Medicine and Health Sciences Commons^™

Giant-Cell Tumor Of The Cervical Spine In An Adult Female With Neck Stiffness: A Casereport, Kuan-Yu Chu, Wen-Sheng Liu, Yen-Ting Lai, I-Pu Juang, Shu-Huan Lin

Rehabilitation Practice and Science

Giant-cell tumor of the bone is relatively common in young adults, especially those in the third decades of life. This tumor occurs most frequently in long bones, such as the distal femur or proximal tibia, but rarely in the cervical spine. Giant-cell tumor of the cervical spine is rarely considered in the differential diagnosis of neck pain; thus, diagnosis of giant-cell tumor of the cervical spine is typically delayed or misdiagnosed. We present a case of giant-cell tumor of the cervical spine in a 25-year-old woman initially diagnosed with neck stiffness and muscle strain. She developed upper trunk numbness in …

Potentials And Limitations Of Real-Time Elastography For Prostate Cancer Detection: A Whole-Mount Step Section Analysis., Daniel Junker, Georg Schäfer, Friedrich Aigner, Peter Schullian, Leo Pallwein-Prettner, Jasmin Bektic, Wolfgang Horninger, Ethan J Halpern, Ferdinand Frauscher

Department of Radiology Faculty Papers

OBJECTIVES: To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type.

MATERIALS AND METHODS: Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prostates were prepared as whole-mount step sections and were compared with imaging findings for analyzing PCa detection rates.

RESULTS: RTE detected 6/62 cancer lesions with a maximum diameter of 0-5 mm (9.7%), 10/37 with a maximum diameter of 6-10 mm (27%), 24/34 with a maximum diameter …

The Effect Of Botulinum Toxin Type A On Chronic Neck-Shoulder Pain: A Casereport, Sin-Hao Ho, Shih-Chung Chang, Yao-Jen Chen, Amy I-Hui Lin, Su-Ju Tsai

Rehabilitation Practice and Science

Neck and shoulder pain is a common clinical complaint. However, the associated mechanism of this condition is thought to be multifactorial and is not yet fully understood. Various studies and multiple clinical experiences have shown the effectiveness of treatment with botulinum toxin type A in the improvement of dystonia and muscle spasticity. The mechanism of the analgesic effect of botulinum toxin type A has also been widely investigated. Many studies have addressed the use of botulinum toxin type A in the treatment of myofascial pain, but its effectiveness and side effects remain controversial. This casereport describes a young woman with …

Effects Of A Modified Module Insole On Foot Deformity And Pain In High Arch Foot, Pin-Yang Hung, Mei-Wun Tsai, Young-Hue Yu, Ming-Jor Lo, Yen-I Chiang, Wei-Hua Ho, Mu-Jung Kao

Rehabilitation Practice and Science

There are no definite conclusions for effective treatments on foot orthosis for high arch foot. The aim of this study was to assess the effectiveness of modified module insole on foot deformity and foot pain in high arch foot patients. This study recruited 81 adults whose arch index of ＞0.21with 37 in the orthosis group and 44 in the control group. All participants have no evidence of neurological deficits at legs, foot deformities and abnormal gait patterns. A modified module insole with 3/4 length arch support was tried for the orthosis group. The 8-week trial was followed by an 8-week …

A Young Stroke Patient With Bardet-Biedl Syndrome: A Casereport, Erh-Chun Chen, Tien-Wen Chen, Ming-Cheng Weng, Chia-Ling Lee

Rehabilitation Practice and Science

Bardet-Biedl syndrome (BBS) is a rare inherited disease. Up to date, there have been 14 known BBS-related mutation genes, resulting in ciliopathy with multiple abnormalities such as obesity, pigmentary retinopathy, polydactyly, learning disabilities, poor coordination, renal dysfunction, diabetes and hypertension. This case was a 29-year-old male, who was diagnosed as Bardet-Biedl syndrome since childhood and then was followed up for control of complications. He suffered from stroke at age of 29. Risks of young stroke were surveyed. Poorly controlled hypertension, hyperlipidemia, hyperglycemia and hyperfibrinogenemia were noted. No other examination revealed abnormality. He had received treatment of stroke in acute phase, …

The Effect Of Ice Pack On Lumbar Range Of Motion In Patients With Low Back Pain And Lumbar Sacralization, Shih-Chieh Lin, Yi-Chun Hung, Yin-Chou Lin, Wei-Han Chang, Yu-Tsai Tu, Shih-Wei Chou

Rehabilitation Practice and Science

Purpose: This research was designed to investigate the short-term effect of an ice pack on lumbar range of motion in patients. Patients with low back pain caused by sacralized fifth lumbar spine were selected after clinical diagnosis.Method: Twenty-four subjects were recruited for this study. Twelve subjects with low back pain who were diagnosed with sacralized fifth lumbar spine were selected as the experimental group, and twelve healthy subjects were selected as the control group. The age, body height, and weight of the patients in the two groups were compared. Measurements of lumbar range of motion were used as the pretest …

The Associated Factors In Home-Based Rehabilitation Utilization Of Stroke Patients, Shu-Chuan Wu, Yu-Chia Chang, Te-Feng Yeh, Ting-Yu Chang, Wei-Chaio Lu, Chien-Tsai Huang, Chuan-Hsiung Lin, Li-Ling Huang

Rehabilitation Practice and Science

This study explores the factors correlated to the use of home-based rehabilitation services by stroke patients for whom care is provided according to the state policy pertaining to the 10-year long-term care plan.During July 2008–June 2010, data were collected from 759 stroke patients by using a long-term care management service evaluation form. These patients had initially applied for services at the long-term care centers of the Bureau of Public Health in Taichung County. Of these, 119(15.7%) eventually used home-based rehabilitation services. Using the Andersen health behavior model, we investigated how various factors influence the use of home-based rehabilitation services by …

(R)-Β-Lysine Modified Elongation Factor P Functions In Translation Elongation, Tammy J. Bullwinkle, S. Betty Zou, Andrei Rajkovic, Steven J. Hersch, Sara Elgamal, Nathaniel Robinson, David Smil, Yuri Bolshan, William Wiley Navarre, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Post-translational modification of bacterial elongation factor P (EF-P) with (R)-β-lysine at a conserved lysine residue activates the protein in vivo and increases puromycin reactivity of the ribosome in vitro. The additional hydroxylation of EF-P at the same lysine residue by the YfcM protein has also recently been described. The roles of modified and unmodified EF-P during different steps in translation, and how this correlates to its physiological role in the cell, have recently been linked to the synthesis of polyproline stretches in proteins. Polysome analysis indicated that EF-P functions in translation elongation, rather than initiation as proposed previously. This was …

Quantitative Investigation Of Effect Of Age And Bolus Characteristics On Laryngeal Movement During Swallowing, Tsui-Fen Yang, Rai-Chi Chan, Shinn-Shing Lee, Jia-Chi Wang

Rehabilitation Practice and Science

Objective: The purpose of this study was to investigate the physiologic changes of swallowing along with normal aging, and to study the influences on swallowing of gender and food consistency.Methods: One hundred adult men and women aged 24 to 80 participated. Each subject underwent a swallowing evaluation, in which a surface transducer was placed on the neck to detect laryngeal movement when they performed a dry swallow and wet swallow for different food consistencies. Main outcome measures included mean onset, mean amplitude and mean duration of the deglutition wave.Results: In this study, the onset of the dry swallow deglutition wave …

Quantitative Evaluation Of Motor Control Of Upper Limbs After Neuro-Robot Rehabilitation, Shu-Min Chen, Yu-Chia Tsai, Ming-Shaung Ju, Bing-Cheng Kung

Rehabilitation Practice and Science

Function of the upper limbs is crucial in daily activities. Motor recovery of upper limbs after stroke is slower and less complete than of lower limbs. During the recovery period, abnormal synergies always disturb daily life activity. Various therapeutic techniques have been developed to improve the function of upper limbs after stroke, such as the neuro-rehabilitation robot, which was developed in recent years and shows numerous positive outcomes for upper-limb facilitation after stroke. For the evaluation of motor recovery after stroke, Brunnstrom stages and the Modified Ashworth scale are commonly used and convenient. However, both depend heavily on the evaluator …

Phase I Cardiac Rehabilitation Among Patients With Acute St-Elevation Myocardial Infarction, Yun-Yi Lin, Chi-Ming Lee, Ching Lan, Ssu-Yuan Chen, Shu-Fang Hsiao, Pei-Chen Lu, Pei-Chin Suen, Mei-Yu Chen, Yen-Ho Wang, Jin-Shin Lai

Rehabilitation Practice and Science

Background and Purpose: Phase I cardiac rehabilitation (CR) programs have been shown to be effective and beneficial for patients with acute myocardial infarction. However, only few studies have evaluated the determinants of treatment frequency in phase I CR. The aim of this study was to investigate the current administration of phase I CR for patients who have acute ST-elevation myocardial infarction (STEMI) and have undergone percutaneous coronary intervention (PCI) in a medical center in Taiwan.Methods: We retrospectively reviewarticleed the medical records of 30 patients with STEMI who were admitted to the coronary care unit (CCU) between December 2009 and March …

Kabuki Syndrome: A Casereport, Hsin-I Wu, Shih-Jay Tzeng, Chang-Hsien Yu

Rehabilitation Practice and Science

Kabuki syndrome (KS) is a rare congenital disorder characterized by distinctive facial features, skeletal anomalies, dermatoglyphic abnormalities, mild to moderate mental retardation and postnatal growth deficiency. Although first reported in Japan, it has been recognized in other parts of the world. The present case with KS is a five-year-old boy. Because of his pervasive developmental delay, he received care in rehabilitation programs hosted by our hospital. He had prominent ears, depressed nasal tip, long palpebral fissures, and long eyelashes. The common features of KS in him are postnatal growth retardation, moderate mental retardation, scoliosis, cleft palate, flat feet, fifth finger …

Torticollis As An Initial Sign Of Septo-Optic Dysplasia: A Casereport, Pei-Chi Hsiao, Yu-Kun Tsui, Li-Chen Tung, Shu-Han Yang, Willy Chou

Rehabilitation Practice and Science

Torticollis is characterized by a lateral head tilt with chin rotation toward the opposite side. Congenital muscular torticollis remains the most common etiology in infancy. However, many different conditions, including anomaly of central nervous system, can cause the condition. The differential diagnosis is therefore important.An 8-month-old baby girl presented to our rehabilitation clinic with torticollis since 3 months of age. Her body weight, height and general appearance were normal at birth. At examination, horizontal nystagmus was noted while she gazed toward the right side, as well as head tilting to the left and chin pointing at the opposite side. There …

The Effect Of Vibration On Shoulder Strength And Flexibility Of Volleyball Athletes, Yun-Tai Lin, Hsing-Kuo Wang, Shao-Yi Liu, Tzyy-Yuang Shiang

Rehabilitation Practice and Science

Purpose: The aim of this study was to compare the effect of vibration and static stretching on shoulder strength and flexibility of volleyball athletes.Methods: Fifteen female volleyball athletes were randomly divided into 2 groups: 8 athletes who received vibration training were allocated to the vibration-stretching group and 7 athletes who did not receive vibration training comprised the static-stretching group. During a 6-week training period, pre- and post-tests were conducted using a Biodex system to evaluate the shoulder flexibility and the maximal isokinetic torque of the biceps and the anterior deltoid muscle.Results: After 4 weeks of training, the maximal isokinetic torque …

Successfully Climbing The "Stairs": Surmounting Failed Translation Of Experimental Ischemic Stroke Treatments, Michael Kahle, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …

Preparasi, Karakterisasi Dan Evaluasi Pelepasan Obat Dari Beads Kalsium Alginat Deksametason Dengan Metode Gelasi Ionik, Christye Aulia, Joshita Djajadisastra

Majalah Ilmu Kefarmasian

Inflammatory Bowel Disease (IBD) is a disease of inflammation in the colon. Targeted delivery systems for the treatment of IBD is designed to increase the drug concentration in the local tissue. Dexamethasone is a drug having anti-inflammatory and antifibrosis effects which is used to repair scar tissue arising from postoperative IBD. This research purpose to create calciumalginate beads dexamethasone to be released only in the colon. Beads were made by using sodium-alginate and Ca2+ as crosslinker by ionic gelation method, with ratio between sodium alginate-dexamethasone (3:1). A concentration of solution sodium alginate 3 % b/v with variation concentration of crosslinker …

Medical School Watercooler Newsletter - December 30, 2012, Lindsey Lyle

Watercooler Newsletter

This is the December 30, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Physicians Named Best Doctors
• USA College of Medicine Mourns Loss of Dr. Susan Gibson

Regulation Of The Mouse And Human Β-Globin Genes By Krüppel Like Transcription Factors Klf1 And Klf2, Yousef N. Alhashem

Theses and Dissertations

Krüppel-like factors KLF1 and KLF2 are closely related transcription factors with three zinc finger domains in their carboxy-termini. KLF1 (erythroid Krüppel-like factor, or EKLF) plays essential roles in embryonic and adult erythropoiesis. KLF2 is a positive regulator of the mouse and human embryonic β- globin genes. KLF1 and KLF2 have overlapping roles in embryonic erythropoiesis, as demonstrated using single and double knockout (KO) mouse models. Ablation of the KLF1 or KLF2 gene causes embryonic lethality, and double KO embryos are more anemic and die sooner than either single KO. We have shown that KLF1 and KLF2 positively regulate the human …

Commentary By Williams, Kristine Williams

Kristine N. Williams

No abstract provided.

Enhancing Communication With Older Adults: Overcoming Elderspeak, Kristine Williams, S Kemper, M Hummert

Kristine N. Williams

No abstract provided.

Elderspeak: Impact On Geriatric Care, Kristine Williams

Kristine N. Williams

No abstract provided.

A Book Review Of De Bot And Makoni, Language And Aging In Multilingual Contexts, Kristine Williams

Kristine N. Williams

No abstract provided.

Gerontological Nursing, Kristine Williams

Kristine N. Williams

No abstract provided.

Reasoning Exercises In Assisted Living (Real) Pilot Study, Kristine Williams

Kristine N. Williams

No abstract provided.

A Case Study Of Resistiveness To Care And Elderspeak, Jacqueline Cunningham, Kristine Williams

Kristine N. Williams

Resistiveness to care (RTC) by persons with dementia significantly adds to subjective and objective burden for caregivers and may be triggered by environmental factors, including communication. This case study evaluated behavioral responses of a nursing home resident with dementia to nursing staff use of elderspeak communication (infantilizing speech). Four videotaped staff-resident interactions that were previously recorded were coded for staff elderspeak communication and resident RTC. Total elderspeak scores (M = 29.5, SD = 25.74) and RTC scores (M = 8.75, SD = 13.79) were correlated r = 0.93, p = .03. This preliminary single-subject observational study suggests a …

Exploring Interventions To Reduce Cognitive Decline In Aging, Kristine Williams

Kristine N. Williams

No abstract provided.

Elderspeak In Institutional Care Of Older Adults, Kristine Williams

Kristine N. Williams

No abstract provided.

Measuring The Person-Centeredness Of Caregivers Working With Nursing Home Residents With Dementia, Kristine Williams

Kristine N. Williams

No abstract provided.

Medicine In The Americas, Kristine A. Petre Mls, Cm, Ahip

Kristine A Petre, MLS, CM, AHIP

Medicine in the Americas is a freely available, searchable collection of historical medical Americana. The collection is part of the Digital Collections repository at the National Library of Medicine’s online digital archives. This review discusses the contents, searching functions, and additional features available in the collection.

Circularized Synthetic Oligodeoxynucleotides Serve As Promoterless Rna Polymerase Iii Templates For Small Rna Generation In Human Cells, Christine I. Seidl, Lodoe Lama, Kevin Ryan

Publications and Research

Synthetic RNA formulations and viral vectors are the two main approaches for delivering small therapeutic RNA to human cells. Here we report findings supporting an alternative strategy in which an endogenous human RNA polymerase (RNAP) is harnessed to make RNA hairpin-containing small RNA from synthetic single-stranded DNA oligonucleotides. We report that circularizing a DNA template strand encoding a pre-microRNA hairpin mimic can trigger its circumtranscription by human RNAP III in vitro and in human cells. Sequence and secondary structure preferences that appear to promote productive transcription are described. The circular topology of the template is required for productive transcription, at …