Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Oral cancer (3)
- Adaptive fuzzy (1)
- Adaptive modeling (1)
- Adaptive techniques (1)
- Aphthous ulcers (1)
-
- Areca quid (1)
- Betel chewers mucosa (1)
- Betel quid (1)
- Betel quid related lesions (1)
- Biobanking (1)
- Buccal mucosa (1)
- Computational sciences (1)
- Data sets (1)
- Databank (1)
- Early detection (1)
- Explanatory power (1)
- Fuzzy concepts (1)
- International conferences (1)
- Lichen planus (1)
- Lichenoid lesions (1)
- Logistic regression (1)
- Logistic regression modeling (1)
- Microarray (1)
- Model based (1)
- OSCC (1)
- Oral cancer awareness (1)
- Oral cancer screening (1)
- Oral mucosal lesions (1)
- Oral squamous cell carcinoma (1)
- Oral tumours (1)
Articles 1 - 4 of 4
Full-Text Articles in Dentistry
Determination Of The Global Gene Expression Profile Of Oral Cancers Using Paraffin-Embedded Tissues, Saleh A., Rosnah Binti Zain, Hussaini H., Abraham M. T., Hamid S., Teo S. H., Cheong S. C.
Determination Of The Global Gene Expression Profile Of Oral Cancers Using Paraffin-Embedded Tissues, Saleh A., Rosnah Binti Zain, Hussaini H., Abraham M. T., Hamid S., Teo S. H., Cheong S. C.
Prof. Dr. Rosnah Binti Zain
Introduction: Oral cancer is a common disease in Asia. However, our ability to deliver effective and targeted therapy remains limited by our lack of understanding of the molecular pathogenesis of oral carcinogenesis. One method to understand the nature of genes and gene products whose aberrant expression promote malignant transformation is by using microarrays. However, such studies have been limited by the availability of specimens with intact RNA and adequate clinical data to enable the identification and validation biomarkers either as predictive or therapeutic tools. Objective: We have determined the global gene expression profiles of oral squamous cell carcinoma (OSCC) of …
Establishment And Characterization Of Asian Oral Cancer Cell Lines As In Vitro Models To Study A Disease Prevalent In Asia, Hamid S., Lim K. P., Rosnah Binti Zain, Ismail S. M., Lau S. H., Mustafa W. M. W., Abraham M. T., Nam N. A., Teo S. H., Cheong S. C.
Establishment And Characterization Of Asian Oral Cancer Cell Lines As In Vitro Models To Study A Disease Prevalent In Asia, Hamid S., Lim K. P., Rosnah Binti Zain, Ismail S. M., Lau S. H., Mustafa W. M. W., Abraham M. T., Nam N. A., Teo S. H., Cheong S. C.
Prof. Dr. Rosnah Binti Zain
We have established 3 cell lines ORL-48, -115 and -136 from surgically resected specimens obtained from untreated primary human oral squamous cell carcinomas of the oral cavity. The in vitro growth characteristics, epithelial origin, in vitro anchorage independency, human papillomavirus (HPV) infection, microsatellite instability status, karyotype and the status of various cell cycle regulators and gatekeepers of these cell lines were investigated. All 3 cell lines grew as monolayers with doubling times ranging between 26.4 and 40.8 h and were immortal. Karyotyping confirmed that these cell lines were of human origin with multiple random losses and gains of entire chromosomes …
Oral Lichen Planus And Lichenoid Reactions: Etiopathogenesis, Diagnosis, Management And Malignant Transformation, Ismail S. B., Kumar S. K., Rosnah Binti Zain
Oral Lichen Planus And Lichenoid Reactions: Etiopathogenesis, Diagnosis, Management And Malignant Transformation, Ismail S. B., Kumar S. K., Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Lichen planus, a chronic autoimmune, mucocutaneous disease affects the oral mucosa (oral lichen planus or OLP) besides the skin, genital mucosa, scalp and nails. An immune mediated pathogenesis is recognized in lichen planus although the exact etiology is unknown. The disease most commonly affects middle-aged females. Oral lichenoid reactions (OLR) which are considered variants of OLP, may be regarded as a disease by itself or as an exacerbation of an existing OLP, by the presence of medication (lichenoid drug reactions) or dental materials (contact hypersensitivity). OLP usually presents as white striations (Wickham's striae), white papules, white plaque, erythema, erosions or …
An Adaptive Fuzzy Regression Model For The Prediction Of Dichotomous Response Variables, Dom R. M., Kareem S. A., Rosnah Binti Zain, Abldin B.
An Adaptive Fuzzy Regression Model For The Prediction Of Dichotomous Response Variables, Dom R. M., Kareem S. A., Rosnah Binti Zain, Abldin B.
Prof. Dr. Rosnah Binti Zain
This paper proposes an adaptive technique in the prediction of dichotomous response variable by combining fuzzy concept with statistical logistic regression. The model was tested on an oral cancer dataset in predicting oral cancer susceptibility. In this paper we will present the development, evaluation and validation of the proposed model based on the experiment carried out. Explanatory power of the adaptive model was calculated and compared with fuzzy neural network and statistical logistic regression models using calibration and discrimination techniques. Area under ROC values calculated indicates that the proposed model has compatible predictive ability to both fuzzy neural network and …