bramstedt

Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pretransplant clinical outcomes in the multisite observational Waiting for a New Heart Study.

Pre-Hospital Electrocardiogram Interpretation And Early Activation For St Segment Elevation Myocardial Infarction Patients Reduces Door To Balloon Times And Hospital Length Of Stay, Andrew C. Miller Do, Gerald A. Coleman Iii Do, Richard S. Mackenzie Md, David M. Richardson Md, J Patrick Kleaveland Md, David A. Cox Md, Bruce Feldman Do, Anne Marie Crown, Valerie A. Rupp Rn, Bsn

Bruce A. Feldman DO

No abstract provided.

Door To Balloon Times Less Than 30 Minutes: The Lehigh Valley Health Network (Lvhn) Experience, M Sarkees, Matthew Martinez, Bruce Feldman, J Kleaveland, Orlando Rivera, Michael Rossi, William Combs, David Cox, Ronald Freudenberger, Nainesh Patel

Bruce A. Feldman DO

No abstract provided.

Pre-Operative Risk Assessment And Risk Reduction: Improving The Process, Bruce Feldman

Bruce A. Feldman DO

No abstract provided.

Cardiopulmonary Resuscitation Prescription Program: A Pilot Randomized Comparator Trial (Poster), Marna Greenberg, Gavin Barr, Valerie Rupp, Nainesh Patel, Kevin Weaver, Kimberly Hamilton, James Reed

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

The Effect Of Severe Pulmonary Hypertension In Mitral Valve Surgery Patients: A Seven Year Single Center Review, James Wu, Kelsey Mcleod, Elizabeth Sander

James K Wu MD

No abstract provided.

Aldosterone Antagonism With Eplerenone Does Not Adversely Affect Plasma Glucose Levels In Patients With Diabetes Mellitus: Findings From A Post Hoc Analysis Of The Ephesus Trial, Prakash Deedwania Md, Bertram Pitt, Ravi V. Desai Md, Marjan Mujib Md, Mph, Inmaculada B. Aban Phd, J Vincent, E Turgonyi, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

Relationship Between Plasma Glucose And Mortality In Non-Diabetic Patients With Acute Coronary Syndrome And Systolic Heart Failure: Insights From The Ephesus Trial, Prakash Deedwania Md, Ravi V. Desai Md, Marjan Mujib Md, Mph, Bertram Pitt, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

Differential Association Of Insulin Resistance And Metabolic Syndrome With Acute Myocardial Infarction And All-Cause Mortality In Older Adults, Ravi Desai, Mustafa Ahmed, Marjan Mujib, Larry Jacobs, Gregg Fonarow, Gilbert Perry, Wilbert Aronow, Michael Zile, Ali Ahmed

Ravi V Desai MD

No abstract provided.

The Association Of Metabolic Syndrome And Insulin Resistance With Incident Heart Failure Is Independent Of Each Other And Other Risk Factors Including C-Reactive Protein, Ravi V. Desai Md, Prakash Deedwania Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Yan Zhang Ms, Msph, Wilbert S. Aronow Md, Gregg C. Fonarow Md, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

Is The Association Of Left Ventricular Geometry With Cardiovascular Outcomes Independent Of Left Ventricular Mass?, Ravi V. Desai Md, Marjan Mujib Md, Mph, Mustafa I. Ahmed Md, Larry E. Jacobs Md, Gregg C. Fonarow, Wilbert S. Aronow, Michael Zile Md, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Effect Of Left Ventricular Diastolic Dysfunction On Incident Heart Failure And Mortality Is Independent Of Left Ventricular Geometry, Mass And Systolic Function, Ravi V. Desai Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Larry E. Jacobs Md, Gregg Fonarow Md, Gilbert J. Perry, Wilbert S. Aronow Md, Michael Zile Md, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

Coronary Artery Bypass Graft Surgery: Improving Cost And Quality Outcomes, Terry Capuano

Terry A Capuano MBA, MSN, RN, FACHE, NE-BC

No abstract provided.

Right Ventricular Mass Index Predicts Pulmonary Vascual Resistance In Pulmonary Vascular Pulmonary Arterial Hypertension: Baseline Cardiac Mri Results Of The Compass-3 Trial, Himanshu Gupta, Ravi Desai, Steven Lloyd, Fernando Orres, Francisco Soto, Myung Park, Chad Mcqueen, Srinivas Murali, Raymond Benza

Ravi V Desai MD

No abstract provided.

Torsional Modulus: A Simple, Novel Index Of Ventricular Stiffness, Steven Lloyd, Ravi Desai, Thomas Denney, Himanshu Gupta, Mustafa Ahmed, Louis Dell'italia

Ravi V Desai MD

No abstract provided.

Cardiovascular Dynamics During Exercise Are Related To Blood Rheology, Michael Simmonds, Julien Tripette, Surendran Sabapathy, Sonya Marshall-Gradisnik, Philippe Connes

Sonya Marshall-Gradisnik

Background: The principal determinants of oxygen uptake (VO2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in VO2 and cardiac output (Qc), or steady-state arteriovenous oxygen difference (a-vO2D) during submaximal cycling.Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ± 1.3 yr; bodymass index: 22.7 ± 2.0 kg..m-2), before each subject cycled at 105% of the first ventilatory threshold. Red …

Outcomes Of Early Versus Late Nephrology Referral In Chronic Kidney Disease – A Systematic Review, Neil A. Smart Assoc. Prof.

Neil Smart

Background As late provision of specialist care, prior to starting dialysis therapy, is believed to be associated with increased morbidity and mortality, a systematic review was undertaken to evaluate clinical outcomes relating to early versus late referral of patients to nephrology services.

Methods: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched up until September 2008 for studies of early versus late nephrology referral in adult (>18 years) patients with chronic kidney disease. Early referral was defined by the time period, at which patients were referred to a nephrologist.

Findings: No randomized, controlled trials were found. …

Systematic Review Of The Effect Of Aerobic And Resistance Exercise Training On Systemic Brain Natriuretic Peptide (Bnp) And N-Terminal Bnp Expression In Heart Failure Patients, N. Smart, M. Steele

Neil Smart

Background: BNP and the N-terminal portion (NT-pro-BNP) have emerged as powerful tools in the diagnosis and prognosis of heart failure on acute presentation. The aim of this work was to systematically review the effect of exercise training on BNP and NT-pro-BNP levels in patients with left ventricular dysfunction. Methods: A systematic search was conducted of Medline (Ovid) (1950–July 2008), Embase.com (1974–current), Cochrane Central Register of Controlled Trials, CINAHL (1981–current) and Web of Science (2000–current) to identify randomized controlled trials of aerobic and/or resistance exercise training in heart failure patients that measured BNP and/or pro-BNP. Primary outcome measures were changes in …