Medicine and Health Sciences Commons^™

Macam Cara Mengobati Herpes Secara Alami Tradisional Dan Ampuh, Produkherpesgenital De Nature

produkherpesgenital de nature

Kapsul Obat Polip Hidung Alami Tanpa Operasi Sembuh Dengan Cepat, Herbalpoliphidung Denature

herbalpoliphidung denature

Ragam Cara Mudah Mengobati Sifilis Dalam 3 Hari, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Ragam Cara Pengobatan Penyakit Kencing Nanah Dengan Ramuan Alami, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Bentuk Cara Mudah Mengobati Kencing Nanah Dengan Cepat, Penyembuhpenyakit Denature

penyembuhpenyakit denature

The Influence Of Traffic, Area Location, And Other Factors On Operating Room Microbial Load, Dotan I. Shvorin

Dr. Dotan Shvorin

Colorectal Cancer-Associated Genes Are Associated With Tooth Agenesis And May Have A Role In Tooth Development, Meredith A. Williams, Cláudia Cristina Biguetti, Miguel Romero-Bustillos, Kanwal Maheshwari, Nuriye Dinckan, Franco Cavalla, Xiaoming Liu, Renato Silva, Sercan Akyalcin, Z. Oya Uyguner

School of Podiatric Medicine Publications and Presentations

Previously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. Here, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a discovery dataset composed of 440 individuals with and without isolated TA. Genome-wide significant associations were found between TA and ATF1 rs11169552 (P = 4.36 × 10−10) and DUSP10 rs6687758 (P = 1.25 × 10−9), and positive association found with CASC8 rs10505477 (P = 8.2 × 10−5). …

Peripheral Blood Epi-Signature Of Claes-Jensen Syndrome Enables Sensitive And Specific Identification Of Patients And Healthy Carriers With Pathogenic Mutations In Kdm5c, Laila C Schenkel, Erfan Aref-Eshghi, Cindy Skinner, Peter Ainsworth, Hanxin Lin, Guillaume Paré, David I Rodenhiser, Charles Schwartz, Bekim Sadikovic

Paediatrics Publications

Background

Claes-Jensen syndrome is an X-linked inherited intellectual disability caused by mutations in the

Results

Genome-wide DNA methylation analysis of 7 male patients affected with Claes-Jensen syndrome and 56 age- and sex-matched controls identified a specific DNA methylation defect (epi-signature) in the peripheral blood of these patients, including 1769 individual CpGs and 9 genomic regions. Six healthy female carriers showed less pronounced but distinctive changes in the same regions enabling their differentiation from both patients and controls. Highly specific computational model using the most significant methylation changes demonstrated 100% accuracy in differentiating patients, carriers, and controls in the training cohort, …

Justifiability And Animal Research In Health: Can Democratisation Help Resolve Difficulties?, Shaun Yon-Seng Khoo

Morality and Ethics of Animal Experimentation Collection

Current animal research ethics frameworks emphasise consequentialist ethics through cost-benefit or harm-benefit analysis. However, these ethical frameworks along with institutional animal ethics approval processes cannot satisfactorily decide when a given potential benefit is outweighed by costs to animals. The consequentialist calculus should, theoretically, provide for situations where research into a disease or disorder is no longer ethical, but this is difficult to determine objectively. Public support for animal research is also falling as demand for healthcare is rising. Democratisation of animal research could help resolve these tensions through facilitating ethical health consumerism or giving the public greater input into deciding …

Muscle Nicotinic Acetylcholine Receptors May Mediate Trans-Synaptic Signaling At The Mouse Neuromuscular Junction, Xueyong Wang, J. Michael Mcintosh, Mark M. Rich

Neuroscience, Cell Biology & Physiology Faculty Publications

Block of neurotransmitter receptors at the neuromuscular junction (NMJ) has been shown to trigger upregulation of the number of synaptic vesicles released (quantal content, QC), a response termed homeostatic synaptic plasticity. The mechanism underlying this plasticity is not known. Here, we used selective toxins to demonstrate that block of α1-containing nicotinic acetylcholine receptors (nAChRs) at the NMJ of male and female mice triggers the upregulation of QC. Reduction of current flow through nAChRs, induced by drugs with antagonist activity, demonstrated that reduction in synaptic current per se does not trigger upregulation of QC. These data led to the remarkable conclusion …

Gillan, Robert Lee, 1916-2009 (Sc 3183), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid and scan (Click on "Additional Files" below) for Manuscripts Small Collection 3183. Letter, 7 August 2006, of Robert Lee Gillan, Thorntown, Indiana, to Martha Harrison. He refers to his interest in genealogy and relates anecdotes about “Aunt Nancy,” an African American woman and caregiver to local families in Barren County, Kentucky. He includes particulars of some of her household advice, folk medicinal treatments and beliefs. He notes that she is buried in Lyons (Lyon) Cemetery.

Repeat-Associated Non-Aug (Ran) Translation And Other Molecular Mechanisms In Fragile X Tremor Ataxia Syndrome, M. Rebecca Glineburg, Peter K. Todd, Nicolas Charlet-Berguerand, Chantal Sellier

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset inherited neurodegenerative disorder characterized by progressive intention tremor, gait ataxia and dementia associated with mild brain atrophy. The cause of FXTAS is a premutation expansion, of 55 to 200 CGG repeats localized within the 5′UTR of FMR1. These repeats are transcribed in the sense and antisense directions into mutants RNAs, which have increased expression in FXTAS. Furthermore, CGG sense and CCG antisense expanded repeats are translated into novel proteins despite their localization in putatively non-coding regions of the transcript. Here we focus on two proposed disease mechanisms for FXTAS: 1) RNA …

Promising Biomarkers Of Environmental Enteric Dysfunction: A Prospective Cohort Study In Pakistani Children., Najeeha Talat Iqbal, Kamran Sadiq, Sana Syed, Tauseefullah Akhund, Fayyaz Umrani, Sheraz Ahmed, Mohammad Yawar Yakoob, Najeeb Rehman, Shahida Qureshi, Syed Asad Ali

Department of Paediatrics and Child Health

Environmental Enteric Dysfunction (EED), a syndrome characterized by chronic gut inflammation, contributes towards stunting and poor response to enteric vaccines in children in developing countries. In this study, we evaluated major putative biomarkers of EED using growth faltering as its clinical proxy. Newborns (n = 380) were enrolled and followed till 18 months with monthly anthropometry. Biomarkersassociated with gut and systemic inflammation were assessed at 6 and 9 months. Linear mixed effects model was used to determine the associations of these biomarkers with growth faltering between birth and 18 months. Fecal myeloperoxidase (neutrophil activation marker) at 6 months [β = …

Cara Megatasi Kelamin Keluar Nanah Seperti Sperma Terasa Panas Dan Perih, Penawarpenyakit Denature

penawarpenyakit denature

Cara Mengatasi Kelamin Luka Seperti Sariawan Paling Ampuh Dan Manjur, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Cara Mengatasi Kelamin Luka Seperti Sariawan Paling Ampuh Dan Manjur, Penawarpenyakit Denature

penawarpenyakit denature

Solusi Keluar Cairan Dari Kelamin Seperti Sperma Terasa Sakit, Penawarpenyakit Denature

penawarpenyakit denature

Solusi Keluar Cairan Dari Kelamin Seperti Sperma Terasa Sakit, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Tablet Obat Tradisional Kencing Sakit Keluar Lendir Putih, Penawarpenyakit Denature

penawarpenyakit denature

Merk Obat Tradisional Buat Kencing Sakit Keluar Cairan Bening, Penawarpenyakit Denature

penawarpenyakit denature

Tablet Obat Tradisional Kencing Sakit Keluar Lendir Putih, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Cara Mengatasi Kelamin Keluar Nanah Seperti Sperma Terasa Panas Dan Perih, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Kapsul Obat Saluran Kencing Keluar Nanah De Nature, Penawarpenyakit Denature

penawarpenyakit denature

Jenis Obat Saat Kencing Keluar Nanah Resep Dokter, Penawarpenyakit Denature

penawarpenyakit denature

Jenis Obat Tradisional Buat Penyakit Kencing Nanah Manjur, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Kapsul Obat Tradisional Infeksi Saluran Kemih Anjuran Dokter, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Macam Obat Tradisional Menghilangkan Infeksi Saluran Kencing, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Pil Obat Penyakit Nanah Keluar Dari Kelamin Pria, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Kapsul Obat Saluran Kencing Keluar Nanah De Nature, Penyembuhpenyakit Denature

penyembuhpenyakit denature

Label Obat Tradisional Mengatasi Kencing Sakit Keluar Nanah, Penyembuhpenyakit Denature

penyembuhpenyakit denature