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Full-Text Articles in Medicine and Health Sciences
Opioid System's Involvement In Ketamine's Antidepressant-Like Effects, Fan Zhang
Opioid System's Involvement In Ketamine's Antidepressant-Like Effects, Fan Zhang
Theses and Dissertations
Depression is one of the most debilitating disorders in the world. The currently available medications typically have a 2-4 week delay in their therapeutic effects and are ineffective for about 40% of patients. In 2000, a subanesthetic dose (0.5 mg/kg i.e.) of the dissociative anesthetic ketamine was reported to have both rapid and robust antidepressant effects in in treatment-resistant depressed patients. However, the mechanisms responsible for ketamine’s antidepressant effects remain unclear. In 2018, a clinical study reported that pretreatment with the nonselective opioid antagonist naltrexone attenuated the rapid antidepressant effect of ketamine in depressed patients. The current study investigated the …
Investigating The Role Of Nicotinic Acetylcholine Receptors (Nachrs) In The Development And Maintenance Of Chemotherpy-Induced Peripheral Neuropathy In Mice, Wisam B. Toma
Theses and Dissertations
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a major dose-limiting side effect of several anticancer drugs. The prevalence of CIPN ranges from one-third to two-thirds of cancer patients. CIPN can persist for months to years after completion of chemotherapy. Despite the efficacious use of paclitaxel in the treatment of tumors, it can induce many sensory symptoms, such as paresthesia, numbness, tingling and burning pain, and mechanical and cold allodynia, which typically are present in the hands and feet. Similar to other types of chronic pain, paclitaxel-induced CIPN is comorbid with depression and anxiety in cancer survivors, and paclitaxel induces changes in affect-like …
Behavioral And Genomic Characterization Of Scheduled Ethanol Deprivation, Jonathan Warner
Behavioral And Genomic Characterization Of Scheduled Ethanol Deprivation, Jonathan Warner
Theses and Dissertations
Alcoholism is a persistent substance abuse disorder that is associated with negative health, social, and economic outcomes. Treatment strategies for alcohol use disorders are limited, and only three drugs have been approved by the FDA for treatment. Although behavioral therapy and drug combination strategies improve abstinence outcomes, the majority of those in treatment will not achieve long-term abstinence. Therefore, better treatment strategies are needed. While much progress has been made toward understanding the neurobiology of alcoholism, this knowledge has not been effectively translated into treatment strategies. Animal models of alcohol drinking have been crucial to this research effort, but until …
Lasting Biological Effects Of Early Influences, René Dubos
Lasting Biological Effects Of Early Influences, René Dubos
MCV/Q, Medical College of Virginia Quarterly
In conclusion: The environment does more than affect our well-being in the here and now. It molds the young, physically and mentally, and thereby determines almost irreversibly their future and the evolution of society.