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Articles 1 - 30 of 45
Full-Text Articles in Neurosciences
Elevation Of Cannabis Knowledge: Higher Learning, Savannah Marie Patterson, Anisha Boetel
Elevation Of Cannabis Knowledge: Higher Learning, Savannah Marie Patterson, Anisha Boetel
Articles, Abstracts, and Reports
No abstract provided.
Submitting Manuscripts But Not For Publication? Black Sheep Authors In Publishing., Karsten Wiechert, Jens R Chapman, Jeffrey C Wang
Submitting Manuscripts But Not For Publication? Black Sheep Authors In Publishing., Karsten Wiechert, Jens R Chapman, Jeffrey C Wang
Articles, Abstracts, and Reports
No abstract provided.
Self-Administered Behavioral Skills-Based At-Home Virtual Reality Therapy For Chronic Low Back Pain: Protocol For A Randomized Controlled Trial., Laura Garcia, Beth Darnall, Parthasarathy Krishnamurthy, Ian Mackey, Josh Sackman, Robert Louis, Todd Maddox, Brandon Birckhead
Self-Administered Behavioral Skills-Based At-Home Virtual Reality Therapy For Chronic Low Back Pain: Protocol For A Randomized Controlled Trial., Laura Garcia, Beth Darnall, Parthasarathy Krishnamurthy, Ian Mackey, Josh Sackman, Robert Louis, Todd Maddox, Brandon Birckhead
Articles, Abstracts, and Reports
BACKGROUND: Chronic pain is one of the most common and debilitating health conditions. Treatments for chronic low back pain typically focus on biomedical treatment approaches. While psychosocial treatments exist, multiple barriers prevent broad access. There is a significant unmet need for integrative, easily accessible, non-opioid solutions for chronic pain. Virtual reality (VR) is an immersive technology allowing innovation in the delivery of behavioral pain treatments. Behavioral skills-based VR is effective at facilitating pain management and reducing pain-related concerns. Continued research on these emerging approaches is needed.
OBJECTIVE: In this randomized controlled trial, we seek to test the efficacy of a …
Upper And Lower Limb Movement Kinematics In Aging, Zheng Wang, Callie Lane, Matthew Terza, Pravin Khemani, Su Lui, Walker S Mckinney, Matthew W Mosconi
Upper And Lower Limb Movement Kinematics In Aging, Zheng Wang, Callie Lane, Matthew Terza, Pravin Khemani, Su Lui, Walker S Mckinney, Matthew W Mosconi
Articles, Abstracts, and Reports
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder associated with a premutation cytosine-guanine-guanine (CGG) trinucleotide repeat expansion of the FMR1 gene. FXTAS is estimated to be the most common single-gene form of ataxia in the aging population. Gait ataxia and intention tremor are the primary behavioral symptoms of FXTAS, though clinical evaluation of these symptoms often is subjective, contributing to difficulties in reliably differentiating individuals with FXTAS and asymptomatic premutation carriers. This study aimed to clarify the extent to which quantitative measures of gait and upper limb kinematics may serve as biobehavioral markers of FXTAS degeneration. Nineteen premutation carriers …
New Beginnings., Jeffrey C Wang, Jens R Chapman, Karsten Wiechert
New Beginnings., Jeffrey C Wang, Jens R Chapman, Karsten Wiechert
Articles, Abstracts, and Reports
No abstract provided.
Conversion From Knee Arthrodesis Back To Arthroplasty: A Particular Challenge In Combination With Fungal Periprosthetic Joint Infection., Sven Frieler, Emre Yilmaz, Ryan Goodmanson, Yannik Hanusrichter, Thomas A Schildhauer, Hinnerk Baecker
Conversion From Knee Arthrodesis Back To Arthroplasty: A Particular Challenge In Combination With Fungal Periprosthetic Joint Infection., Sven Frieler, Emre Yilmaz, Ryan Goodmanson, Yannik Hanusrichter, Thomas A Schildhauer, Hinnerk Baecker
Articles, Abstracts, and Reports
A 58-year-old female treated at an outside facility with knee arthrodesis due to persistent periprosthetic joint infection fulfilled all prerequisites for a conversion back to arthroplasty, as part of a 2-stage revision. Owing to the detection of Candida parapsilosis, the treatment concept was converted to a three-stage procedure. A scheduled spacer exchange with additional amphotericin B-loaded polymethylmethacrylate was conducted as an intermediate revision before reimplantation. Conversion in the setting of fungal periprosthetic joint infection presents a challenge, and successful treatment hinges on the use of proper antifungal and antimicrobial protocols, advanced surgical techniques, and a multidisciplinary team approach. At …
Fall Prevention In A Neurosurgery Clinic, Beth Ann Bremer, Brenda Senger, Jonathan Dennis Carlson, Teresa Bigand, Deborah Smith
Fall Prevention In A Neurosurgery Clinic, Beth Ann Bremer, Brenda Senger, Jonathan Dennis Carlson, Teresa Bigand, Deborah Smith
Articles, Abstracts, and Reports
No abstract provided.
Feasibility Of Treating High Grade Gliomas In Children With Tumor-Treating Fields: A Case Series., John Crawford, Marlon G Saria, Girish Dhall, Ashley Margol, Santosh Kesari
Feasibility Of Treating High Grade Gliomas In Children With Tumor-Treating Fields: A Case Series., John Crawford, Marlon G Saria, Girish Dhall, Ashley Margol, Santosh Kesari
Articles, Abstracts, and Reports
Children diagnosed with high grade gliomas (HGG) have dismal prognoses and treatment options remain limited. Tumor treating fields (TTFields) in combination with temozolomide (TMZ) is approved for the treatment of newly diagnosed and recurrent glioblastoma (GBM) in adult patients. However, clinical experience with TTFields in the pediatric HGG population is lacking. This retrospective review of four clinical cases was undertaken to evaluate the feasibility of treating children diagnosed with HGG off-label with TTFields. Patients were evaluated for device compliance, safety, and outcome. Treatment with TTFields was delivered via four transducer arrays placed on the shaved scalp, which were connected to …
2021: Will It Be The Best Season For International Spine Meetings Ever?, Karsten Wiechert, Jens R Chapman, Jeffrey C Wang
2021: Will It Be The Best Season For International Spine Meetings Ever?, Karsten Wiechert, Jens R Chapman, Jeffrey C Wang
Articles, Abstracts, and Reports
No abstract provided.
Classifying Complications: Assessing Adult Spinal Deformity 2-Year Surgical Outcomes., Eric O Klineberg, Peter G Passias, Gregory W Poorman, Cyrus M Jalai, Abiola Atanda, Nancy Worley, Samantha Horn, Daniel M Sciubba, D Kojo Hamilton, Douglas C Burton, Munish Chandra Gupta, Justin S Smith, Alexandra Soroceanu, Robert A Hart, Brian Neuman, Christopher P Ames, Frank J Schwab, Virginie Lafage
Classifying Complications: Assessing Adult Spinal Deformity 2-Year Surgical Outcomes., Eric O Klineberg, Peter G Passias, Gregory W Poorman, Cyrus M Jalai, Abiola Atanda, Nancy Worley, Samantha Horn, Daniel M Sciubba, D Kojo Hamilton, Douglas C Burton, Munish Chandra Gupta, Justin S Smith, Alexandra Soroceanu, Robert A Hart, Brian Neuman, Christopher P Ames, Frank J Schwab, Virginie Lafage
Articles, Abstracts, and Reports
STUDY DESIGN: Retrospective review of prospective database.
OBJECTIVE: Complication rates for adult spinal deformity (ASD) surgery vary widely because there is no accepted system for categorization. Our objective was to identify the impact of complication occurrence, minor-major complication, and Clavien-Dindo complication classification (Cc) on clinical variables and patient-reported outcomes.
METHODS: Complications in surgical ASD patients with complete baseline and 2-year data were considered intraoperatively, perioperatively (<6 >weeks), and postoperatively (>6 weeks). Primary outcome measures were complication timing and severity according to 3 scales: complication presence (yes/no), minor-major, and Cc score. Secondary outcomes were surgical outcomes (estimated blood loss [EBL], …6>
Functional Outcome Of Traumatic Spinopelvic Instabilities Treated With Lumbopelvic Fixation., Emre Yilmaz, Martin F Hoffmann, Alexander Von Glinski, Christiane Kruppa, Uwe Hamsen, Cameron K Schmidt, Ahmet Oernek, Matthias Koenigshausen, Marcel Dudda, Thomas A Schildhauer
Functional Outcome Of Traumatic Spinopelvic Instabilities Treated With Lumbopelvic Fixation., Emre Yilmaz, Martin F Hoffmann, Alexander Von Glinski, Christiane Kruppa, Uwe Hamsen, Cameron K Schmidt, Ahmet Oernek, Matthias Koenigshausen, Marcel Dudda, Thomas A Schildhauer
Articles, Abstracts, and Reports
The aim of this study was to assess the functional outcome after lumbopelvic fixation (LPF) using the SMFA (short musculoskeletal functional assessment) score and discuss the results in the context of the existing literature. The last consecutive 50 patients who underwent a LPF from January 1st 2011 to December 31st 2014 were identified and administered the SMFA-questionnaire. Inclusion criteria were: (1) patient underwent LPF at our institution, (2) complete medical records, (3) minimum follow-up of 12 months. Out of the 50 recipients, 22 questionnaires were returned. Five questionnaires were incomplete and therefore seventeen were included for analysis. The mean age …
Gsj Gets A Fresh New Look, Jeffrey C Wang, Jens R Chapman, Karsten Wiechert
Gsj Gets A Fresh New Look, Jeffrey C Wang, Jens R Chapman, Karsten Wiechert
Articles, Abstracts, and Reports
No abstract provided.
Artificial Intelligence For Rapid Meta-Analysis: Case Study On Ocular Toxicity Of Hydroxychloroquine., Matthew Michelson, Tiffany Chow, Neil A Martin, Mike Ross, Amelia Tee Qiao Ying, Steven Minton
Artificial Intelligence For Rapid Meta-Analysis: Case Study On Ocular Toxicity Of Hydroxychloroquine., Matthew Michelson, Tiffany Chow, Neil A Martin, Mike Ross, Amelia Tee Qiao Ying, Steven Minton
Articles, Abstracts, and Reports
BACKGROUND: Rapid access to evidence is crucial in times of an evolving clinical crisis. To that end, we propose a novel approach to answer clinical queries, termed rapid meta-analysis (RMA). Unlike traditional meta-analysis, RMA balances a quick time to production with reasonable data quality assurances, leveraging artificial intelligence (AI) to strike this balance.
OBJECTIVE: We aimed to evaluate whether RMA can generate meaningful clinical insights, but crucially, in a much faster processing time than traditional meta-analysis, using a relevant, real-world example.
METHODS: The development of our RMA approach was motivated by a currently relevant clinical question: is ocular toxicity and …
Prospective Home-Use Study On Non-Invasive Neuromodulation Therapy For Essential Tremor., Stuart H Isaacson, Elizabeth Peckham, Winona Tse, Olga Waln, Christopher Way, Melita T Petrossian, Nabila Dahodwala, Michael J Soileau, Mark Lew, Cameron Dietiker, Nijee Luthra, Pinky Agarwal, Rohit Dhall, John Morgan, Nicole Calakos, Theresa A Zesiewicz, Ejaz A Shamim, Rajeev Kumar, Peter Lewitt, Holly A Shill, Adam Simmons, Fernando L Pagan, Pravin Khemani, Jessica Tate, Brian Maddux, Lan Luo, William Ondo, Mark Hallett, Apoorva Rajagopal, Paula Chidester, Kathryn H Rosenbluth, Scott L Delp, Rajesh Pahwa
Prospective Home-Use Study On Non-Invasive Neuromodulation Therapy For Essential Tremor., Stuart H Isaacson, Elizabeth Peckham, Winona Tse, Olga Waln, Christopher Way, Melita T Petrossian, Nabila Dahodwala, Michael J Soileau, Mark Lew, Cameron Dietiker, Nijee Luthra, Pinky Agarwal, Rohit Dhall, John Morgan, Nicole Calakos, Theresa A Zesiewicz, Ejaz A Shamim, Rajeev Kumar, Peter Lewitt, Holly A Shill, Adam Simmons, Fernando L Pagan, Pravin Khemani, Jessica Tate, Brian Maddux, Lan Luo, William Ondo, Mark Hallett, Apoorva Rajagopal, Paula Chidester, Kathryn H Rosenbluth, Scott L Delp, Rajesh Pahwa
Articles, Abstracts, and Reports
Highlights: This prospective study is one of the largest clinical trials in essential tremor to date. Study findings suggest that individualized non-invasive neuromodulation therapy used repeatedly at home over three months results in safe and effective hand tremor reduction and improves quality of life for many essential tremor patients.
Background: Two previous randomized, controlled, single-session trials demonstrated efficacy of non-invasive neuromodulation therapy targeting the median and radial nerves for reducing hand tremor. This current study evaluated efficacy and safety of the therapy over three months of repeated home use.
Methods: This was a prospective, open-label, post-clearance, single-arm study with 263 …
Editorial Perspective: Time For Another Grading System-From Prisma To Amstar 2., Jens R Chapman
Editorial Perspective: Time For Another Grading System-From Prisma To Amstar 2., Jens R Chapman
Articles, Abstracts, and Reports
No abstract provided.
Perioperative Anticoagulation Management In Spine Surgery: Initial Findings From The Ao Spine Anticoagulation Global Survey., Philip Louie, Garrett Harada, James Harrop, Thomas Mroz, Khalid Al-Saleh, Giovanni Barbanti Brodano, Jens R Chapman, Michael Fehlings, Serena Hu, Yoshiharu Kawaguchi, Michael Mayer, Venugopal Menon, Jong-Beom Park, Sheeraz Qureshi, Shanmuganathan Rajasekaran, Marcelo Valacco, Luiz Vialle, Jeffrey C Wang, Karsten Wiechert, K Daniel Riew, Dino Samartzis
Perioperative Anticoagulation Management In Spine Surgery: Initial Findings From The Ao Spine Anticoagulation Global Survey., Philip Louie, Garrett Harada, James Harrop, Thomas Mroz, Khalid Al-Saleh, Giovanni Barbanti Brodano, Jens R Chapman, Michael Fehlings, Serena Hu, Yoshiharu Kawaguchi, Michael Mayer, Venugopal Menon, Jong-Beom Park, Sheeraz Qureshi, Shanmuganathan Rajasekaran, Marcelo Valacco, Luiz Vialle, Jeffrey C Wang, Karsten Wiechert, K Daniel Riew, Dino Samartzis
Articles, Abstracts, and Reports
STUDY DESIGN: Cross-sectional, international survey.
OBJECTIVES: This study addressed the global perspectives concerning perioperative use of pharmacologic thromboprophylaxis during spine surgery along with its risks and benefits.
METHODS: A questionnaire was designed and implemented by expert members in the AO Spine community. The survey was distributed to AO Spine's spine surgeon members (N = 3805). Data included surgeon demographic information, type and region of practice, anticoagulation principles, different patient scenarios, and comorbidities.
RESULTS: A total of 316 (8.3% response rate) spine surgeons completed the survey, representing 64 different countries. Completed surveys were primarily from Europe (31.7%), South/Latin America (19.9%), and …
Sphingosine-1-Phosphate: Its Pharmacological Regulation And The Treatment Of Multiple Sclerosis: A Review Article., Stanley Cohan, Elisabeth Lucassen, Kyle E Smoot, Justine Brink, Chiayi Chen
Sphingosine-1-Phosphate: Its Pharmacological Regulation And The Treatment Of Multiple Sclerosis: A Review Article., Stanley Cohan, Elisabeth Lucassen, Kyle E Smoot, Justine Brink, Chiayi Chen
Articles, Abstracts, and Reports
Sphingosine-1-phosphate (S1P), via its G-protein-coupled receptors, is a signaling molecule with important regulatory properties on numerous, widely varied cell types. Five S1P receptors (S1PR1-5) have been identified, each with effects determined by their unique G-protein-driven downstream pathways. The discovery that lymphocyte egress from peripheral lymphoid organs is promoted by S1P via S1PR-1 stimulation led to the development of pharmacological agents which are S1PR antagonists. These agents promote lymphocyte sequestration and reduce lymphocyte-driven inflammatory damage of the central nervous system (CNS) in animal models, encouraging their examination of efficacy in the treatment of multiple sclerosis (MS). Preclinical research has also demonstrated …
Integrated Assessment Of Circulating Cell-Free Microrna Signatures In Plasma Of Patients With Melanoma Brain Metastasis., Matias Bustos, Kevin Tran, Negin Rahimzadeh, Rebecca Gross, Selena Y Lin, Yoshiaki Shoji, Tomohiro Murakami, Christine L Boley, Linh T Tran, Hunter Cole, Daniel F Kelly, Steven J O'Day, Dave Hoon
Integrated Assessment Of Circulating Cell-Free Microrna Signatures In Plasma Of Patients With Melanoma Brain Metastasis., Matias Bustos, Kevin Tran, Negin Rahimzadeh, Rebecca Gross, Selena Y Lin, Yoshiaki Shoji, Tomohiro Murakami, Christine L Boley, Linh T Tran, Hunter Cole, Daniel F Kelly, Steven J O'Day, Dave Hoon
Articles, Abstracts, and Reports
Primary cutaneous melanoma frequently metastasizes to distant organs including the brain. Identification of cell-free microRNAs (cfmiRs) found in the blood can be used as potential body fluid biomarkers for detecting and monitoring patients with melanoma brain metastasis (MBM). In this pilot study, we initially aimed to identify cfmiRs in the blood of MBM patients. Normal donors plasma (healthy, n = 48) and pre-operative MBM patients' plasma samples (n = 36) were compared for differences in >2000 microRNAs (miRs) using a next generation sequencing (NGS) probe-based assay. A 74 cfmiR signature was identified in an initial cohort of MBM plasma …
The New Future Of Global Spine Journal, Jeffrey C Wang, Karsten Wiechert, Jens R Chapman
The New Future Of Global Spine Journal, Jeffrey C Wang, Karsten Wiechert, Jens R Chapman
Articles, Abstracts, and Reports
No abstract provided.
Ire1Α And Igf Signaling Predict Resistance To An Endoplasmic Reticulum Stress-Inducing Drug In Glioblastoma Cells., Jeffrey J Rodvold, Su Xian, Julia Nussbacher, Brian Tsui, T Cameron Waller, Stephen C Searles, Alyssa Lew, Pengfei Jiang, Ivan Babic, Natsuko Nomura, Jonathan H Lin, Santosh Kesari, Hannah Carter, Maurizio Zanetti
Ire1Α And Igf Signaling Predict Resistance To An Endoplasmic Reticulum Stress-Inducing Drug In Glioblastoma Cells., Jeffrey J Rodvold, Su Xian, Julia Nussbacher, Brian Tsui, T Cameron Waller, Stephen C Searles, Alyssa Lew, Pengfei Jiang, Ivan Babic, Natsuko Nomura, Jonathan H Lin, Santosh Kesari, Hannah Carter, Maurizio Zanetti
Articles, Abstracts, and Reports
To date current therapies of glioblastoma multiforme (GBM) are largely ineffective. The induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential new therapeutic strategy. Here we tested 12ADT, a sarcoendoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor, on a panel of unselected patient-derived neurosphere-forming cells and found that GBM cells can be distinguished into "responder" and "non-responder". By RNASeq analysis we found that the non-responder phenotype is significantly linked with the expression of UPR genes, and in particular ERN1 (IRE1) and ATF4. We also identified two additional genes selectively overexpressed among non-responders, IGFBP3 and IGFBP5. CRISPR-mediated deletion of …
Are "Replicants" The Spine Surgeons Of The Future?, Jens R Chapman, Jeffrey C Wang, Karsten Wiechert
Are "Replicants" The Spine Surgeons Of The Future?, Jens R Chapman, Jeffrey C Wang, Karsten Wiechert
Articles, Abstracts, and Reports
No abstract provided.
Changing The Game: Spine Care In The Era Of Artificial Intelligence And Deep Learning Algorithms., Karsten Wiechert, Jeffrey C Wang, Jens R Chapman
Changing The Game: Spine Care In The Era Of Artificial Intelligence And Deep Learning Algorithms., Karsten Wiechert, Jeffrey C Wang, Jens R Chapman
Articles, Abstracts, and Reports
No abstract provided.
Radiological Data Of Brachial Plexus Avulsion Injury Associated Spinal Cord Herniation (Bpai-Sch) And Comparison To Anterior Thoracic Spinal Cord Herniation (Atsch)., Andrew Jack, Jens R Chapman, Praveen V Mummaneni, Carter S Gerard, Line Jacques
Radiological Data Of Brachial Plexus Avulsion Injury Associated Spinal Cord Herniation (Bpai-Sch) And Comparison To Anterior Thoracic Spinal Cord Herniation (Atsch)., Andrew Jack, Jens R Chapman, Praveen V Mummaneni, Carter S Gerard, Line Jacques
Articles, Abstracts, and Reports
Spinal cord herniation (SCH) is a rare cause of myelopathy. When reported, SCH has most commonly been described as occurring spontaneously in the thoracic spine, and being idiopathic in nature (anterior thoracic spinal cord herniation, ATSCH) [1-3]. Several theories have been proposed to explain its occurrence, including congenital, inflammatory, and traumatic etiologies alike [1-4]. Even more rarely, SCH has been described to occur in the cervical spine in association with brachial plexus avulsion injuries (BPAI-SCH). In our accompanying article, "Late Cervical Spinal Cord Herniation Resulting from Post-Traumatic Brachial Plexus Avulsion Injury," two cases of BPAI-SCH are presented and discussed in …
Effect Of Dimethyl Fumarate On Lymphocyte Subsets In Patients With Relapsing Multiple Sclerosis., Guy Buckle, Daniel Bandari, Jeffrey Greenstein, Mark Gudesblatt, Bhupendra Khatri, Mariko Kita, P Repovic, Emily Riser, Bianca Weinstock-Guttman, Ben Thrower, Sherrill Loring, Katherine Riester, Nick Everage, Claudia Prada, Irene Koulinska, Monica Mann
Effect Of Dimethyl Fumarate On Lymphocyte Subsets In Patients With Relapsing Multiple Sclerosis., Guy Buckle, Daniel Bandari, Jeffrey Greenstein, Mark Gudesblatt, Bhupendra Khatri, Mariko Kita, P Repovic, Emily Riser, Bianca Weinstock-Guttman, Ben Thrower, Sherrill Loring, Katherine Riester, Nick Everage, Claudia Prada, Irene Koulinska, Monica Mann
Articles, Abstracts, and Reports
Background: In patients treated with dimethyl fumarate, absolute lymphocyte count decline typically occurs during the first year and then plateaus; early drops have been associated with the development of severe prolonged lymphopenia.
Objective: We investigated the effect of dimethyl fumarate on absolute lymphocyte counts and CD4+/CD8+ T cells in patients with relapsing-remitting multiple sclerosis treated with dimethyl fumarate in routine practice.
Methods: Lymphocyte data were collected via medical chart abstraction. Primary endpoint: change from baseline in absolute lymphocyte count and CD4+/CD8+ counts at 6-month intervals following dimethyl fumarate initiation.
Results: Charts of 483 patients were abstracted and 476 patients included …
Editorial Response To Letter To Editor And Response By Authors Regarding "Posterior Subaxial Cervical Spine Screw Fixation: A Review Of Techniques" By Joaquim Et Al., Jens R Chapman, Jeffrey C Wang, Karsten Wiechert
Editorial Response To Letter To Editor And Response By Authors Regarding "Posterior Subaxial Cervical Spine Screw Fixation: A Review Of Techniques" By Joaquim Et Al., Jens R Chapman, Jeffrey C Wang, Karsten Wiechert
Articles, Abstracts, and Reports
No abstract provided.
Transcriptomic Evidence That Von Economo Neurons Are Regionally Specialized Extratelencephalic-Projecting Excitatory Neurons., Rebecca D Hodge, Jeremy A Miller, Mark Novotny, Brian E Kalmbach, Jonathan T Ting, Trygve E Bakken, Brian D Aevermann, Eliza R Barkan, Madeline L Berkowitz-Cerasano, Charles Cobbs, Francisco Diez-Fuertes, Song-Lin Ding, Jamison Mccorrison, Nicholas J Schork, Soraya I Shehata, Kimberly A Smith, Susan M Sunkin, Danny N Tran, Pratap Venepally, Anna Marie Yanny, Frank J Steemers, John W Phillips, Amy Bernard, Christof Koch, Roger S Lasken, Richard H Scheuermann, Ed S Lein
Transcriptomic Evidence That Von Economo Neurons Are Regionally Specialized Extratelencephalic-Projecting Excitatory Neurons., Rebecca D Hodge, Jeremy A Miller, Mark Novotny, Brian E Kalmbach, Jonathan T Ting, Trygve E Bakken, Brian D Aevermann, Eliza R Barkan, Madeline L Berkowitz-Cerasano, Charles Cobbs, Francisco Diez-Fuertes, Song-Lin Ding, Jamison Mccorrison, Nicholas J Schork, Soraya I Shehata, Kimberly A Smith, Susan M Sunkin, Danny N Tran, Pratap Venepally, Anna Marie Yanny, Frank J Steemers, John W Phillips, Amy Bernard, Christof Koch, Roger S Lasken, Richard H Scheuermann, Ed S Lein
Articles, Abstracts, and Reports
von Economo neurons (VENs) are bipolar, spindle-shaped neurons restricted to layer 5 of human frontoinsula and anterior cingulate cortex that appear to be selectively vulnerable to neuropsychiatric and neurodegenerative diseases, although little is known about other VEN cellular phenotypes. Single nucleus RNA-sequencing of frontoinsula layer 5 identifies a transcriptomically-defined cell cluster that contained VENs, but also fork cells and a subset of pyramidal neurons. Cross-species alignment of this cell cluster with a well-annotated mouse classification shows strong homology to extratelencephalic (ET) excitatory neurons that project to subcerebral targets. This cluster also shows strong homology to a putative ET cluster in …
Comparison Of Outcomes Following Minimally Invasive And Open Posterior Cervical Foraminotomy: Description Of Minimally Invasive Technique And Review Of Literature., Andrew Platt, Carter S Gerard, John E O'Toole
Comparison Of Outcomes Following Minimally Invasive And Open Posterior Cervical Foraminotomy: Description Of Minimally Invasive Technique And Review Of Literature., Andrew Platt, Carter S Gerard, John E O'Toole
Articles, Abstracts, and Reports
Although minimally invasive posterior cervical foraminotomy (MIS-PCF) is frequently employed in the treatment of cervical radiculopathy, there are very few studies directly comparing outcomes between MIS-PCF and open posterior cervical foraminotomy and between MIS-PCF and percutaneous endoscopic (full-endoscopic) posterior cervical foraminotomy (FE-PCF). This study includes a description of technique and systematic review of literature and analysis of clinical studies comparing outcomes between MIS-PCF and open posterior cervical foraminotomy and between MIS-PCF and FE-PCF. Six comparative studies, including one randomized controlled trial were included in analysis. Average operative time ranged from 60.5 to 171 minutes in the open group and 77.65 …
Editorial., Jeffrey C Wang, Jens R Chapman, Karsten Wiechert
Editorial., Jeffrey C Wang, Jens R Chapman, Karsten Wiechert
Articles, Abstracts, and Reports
No abstract provided.
Non-Invasive Mri Quantification Of Cerebrospinal Fluid Dynamics In Amyotrophic Lateral Sclerosis Patients., Lucas R Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle Mccain, Tavara Freeman, Gregory T Carter, Douglas L Weeks, Brian Petersen, Jason Aldred, Dena Wingett, Bryn A Martin
Non-Invasive Mri Quantification Of Cerebrospinal Fluid Dynamics In Amyotrophic Lateral Sclerosis Patients., Lucas R Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle Mccain, Tavara Freeman, Gregory T Carter, Douglas L Weeks, Brian Petersen, Jason Aldred, Dena Wingett, Bryn A Martin
Articles, Abstracts, and Reports
BACKGROUND: Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due to close proximity of cerebrospinal fluid (CSF) to affected tissues. Development of effective intrathecal pharmaceuticals will rely on accurate models of how drugs are dispersed in the CSF. Therefore, a method to quantify these dynamics and a characterization of differences across disease states is needed.
METHODS: Complete intrathecal 3D CSF geometry and CSF flow velocities at six axial locations in the spinal canal were collected by T2-weighted and phase-contrast MRI, respectively. Scans were …
Resting-State Static And Dynamic Functional Abnormalities In Active Professional Fighters With Repetitive Head Trauma And With Neuropsychological Impairments., Xiaowei Zhuang, Virendra Mishra, Rajesh Nandy, Zhengshi Yang, Karthik Sreenivasan, Lauren Bennett, Charles Bernick, Dietmar Cordes
Resting-State Static And Dynamic Functional Abnormalities In Active Professional Fighters With Repetitive Head Trauma And With Neuropsychological Impairments., Xiaowei Zhuang, Virendra Mishra, Rajesh Nandy, Zhengshi Yang, Karthik Sreenivasan, Lauren Bennett, Charles Bernick, Dietmar Cordes
Articles, Abstracts, and Reports
Previous neuroimaging studies have identified structural brain abnormalities in active professional fighters with repetitive head trauma and correlated these changes with fighters' neuropsychological impairments. However, functional brain changes in these fighters derived using neuroimaging techniques remain unclear. In this study, both static and dynamic functional connectivity alterations were investigated (1) between healthy normal control subjects (NC) and fighters and (2) between non-impaired and impaired fighters. Resting-state fMRI data were collected on 35 NC and 133 active professional fighters, including 68 impaired fighters and 65 non-impaired fighters, from the Professional Fighters Brain Health Study at our center. Impaired fighters performed worse …