Medicine and Health Sciences Commons^™

Functional Cognitive Activities For Adults With Traumatic Brain Injury: Pilot Case Studies, Ajay Pala, Karen Huang, Ashley Cook

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of these pilot case studies were to investigate the effectiveness of the Functional Cognitive Activities for Adults with Brain Injury: A Sequential Approach (FCA) in generalizing functional cognitive skills across meaningful occupations for adults with traumatic brain injury (TBI). This study was a pretest-posttest design consisted of two participants with TBI.

Both participants attended 14 out of the 16 intervention sessions, twice-a-week for eight-weeks. Pretest-posttest measurements, including the Canadian Occupational Performance Measure (COPM), Kohlman Evaluation of Living Skills, and Goal Attainment Scale (GAS), were used to measure changes in occupational performance. Additionally, a four-month follow-up phone interview using …

Survey Of Sensory Diet Use Among California Occupational Therapy Practitioners, Morganne Peterson, Allison Hunt, Emily White

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to examine the use of sensory diets in the field of occupational therapy. This study investigated the use of sensory diets among California occupational therapy practitioners. A mixed-methods design was used to collect data through an online survey. The survey was sent out to members of the Occupational Therapy Association of California (OTAC) and received 98 respondents within one month. Participants worked among various clinical settings and implemented sensory diets with various client populations. Practitioners reported using terms such as “sensory strategies,” “sensory tools,” and “sensory supports” which indicates an overall misunderstanding associated with …

Age-Related Changes In Visual Processing Speed: A Pilot Study Using The Motor Free Visual Perception Test- 4, Amber Zadravecz, Kassidy Ha, Lauren Gollnick, Stephanie Pawek, Zoe Studer

Dissertations, Masters Theses, Capstones, and Culminating Projects

Older adults are at a significantly increased risk of being involved in motor vehicle accidents. Evidence reveals that visual processing speed decreases with age, which may impact driving. The Motor-Free Visual Perception Test- Third Edition (MVPT-3) is used as a pre-driving assessment and has an age-normed Response Time Index that measures visual processing speed. In 2015, a new version, the new Motor-Free Visual Perception Test- Fourth Edition (MVPT-4), was published. The new MVPT-4 does not yet demonstrate its utility in measuring visual processing speed. The purpose of this study was to explore if differences in visual processing speed between younger …

Managing Fatigue With Technology For Individuals With Multiple Sclerosis, Janie Grant, May Anne Gamueda, America Ortega, Jordan Song

Dissertations, Masters Theses, Capstones, and Culminating Projects

OBJECTIVE: The purpose of this study was to investigate whether the use of a mobile health application (mHealth app) in conjunction with energy conservation management techniques will result in a decrease in fatigue for adults with multiple sclerosis.

METHOD: Using a quantitative, exploratory, pre-posttest design, we examined outcomes associated with the use of the mHealth app, Pace My Day, by seven participants during one chosen task over two weeks. The app reinforced the use of energy conservation management techniques during the chosen task. Outcome measures included Modified Fatigue Impact Scale (MFIS) and Canadian Occupational Performance Measure (COPM).

RESULTS: There was …

Resilience And Protective Factors In Older Adults, Jessica Mcclain, Katelyn Gullatt, Caroline Lee

Dissertations, Masters Theses, Capstones, and Culminating Projects

Evidence suggests resilience promotes successful aging in place and protective factors promote resilience. This study sought to investigate whether or not the combination of three protective factors, physical health, social support, and self-efficacy are all of equal importance in predicting resilience among Marin County older adults, or if some individual protective factors have a greater impact on resilience than the others. Fifty-eight participants ages 62 and higher were recruited from senior community programs and personal contacts. Four self-report questionnaires were completed by the participants in this exploratory, cross-sectional, quantitative design. SPSS was used for a descriptive and multivariate analyses to …

Measuring Physiological Responses To Sensation In Typical Adults, Sarah Button, Kristen Christensen, Emily Minor

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective: Sensory processing issues can have a large negative impact on the ability to participate in daily occupations such as ADLs, access to work, school and leisure environments, and social interactions (Dunn, 2001). The evidence documenting sensory processing issues in adults is sparse. Physiological information can be used as objective evidence to support the claim that those with over-responsivity to sensations are experiencing their environment differently than the typical population. Understanding more about sensory processing in adults may lead to increased recognition of the problem and more opportunities for intervention to increase occupational participation. The purpose of this quantitative study …

Different Methodologies To Characterize And Diagnose Sickle Cell Disease In Both Developed And Developing Nations, Mohammed Alharbi

Dissertations, Masters Theses, Capstones, and Culminating Projects

Sickle cell disease (SCD) is a genetic blood disorder that causes the RBC to become sickle shaped due to a mutation in the β-globin gene encoding the protein hemoglobin. This disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection susceptibility. SCD affects around 100,000 individuals in USA alone and 14 million people globally. SCD affected individuals have high mortality rates. Early detection and constant monitoring of this disease is essential. The following review focuses on various methodologies that have emerged in the diagnosis of SCD. Also, low cost methods that can be easily …

Implementation Plan To Integrate The Nanosphere Verigene Assay In A High-Volume Reference Laboratory And The Anticipated Workflow Benefits To Adopting Rapid Blood Culture Testing, Sofia Nazar

Dissertations, Masters Theses, Capstones, and Culminating Projects

Laboratory processing pathways have a significant impact on the overall management of patients with sepsis. Retrieval and isolation of the suspected pathogen from a patient blood culture specimen is required for a definitive diagnosis of bacterial septicemia. Reference laboratories are high-volume facilities most often located some distance away from the collecting facility. Given the lengthy work up already required for blood culture pathogen analysis, reference laboratories must identify ways to optimize every step of the blood culture pathway in the effort to decrease turnaround time and mitigate lag time to final pathogen identification incurred by prolonged collection-to-incubation times. Rapid molecular …

Determination Of The Feasibility Of Using Cell-Free Dna (Cfdna) In The Q-Clamp Kras Codon Specific Mutation Test, Manuel Garcia

Dissertations, Masters Theses, Capstones, and Culminating Projects

KRAS is a proto-oncogene which was first identified in Kirsten rat sarcoma virus. The normal KRAS protein performs an essential function in normal tissue signaling and a mutation of a KRAS gene is an essential step in the development of many cancers. Q-Clamp® KRAS codon specific mutation test is an in vitro real-time qualitative PCR assay for the detection of mutations in the targeted regions and KRAS mutation often serves as a useful marker in drug response. The Q-Clamp® KRAS codon specific mutation test experiment was performed using cell-free extracted DNA (cfDNA) instead of FFPE extracted DNA. The results of …

Combinational Therapy To Mitigate Α-Dicarbonyl Toxicity, Jessica Ramirez

Dissertations, Masters Theses, Capstones, and Culminating Projects

Diabetes mellitus is a metabolic disease characterized by hyperglycemia that affects 30 million children and adults in the United States alone. Patients suffering from diabetes have high concentrations of reactive α-dicarbonyls (α-DCs) like, methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, nephropathy and cardiomyopathy. A recently discovered TRPA-1-Nrf-2 pathway is a conserved mechanism in vertebrates and invertebrates that detoxifies α-DCs; however, regulators that activate the detoxification mechanism are currently unknown. Several supplement grade compounds were screened for TRPA-1-Nrf2 induced …

Poct Testing And Importance Of Operator Lock-Out, Nuha Fadlalla

Dissertations, Masters Theses, Capstones, and Culminating Projects

Point-of-Care Testing (POCT) is usually performed at the patient’s bedside by healthcare providers other than laboratory- trained professionals. Rapid growth of POCT is supported by numerous factors which include healthcare provider efficiency, improving diagnostic insight and better patient outcomes. This project study is done to make sure POCT users have adequate training to ensure and enhance the quality and patient safety. The individual performing these tests to be trained properly before he/she is approved to operate the POC devices. One method to ensure POCT operators have met the required training is the lock out approach which will not allow them …

A Change Of Heart: Internal Narratives, Forgiveness & Health, Keiko Ehret

Dissertations, Masters Theses, Capstones, and Culminating Projects

In this thesis I investigate the interconnectedness of forgiveness as a narrative, as a philosophical, religious and cultural phenomenon, and the ways in which forgiveness is increasingly being used as a vehicle for improving health and psychological well-being. By threading together how scholars in a variety of fields have approached these areas of study, we can better understand the way the interdisciplinary nature of forgiveness grants access to heal not merely relationships with others, but also our bodies, our minds, and our relationship with ourselves.

Important to my investigation is understanding that the life circumstances that prompt forgiveness consist of …

Older Adults’ Perspective: Exploring The Experience Of Owning A Guide Dog, Jeffrey Kou, Yvonne Lam, Patricia Lyons, Susan Nguyen

Dissertations, Masters Theses, Capstones, and Culminating Projects

Guide dogs have been shown to be an effective assistive device that can help older adults with low vision navigate their community and improve overall well-being. Despite vast research conducted on pet therapy and dog companionship, limited research exists on the facilitators and barriers of owning a dog guide among older adults with low vision. The purpose of this qualitative phenomenological study is to explore the facilitators and barriers of owning a guide dog as experienced by older adults with low vision participating in Guide Dogs for the Blind (GDB) organization. Data were gathered among seven participants using semi-structured phone …

Measuring The Outcomes Of Therapeutic Listening In Children With Learning And Developmental Disabilities, Hannah Tashjian, Donielle Hair, Phoebe Taasan

Dissertations, Masters Theses, Capstones, and Culminating Projects

Anecdotal reports of the Therapeutic Listening ®-Quickshifts (TL-Q) technique report positive effects on child behavior but the individualized approach requires further supporting evidence. TL-Q is an individualized sound-based program used to facilitate sensory processing skills and is believed to improve interpersonal, social, and cognitive skills (Frick & Hacker, 2001). This study examines the use of a standardized protocol to measure the specific outcomes of the TL-Q program using a practice-based evidence (PBE) approach for the purpose of aggregating data for clinical practice. The protocol was used to measure the outcomes of the TL-Q program in a convenience sample of 23 …

Living With Fragile X Syndrome: Occupations As An Outcome Measure In A Clinical Trial, Theresa Chase, Ty Duong, Ana Baldinger, Kaylee Gothelf

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of …

Evaluating The Effectiveness Of A Formal Dementia Care Training Program: Abilities Care Experts™, Carmen Joaquin, Michelle D'Amato, April Perez, Louiza Alexandria Villarina, Sophie E. Miller

Dissertations, Masters Theses, Capstones, and Culminating Projects

Overview: Abilities Care Experts™ (ACE™) is an educational training program for nursing staff who care for individuals with dementia in skilled nursing facilities (SNF). The objective of the program is to provide the nursing staff with knowledge, and methods to engage residents’ remaining abilities in order to maximize occupational participation using a stage-specific dementia care approach. ACE™ training has yet to be evaluated for effectiveness in a controlled study design.

Objectives: This study sought to evaluate the effectiveness of the ACE™ training.

Design: The study employed a quantitative, cross-sectional, quasi-experimental design.

Participants: A total of 29 CNAs, 13 ACE™ trained …

Optimization Of Braf V600 Assay As A 2-Step Real-Time Pcr Protocol, Mimi Phuong

Dissertations, Masters Theses, Capstones, and Culminating Projects

The QClamp® BRAF Codon Specific Mutation Detection Kit is a real-time PCR assay for the detection of somatic mutations in codon 600 Valine at exon 15 in the BRAF gene which encodes the serine/threonine protein kinase, using purified DNA. The V600E mutation is the most common BRAF gene mutation found in human cancers. This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell growth and division. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even …

Identification Of Substrate-Selective Histone Deacetylases And Their Inhibitors That Mediate Her2 Transcript Stability, Mariah Alejo

Dissertations, Masters Theses, Capstones, and Culminating Projects

Breast cancer is the most common malignancy diagnosed in women. 15-20% of these cancers overexpress the HER2 (ERRB2) oncoprotein. HER2-positive breast cancers are generally aggressive and are associated with poor prognosis. Unfortunately, only a mere 30% of HER2-positve patients respond to therapies when they are used as a single agent. Combining therapeutics can potentially lead to synergy and improved anticancer efficacy, and there is clearly a need for the development of new HER2-directed therapeutics. Newer approaches include the utilization of histone deacetylase (HDAC) inhibitors. It has been observed that HDAC inhibitors can induce the rapid decay of oncogenic transcripts such …

Nursing News & Views - May 2018, Christine Klucznik Rn

Nursing Newsletters

No abstract provided.

Mdma-Assisted Psychotherapy For Posttraumatic Stress Disorder: A Review Of The Literature, Erin Solomon

Student Works

A growing number of people suffer chronic, treatment-resistant posttraumatic stress disorder (PTSD; Amoroso & Workman, 2016; Buoso, Doblin, Farré, Alcázar, & Gómez-Jarabo, 2008; Mithoefer, Wagner, Mithoefer, Jerome, & Doblin, 2011; Oehen, Traber, Widmer, & Schnyder, 2013). The most popular treatments, including exposure therapy, may not be effective for some people (Amoroso & Workman, 2016; Mithoefer et al., 2011). Treatment dropout and suicidality are high among people for whom therapy is minimally effective (Amoroso, 2015; Amoroso & Workman, 2016; Mithoefer et al., 2011; Oehen et al., 2013). Researchers have begun to investigate 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy as a possible treatment for PTSD …

A Leap To Hybrid Governance For European Union Healthcare On Organ Donations, Tasnim Ahmed

Journal of Law and Health

This article evaluates two proposals that the Organs Directive along with the commission’s Action Plan 2009-2015 can be viewed as a form of hybrid governance. The Organs Directive is the first legally-binding supranational risk regulation devised in the field of organ donation and transplantation. The Directive is modelled on the earlier Directive dealing with blood, tissue, and cells. The Action Plan, which is soft law, will complement the Directive. The Directive and Action Plan requires additional administration procedures from the Member States with the EU Commission regularly monitoring the implementation of the work programme to ensure it is manageable for …

Identification Of Barriers To Sbarb At The Bedside In An Acute Care Setting, Elizabeth Bryand

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Nurse to nurse handoff that occurs at the end of each shift is a known area of potential safety risk due to poor communication and inadequate safety checks. The Joint Commission (TJC) reported that communication between healthcare providers or between patient and healthcare providers was the leading root cause of sentinel events. Research supports the benefits of a structure handoff at the bedside to patient safety and satisfaction. Despite these proven benefits, staff nurses have not consistently embraced the practice. The purpose of this study was to identify nurses’ perceived barriers to performing SBARP (Situation, Background, Assessment, Recommendation and Patient) …

An Integrative Review Of Fluid Management In Cardiac Surgery, Beena George

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Adequate fluid administration during and after cardiac surgery is essential to ensure adequate oxygen delivery to the tissues, while simultaneously avoiding the dangers of hypervolemia and fluid overload. In both cardiac and non-cardiac surgery there has been debate on what the best approach to fluid management is, what hemodynamic parameters should be used to assess fluid requirements, and what type of fluids should be used. There are several studies in non-cardiac surgery that examine these issues, while they are fewer in the field of cardiac surgery. An integrative review design was used to examine the current evidence on fluid management …

Effects Of Mitochondrial Nadp+-Dependent Isocitrate Dehydrogenase Deficiency On Fructose-Induced Obesity In Mice, Allison Michelle Montalbano, Kaleigh Elizabeth Beane

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia. Among many contributing factors to obesity, fructose may be one of the major reasons as it disrupts the antioxidant system thereby resulting in an accumulation of reactive oxidative species and leading to obese conditions. The enzyme, isocitrate dehydrogenase 2 (IDH2), reduces nicotinamide adenine dinucleotide phosphate from the TCA Cycle, hence might be implicated with not only energy metabolism but also cellular redox homeostasis. Therefore, the hypothesis was that IDH2 deficiency in mice would exacerbate hepatic lipid …

Children’S Perspectives Of Their Psychosocial Wellbeing In Tanzanian Orphanages, Agnes Msoka, Eleanor Holroyd

School of Nursing & Midwifery, East Africa

The aim of this study was to explore factors affecting the wellbeing of institutionalized orphaned children in Dar es Salaam, Tanzania. A descriptive qualitative study was used to collect data from Tanzanian orphaned children receiving orphanage care. Purposive sampling was employed to select 10 orphanage centers from which 123 orphaned children were recruited. A semi-structured interview guide relevant to the study objectives was developed from the literature and was used to guide the focus group interviews. Data was analysed by way of thematic analysis. There were 76 male and 47 female orphans; orphans without one or both parents were 87 …

Tracking The Trajectory Of Resident Learning Through The Lens Of Self-Determination Theory., Susan E. Hansen Ma, Nicole L. Defenbaugh Phd, Susan S. Mathieu Md, Linda Garufi Md, Med, Julie Dostal Md

Department of Family Medicine

No abstract provided.

Mr Fiscal: Medical Residency Financial Skills Curriculum To Advance Financial Literacy, Carl Bryce Md, Rachel Carpenter Md, John Ewing Do, Roselyn Clemente-Fuente Md, Faafp, Christine Huang Do, Scott Kellner Md, Faafp, Rebecca K. Kemmet Md, Caqsm, Robert Poetta Md, Caitlyn Rerucha Md, Ashley Williams Md, Todd Zakrajsek Phd

Department of Family Medicine

No abstract provided.

Examining Relational Dynamics In Couples Through An Art-Making Experience: A Replication Study, Kuangheng Hwang, Anna Mcnerney, Grace Palenik, Kathleen Scheppe

LMU/LLS Theses and Dissertations

This qualitative research looked at the relational dynamics and attachment styles of research participants through individual and dyadic art-making tasks. This research is a replication study of Snir & Wiseman’s (2010) research on Attachment in Romantic Couples and Perceptions of a Joint Drawing Session. In this particular research, three couples completed a demographic questionnaire, the ECR-S, the DAS, an individual art-making task, and a joint nonverbal drawing task with their partner, followed by a verbal reflection facilitated by researchers. Researchers found patterns suggesting attachment style may be correlated with an individual’s cultural background, relationship satisfaction, past relationship experience, and the …

Permission To Publish Agreement, Concepts In Animal Parasitology, University Of Nebraska-Lincoln Libraries

Concepts in Animal Parasitology Textbook

Blank Permission to Publish agreement form for authors of the Concepts in Animal Parasitology textbook/open educational resource.

A Case Of Flash Pulmonary Edema Caused By Iliac Artery Stenosis, Grace Chong Do, Joseph Moran Do, Fnu Vikram Md, Benjamin Sanchez Md

Department of Medicine

No abstract provided.