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Articles 1081 - 1110 of 2036

Full-Text Articles in Medicine and Health Sciences

Association Of Waist Circumference With Outcomes In An Acute General Surgical Unit, T Ryan, P Gosal, A Seal, J Mcgirr, N Williams Jan 2017

Association Of Waist Circumference With Outcomes In An Acute General Surgical Unit, T Ryan, P Gosal, A Seal, J Mcgirr, N Williams

Medical Papers and Journal Articles

Background: Obesity prevalence is increasing in Australia, particularly in non-metropolitan areas. The effect of obesity on acute surgical outcomes is not known. We aimed to record waist circumference (WC) (surrogate for obesity) amongst acute surgical unit (ASU) patients in a New South Wales regional hospital, and compare outcome measures (length of stay (LOS), unplanned return to theatre, readmission rates, intensive care unit (ICU) admission and mortality).

Methods: Retrospective cohort study of 4 months of consecutive ASU admissions, excluding age

Results: Of 695 admissions, 512 met the inclusion criteria (47.1% female, average age 52.8 years (SD 22.3)), with 85.1% (P < 0.001) of females and 69.4% (P =0.166)ofmales having an increased- or high-risk WC. This compares to rates amongst inner regional populations of 71.0% (female) and 66.4% (male). LOS was longer for high-risk patients (5.0 days versus 3.7 days, P = 0.002). However, the mean age of high-risk patients was greater (56.6 years versus 46.9 years, P = 0.001) and LOS was longer for those aged ≥60 (P < 0.001). After controlling for age, high-risk WC was not associated with any outcome measure, except amongst ICU admissions, where high-risk patients stayed longer (15.5 days versus 6.8 days, P <0.001).

Conclusion: …


Diabetes Self-Management Problems Of Older, Low-Income African American Women, Pearlean Day Day Jan 2017

Diabetes Self-Management Problems Of Older, Low-Income African American Women, Pearlean Day Day

Walden Dissertations and Doctoral Studies

Type 2 diabetes disproportionately affects low-income African American women, age 50 years and older: 30% to 40% of this population has this chronic disease. Two significant factors affecting poor diabetes practice adherence are food insecurity and depression; another is obesity. The purpose of this quantitative correlational study was to determine if either food insecurity or depression significantly affect Type 2 diabetes self-management practices; and/or if food insecurity significantly influences practice adherence indirectly, through the mediator of depression, while controlling for obesity. The research questions were aligned with the theoretical pathways posited in Matthews's reserve capacity model (RCM) and used the …


Associations Between Obesity And The Radiographic Phenotype In Knee Osteoarthritis, Mehmet Derya Demi̇rağ, Seçi̇l Özkan, Şemi̇nur Haznedaroğlu, Evi̇n Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Goker Jan 2017

Associations Between Obesity And The Radiographic Phenotype In Knee Osteoarthritis, Mehmet Derya Demi̇rağ, Seçi̇l Özkan, Şemi̇nur Haznedaroğlu, Evi̇n Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Goker

Turkish Journal of Medical Sciences

Background/aim: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. Materials and methods: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal. Results: Obese patients had a significantly more frequent osteophyte-dominant pattern compared to nonobese subjects (74.5% and 38%, respectively, P < 0.001). Logistic regression analysis demonstrated that obesity had a stronger association with an osteophytedominant pattern compared to a JSN-dominant pattern (OR and 95% CI = 7.16 (3.15-16.26) and 1.63 (0.96-2.78), respectively). Age had a very weak effect on the distinction to an osteophyte-dominant pattern and no effect on JSN dominance (OR and 95% CI = 1.1 (1.06-1.15) and 1.02 (0.99-1.05), respectively). Conclusion: There might be an association between obesity and the radiographic phenotype in patients with knee osteoarthritis. The findings suggest that the association between obesity and the osteophyte formation is stronger than that of JSN.


Development And Validation Of An Adult Diet And Physical Activity Program In Primary Care Setting, Christiana Chinyere Keke-Ekekwe Jan 2017

Development And Validation Of An Adult Diet And Physical Activity Program In Primary Care Setting, Christiana Chinyere Keke-Ekekwe

Walden Dissertations and Doctoral Studies

Obesity is a national health problem with serious medical, psychological, and economic outcomes. Nurses and nurse practitioners (NPs) are frequently the first point of patient contact and play an essential role in the management of obesity. The current literature noted that practitioners working in primary care settings demonstrate inadequate knowledge related to evidence based practice (EBP) strategies to treat obesity, including diet modification and physical activity. The purpose of this DNP project was to develop and validate an EBP provider educational module related to diet modification and physical activity education for adult patients diagnosed with obesity in a primary care …


The Perceptions And Experiences Of African American Parents In The Management And Care Of Obese Children, Priscilla Ann Huggins Jan 2017

The Perceptions And Experiences Of African American Parents In The Management And Care Of Obese Children, Priscilla Ann Huggins

Walden Dissertations and Doctoral Studies

Childhood obesity is a global concern among all ethnic groups. Childhood obesity is a problem that continues into adulthood, exacerbating the incidence of diseases such as diabetes or heart disease. The purpose of this phenomenological study was to explore, understand, and describe the perceptions and experiences of African American parents in the management and care of their obese or overweight children. This study used the health-belief model (HBM) as its theoretical foundation, focusing on the constructs of perceived susceptibility, perceived severity, perceived benefits, perceived barriers, cues to action, and self-efficacy. This research study used an interview tool and an 8-item …


Assessing For Awareness And Knowledge Regarding Diabetes In Pre-Diabetes Obese Patients, Remona Lysa Brown Jan 2017

Assessing For Awareness And Knowledge Regarding Diabetes In Pre-Diabetes Obese Patients, Remona Lysa Brown

Walden Dissertations and Doctoral Studies

Over the past few decades, there has been an increase in prevalence of diabetes in the United States. Prevention of diabetes and improving patients' knowledge and awareness of diabetes are crucial for healthcare providers. Using the Health Belief Model (HBM) as a theoretical foundation, the student used the National Diabetes Prevention Program (NDPP) from the Centers for Disease Control and Prevention (CDC), to improve awareness and knowledge of diabetes among obese individuals with prediabetes. The key research question of this project was to determine whether the patients' diabetes knowledge and awareness improved after the NDPP program. A convenience sample of …


Effectiveness Of A 10-Week Weight Reduction Program In A Retail Clinic, Love Chibuihe Nzeako Jan 2017

Effectiveness Of A 10-Week Weight Reduction Program In A Retail Clinic, Love Chibuihe Nzeako

Walden Dissertations and Doctoral Studies

Obesity is a serious health problem that leads to several chronic diseases and premature deaths. TheIn this project,was used to evaluate the effectiveness of the the Weigh Forward (WF) program, a 10-week weight-loss program administered in retail clinics, was evaluated, and it is provided in retails stores. The project analysis was completed on a limited data set on The population consisted of 15 obese participantsmembers of the program, 18 years and above, at 13 dispersed clinics in Maryland and Virginia.in the WF program from 13 dispersed clinics in Maryland and VirgiObesity is a body mass index (BMI) > 30 kg/m2. Participants …


The Experiences Of African American Women Participating In Church-Based Weight Loss Programs, Mangle L. Shanks Jan 2017

The Experiences Of African American Women Participating In Church-Based Weight Loss Programs, Mangle L. Shanks

Walden Dissertations and Doctoral Studies

While obesity is a nationwide phenomenon, African Americans - especially women - continue to be more severely affected than any other ethnic group. According to the Centers for Disease Control and Prevention, over 20% of African American women are obese compared to 15.6% of Caucasian women. The church is an important community center for many African Americans, and is often a site for health promotion programs, though little is known of the effectiveness of these programs. The purpose of this qualitative study was to study the experiences and attitudes of African American women who have gone through a church-based weight-loss …


A Minority Perspective On The Public Health Response To The Obesity Epidemic, Rickey L. Ford Jan 2017

A Minority Perspective On The Public Health Response To The Obesity Epidemic, Rickey L. Ford

Walden Dissertations and Doctoral Studies

Obesity is currently viewed as one of the most important health concerns in the United States. Researchers have minimally investigated perspectives surrounding obesity within the African-American female population. This lack of research presented a gap in knowledge concerning the perceived social, environmental, and cultural influences of obesity within this population. The research questions asked African-American females about their views toward these influences. This research was guided by tenets of the social cognitive theory and the transtheoretical model for behavioral change. Thirteen African-American females participated in the interviews. The data collected were reviewed and coded using word frequencies and themes. Findings …


10,000 Step Challenge For Bedside Registered Nurses Working 12 Hour Shifts, Katherine Louise Schnebly Jan 2017

10,000 Step Challenge For Bedside Registered Nurses Working 12 Hour Shifts, Katherine Louise Schnebly

Walden Dissertations and Doctoral Studies

Obesity is a pandemic that directly affects chronic health problems and mortality. Researchers have shown that more than 54% of nurses are obese. The increasing rate of obesity among nurses and the long hours they work make healthy lifestyles, including daily physical activity, difficult. Tracking daily activity using a pedometer or fitness application has shown improved awareness and sustainability of daily physical activity. This project was an investigation of the daily steps of bedside nurses working a 12-hour shift, and their subsequent awareness of their daily physical activity. Pender's Health Promotion Model was used to consider motivating factors for improving …


Experiences Of Middle-Aged, African American Women With Excessive Weight, Tina Ann Mcclaire Jan 2017

Experiences Of Middle-Aged, African American Women With Excessive Weight, Tina Ann Mcclaire

Walden Dissertations and Doctoral Studies

Obesity and overweight issues are nationally recognized crises for African American women. A noteworthy gap remains in the literature regarding this population's experiences with excessive weight, specifically, the role of culture and social support networks on their experience with being overweight. Without an understanding of the experience and meaning of being overweight for African American women, physicians and clinicians will not be able to fully support African American women in their weight loss journeys. Using the social learning theory as a framework, the purpose of this phenomenological research study was to explore experiences of obese or overweight middle-aged African American …


Perceived Barriers To Lifestyle Change In Obese, Low-Income Hispanic Women, Mariana Daniela Torchia Jan 2017

Perceived Barriers To Lifestyle Change In Obese, Low-Income Hispanic Women, Mariana Daniela Torchia

Walden Dissertations and Doctoral Studies

Low-income Hispanic women are the fastest growing minority population in the United States, and they have increased risks of obesity and secondary health issues, such as diabetes, related to their obesity. The purpose of this phenomenological study was to explore the barriers to lifestyle change among obese, low-income Hispanic women (OLHW). A health belief model lens was used. The study sample consisted of 15 OLHW who were clinic patients and ranged in age from 20-59. Recruitment occurred in a low-income, Southern California, outpatient clinic setting through volunteer participation from recruitment flyers. Fifteen women took part in 1-hour, in-depth interviews, which …


Walkability Assessment To Reduce Childhood Obesity In Wilson County Kansas, Nancy Lee Carpenter Jan 2017

Walkability Assessment To Reduce Childhood Obesity In Wilson County Kansas, Nancy Lee Carpenter

Walden Dissertations and Doctoral Studies

Promoting physical exercise is necessary to combat childhood obesity. Walking to school is an encouraged physical activity, but the feasibility of walking to school depends on the walkability of the environment. During the last 40 years, the number of U.S. schoolchildren who walk to school has declined. The purpose of this evidence-based practice project was to perform a walkability assessment of the 2 largest communities in Wilson County Kansas to identify and address walkability issues. Frameworks for this practice initiative were social cognitive theory and the Health Promotion model. Questions for the project addressed whether sidewalks along the main pedestrian …


An Evaluation Of The Feasibility Of Implementing The National Institute Of Children’S Health Quality (Nichq) Physical Activity And Nutrition Survey In Pediatric Primary Care, Candice Greene Jan 2017

An Evaluation Of The Feasibility Of Implementing The National Institute Of Children’S Health Quality (Nichq) Physical Activity And Nutrition Survey In Pediatric Primary Care, Candice Greene

Doctor of Nursing Practice (DNP) Projects

Pediatric obesity is a growing problem in the United States of America causing both immediate and long-term health implications including: cardiovascular disease, diabetes, bone and joint problems, sleep apnea, and social and psychological problems (Centers for Disease Control and Prevention, 2015). The purpose of this quality improvement project is to implement and evaluate an evidence-based screening tool for identifying modifiable risk factors for childhood obesity in children in a pediatric primary care office. The National Institute for Children’s Health Quality (NICHQ) Physical Activity and Nutrition Survey (Appendix A) was administered to 25 pediatric patients ages 2-18 presenting to their primary …


Motivational Interviewing, And Healthy Eating Intervention With Low Income Diabetic Patients, Cornelius Bela Jan 2017

Motivational Interviewing, And Healthy Eating Intervention With Low Income Diabetic Patients, Cornelius Bela

Doctor of Nursing Practice (DNP) Projects

Purpose: The project’s aim was to investigate whether motivational interviewing made a difference for the participants in terms of healthy behaviors, as measured by their weight, BMI, HgA1C and total health eating habits score.

Method: A motivational interviewing intervention was used on thirteen diabetic patients in three monthly group meetings and weekly phone calls surrounding healthy eating. The health behaviors such as improving dietary choices, decreasing sedentary behaviors, and increasing habitual physical activity and exercises were assessed at both pre and post intervention as well as weight, body mass index (BMI), Hemoglobin A1c, and healthy eating habits total score.

Results: …


Predictors Of Loss To Follow-Up Among Children With Type 2 Diabetes., Ashley Shoemaker, Peiyao Cheng, Robin L. Gal, Craig Kollman, William V. Tamborlane, Georgeanna J. Klingensmith, Mark A. Clements, Tamara S. Hannon, Rubina Heptulla, Joane Less, Jamie Wood, Pediatric Diabetes Consortium Jan 2017

Predictors Of Loss To Follow-Up Among Children With Type 2 Diabetes., Ashley Shoemaker, Peiyao Cheng, Robin L. Gal, Craig Kollman, William V. Tamborlane, Georgeanna J. Klingensmith, Mark A. Clements, Tamara S. Hannon, Rubina Heptulla, Joane Less, Jamie Wood, Pediatric Diabetes Consortium

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND/AIMS: Youth with type 2 diabetes (T2D) have poor compliance with medical care. This study aimed to determine which demographic and clinical factors differ between youth with T2D who receive care in a pediatric diabetes center versus youth lost to follow-up for >18 months.

METHODS: Data were analyzed from 496 subjects in the Pe-diatric Diabetes Consortium registry. Enrollment variables were selected a priori and analyzed with univariable and multivariable logistic regression models.

RESULTS: After a median of 1.3 years from enrollment, 55% of patients were lost to follow-up. The final model included age, race/ethnicity, parent education, and estimated distance to …


Comparison Of Anthropometric Measurements Of Abdominal Obesity As Predictors Of Cardiometabolic Risk Factors: Nhanes 2011-2014, Carli Kettel Jan 2017

Comparison Of Anthropometric Measurements Of Abdominal Obesity As Predictors Of Cardiometabolic Risk Factors: Nhanes 2011-2014, Carli Kettel

All Master's Theses

Background It has been well established that screening tools for cardiometabolic diseases are less useful among obese populations as risk of these diseases is already high. However, research is lacking in regard to efficient screening tools for cardiometabolic diseases among normal weight and overweight populations. Objective This study compared the predictive strengths of body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), sagittal abdominal diameter (SAD), and SAD-to-height ratio (SADHtR) with respect to risk of cardiometabolic disorders in normal and overweight U.S. populations. Design This cross-sectional study utilized data from the 2011-2014 National Health and Nutrition Examination Survey. Participants/setting …


Cardiometabolic Risk Factors, Metabolic Syndrome And Pre-Diabetes In Adolescents In The Sierra Region Of Ecuador, Sharon L. Casapulla, Cheryl A. Howe, Gabriela Rosero Mora, Darlene Berryman, Mario J. Grijalva, Edgar W. Rojas, Jay H. Shubrook Jan 2017

Cardiometabolic Risk Factors, Metabolic Syndrome And Pre-Diabetes In Adolescents In The Sierra Region Of Ecuador, Sharon L. Casapulla, Cheryl A. Howe, Gabriela Rosero Mora, Darlene Berryman, Mario J. Grijalva, Edgar W. Rojas, Jay H. Shubrook

Faculty Publications & Research of the TUC College of Osteopathic Medicine

Background: Excess weight (overweight and obesity) is the major modifiable risk factor for type 2 diabetes mellitus (T2DM) and other non-communicable diseases. However, excess weight may not be as predictive of diabetes risk as once thought. While excess weight and other obesity-related non-communicable diseases are of growing concern in low-middle income countries in Latin America, there is limited research on risk factors associated with T2DM in adolescents. This study investigated prevalence of overweight, obesity, prediabetes, diabetes and metabolic syndrome in adolescents in Ecuador.

Methods: A cross-sectional study was conducted with 433 adolescents from two schools in a small …


Sarcopenia: Prevalence, And Impact On Operative And Oncologic Outcomes In The Multimodal Management Of Locally Advanced Esophageal Cancer, Jessie Elliott, Suzanne Doyle, Conor Murphy, Sinead King, Emer Guinan, Peter Beddy, Narayanasamy Ravi, John Reynolds Jan 2017

Sarcopenia: Prevalence, And Impact On Operative And Oncologic Outcomes In The Multimodal Management Of Locally Advanced Esophageal Cancer, Jessie Elliott, Suzanne Doyle, Conor Murphy, Sinead King, Emer Guinan, Peter Beddy, Narayanasamy Ravi, John Reynolds

Articles

Objective: The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes.

Summary of background data: Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied.

Methods: Two hundred fifty-two consecutive patients were studied. Lean body mass (LBM), skeletal muscle index (SMI), and fat mass (FM) were determined pre-treatment, preoperatively, and 1 year postoperatively. Sarcopenia was defined by computed tomography (CT) at L3 …


Cancer Incidence In Ireland—The Possible Role Of Diet, Nutrition And Lifestyle, Daniel Mccartney, Declan Byrne, Marie Cantwell, Michael Turner Jan 2017

Cancer Incidence In Ireland—The Possible Role Of Diet, Nutrition And Lifestyle, Daniel Mccartney, Declan Byrne, Marie Cantwell, Michael Turner

Articles

Aim This observational ecological study aims to compare Ireland’s age-specific cancer incidence rates (ASRs) with equivalent European and global data and to highlight possible dietary, nutritional and lifestyle contributors to cancer in Ireland.

Subjects and methods Using the International Agency for Research on Cancer’s (IARC) GLOBOCAN database, Irish ASRs for all-site cancer and for "lifestyle-related" cancers such as those of the colo-rectum, oesophagus, breast, lung and prostate were compared with European and global incidence data. Irish dietary and nutrient intake data were reviewed and evaluated in the context of these cancer incidence data and in relation to the established dietary, …


Engaging Parents To Promote Children’S Nutrition And Health: Providers’ Barriers And Strategies In Head Start And Child Care Centers, Dipti A. Dev, Courtney Byrd-Williams, Samantha Ramsay, Brent A. Mcbride, Deepa Srivastava, Ashleigh L. Murriel, Chrisa Arcan, Anna M. Adachi-Mejia Jan 2017

Engaging Parents To Promote Children’S Nutrition And Health: Providers’ Barriers And Strategies In Head Start And Child Care Centers, Dipti A. Dev, Courtney Byrd-Williams, Samantha Ramsay, Brent A. Mcbride, Deepa Srivastava, Ashleigh L. Murriel, Chrisa Arcan, Anna M. Adachi-Mejia

Department of Child, Youth, and Family Studies: Faculty Publications

Purpose: Using the Academy of Nutrition and Dietetics benchmarks as a framework, this study examined childcare providers’ (Head Start [HS], Child and Adult Care Food Program [CACFP] funded, and non-CACFP) perspectives regarding communicating with parents about nutrition to promote children’s health.

Design: Qualitative.

Setting: State-licensed center-based childcare programs.

Participants: Full-time childcare providers (n ¼ 18) caring for children 2 to 5 years old from varying childcare contexts (HS, CACFP funded, and non-CACFP), race, education, and years of experience.

Methods: In-person interviews using semi-structured interview protocol until saturation were achieved. Thematic analysis was conducted.

Results: Two overarching themes were barriers and …


Influence Of Media Messages On Obesity And Health Perceptions Among African American Women, Carolyn Grant Jan 2017

Influence Of Media Messages On Obesity And Health Perceptions Among African American Women, Carolyn Grant

Walden Dissertations and Doctoral Studies

African American women have the highest prevalence of overweight and obesity in the United States, thus increasing their risks for chronic diseases. Their understanding of their health status and response to it could be triggered by messages in the media, yet few researchers have examined this topic with African American women. The purpose of this phenomenological study was to explore how advertisement and editorial content in media contributed to perceptions African American women have about overweight and obesity. Following the theoretical foundation of the social cognitive theory, the research questions explored what messages study participants encountered and which messages prompted …


Assessing Plant-Based Food Lifestyle To Reduce Obesity Risk, Erna Siregar Jan 2017

Assessing Plant-Based Food Lifestyle To Reduce Obesity Risk, Erna Siregar

Walden Dissertations and Doctoral Studies

Despite an increasing number of healthy lifestyles throughout the country, Americans, including Native Hawaiians, keep gaining weight. Unlike several American lifestyles that have resulted in weight gain within the American population, the vegetarian lifestyle is a scientifically proven method for decreasing body weight and maintaining the weight loss for more than 1 year. This study aimed to compare the lifestyle patterns of 4 vegetarian lifestyles and 1 nonvegetarian lifestyle among Native Hawaiians aged 21 and older using their body mass index (BMI). This quantitative study utilized a correlational design, which is particularly suitable for examining the relationship of BMI to …


Do Images Of A Personalised Future Body Shape Help With Weight Loss? A Randomised Controlled Study, Gemma Ossolinski, Moyez Jiwa, Alexandra Mcmanus, Richard Parsons Jan 2017

Do Images Of A Personalised Future Body Shape Help With Weight Loss? A Randomised Controlled Study, Gemma Ossolinski, Moyez Jiwa, Alexandra Mcmanus, Richard Parsons

Medical Papers and Journal Articles

Background: This randomised controlled study evaluated a computer-generated future self-image as a personalised, visual motivational tool for weight loss in adults.

Methods: One hundred and forty-five people (age 18–79 years) with a Body Mass Index (BMI) of at least 25 kg/m2 were randomised to receive a hard copy future self-image at recruitment (early image) or after 8 weeks (delayed image). Participants received general healthy lifestyle information at recruitment and were weighed at 4-weekly intervals for 24 weeks. The image was created using an iPad app called ‘Future Me’. A second randomisation at 16 weeks allocated either an additional future self-image …


Exploring The Role Of Dopamine Circuits In Eating Behavior, Kara Elizabeth Furman Jan 2017

Exploring The Role Of Dopamine Circuits In Eating Behavior, Kara Elizabeth Furman

Yale Medicine Thesis Digital Library

In its simplest terms, obesity is a disease of exaggerated food intake. While current treatment of obesity focuses on changing behavior, few successful models of behavior modification have been developed. Even those treatments that are successful in the short-term, have failed to demonstrate lasting effect. The problem of over-eating, then, needs to be studied in terms of basic motivational programs that are encoded by the brain’s reward system. Understanding the way in which reward system activity directs eating behavior will allow more sophisticated and efficacious treatment options in the future. Several studies have focused on the nucleus accumbens (NAc) as …


Genome-Wide Meta-Analysis Of 241,258 Adults Accounting For Smoking Behaviour Identifies Novel Loci For Obesity Traits, Anne E. Justice, Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia A. Fisher, Kristin Leonard, Kristin Young, Llilda Barata, Xuan Deng, John Blangero, Joanne E. Curran Jan 2017

Genome-Wide Meta-Analysis Of 241,258 Adults Accounting For Smoking Behaviour Identifies Novel Loci For Obesity Traits, Anne E. Justice, Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia A. Fisher, Kristin Leonard, Kristin Young, Llilda Barata, Xuan Deng, John Blangero, Joanne E. Curran

School of Medicine Publications and Presentations

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an …


Multiethnic Genome-Wide Meta-Analysis Of Ectopic Fat Depots Identifies Loci Associated With Adipocyte Development And Differentiation, Audrey Y. Chu, Xuan Deng, Virginia A. Fisher, Alexander Drong, Yang Zhang, Mary F. Feitosa, Ching-Ti Liu, Olivia Weeks, Audrey C. Choh, Qing Duan, Thomas D. Dyer Jan 2017

Multiethnic Genome-Wide Meta-Analysis Of Ectopic Fat Depots Identifies Loci Associated With Adipocyte Development And Differentiation, Audrey Y. Chu, Xuan Deng, Virginia A. Fisher, Alexander Drong, Yang Zhang, Mary F. Feitosa, Ching-Ti Liu, Olivia Weeks, Audrey C. Choh, Qing Duan, Thomas D. Dyer

School of Medicine Publications and Presentations

Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men for six ectopic fat traits in European, African, Hispanic, and Chinese ancestry populations, with and without sex stratification. In total, 7 new loci were identified in association with ectopic fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; PATXN1 and UBE2E2 …


Contributors To Processing Speed Deficit In Old Age: A Focus On History Of Obesity And Medical Conditions, Melissa E. Pulcini Jan 2017

Contributors To Processing Speed Deficit In Old Age: A Focus On History Of Obesity And Medical Conditions, Melissa E. Pulcini

Master's Theses and Doctoral Dissertations

Obesity has been associated with impairment in most cognitive domains, but the nature of this relationship is unclear. Most studies have examined the relationship between cognitive impairment and current obesity and/or history of obesity-related medical conditions. However, a number of “lower-level” obesity factors (e.g., increased adipokines, low grade inflammation, chronic mild hypoventilation) are present even among the otherwise healthy obese population, and it is possible that many of these factors have differential impact on cognition according to magnitude and duration of exposure. Knowledge of a person’s weight history, which may serve as a proxy for a number of lower-level obesity …


Factors Regulating Features Of Metabolic Syndrome, Sonja S. Pijut Jan 2017

Factors Regulating Features Of Metabolic Syndrome, Sonja S. Pijut

Theses and Dissertations--Pharmacy

The collective presence of central obesity, low HDL-cholesterol, and elevated triglycerides, blood pressure, and fasting blood glucose constitutes Metabolic Syndrome (MetS), a disease state that increases the risk of cardiovascular disease (CVD) and Type 2 Diabetes Mellitus (T2DM). Nonalcoholic fatty liver disease (NAFLD), present in up to 90% of obese adults, is also linked to MetS. As in CVD, disruptions in cholesterol metabolism play a contributing role in the development of T2DM and NAFLD. Genes involved in cholesterol synthesis, secretion, and catabolism are diurnally regulated in the liver and adipose. Disruptions in the sleep-wake cycle are thought to potentiate metabolic …


Parental Self-Efficacy, Feeding Practices And Styles, And Obesity In Mexican American Children, Maria Carmen Goodwin Jan 2017

Parental Self-Efficacy, Feeding Practices And Styles, And Obesity In Mexican American Children, Maria Carmen Goodwin

Walden Dissertations and Doctoral Studies

Childhood obesity rates among Mexican Americans have risen along with the concerns of public health professionals. The purpose of this cross-sectional study, based on social cognitive theory, was to investigate the relationships among parental self-efficacy, parental feeding practices and styles, and childhood obesity, as measured by the parental perception of child weight, among Mexican Americans in Texas. Mothers and fathers (n=83; 33 males, 64 females), with at least 1 child between 8 and10 years, formed the sample. Relationships were assessed using the Tool to Measure Parenting Self-Efficacy questionnaire, the Parental Feeding Practices Questionnaire for Mexican American parents, the Parenting Dimensions …