Medicine and Health Sciences Commons^™

Jefferson Alumni Bulletin – Volume 50, Number 1, December 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 50, Number 1, December 2000 Helping troubled teens to heal, page 4 Where does Jefferson go next? Asks Dr. Gonnella, page 8 Grave Robbers and Jefferson’s anatomist-Surgeons in the 19th century, page 10 New professorship in health policy, a rare field, page 16 Alumni Deans and department chairs: Jeffersonians at the helm at other Schools, page 23 A surgeon puts his heart into service abroad, page 26

Technology Evaluation: Pro-542, Progenics Pharmaceuticals Inc., Muhammad Mukhtar, Zahida Parveen, Roger J Pomerantz

Department of Medicine Faculty Papers

Progenics's rCD4-IgG2 (PRO-542) is a recombinant fusion protein, which has been developed using the company's Universal Antiviral Binding (UnAB) technology, and is in phase I/II clinical trials for the treatment of human immunodeficiency virus type I (HIV-1) infection [273391]. At the beginning of 1997, Progenics received a Phase II Small Business Innovation Research Program (SBIR) grant from the National Institute of Allergy and Infectious diseases (NIAID) to fund the development of PRO-542 [236048]. A further grant of $2.7 million was awarded in August 1998 for the clinical evaluation of PRO-542 and other anti-HIV therapies [294200]. Progenics is collaborating with the …

Global Connections In A Changing World: Romanian And U.S. Nurses Unite, Mary G. Schaal, Molly A. Rose, Ann Doherty, Adriana Vilan

College of Nursing Faculty Papers & Presentations

This article describes an international, interdisciplinary, university partnership project to collaborate with health professionals in the city of Cluj-Napoca, Transylvania, Romania, to improve the health status of Romanian workers. Academic and service-based public health nurses from the United States used the model of community competence in outlining the nursing aspect of the project. This model guided the assessment, objectives, collaborative activities, and the outcome evaluation of the project. The dimensions of the model (e.g., commitment, self-other awareness, articulateness, conflict accommodation, management of relations with larger society, and leadership) were used within the context of the political and social environment of …

Nurses Alumni Association Bulletin, Fall 2000, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers, Sally H. Wagner, John W. Wagner

Nursing Alumni Bulletins

2000 - 2001 Meeting Date Calendar

2001 Annual Luncheon & Meeting Notice

2000 Fall Social

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

Resume of Minutes

Alumni Office News

Committee Reports

• Nurses Relief Trust Fund
• Clara Melville - Adele Lewis Scholarship Fund
• Satellite Report - Harrisburg Satellite
• The Fall Luncheon
• Nominating
• Alumni Bulletin
• Development

News about our Graduates

Presentation on Leadership -Tribute to Janet C. Hindson

Thank You Patient Assimilators

Third Janet C. Hindson Award

Janet C. Hindson Award Qualifications

Pinning Ceremony

Jeff HOPE

Keepsakes

Memoirs

Happy Birthday

50th Anniversary Class

Luncheon Photos

Kodak Moment

In …

Role Perceptions Of Occupational Therapists Providing Support And Education For Caregivers Of Persons With Dementia., Susan Toth-Cohen

Department of Occupational Therapy Faculty Papers

OBJECTIVE: This pilot study explored occupational therapists' perceptions of their roles as interventionists providing education and support for caregivers of persons with dementia. The intervention was provided in caregivers' homes as part of a larger funded study.

METHOD: Interviews were conducted with four occupational therapists to elicit their reflections on practice and their views on occupational therapy services on the basis of their experiences providing support and education for caregivers in the funded study.

RESULTS: Key themes consisted of the contrasts between the therapists' roles in the study and their customary practices and the professional and personal impact of their …

Jefferson Alumni Bulletin – Volume Xlix, Number 4, September 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 4, September 2000 Next board chair is Douglas MacMaster, Esg, page 8 Tom Nasca’75 is honored with portrait – and new post, page 8 West coast transplant expert heads surgery, page 9 Alumni awards honor researchers in AIDS and pediatric immunology, page 11 The choir at 30: in perfect health, page 13 Alumni-related giving nears $10 million, page 16 Two medical schools select Jeff Alumni as their top executives, page 41 Two schools establish professorships honoring Jeffersonians, page 43

Evaluations Of The Effectiveness Of A Web-Based Graduate Epidemiology Course, Molly A. Rose, Anthony J. Frisby, Michael D. Hamlin, Susan S. Jones

College of Nursing Faculty Papers & Presentations

An online epidemiology course was developed, implemented, and evaluated for graduate nursing students through the collaborative efforts of nursing faculty and information, education, and instructional design staff of the library at a health sciences university. This epidemiology course is a core curriculum course for graduate nursing students. The course was piloted with 14 students (one student in Romania); the initial online offering ran concurrently with a traditional classroom section. Extensive evaluation data were collected and analyzed to compare the effectiveness of the classroom and distance-learning formats. Areas of evaluation included objective measures, such as midterm and final examination scores and …

Development And Validation Of A Questionnaire To Evaluate Patient Satisfaction With Diabetes Disease Management, Lisa E. Paddock, J J. Veloski, Mary Lou Chatterton, Felicia O. Gevirtz, David B. Nash

CRMEHC Faculty Papers

OBJECTIVE: To develop a reliable and valid questionnaire to measure patient satisfaction with diabetes disease management programs.

RESEARCH DESIGN AND METHODS: Questions related to structure, process, and outcomes were categorized into 14 domains defining the essential elements of diabetes disease management. Health professionals confirmed the content validity. Face validity was established by a patient focus group. The questionnaire was mailed to 711 patients with diabetes who participated in a disease management program. To reduce the number of questionnaire items, a principal components analysis was performed using a varimax rotation. The Scree test was used to select significant components. To further …

Thomas Jefferson University 2000 Annual Report, Douglas J. Macmaster, Jack Farber, Paul C. Brucker

Thomas Jefferson University Administrative Documents and Reports

No abstract provided.

The Review - Summer 2000

Jefferson Review

IN THIS ISSUE

• 1 - Message From The Dean
• 2 - Laboratory Sciences Now Has More Options Than Any Other LS Program In The Country
• 2 - Nursing Expands Master’s Speciality Tracks
• 2 - Online And CD-ROM Courses: The Wave Of The Future?
• 3 - Nuclear Medicine Technology Enhances Image Of DI Department
• 3 - Foundation Doubles Support Of Scholarship Fund At CHP
• 4 - Alumni Relations Office Update: Rockin’ Good Times 5 Commencement 2000
• 5 - Byrne Recognized For Significant Contributions To College And Community
• 6 - Message From Alumni President
• 7 - Alumni Update
• 8 - College Notes

Long-Term Prevention Of Renal Insufficiency, Excess Matrix Gene Expression, And Glomerular Mesangial Matrix Expansion By Treatment With Monoclonal Antitransforming Growth Factor-Ss Antibody In Db/Db Diabetic Mice , Fuad N. Ziyadeh, Brenda B. Hoffman, Dong Cheol Han, M. Carmen Iglesias-De La Cruz, Soon Won Hong, Motohide Isono, Sheldon Chen, Tracy A. Mcgowan, Kumar Sharma

Department of Medicine Faculty Papers

Emerging evidence suggests that transforming growth factor-(TGF-β) is an important mediator of diabetic nephropathy. We showed previously that short-term treatment with a neutralizing monoclonal anti-TGF-antibody (αT) in streptozotocin-diabetic mice prevents early changes of renal hypertrophy and increased matrix mRNA. To establish that overactivity of the renal TGF-system mediates the functional and structural changes of the more advanced stages of nephropathy, we tested whether chronic administration of αT prevents renal insufficiency and glomerulosclerosis in the db/db mouse, model of type 2 diabetes that develops overt nephropathy. Diabetic db/db mice and nondiabetic db/m littermates were treated intraperitoneally with α or control IgG, …

Jefferson Alumni Bulletin – Volume Xlix, Number 3, June 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 3, June 2000 Synergy of clinical skills and behavioral medicine, page 4 African-American students at Jefferson, page 8 Competency based training: a new paradigm?, page 15 An answer on acute respiratory distress syndrome, page 17 FHIT gene implicated in many types of tumors, page 17 Pinpointing genetics of hereditary colorectal cancer, page 19 Phil Marone’57: associate Dean for Alumni relations, page 25

Evaluating The Sensitivity Of The Nanostrong Ncounter® Analysis System To Determine Gene Expression Changes Associated With Chemotherapy Treatment, Katerina Dukleska, Md, Christopher W. Schultz, Bs, Mahsa Zarei, Phd, David Mckeown, Md, Charles J. Yeo, Md, Jonathan Brody, Phd, Jordan M. Winter, Md

Department of Surgery Posters

Introduction

• Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease with a 5-year survival of 8% for all stages combined (Siegel RL et al.). Currently, it’s the third leading cause of cancer-related deaths in the United States and by 2020 it is projected to become the second leading cause (Rahib L, et al).
• The poor prognosis in PDA is in part due to the limited therapies that are currently available.
• This highlights the importance of high-throughput technologies for gene expression analyses and drug screens.
• A recently developed NanoString Technologies nCounter® analysis system, an example of high-throughput technology, utilizes a color-coded barcode …

2000 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Membrane Cholesterol Content Modulates Activation Of Volume-Regulated Anion Current In Bovine Endothelial Cells., I Levitan, A E Christian, T N Tulenko, G H Rothblat

Department of Biochemistry and Molecular Biology Faculty Papers

Activation of volume-regulated anion current (VRAC) plays a key role in the maintenance of cellular volume homeostasis. The mechanisms, however, that regulate VRAC activity are not fully understood. We have examined whether VRAC activation is modulated by the cholesterol content of the membrane bilayer. The cholesterol content of bovine aortic endothelial cells was increased by two independent methods: (a) exposure to a methyl-beta-cyclodextrin saturated with cholesterol, or (b) exposure to cholesterol-enriched lipid dispersions. Enrichment of bovine aortic endothelial cells with cholesterol resulted in a suppression of VRAC activation in response to a mild osmotic gradient, but not to a strong …

Ubinuclein, A Novel Nuclear Protein Interacting With Cellular And Viral Transcription Factors., S Aho, M Buisson, T Pajunen, Y W Ryoo, J F Giot, H Gruffat, A Sergeant, Jouni Uitto

Department of Dermatology and Cutaneous Biology Faculty Papers

The major target tissues for Epstein-Barr virus (EBV) infection are B lymphocytes and epithelial cells of the oropharyngeal zone. The product of the EBV BZLF1 early gene, EB1, a member of the basic leucine-zipper family of transcription factors, interacts with both viral and cellular promoters and transcription factors, modulating the reactivation of latent EBV infection. Here, we characterize a novel cellular protein interacting with the basic domains of EB1 and c-Jun, and competing of their binding to the AP1 consensus site. The transcript is present in a wide variety of human adult, fetal, and tumor tissues, and the protein is …

Jefferson Alumni Bulletin – Volume Xlix, Number 2, March 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 2, March 2000 Integrative medicine: Broadening the mainstream, page 4 Orthopaedics circa 2013, page 8 Doctoring a sickly system: medical errors, page 10 The two logos: university and health system, page 12 University expands neuroscience programs; Wills eye to construct sophisticated new building, page 14 Jeff hosts international medical students program, page 17 Rb2 gene therapy could shrink lung tumors, and may improve angioplasty, page 19 Gene repair could fix various inherited diseases, page 20 Alumni affairs: Events, notices, dates to remember, page 22

Single-Channel Properties In Endoplasmic Reticulum Membrane Of Recombinant Type 3 Inositol Trisphosphate Receptor., D O Mak, S Mcbride, V Raghuram, Y Yue, Suresh K. Joseph, J K Foskett

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is an intracellular Ca(2+)-release channel localized in endoplasmic reticulum (ER) with a central role in complex Ca(2+) signaling in most cell types. A family of InsP(3)Rs encoded by several genes has been identified with different primary sequences, subcellular locations, variable ratios of expression, and heteromultimer formation. This diversity suggests that cells require distinct InsP(3)Rs, but the functional correlates of this diversity are largely unknown. Lacking are single-channel recordings of the recombinant type 3 receptor (InsP(3)R-3), a widely expressed isoform also implicated in plasma membrane Ca(2+) influx and apoptosis. Here, we describe functional expression and single-channel …

The Pl(A2) Polymorphism Of Integrin Beta(3) Enhances Outside-In Signaling And Adhesive Functions., K Vinod Vijayan, Pascal J. Goldschmidt-Clermont, Christine Roos, Paul F. Bray

Cardeza Foundation for Hematologic Research

Genetic factors are believed to influence the development of arterial thromboses. Because integrin alpha(IIb)beta(3) plays a crucial role in thrombus formation, we analyzed receptor adhesive properties using Chinese hamster ovary and human kidney embryonal 293 cells overexpressing the Pl(A1) or Pl(A2) polymorphic forms of alpha(IIb)beta(3). Soluble fibrinogen binding was no different between Pl(A1) and Pl(A2) cells, either in a resting state or when alpha(IIb)beta(3) was activated with anti-LIBS6. Pl(A1) and Pl(A2) cells bound equivalently to immobilized fibronectin. In contrast, significantly more Pl(A2) cells bound to immobilized fibrinogen in an alpha(IIb)beta(3)-dependent manner than did Pl(A1) cells. Disruption of the actin cytoskeleton …

Department Of Radiology-Annual Executive Summary Report-July 1, 1999 To June 30, 2000, David Levin, M.D.

Department of Radiology Administrative Documents and Reports

90 page Department of Radiology Annual Executive Summary Report, July 1, 1999 to June 30, 2000, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

A Cultivated Taste For Yeast., C Brenner

Kimmel Cancer Center Faculty Papers

The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define protein function, to define drug targets, and to discover and characterize drugs.