Medicine and Health Sciences Commons^™

Cartilage Regeneration On A Large Articular Surface Facilitated By Stress Shielding, Charles L. Mcdowell, Jennifer S. Wayne, Robert Tuten, Hunter H. Mcguire Jr.

Virginia Journal of Science

An animal model for the study of articular cartilage regeneration in-vivo facilitated by stress-shielding is introduced. The object of the model is to test the hypothesis that some form of cartilaginous tissue will grow upon a large joint surface in vivo with the joint in normal motion. The model utilizes the known capability of immature cells to differentiate. The source of cells is bleeding subchondral bone. In addition, the model provides a mechanically shielded environment in which cell differentiation and maturation can occur. The study showed that a substantial amount of tissue will grow in the animal model only when …

A Study On The Effects Of The N-Terminal Amino Acid Sequence On The Activation Of Human T-Cell Leukemia Virus Type 1 Protease, Hidayah Muhammad Kendall

Chemistry & Biochemistry Theses & Dissertations

Human T-cell leukemia virus type 1 (HTL V-1) is dependent upon the enzymatic activity of its protease for maturation. Maturation of the protease is facilitated by cleavage of specific amino acid residues, followed by dimerization. The effects of the amino acid sequence located N-terminally to the cleavage site on the ability of the protease to become active were the focus of the current study. These amino acid sequences were contributed by the plasmid vector into which the protease gene was inserted.

Surface probability analyses (SPAs) of the vectors, as well as for native sequences which produce the mature protease and …

African American Community Mental Health Center Service Utilization: A Test Of The Cultural Compatibility Hypothesis, Alicia Michelle Marsh

Psychology Theses & Dissertations

This exploratory study examined whether community mental health centers (CMHCs) in Virginia that had services evaluated as being more compatible with the cultural needs of African Americans attracted a higher percentage of adult African American service users from their catchment areas than CMHCs which were evaluated as being less culturally compatible. The cultural compatibility of 36 CMHCs was assessed via a telephone interview with their clinical directors using a modified version of the Cultural Competence Self-Assessment Questionnaire: Administrative Version (Mason, J., 1995). This study did not find a correlation between CMHCs' cultural compatibility and their success at attracting African American …

Factors Which Affect Post-Hospital Resource Use And Patient Health Outcomes Among Taiwanese Older Adults, Chouh-Jiaun Lin

Health Services Research Dissertations

The purpose of this study was to explore relationships among population characteristics, patient post-hospital resource use and patient health outcomes in terms of the Andersen health behavioral model. An additional purpose of this study was to examine a discharge planning screening instrument used in a large urban hospital in Taiwan to determine if it predicts resource use and patient outcomes. A longitudinal research design was adopted for this study. Data were collected from the general medicine departments of an 800-bed university teaching hospital. Out of 109 patients who were interviewed, 78 participants qualified (participation rate = 71.6%).

The majority of …

An Exploratory Study Of The Correlates Of Drug Use Among Juveniles: Analysis Of Regional Variations In The United States, Denise D. Nation

Sociology & Criminal Justice Theses & Dissertations

Research on substance use and abuse has increased exponentially over the past twenty-five years. However, research focusing on regional differences in drug use seems to be very limited. The purpose of this study is to examine the correlates of drug use among juveniles in the four major geographic regions of the United States: the Northeast, the North Central, the South and the West. Here, drug use is defined in terms of alcohol and marijuana use for the age group 12-19. Four research hypotheses are proposed. The 1996 National Household Survey on Drug Abuse data was used to assess and analyze …

Home Health Nurses: Are They Satisfied With Their Work Environment, Said Abu Salem

Nursing Theses & Dissertations

Objectives. This study addressed the questions, (1) To what degree are home health nurses satisfied in their job? (2) What variable ranks as the most important for home health nurses' satisfaction? and, (3) Is there a difference between job satisfaction of full time employment, part time, and per diem home health nurses?

Methods. The data were collected from six home health agencies in the Hampton Roads Area resulting in a sample of (N = 72). The McCloskey and Mueller Satisfaction Scale developed in 1990 (MMSS) was used to measure home health nurses' satisfaction.

Results. The home health …

The Effects Of Group Counseling On The Self-Esteem, Anxiety, And Behavior Of Children With Deployed Parents, Nancy Taylor Mitchum

Psychology Theses & Dissertations

The purpose of this study was to examine the effectiveness of a six-session group counseling intervention for children who had a parent experiencing military-induced deployment. Participants were 65 children (30 boys, 35 girls) of enlisted military personnel attending elementary schools near the Norfolk Naval Base. Elementary school counselors facilitated the counseling groups.

An experimental/control group pretest-posttest design was employed. Independent variables were the child's participation in the Children of Deployed Parents-Group/control group, child gender and age. Dependent variables were self-esteem, anxiety, and behavior as measured by the Coopersmith Self-Esteem Inventory (SEI), the State-Trait Anxiety Inventory for Children (STAIC), the Child …

Identification And Characterization Of Determinants Of Head And Neck Tumor Cell Invasion, Yangguan Wu

Theses and Dissertations in Biomedical Sciences

Head and neck squamous cell carcinoma (HNSCC) is a common malignant disease with poor prognosis. The majority of patients die from local invasion or lymphatic metastasis. The mechanism(s) underlining the invasiveness of HNSCC are poorly understood. Utilizing a panel of HNSCC cell lines previously established in our laboratory, we tested the application and relevance of the three-step hypothesis of tumor invasion to HNSCC and investigated the mechanism(s) pertaining to the regulation of each step in the invasive process. Data presented in this thesis demonstrated that tumor cell invasion in HNSCC is a complex process involving three repeated sequential steps: adhesion, …

Generation Of Human Chorionic Gonadotropin Beta Subunit Specific Monoclonal Antibody Using A Synthetic Peptide, Zhe Huang

Chemistry & Biochemistry Theses & Dissertations

Human chorionic gonadotropin (hCG) is well known for early immunological and bioassay tests for early detection of pregnancy. Since the hormone specific beta subunit confers unique biological and immunological specificity to hCG, immunochemical measurement of hCG has achieved greater specificity and sensitivity in recent years by using either the beta subunit as an immunogen or a partially reduced beta subunit polypeptide chain. However, antiserum raised against the entire hCG beta subunit usually cross-reacts to some extent with human luteinizing hormone (hLH). hCG has been found to be present in the extract of tumors and minute quantities of hCG are synthesized …

An Extracellular Protein Produced By Staphylococcus Hominis Strain Αm With Antimicrobial Activity Against Mycobacterium Spp, Sandra May Jacobsen

Biological Sciences Theses & Dissertations

The inhibitory activity exhibited by Staphylococcus hominis strain αM toward Mycobacterium species was examined. These studies included determining the conditions that maximized inhibitory agent production, analyzing characteristics of the agent, determining the time of agent production, ascertaining plasmid possession and the role of plasmids in the production of this inhibitory agent, and ascertaining the antimicrobial activity of other strains of S. hominis. On solid and in liquid media, S. hominis strain αM exhibits a unique inhibitory activity toward Mycobacterium species that is not demonstrated by Staphylococcus epidermidis or other S. hominis strains. Maximum agent production and recovery was …

The Accuracy Of Nitrous Oxide Passive Dosimeters As Compared With An Infra-Red Spectrographic Reference Method, Susan Allen

Community & Environmental Health Theses & Dissertations

Nitrous oxide is a gas often used in dental, surgical and veterinary operations as an anesthetic agent. Employees stationed in proximity of fugitive gas emissions may potentially suffer adverse health effects from chronic exposure to this agent. Passive dosimeters can be worn in the breathing zone of potentially affected personnel during exposure periods, then later analyzed to quantify nitrous oxide exposure. This study sought to establish the accuracy of several commercially available passive monitoring devices for nitrous oxide by comparison against an infra-red spectrophotometric reference method.

Insulinlike Growth Factor 1- And 2-Augmented Collagen Gel Repair Of Facial Osseous Defects, James S. Toung, Roy C. Ogle, Raymond F. Morgan, William H. Lindsey

Medical Diagnostics & Translational Sciences Faculty Publications

BACKGROUND: Defects of the facial bone structure are common problems for the facial plastic surgeon. Native type 1 collagen gels (T1CGs) have been shown to mediate repair of facial critical-size defects in rat models.

OBJECTIVE: To evaluate the efficacy of T1CG augmented with insulinlike growth factor (IGF) 1, IGF-2, and a combination of IGF-1 and IGF-2 on the repair of facial critical-size defects in a rodent model.

METHODS: Twenty-four retired male breeder Sprague-Dawley rats were divided into 4 groups of 6 animals. Facial critical-size defects were created by removing the nasalis bones with a bone-cutting drill. Defects were treated with …

A Study Of The Knowledge And Attitudes Of Physicians Toward Victims Of Spouse Abuse, Ramani N. Garimella

Health Services Research Dissertations

The purpose of this study is to measure the knowledge and attitudes of physicians toward victims of spouse abuse. All 150 practitioners in the specialities of emergency medicine, family medicine, obstetrics-gynecology and psychiatry, in a large area general hospital are included in the sampling frame; 76 responded (RR = 51%). Knowledge and attitudes were measured using the Physician Survey on Spouse Abuse. Rosenberg's Tripartite Model of Attitude formed the theoretical basis for this study. Participants were 72% male, 90% white, 88% currently married, with a mean age of 44 years (SD = 7.99). Mean years in practice was 14.61 (SD …

Sexual Harassment In The Virginia Dental Hygiene Profession, Anne Pennington

Dental Hygiene Theses & Dissertations

No abstract provided.

Cultural Adaptability Of Students Attending Culturally Diverse And Non-Culturally Diverse Dental Hygiene Programs, Katrina White Magee

Dental Hygiene Theses & Dissertations

The purpose of this descriptive investigation was to determine the cultural adaptability of students attending culturally diverse and nonculturally diverse dental hygiene programs throughout the U.S. The dental hygiene schools were identified according to their ethnic diversity as reported by the ADA Commission on Dental Accreditation in the 1996-1997 Survey of Dental Hygiene Education Programs. Once the programs were identified, a random sample was taken from the diverse and non-diverse dental hygiene programs. A 50-item inventory, the Cross-Cultural Adaptability Inventory (CCAI), was mailed to the participating dental hygiene programs. One-hundred eighty-eight students represented U.S. dental hygiene programs in the …

Medicaid Fraud: Medical Students' And Physicians' Attitudes And Perceptions, Kristin M. Byars

Sociology & Criminal Justice Theses & Dissertations

The purpose of this study is to determine the attitudes and perceptions of medical students and physicians concerning Medicaid fraud. The primary tool was an anonymous survey distributed to both medical students and physicians in the Hampton Roads area. Previous research suggests that physicians would be more likely to view Medicaid fraud as less serious and less justifiable than medical students would. Since little research looks specifically at the attitudes and perceptions of medical students and physicians two theories, Differential Association and the Theory of Organizational Misconduct, were used because they best fit the research already out there. The analyses …

Transgenerational Attachment, Life Stress, And The Development Of Disruptive Behavior In Preschool Children, Mary Jane Call

Psychology Theses & Dissertations

While a great deal of research focuses on representations of attachment, behavioral disorders, and life stress separately, research integrating these concepts has just recently begun (DeKlyen, 1996). The current study focuses on the links between transgenerational attachment, life stress, maternal psychopathology, and the development of behavior problems in preschool boys. Participants included 52 mothers of preschool boys (Mean Age = 56 months) who attended private preschool (N = 23) or a Head Start Program (N = 29). Participants completed a battery of assessment instruments including the Attachment Style Inventory (ASI) (Sperling & Berman, 1991), the Q-Set (Waters & Deane, 1985), …

A Cohort Study To Determine The Epidemiology Of Estuary-Associated Syndrome, Elizabeth Turf, Lily Ingsrisawang, Megan Turf, J.D. Ball, Michael Stutts, John Taylor, Suzanne Jenkins

Virginia Journal of Science

From the Introduction:

Estuary-Associated Syndrome (EAS) is the name given to a potential illness characterized primarily by changes in an individual's cognitive abilities, including acute onset of memory loss or the sudden inability to solve simple problems. Other possible signs of illness include respiratory symptoms, skin rash, or gastrointestinal distress. This illness appears to arise following exposure to toxin produced by Pfiesteria piscicida, or other toxic dinoflagellates, that resides in estuary waters.

….

In order to learn more about this possible syndrome and to determine if a causal relationship exists between association to waters containing Pfiesteria or other toxic …

Alcoholism In Third-World Literature: Buchi Emecheta, Athol Fugard, And Anita Desai, Nancy Topping Bazin

English Faculty Publications

ALCOHOLISM IS A MAJOR PROBLEM IN MOST COUNTRIES; yet in only a few countries has it become a social issue and a topic to be discussed seriously and openly. Within universities, substantive knowledge about alcoholism appears co be confined mainly to medical and sociology departments. Certainly, alcoholism is a neglected topic in literary studies. Almost all critics and teachers of literature are blind to its impact on a surprising number of characters and their relationships- even when alcoholism is the primary cause of suffering. Unless a teacher is a recovering alcoholic or knows well someone who is, ignorance or self-censorship …

Classification Of Participants Into Two Health Resource Utilization Groups By The Health Enrollment Assessment Review (Hear) Survey, Jody W. Donehoo

Health Services Research Dissertations

The study examined the ability of the Health Enrollment Assessment Review (HEAR) survey instrument to classify participants into one of two groups according to utilization of health resources anticipated in the following year. Developed by the U.S. Air Force, the HEAR survey is used worldwide by the Department of Defense for enrollees in TRICARE Prime, the military's adaptation of the HMO model of managed care. Individual HEAR reports are prepared for survey participants and their primary care providers in TRICARE Prime. Although it is currently administered worldwide to a majority of the 8.4 million health care beneficiaries of the Department …

Field Sampling And Necropsy Examination Of Fish, A. S. Kane, A. Baya, R. Reimschuessel, K. M. St. Pé, C. A. Poukish, C. P. Driscoll

Virginia Journal of Science

This paper presents an overview of observational and fish sampling tech­niques for investigating fish lesions, morbidity and mortality. These sam­pling techniques and investigations are much like detective work and require attention to detail, common sense, technical proficiency and experience. To solve the mystery of a fish kill, the investigator must use available evidence and clues to piece together a series of events that often have long since passed. The cause of these field events may be chemical, biological or physical; more often, it is some combination of these. An initial categorization approach may be used to reduce the great number …

Virginia's Pfiesteria Monitoring Program: Water Quality, Roger K. Everton, Wick T. Harlan, Jonathan W. Priest, Mark S. Alling

Virginia Journal of Science

During the summer and early fall of 1998, 34 estuarine stations in Virginia were sampled for Pfiesteria like organisms (PLOs) and associated water quality conditions. Stations were sampled either bimonthly (20 stations) or monthly (14 stations) from June to October 1998. At each station, a set of live and Lugol' s preserved samples were collected for presumptive counts of PLOs and water quality conditions were determined. Water quality parame­ters measured included standard field parameters, nutrients (total, dissolved, and particulate), chlorophyll a, and conventional water quality indicators. Although PLOs were relatively low in 1998 as compared to 1997, presump­tive PLO counts …

The Biotech Century (Book Review), Philip A. Reed

STEMPS Faculty Publications

No abstract provided.

Effect Of 14 Weeks Of Resistance Training On Lipid Profile And Body Fat Percentage In Premenopausal Women, Bharathi Prabhakaran, Elizabeth A. Dowling, J. David Bramch, David P. Swain, Brian C. Leutholtz

Human Movement Sciences Faculty Publications

Objectives-To study the effects of a supervised, intensive (85% of one repetion maximum (1-RM)) 14 week resistance training programme on lipid profile and body fat percentage in healthy sedentary, premenopausal women.

Subjects-Twenty four women (mean (SD) age 27 (7) years) took part in the study Subjects were randomly assigned to either a non-exercising control group or a resistance exercise training group. The resistance exercise training group took part in supervised 45-50 minute resistance training sessions (85% of 1-RM I), three days a week on non-consecutive days for 14 weeks. The control group did not take part in any …

Pumping Dietary Iron: Implications For Aerobic Endurance Exercise, Melvin H. Williams

Human Movement Sciences Faculty Publications

(First paragraph) In an earlier issue of ACSM's Health & Fitness Journal (Sept/Oct, 988), Barry A. Franklin, Ph. D., FACSM, president of ACSM, authored an article called," Pumping Iron: Rationale, Benefits, Safety, and Prescription" where he presented evidence supporting the health benefits of resistance training an anaerobic type of exercise training. As we all know, aerobic endurance exercise training also conveys multiple health benefits.

Needle Localization For Breast Biopsy: The Patient's Experience, Marian De Walt Morgan

Psychology Theses & Dissertations

The needle localization procedure for breast biopsy (NLP) can be painful and distressing for some women. This study was carried out to learn what factors might increase or decrease NLP pain and distress, and to gain insight into possible interventions to make the procedure more comfortable for all patients. One hundred and thirty-eight women were surveyed following breast needle localization at two central Virginia hospitals. The influence of eight variables (lidocaine, self-regulation, anxiety, worry about breast cancer, breast tenderness, finding mammography painful, difficulty with surgery, and distress of blood drawing) on four outcome variables (pain incidence, pain intensity, pain unpleasantness, …