Medicine and Health Sciences Commons^™

Utilizing Livers From Donors Older Than 65: A Single Center Experience, Krishnaraj Mahendraraj, Jorge H. Castro, Sean Devitt, Chad Gorn, Cataldo Doria, Adam Frank, Warren Maley, Carlo G. Ramirez

Adam M. Franks, MD

Conclusions:

Use of liver grafts from older donors presents similar survival outcomes as grafts from younger donor age. Therefore, it offers a viable option to expand the donor pool and increase number of OLTs.

However, there is higher incidence of retransplantation due to primary graft non-function, and longer hospital length of stay observed in the older donor age group.

Further studies using larger patient populations are needed to validate our results.

Silencing Of The Pink1 Gene Expression By Conditional Rnai Does Not Induce Dopaminergic Neuron Death In Mice., Hongxia Zhou, Björn H Falkenburger, Jörg B Schulz, Kim Tieu, Zuoshang Xu, Xu Gang Xia

Kim Tieu

Transgenic RNAi, an alternative to the gene knockout approach, can induce hypomorphic phenotypes that resemble those of the gene knockout in mice. Conditional transgenic RNAi is an attractive choice of method for reverse genetics in vivo because it can achieve temporal and spatial silencing of targeted genes. Pol III promoters such as U6 are widely used to drive the expression of RNAi transgenes in animals. Tested in transgenic mice, a Cre-loxP inducible U6 promoter drove the broad expression of an shRNA against the Pink1 gene whose loss-of-functional mutations cause one form of familial Parkinson's disease. The expression of the shRNA …

High-Resolution Physical Map For Chromosome 16q12.1-Q13, The Blau Syndrome Locus., Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams, Gerard Tromp

Charlene Williams

BACKGROUND: The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers, hampered us from further refining the genetic locus for the Blau syndrome. To address this problem, we constructed our own high-resolution physical map for the Blau susceptibility region. RESULTS: We generated a high-resolution physical map that provides more than 90% coverage of a refined Blau susceptibility region. The map consists of four contigs of sequence tagged site-based bacterial artificial chromosomes with a total of 124 bacterial artificial chromosomes, …

Public Reporting Of Cardiac Surgery Outcomes In Pennsylvania: A 20 Year Personal Perspective, Raymond Singer, Md, Mmm, Cpe

Raymond L Singer MD

This forum presentation will describe the national trends of public reporting, pay for performance, and related health care reform measures as well as describe both the intended and unintended consequences of public reporting of cardiac surgery outcomes. PowerPoint slides attached below: 65 slides Presentation: 51 minutes

Developing Ambulatory Care Registered Nurse Competencies For Care Coordination And Transition Management, Sheila Haas, Beth Ann Swan, Traci Haynes

Sheila A. Haas, PhD, NP, FAAN

The need for care coordination and management of transitions between Patient-Centered Medical Home providers, outpatient and community settings, including the Accountable Care Organization is often overlooked, episodic, and accountability for coordinating care and managing transitions between providers and services is lacking.

Health Care Reform: Current Updates And Future Initiatives For Ambulatory Care Nursing, Beth Ann Swan, Phd, Crnp, Faan, Sheila Haas, Phd, Np, Faan

Sheila A. Haas, PhD, NP, FAAN

Executive Summary: While the signing of the Patient Protection and Affordable Care Act was a historical event marking the beginning of health care reform in the United States, it signaled the start of a golden age for ambulatory care nursing. Ambulatory care RNs are well-positioned to fully participate in health care reform initiatives. RNs are well-positioned to lead, facilitate, and/or participate in all patient care medical homes' and accountable care organizations'quality and safety initiatives through enhanced use of major ambulatory care RN role dimensions such as advocacy, telehealth, patient education, care coordination and transitional care, and community outreach. RNs are …

Jefferson Digital Commons Quarterly Report: October-December 2012, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Jefferson Digital Commons quarterly report includes statistics, top 10 most downloaded items and new assets added to the collection.

Jefferson Digital Commons Quarterly Report: October-December 2012, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Jefferson Digital Commons quarterly report includes statistics, top 10 most downloaded items and new assets added to the collection.

Early Results Of Prostate Cancer Radiation Therapy: An Analysis With Emphasis On Research Strategies To Improve Treatment Delivery And Outcomes., Kosj Yamoah, Kwamena Beecham, Sarah E Hegarty, Terry Hyslop, Timothy Showalter, Joel Yarney

Sarah E Hegarty

ABSTRACT: BACKGROUND: There is scant data regarding disease presentation and treatment response among black men living in Africa. In this study we evaluate disease presentation and early clinical outcomes among Ghanaian men with prostate cancer treated with external beam radiotherapy (EBRT). METHODS: A total of 379 men with prostate cancer were referred to the National Center for Radiotherapy, Ghana from 2003 to 2009. Data were collected regarding patient-and tumor-related factors such as age, prostate specific antigen (PSA), Gleason score (GS), clinical stage (T), and use of androgen deprivation therapy (ADT). For patients who received EBRT, freedom from biochemical failure (FFbF) …

Radiation Therapy After Radical Prostatectomy For Prostate Cancer: Evaluation Of Complications And Influence Of Radiation Timing On Outcomes In A Large, Population-Based Cohort., Sarah E Hegarty, Terry Hyslop, Adam Dicker Md, Phd, Timothy Showalter Md

Sarah E Hegarty

PURPOSE: To evaluate the influence of timing of salvage and adjuvant radiation therapy on outcomes after prostatectomy for prostate cancer.

METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified prostate cancer patients diagnosed during 1995-2007 who had one or more adverse pathological features after prostatectomy. The final cohort of 6,137 eligible patients included men who received prostatectomy alone (n = 4,509) or with adjuvant (n = 894) or salvage (n = 734) radiation therapy. Primary outcomes were genitourinary, gastrointestinal, and erectile dysfunction events and survival after treatment(s).

RESULTS: Radiation therapy after prostatectomy was associated with higher rates …

Jefferson Digital Commons Quarterly Report: April-June 2015, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi

Daniel G. Kipnis

This quarterly report includes: 10,000th Asset Pennsylvania Research Commons Faculty Day presentations Variety of new assets in the JDC Inside Out literary journal What people are saying about the JDC

Jefferson Digital Commons Quarterly Report: January-March 2015, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi

Daniel G. Kipnis

Outline of report:

• 10 year birthday for the JDC
• Parenting and Emotional Growth content from Henri Parens, MD
• Jefferson Faculty Books
• Women at Jefferson: New Oral Histories
• Assorted asset highlights
• What people are saying about the JDC

New Cwic-Ph Posters In Jefferson Digital Commons, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Twenty four new College within the College posters have been added to the Jefferson Digital Commons. College within the College (CwiC) is a four year academic area of concentration designed to enrich the Jefferson Medical College curriculum for those students who seek additional training in Population Health. This program aims to step beyond the individual-level focus of mainstream medicine by addressing a broad range of factors that impact health, such as environment, literacy, ethnicity, social structure, resource distribution, health systems and health education/promotion. This collection consists of posters and presentations developed by Jefferson CwiC-PH medical students in their exploration of …

10,000th Asset Archived In The Jdc, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Rejoice! Hooray!! The Jefferson Digital Commons has archived its 10,000th item. The lucky 10,000th item was published by David Nash, MD, MBA and Eugene Mochan, PhD, DO from the Jefferson School of Population Health, Thomas Jefferson University.

Conference Poster Season, Daniel G. Kipnis, Msi

Daniel G. Kipnis

The Jefferson Digital Commons (JDC) has nearly 500 archived conference posters. Don’t let your conference posters collect dust and sit in hallways where only your colleagues view them on a daily basis. Send them to the JDC to reach a global audience.

Jefferson Faculty Books In The Jdc, Daniel G. Kipnis, Msi

Daniel G. Kipnis

The Jefferson Digital Commons has a new series: Jefferson Faculty Books, a collection of recent works published by Thomas Jefferson University faculty. This list will be updated as Jefferson authors continue to publish new titles. Each record includes a link to Amazon for those interested in purchase, as well as a WorldCat link to help researchers locate the closest library that owns a copy of the book.

Assorted Grand Rounds From April And May 2015, Daniel G. Kipnis, Msi

Daniel G. Kipnis

The Jefferson Digital Commons has a varied collection of grand rounds archived from numerous departments including: Surgery Otolaryngology Kimmel Cancer Center Family and Community Medicine Integrative Medicine

Jdc Quarterly Report For January-March 2015 Now Available, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Outline of report: 10 year birthday for the JDC Parenting for Emotional Growth content from Henri Parens, MD Jefferson Faculty Books Women at Jefferson: New Oral Histories Assorted asset highlights What people are saying about the JDC

Jdc Editor A 2015 Ir All-Star, Daniel G. Kipnis, Msi

Daniel G. Kipnis

JDC Editor Dan Kipnis has been recognized as a “2015 IR All-Star” in the DC Telegraph, a blog of the bepress Digital Commons community, for his outstanding promotion of the Jefferson Digital Commons. The JDC is Thomas Jefferson University’s institutional repository designed to enhance the visibility of Jefferson scholarship and to promote Jefferson authors. With more than 10,000 assets to date, the JDC recently exceeded 2 million downloads.

Latest School Of Population Health Capstones In The Jdc, Daniel G. Kipnis, Msi

Daniel G. Kipnis

The latest round of capstone presentations by students in the TJU School of Population Health have been loaded in the Jefferson Digital Commons.

Crosstalk Between Desmoglein 2 And Patched 1 Accelerates Chemical-Induced Skin Tumorigenesis., Donna M Brennan-Crispi, Claudia Hossain, Joya Sahu, Mary Brady, Natalia A Riobo, M G Mahoney

Claudia Hossain

Aberrant activation of Hedgehog (Hh) signaling is causative of BCCs and has been associated with a fraction of SCCs. Desmoglein 2 (Dsg2) is an adhesion protein that is upregulated in many cancers and overexpression of Dsg2 in the epidermis renders mice more susceptible to squamous-derived neoplasia. Here we examined a potential crosstalk between Dsg2 and Hh signaling in skin tumorigenesis. Our findings show that Dsg2 modulates Gli1 expression, in vitro and in vivo. Ectopic expression of Dsg2 on Ptc1+/lacZ background enhanced epidermal proliferation and interfollicular activation of the Hh pathway. Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous …

Postoperative Glycemic Variability In Diabetic And Non Diabetic Patients, Boris Mraovic, Md, Brian Hipszer, Md, Zvi Grunwald, Md, David Gratch, Do, Charles J. Yeo, Md, Jennifer Lessin, Rn, Kathleen O'Malley, Rn, Angela Gulino, Md, Peter Simpson, Meng, Jeffrey Joseph

David Gratch, DO

Objectives: Glycemic variability increases oxidative stress and may trigger the inflammation and coagulation cascades. Variability may be associated with increase morbidity and mortality in ICU patients. We analyzed glycemic variability after major surgery in diabetic (DM) and non-diabetic (NDM) patients using an automated intravenous blood glucose monitor (IVBG).

Jdc Celebrates 10 Years!, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Do you remember what you were doing on January 13, 2005? Probably not, but on that date the Scott Memorial Library activated their institutional repository, the Jefferson Digital Commons. Yes, it has been a decade since the JDC hit the internet.

100 Pulmonary And Critical Care Grand Rounds Archived In The Jefferson Digital Commons, Daniel G. Kipnis, Msi

Daniel G. Kipnis

The Department of Pulmonary and Critical Care Medicine has archived 100 grand rounds in the Jefferson Digital Commons.

Digitized! Ten Years Of Jefferson Medical College Yearbooks Added To The Jdc, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Scott Memorial Library and University Archives and Special Collections have just digitized and uploaded ten years (1950 to 1960) of Jefferson Medical College yearbooks to the Jefferson Digital Commons. To date, JMC yearbooks from 1899 to 1960 have been digitized. Relive the glory, the tradition, and the history of Jefferson.

Jefferson Digital Commons Quarterly Report: Apr-Jun 2014, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi

Daniel G. Kipnis

Contents for this quarterly report: A few numbers 6th Annual Faculty Days Data Management and the Jefferson Digital Commons Two new handouts Announcing New Grand Rounds-Department of Medicine Assorted new assets deposited in the JDC, including: faculty posters, MPH student capstones, Grand rounds, lectures and podcasts Jefferson Medical College yearbooks scanned 1950-1960 Meet Sumner Waldron Jackson, JMC graduate of 1914, hero martyr of the French Resistance during WWII. What is being said about the Jefferson Digital Commons

2014 Jcipe Conference, Daniel G. Kipnis, Msi

Daniel G. Kipnis

The internationally-renowned Jefferson Center for Interprofessional Education (JCIPE) hosted a conference, Interprofessional Care for the 21st Century: Redefining Education and Practice, in Philadelphia on October 10-12, 2014. Conference presentations and posters have been loaded in the Jefferson Digital Commons.

Jefferson Digital Commons Quarterly Report: January-March 2013, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Jefferson Digital Commons quarterly report includes statistics, new libguide for the Jefferson Digital Commons, new assets added to the collection.

In The Jdc: John Heysham Gibbon, Jr. Memorial Service, Daniel G. Kipnis, Msi

Daniel G. Kipnis

The latest addition to the Jefferson Digital Commons historical biographies is from a memorial service for Dr. John Heysham Gibbon, Jr. Read the transcript or listen to an audio file.

Create Day Presentations Now In Jefferson Digital Commons, Daniel G. Kipnis, Msi

Daniel G. Kipnis

Collaborative Research and Evidence Among Therapists and Educators (CREATE) Day is a clinical education program presented by occupational therapy graduate students in partial fulfillment of the Master of Science degree in Occupational Therapy at Thomas Jefferson University.