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2017

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Articles 1 - 19 of 19

Full-Text Articles in Medicine and Health Sciences

Effects Of 8 And 12 Hour Non-Rotating Shift Schedules For Security And Protective Services Workers, Zuleyha Aydin Dec 2017

Effects Of 8 And 12 Hour Non-Rotating Shift Schedules For Security And Protective Services Workers, Zuleyha Aydin

Theses

Shiftwork is a major feature of working life in today’s world. Increasing the workday length is a new trend in alternative work schedules. The features of a shift system operation can have an impact on sleep, alertness, and the well-being of shif


Computational And Experimental Determination Of The Mixing Efficiency Of A Microfluidic Serpentine Micromixer, Siril Arockiam Dec 2017

Computational And Experimental Determination Of The Mixing Efficiency Of A Microfluidic Serpentine Micromixer, Siril Arockiam

Theses

In microfluidics, efficiency and mixing time are the greatest disadvantages. These parameters hinder the application of microfluidic devices for biochemical and immunological assays. However, once these disadvantages have been overcome by optimizing th


Comparative Analysis Of The Dissolution Performance Of Aspirin Tablets In The Usp Apparatus 2 And In A Minivessel Dissolution System, Annmarie C. Walker Dec 2017

Comparative Analysis Of The Dissolution Performance Of Aspirin Tablets In The Usp Apparatus 2 And In A Minivessel Dissolution System, Annmarie C. Walker

Theses

Dissolution testing is a critical component of quality control procedures in the pharmaceutical industry in order to ensure that the final solid dosage forms have consistent dissolution properties. Dissolution tests are also routinely conducted to eval


The Effects Of Frondoside A In Acute Leukemia, Fatma Hussain Sajwani Aug 2017

The Effects Of Frondoside A In Acute Leukemia, Fatma Hussain Sajwani

Theses

Among hematological malignancies, acute leukemia is the major cause of mortality. Despite improvement of survival with current chemotherapies, some patients still diefrom the disease or the treatment side effects. Thus, new therapeutic agents are needed. Anti-cancer drugs derived from natural products are of interest. Frondoside A is a triterpenoid glycoside form the sea cucumber, Cucumaria frondosa that has shown potent antitumor effects in various cancers. Previous studies in acute leukemia are limited. The current study investigated the effects of frondoside a in acute leukemia cell lines alone and in combination with drugs currently used for this malignancy. This study is ...


Power Dissipation And Power Correlations For A Retreatblade Impeller Under Different Baffling Conditions, Chadakarn Sirasitthichoke May 2017

Power Dissipation And Power Correlations For A Retreatblade Impeller Under Different Baffling Conditions, Chadakarn Sirasitthichoke

Theses

Glass-lined stirred reactors and tanks are commonly used in the pharmaceutical industry because of their corrosion resistance, ease of cleanliness and minimization of product contamination. Most industrial glass-lined tank reactors are provided with a


Network Exploration Of Correlated Multivariate Protein Data For Alzheimer's Disease Association, Matthew J. Lane Apr 2017

Network Exploration Of Correlated Multivariate Protein Data For Alzheimer's Disease Association, Matthew J. Lane

Theses

Alzheimer Disease (AD) is difficult to diagnose by using genetic testing or other traditional methods. Unlike diseases with simple genetic risk components, there exists no single marker determining as to whether someone will develop AD. Furthermore, AD is highly heterogeneous and different subgroups of individuals develop the disease due to differing factors. Traditional diagnostic methods using perceivable cognitive deficiencies are often too little too late due to the brain having suffered damage from decades of disease progression. In order to observe AD at early stages prior to the observation of cognitive deficiencies, biomarkers with greater accuracy are required. By using ...


Short-Term Bilateral Adrenalectomy: Biochemical And Morphological Alterations In The Rat Hippocampus, Ahlam Said Abi Issa Apr 2017

Short-Term Bilateral Adrenalectomy: Biochemical And Morphological Alterations In The Rat Hippocampus, Ahlam Said Abi Issa

Theses

Several studies showed the effects of glucocorticoid hormones on the hippocampus. It has been reported that the chronic administration of high dose glucocorticoids (GC) results in the degeneration of pyramidal neurons. However, bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively, there are few publications on the effects of short-term bilateral adrenalectomy (ADX). We aimed to investigate the effects of ADX on levels of pro-inflammatory cytokines interleukin-1β (IL-1β), interkeukin-6 (IL-6) and tumor necrosis factor-α (TNF-α); levels of growth factors, response of microglia and astrocytes to neuronal death, and oxidative ...


Genetic Polymorphism Of Cytochrome P450-1a2 (Cyp1a2) And N-Acetyltransferase-2 (Nat2) Among Emiratis, Mohammed Majed Al-Ahmad Mar 2017

Genetic Polymorphism Of Cytochrome P450-1a2 (Cyp1a2) And N-Acetyltransferase-2 (Nat2) Among Emiratis, Mohammed Majed Al-Ahmad

Theses

Brief introduction: There are limited studies on CYP1A2 and NAT2 polymorphisms among Emiratis. Aims: This study aims to determine CYP1A2 and NAT2 alleles and genotypes and correlate these genotypes with caffeine metabolism phenotypes among Emiratis. Methods: After obtaining informed consent, five hundred and eighty-one non-smoker subjects were given 300ml of caffeinated soft drink and were asked to provide a buccal swab and a urine sample two hours later. TaqMan Real Time PCR, PCR-RFLP, DNA sequencing were performed to determine CYP1A2 and NAT2 alleles and genotypes. Phenotyping was carried out by analysing the caffeine metabolites using HPLC analysis. Results: We found ...


Get A Grip: Analysis Of Muscle Activity And Perceived Comfort In Using Stylus Grips, Evanda Vanease Henry Jan 2017

Get A Grip: Analysis Of Muscle Activity And Perceived Comfort In Using Stylus Grips, Evanda Vanease Henry

Theses

The design of handwriting instruments has been based primarily on touch, feel, aesthetics, and muscle exertion. Previous studies make it clear that different pen characteristics have to be considered along with hand-instrument interaction in the design


Novel Experimental Method For The Determination Of The Minimum Agitation Speed For Solids Suspension In Flat-Bottomed Stirred Tank Reactors, Shriarjun Shastry Jan 2017

Novel Experimental Method For The Determination Of The Minimum Agitation Speed For Solids Suspension In Flat-Bottomed Stirred Tank Reactors, Shriarjun Shastry

Theses

Knowledge of the minimum agitation speed, Njs, required to suspend finely divided solids in vessels stirred by an impeller is a critical parameter to properly operate industrial tanks in a large number of industrial operations. The most common


Exploring The Concept Of Receptivity To Bereavement Support: Implications For Palliative Care Services In Rural, Regional And Remote Western Australia, Pippa Blackburn Jan 2017

Exploring The Concept Of Receptivity To Bereavement Support: Implications For Palliative Care Services In Rural, Regional And Remote Western Australia, Pippa Blackburn

Theses

Background: Palliative care services are primary organisations that provide bereavement support in Australia and aim to mitigate potential adverse outcomes of grief and bereavement The success of bereavement services depends, in part, on how ‘receptive’ the bereaved are to receiving support. Although palliative care services provide support services for bereaved carers and families, there still remains a discord between what is delivered, what is needed and factors that deter or encourage a person’s receptiveness to support.

Purpose: The aim of this research was to examine utilisation of bereavement support through the ‘lens’ of receptivity. Bereavement and receptivity are complex ...


Development, Implementation, Evaluation And Validation Of A Haemophilia Nurses’ Education Program In South Africa, Jill Smith Jan 2017

Development, Implementation, Evaluation And Validation Of A Haemophilia Nurses’ Education Program In South Africa, Jill Smith

Theses

Haemophilia is a rare, inherited bleeding disorder found in all races and ethnic groups. Intervention regimens are more complicated in developing countries, such as South Africa, where numerous challenges present impediments to effective health care. This study investigated the value of the Haemophilia Nurses’ Education Program (HNEP) in the South African context where no comparable program of training for haemophilia nurses exists.

The HNEP has been in operation in South Africa for some fifteen years. The researcher, as one of the key instigators of the HNEP, was keen to determine whether the course was delivering the outcomes that had been ...


Bioimpedance Spectroscopy - Can It Be Used As A Tool For Monitoring Fluid Shifts In Burns?, Pippa Kenworthy Jan 2017

Bioimpedance Spectroscopy - Can It Be Used As A Tool For Monitoring Fluid Shifts In Burns?, Pippa Kenworthy

Theses

Large fluid shifts and oedema are features of burn injuries. Oedema hampers burn wound healing and is directly related to the size and depth of the burn. The degree of oedema in burns covers a broad spectrum: Minor burns cause localised or peripheral oedema, whilst major burns may result in a systemic inflammatory response which can be life threatening and necessitates formal fluid resuscitation. Acute burn fluid resuscitation is paramount in decreasing patient morbidity and mortality but can contribute to already large amounts of oedema. There is currently no single clinically applicable, non-invasive and accurate outcome measure to titrate fluid ...


Assessment Of The Neuroprotective Potential Of Poly-Arginine Peptides In Stroke Models, Diego Milani Jan 2017

Assessment Of The Neuroprotective Potential Of Poly-Arginine Peptides In Stroke Models, Diego Milani

Theses

Currently, there is no available neuroprotective treatment for reducing acute brain injury following stroke. Recent studies have demonstrated that poly-arginine and arginine-rich peptides (e.g. R18; R = arginine residues) exhibit potent neuroprotective properties in both in vitro and in vivo stroke models, and therefore have the potential to be developed into a neuroprotective treatment for stroke.

Consequently, the aim of this thesis was to further assess the neuroprotective efficacy of several poly-arginine and arginine-rich peptides in permanent and transient middle cerebral artery occlusion (MCAO) stroke models in the rat.

The poly-arginine peptides R12, R15, R18 and the arginine-rich peptide protamine ...


The Lived Experience Of The Western Australian Graduate Registered Nurse Who Is Male, Dianne Juliff Jan 2017

The Lived Experience Of The Western Australian Graduate Registered Nurse Who Is Male, Dianne Juliff

Theses

Nursing professionals are ageing and alternate career opportunities for females threatens nursing workforce sustainability. Largely untapped human resource and underrepresented within nursing in Australia are men. Therefore, the attraction and retention of men into nursing is imperative for the profession to support a sustainable workforce.

A qualitative longitudinal phenomenological study, explored the lived experience of nine newly graduated registered nurses who are male during their first year in their professional-practice environment. The methodological approach that guided this study was Interpretive Phenomenological Analysis (IPA). The IPA enhanced the exploration of the lived experiences of these participants by investigating the meaning of ...


The Influence Of The Supernumerary Clinical Nurse Educator Role On Advancing Graduate Nurses’ Quality Of Patient Care: A Mixed-Methods Study In A Private Western Australian Health Service, Tracey Coventry Jan 2017

The Influence Of The Supernumerary Clinical Nurse Educator Role On Advancing Graduate Nurses’ Quality Of Patient Care: A Mixed-Methods Study In A Private Western Australian Health Service, Tracey Coventry

Theses

Theoretical and anecdotal evidence suggests that the presence of the supernumerary clinical nurse educator (CNE) in the acute care hospital clinical environment will positively affect patient quality outcomes. However, the supernumerary role suffers from scrutiny in response to the financial constraints of healthcare organisations, and is questioned regarding sustainability. The lack of empirical research diminishes the CNE role and its benefit for patient quality of care. This research focuses on newly qualified graduate registered nurses (GRNs) employed in a graduate programme and supported by the CNE in the clinical environment in order to articulate the effect of the supernumerary CNE ...


Hospitalisation And Comorbidities In Parkinson's Disease: A Large Australian Retrospect Study, Michal Lubomski Jan 2017

Hospitalisation And Comorbidities In Parkinson's Disease: A Large Australian Retrospect Study, Michal Lubomski

Theses

Parkinson’s disease (PD) is a progressive and disabling neurological disorder that affects approximately 1% of the adult population aged over 65 years in Australia. Parkinson’s disease, as with many other chronic illnesses, results in frequent patient hospitalisations. There is a paucity of information on the causes and related co-morbidities that lead to hospitalisation among these patients in an Australian setting. The aim of this study was to examine patterns of hospitalisation of Parkinson’s disease patients with regards to demographic factors, co-morbidities and aspects relating to clinical management. In this study, data was extracted from the NSW Ministry ...


The Modification Of Two Tools To Measure Emotional Intelligence In Undergraduate Student Nurses: A Mixed Method Pilot Study, Laurel Collin Jan 2017

The Modification Of Two Tools To Measure Emotional Intelligence In Undergraduate Student Nurses: A Mixed Method Pilot Study, Laurel Collin

Theses

Nurses need a range of strategies to manage their clinical practice while helping patients to cope with their health problems. Stress and inefficient coping skills of student nurses have been shown to lead to attrition within the university and later, on graduation, in the workplace. Student nurses can learn some of these strategies as they are expected to cope with issues associated with the practical nature of nursing, university demands and home life. One strategy offered is the use of emotional intelligence (EI). An ability to monitor and regulate emotions may contribute to an increase in the repertoire of coping ...


The Effect Of Continuing Professional Development From The Perspective Of Nurses And Midwives Who Participated In Continuing Education Programs Offered By Global Health Alliance Western Australia: A Mixed-Method Study, Yan Ing (Jenni) Ng Jan 2017

The Effect Of Continuing Professional Development From The Perspective Of Nurses And Midwives Who Participated In Continuing Education Programs Offered By Global Health Alliance Western Australia: A Mixed-Method Study, Yan Ing (Jenni) Ng

Theses

Continuing professional development (CPD) opportunities for nurses and midwives are central to improving knowledge, broadening skills and maintaining competencies to provide best practice and clinical care. This is gained through participating in continuing education (CE). CPD is readily accessible and a mandatory requirement for nurses and midwives in developed nations, such as Australia. However, in developing countries, such as Tanzania, while CPD is promoted, it has limited availability. As such, the Global Health Alliance Western Australia (GHAWA), an international health development program, seeks to provide further sustainable CPD opportunities for nurses and midwives in Tanzania.

The purpose of this research ...