Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (119)
- Public Health (68)
- Life Sciences (45)
- Medical Sciences (44)
- Pharmacy and Pharmaceutical Sciences (41)
-
- Dentistry (31)
- Physical Sciences and Mathematics (24)
- Surgery (18)
- Cardiology (17)
- Social and Behavioral Sciences (17)
- Epidemiology (16)
- Medical Microbiology (15)
- Orthopedics (15)
- Psychiatry and Psychology (15)
- Statistics and Probability (15)
- Biostatistics (13)
- Medical Immunology (13)
- Neurology (13)
- Pediatrics (12)
- Mental and Social Health (11)
- Nursing (11)
- Ophthalmology (11)
- Otolaryngology (11)
- Biochemistry, Biophysics, and Structural Biology (10)
- Engineering (10)
- Medical Cell Biology (10)
- Pathology (10)
- Rehabilitation and Therapy (10)
- Emergency Medicine (9)
- Keyword
-
- Breast cancer (12)
- Rural (10)
- West Virginia (10)
- Inflammation (9)
- Aging (8)
-
- Chemotherapy (8)
- Meta-analysis (8)
- Neuroinflammation (8)
- Appalachia (7)
- Atrial fibrillation (7)
- Physical activity (7)
- Alzheimer’s disease (6)
- Diabetes (6)
- Public health (6)
- Brain metastases (5)
- Cancer (5)
- Cardiovascular disease (5)
- Chronic pain (5)
- Depression (5)
- Electron paramagnetic resonance (5)
- Fanconi anemia (5)
- HIV (5)
- Inhalation (5)
- Intervention (5)
- Mitochondria (5)
- NHANES (5)
- Obesity (5)
- Ovarian cancer (5)
- Rural health (5)
- Stroke (5)
- Publication Year
Articles 1 - 30 of 727
Full-Text Articles in Medicine and Health Sciences
Psychological Distress Among Asian Indians And Non-Hispanic Whites In The United States, Zasim Azhar Siddiqui, Usha Sambamoorthi
Psychological Distress Among Asian Indians And Non-Hispanic Whites In The United States, Zasim Azhar Siddiqui, Usha Sambamoorthi
Faculty & Staff Scholarship
Introduction: The prevalence of psychological distress (PD) among Asian Indians is unknown. This study estimated and compared moderate–serious PD in Asian Indians and non-Hispanic Whites (NHWs) in the United States.
Methods: We used a cross-sectional design using the National Health Interview Survey (2012–2017). Adult (age >18 years) NHWs and Asian Indians (N=2,218) were included. PD was measured using the six-item Kessler (K6) scale. We used multivariable logistic regression to determine the association of Asian Indian ethnicity with PD.
Results: In the analysis, 19.9% of NHWs and 11.0% of Asian Indians reported moderate–serious PD. Asian Indians were less likely …
Genetics Education In Primary Care Residency Training: Satisfaction And Current Barriers, Nadia Falah, Amna Umer, Emilea Warnick, Manuel Vallejo, Timothy Lefeber
Genetics Education In Primary Care Residency Training: Satisfaction And Current Barriers, Nadia Falah, Amna Umer, Emilea Warnick, Manuel Vallejo, Timothy Lefeber
Faculty & Staff Scholarship
Background
Genetics education can be integrated into general care medicine through primary care residency programs. A study of primary care residents was done to evaluate quality, satisfaction, and barriers in genetics education in residency training programs. Thus, providing more evidence for the necessity for its development and progress.
Methods
A cross-sectional descriptive self-administered questionnaire survey was delivered to four primary care West Virginia University (WVU) residency training programs in 2020–2021. The anonymous 14-item survey included the following questionnaire domains: general data, genetics training satisfaction, and genetics education barriers.
Results
The survey response rate was 52% (70/123) and 59 participants completed …
Synthesis, Characterization, And In Vivo Cytokinome Profile Of Il-12-Loaded Plga Nanospheres, Ryan A. Lacinski, Justin E. Markel, Jabeen Noore, Hillary G. Pratt, Brock A. Lindsey
Synthesis, Characterization, And In Vivo Cytokinome Profile Of Il-12-Loaded Plga Nanospheres, Ryan A. Lacinski, Justin E. Markel, Jabeen Noore, Hillary G. Pratt, Brock A. Lindsey
Faculty & Staff Scholarship
We report the successful encapsulation and elution of recombinant murine IL-12 (rmIL-12) from poly(lactide-co-glycolic) acid (PLGA) nanospheres (IL-12-NS) synthesized using the double emulsion/solvent evaporation (DESE) technique with microsphere depletion through ultracentrifugation. Images obtained with scanning electron microscopy (SEM) showcased a characteristic spherical shape with a mean particle diameter of and zeta potential of . These values suggest minimal flocculation when in solution, which was reflected in an in vivo biodistribution study that reported no observed morbidity/mortality. Encapsulation efficiency (EE) was determined to be with average particle concentration obtained per batch of particles/mL. Disparate zeta (ζ) potentials obtained from …
Brief Report: Cause Of Death Among People Discharged From Infective Endocarditis Related Hospitalization—West Virginia, 2016–2019, Zheng Dai, Gordon S. Smith, Brian Hendricks, Ruchi Bhandari
Brief Report: Cause Of Death Among People Discharged From Infective Endocarditis Related Hospitalization—West Virginia, 2016–2019, Zheng Dai, Gordon S. Smith, Brian Hendricks, Ruchi Bhandari
Faculty & Staff Scholarship
Background and Objectives
Compare proportion of all-cause and cause-specific mortality among West Virginia Medicaid enrollees who were discharged from infective endocarditis (IE) hospitalization with and without opioid use disorder (OUD) diagnosis.
Methods
The proportions of cause-specific deaths among those who were discharged from IE-related hospitalizations were compared by OUD diagnosis.
Results
The top three underlying causes of death discharged from IE hospitalization were accidental drug poisoning, mental and behavioral disorders due to polysubstance use, and cardiovascular diseases. Of the total deaths occurring among patients discharged after IE-related hospitalization, the proportion has increased seven times from 2016 to 2019 among the …
Simplifying External Load Data In Ncaa Division-I Men's Basketball Competitions: A Principal Component Analysis, Jason D. Stone, Justin J. Merrigan, Jad Ramadan, Robert Shaun Brown, Gerald T. Cheng, William Guy Hornsby, Holden Smith, Scott M. Galster, Joshua A. Hagen
Simplifying External Load Data In Ncaa Division-I Men's Basketball Competitions: A Principal Component Analysis, Jason D. Stone, Justin J. Merrigan, Jad Ramadan, Robert Shaun Brown, Gerald T. Cheng, William Guy Hornsby, Holden Smith, Scott M. Galster, Joshua A. Hagen
Faculty & Staff Scholarship
The primary purpose was to simplify external load data obtained during Division-I (DI) basketball competitions via principal component analysis (PCA). A secondary purpose was to determine if the PCA results were sensitive to load demands of different positional groups (POS). Data comprised 229 observations obtained from 10 men's basketball athletes participating in NCAA DI competitions. Each athlete donned an inertial measurement unit that was affixed to the same location on their shorts prior to competition. The PCA revealed two factors that possessed eigenvalues >1.0 and explained 81.42% of the total variance. The first factor comprised total decelerations (totDEC, 0.94), average …
Neuroimaging And Csf Findings In Patients With Autoimmune Encephalitis: A Report Of Eight Cases In A Single Academic Center, Hongyan Wu, Hongxuyang Yu, Joe Joseph, Shruti Jaiswal, Shreya R. Pasham, Shitiz Sriwastava
Neuroimaging And Csf Findings In Patients With Autoimmune Encephalitis: A Report Of Eight Cases In A Single Academic Center, Hongyan Wu, Hongxuyang Yu, Joe Joseph, Shruti Jaiswal, Shreya R. Pasham, Shitiz Sriwastava
Faculty & Staff Scholarship
Autoimmune Encephalitis (AIE) is a rare and complex group of disorders wherein the body’s immune system attacks and causes inflammatory changes in the central nervous system (CNS). It presents with altered mental status and a diverse range of typical and atypical symptoms and neuroimaging and cerebrospinal fluid (CSF) findings. The objective of this article is to highlight the importance of early identification of neurological symptoms, prompt diagnosis with neuroimaging and CSF findings, and timely management for early and complete resolution of the disease and long-term benefits. We report eight AIE cases from a single academic center confirmed by the presence …
Distance Runners In Appalachia: A Survey Of Injuries, Training, And Dietary Habits, Justine Falcone Md, Katherine Langley Md, Brenden Balcik Md, Rosanna Sikora Md, Melinda Sharon Mph, Aaron Monseau Md
Distance Runners In Appalachia: A Survey Of Injuries, Training, And Dietary Habits, Justine Falcone Md, Katherine Langley Md, Brenden Balcik Md, Rosanna Sikora Md, Melinda Sharon Mph, Aaron Monseau Md
Faculty & Staff Scholarship
Objectives: The purpose was to examine characteristics of an Appalachian population of runners. The primary aim was to examine risk factors for running related injury (RRI), including mileage per week, experience, and use of applications/training programs. A second aim was to characterize dietary habits among runners. Methods: This study was conducted in September 2015 in North Central Appalachian West Virginia. The Morgantown Marathon consists of three races offered every September: an 8K, half marathon, and full marathon. Surveys were offered to runners ages 18 and older during packet pick-up. For this survey study, questions consisted of multiple choice and open-ended …
The “Ebb And Flow” Of Documentation: Does The Transition Between Two Electronic Medical Records Systems Affect Emergency Department Efficiency?, Michelle Angeline Md, Erica B. Shaver Md, Christopher Kiefer Md, Kimberly D. Quedado Phd, Melinda Sharon, Stephen Davis Phd, Kyle Hurst Md, Christopher S. Goode Md, Thomas C. Marshall Md
The “Ebb And Flow” Of Documentation: Does The Transition Between Two Electronic Medical Records Systems Affect Emergency Department Efficiency?, Michelle Angeline Md, Erica B. Shaver Md, Christopher Kiefer Md, Kimberly D. Quedado Phd, Melinda Sharon, Stephen Davis Phd, Kyle Hurst Md, Christopher S. Goode Md, Thomas C. Marshall Md
Faculty & Staff Scholarship
Background: Electronic Medical Record (EMR) systems are electronic databases for compiling patient records. As healthcare networks expand, it is critical for providers to have access to patient data more broadly. As a result individual healthcare facilities must adjust to enterprise wide EMRs.
Objective: This study examined the operational effects of transitioning from an Emergency Department (ED) specific EMR to an enterprise wide EMR by evaluating throughput metrics in a community ED.
Methods: During a 6-month transition period (July-December 2017) in a community-based, academic ED located in North Central West Virginia, length of stay (LOS) and the following operational metrics were …
Pre-Existing Cardiovascular Disease Increases Risk Of Atrial Arrhythmia And Mortality In Cancer Patients Treated With Ibrutinib, Juan Carlo Avalon, Jacob Fuqua, Tyler Miller, Seth Deskins, Chelby Wakefield, Austin King, Sonya Inderbitzin-Brooks, Christopher Bianco, Lauren Veltri, Wei Fang, Michael Craig, Abraham Kanate, Kelly Ross, Midhun Malla, Brijesh Patel
Pre-Existing Cardiovascular Disease Increases Risk Of Atrial Arrhythmia And Mortality In Cancer Patients Treated With Ibrutinib, Juan Carlo Avalon, Jacob Fuqua, Tyler Miller, Seth Deskins, Chelby Wakefield, Austin King, Sonya Inderbitzin-Brooks, Christopher Bianco, Lauren Veltri, Wei Fang, Michael Craig, Abraham Kanate, Kelly Ross, Midhun Malla, Brijesh Patel
Faculty & Staff Scholarship
Background
Ibrutinib is a Bruton’s tyrosine kinase inhibitor used in the treatment of hematological malignancies. The most common cardiotoxicity associated with ibrutinib is atrial arrhythmia (atrial fibrillation and flutter). It is known that patients with cardiovascular disease (CVD) are at an increased risk for developing atrial arrhythmia. However, the rate of atrial arrhythmia in patients with pre-existing CVD treated with ibrutinib is unknown.
Objective
This study examined whether patients with pre-existing CVD are at a higher risk for developing atrial arrhythmias compared to those without prior CVD.
Methods
A single-institution retrospective chart review of patients with no prior history of …
Lower-Third Standardized Letters Of Evaluation In Emergency Medicine: Does Gender Make A Difference In Match Outcome?, Erica B. Shaver, Haley D. Frauen, Rachel Z. Polinski, Stephen M. Davis, Kimberly D. Quedado, Joseph Hansroth, Kristin H. Davis, Michelle R. Angeline, Christopher S. Kiefer
Lower-Third Standardized Letters Of Evaluation In Emergency Medicine: Does Gender Make A Difference In Match Outcome?, Erica B. Shaver, Haley D. Frauen, Rachel Z. Polinski, Stephen M. Davis, Kimberly D. Quedado, Joseph Hansroth, Kristin H. Davis, Michelle R. Angeline, Christopher S. Kiefer
Faculty & Staff Scholarship
Objective The purpose of this study was to determine whether gender influences the likelihood of receiving a lowerthird global assessment (GA) on the standardized letter of evaluation (SLOE) submitted as part of the emergency medicine (EM) application process as well as the impact of gender on ultimate match outcomes for applicants receiving a lower-third GA ranking. Our hypothesis was that female applicants with a lowerthird GA ranking have a higher risk of not matching.
Methods We conducted a retrospective cohort study evaluating U.S.-based allopathic applicants to a single EM residency program in the Mid-Atlantic region during the 2017-2018 and 2018-2019 …
Apoe Gene Associated With Cholesterol-Related Traits In The Hispanic Population, Stephanie Lozano, Victoria Padilla, Manuel Lee Avila, Mario Gil, Gladys Maestre, Kesheng Wang, Chun Xu
Apoe Gene Associated With Cholesterol-Related Traits In The Hispanic Population, Stephanie Lozano, Victoria Padilla, Manuel Lee Avila, Mario Gil, Gladys Maestre, Kesheng Wang, Chun Xu
Faculty & Staff Scholarship
Genetic variants in the apolipoprotein E (APOE) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the Hispanic population; therefore, our aim for this study is to examine the APOE gene’s associations with cholesterol level and its related phenotypes. The APOE gene consists of three different alleles, ε2, ε3, and ε4, with ε4 being associated with dementia and cardiovascular diseases. A total of 1,382 subjects were collected from the Texas Alzheimer’s Research and Care Consortium (TARCC, N = 1320) and the …
Pivoting A Health Sciences Leisure Reading Collection In A New Direction, Susan Arnold, Jenn Monnin
Pivoting A Health Sciences Leisure Reading Collection In A New Direction, Susan Arnold, Jenn Monnin
Faculty & Staff Scholarship
Background:
The dual pandemics of COVID-19 and racial inequity brought renewed attention to establishing a leisure reading collection in our Health Sciences Library. Such a collection had long been on our wish list, but had never been achievable due to budget constraints. With a renewed University emphasis on diversity, equity and inclusion, and an unexpected $5,000 donation, the decision was made to feature books written by patients and medical practitioners of marginalized groups and those offering diverse perspectives on the practice of medicine. This emphasis dovetailed with the Libraries’ Strategic Roadmap goals and the campus’s Wellbeing Priorities. It is hoped …
What Sets Physically Active Rural Communities Apart From Less Active Ones? A Comparative Case Study Of Three Us Counties, Christiaan G. Abildso, Cynthia K. Perry, Lauren Jacobs, M. Renée Umstattd Meyer, Megan Mcclendon, Michael B. Edwards, James N. Roemmich, Zachary Ramsey, Margaret Stout
What Sets Physically Active Rural Communities Apart From Less Active Ones? A Comparative Case Study Of Three Us Counties, Christiaan G. Abildso, Cynthia K. Perry, Lauren Jacobs, M. Renée Umstattd Meyer, Megan Mcclendon, Michael B. Edwards, James N. Roemmich, Zachary Ramsey, Margaret Stout
Faculty & Staff Scholarship
Background: Rural US communities experience health disparities, including a lower prevalence of physical activity (PA). However, “Positive Deviants”—rural communities with greater PA than their peers—exist. The purpose of this study was to identify the factors that help create physically active rural US communities. Methods: Stakeholder interviews, on-site intercept interviews, and in-person observations were used to form a comparative case study of two rural counties with high PA prevalence (HPAs) and one with low PA prevalence (LPA) from a southern US state, selected based on rurality and adult PA prevalence. Interview transcripts were inductively coded by three readers, resulting in a …
Does The Medical Student Performance Evaluation Change The Decision To Invite Residency Applicants?, Terra N. Thimm, Christopher S. Kiefer, Mara S. Aloi, Moira Davenport, Jared Kilpatrick, Jeffrey S. Bush, Lindsey Jennings, Stephen M. Davis, Kimberly Quedado, Erica B. Shaver
Does The Medical Student Performance Evaluation Change The Decision To Invite Residency Applicants?, Terra N. Thimm, Christopher S. Kiefer, Mara S. Aloi, Moira Davenport, Jared Kilpatrick, Jeffrey S. Bush, Lindsey Jennings, Stephen M. Davis, Kimberly Quedado, Erica B. Shaver
Faculty & Staff Scholarship
Introduction: Although emergency medicine (EM) residency program directors (PD) have multiple sources to evaluate each applicant, some programs await the release of the medical student performance evaluation (MSPE) to extend interview offers. While prior studies have demonstrated that MSPE content is variable and selectively positive, no prior work has evaluated the impact of the MSPE on the likelihood to invite (LTI) applicants for a residency interview. This study aimed to evaluate how information in the MSPE impacted LTI, with the hypothesis that changes in LTI would be relatively rare based on MSPE review alone.
Methods: We conducted a prospective, observational …
Sublingual Buprenorphine/Naloxone And Multi-Modal Management For High-Risk Chronic Pain Patients, Shane Kaski, Patrick Marshalek, Jeremy Herschler, Sijin Wen, Wanhong Zheng
Sublingual Buprenorphine/Naloxone And Multi-Modal Management For High-Risk Chronic Pain Patients, Shane Kaski, Patrick Marshalek, Jeremy Herschler, Sijin Wen, Wanhong Zheng
Faculty & Staff Scholarship
Patients with chronic pain managed with opioid medications are at high risk for opioid overuse or misuse. West Virginia University (WVU) established a High-Risk Pain Clinic to use sublingual buprenorphine/naloxone (bup/nal) plus a multimodal approach to help chronic pain patients with history of Substance Use Disorder (SUD) or aberrant drug-related behavior. The objective of this study was to report overall retention rates and indicators of efficacy in pain control from approximately six years of High-Risk Pain Clinic data. A retrospective chart review was conducted for a total of 78 patients who enrolled in the High-Risk Pain Clinic between 2014 and …
Excision Of A Rare Triquetral Body Fracture Nonunion, Michael J. Niemann, William C. Brooks, Priscilla Cavanaugh, Andrea B. Lese, John S. Taras
Excision Of A Rare Triquetral Body Fracture Nonunion, Michael J. Niemann, William C. Brooks, Priscilla Cavanaugh, Andrea B. Lese, John S. Taras
Faculty & Staff Scholarship
Aside from the more common dorsal avulsion fractures, isolated triquetral body fractures are a rare injury and often missed. When they are identified, conservative treatment via immobilization is often the standard of care for initial treatment. Rarely, triquetral body fractures can develop into symptomatic nonunions, causing considerable pain and disability. Multiple classification schemes have been described to categorize triquetrum fractures; however, distal triquetrum fractures fit into none of the established models. There is scarce literature describing treatment of triquetral body fracture nonunions. The few reports that exist often use a variation of open reduction internal fixation with or without grafting …
Meta-Analysis Comparing Direct Oral Anticoagulants Versus Vitamin K Antagonists In Patients With Left Ventricular Thrombus, Kazuhiko Kido, Yasir Abdul Ghaffar, James C. Lee, Christopher Bianco, Mikiko Shimizu, Tsuyoshi Shiga, Masayuki Hashiguchi
Meta-Analysis Comparing Direct Oral Anticoagulants Versus Vitamin K Antagonists In Patients With Left Ventricular Thrombus, Kazuhiko Kido, Yasir Abdul Ghaffar, James C. Lee, Christopher Bianco, Mikiko Shimizu, Tsuyoshi Shiga, Masayuki Hashiguchi
Faculty & Staff Scholarship
Current American College of Cardiology/American Heart Association guidelines for stroke or ST-elevation myocardial infarction recommend the use of oral vitamin K antagonists (VKAs) as a first-line anticoagulant. Although several studies have compared the use of direct oral anticoagulants (DOACs) to VKAs for left ventricular thrombus (LVT) anticoagula- tion therapy, they are small scale and have produced conflicting results. Thus, this meta- analysis was performed to aggregate these studies to better compare the efficacy and safety of DOACs with VKAs in patients with LVT. Cochrane Library, Google Scholar, MED- LINE, and Web of Science database searches through January 10, 2021 were …
Field Test Of A Passive Infrared Camera For Measuring Trail-Based Physical Activity, Christiaan G. Abildso, Vaike Haas, Shay M. Daily, Thomas K. Bias
Field Test Of A Passive Infrared Camera For Measuring Trail-Based Physical Activity, Christiaan G. Abildso, Vaike Haas, Shay M. Daily, Thomas K. Bias
Faculty & Staff Scholarship
Introduction: Trails are ubiquitous and far-reaching, but research on the impact trails have on physical activity is limited by the lack of resource-efficient, accurate, and practical systematic observation tools. Commonly used infrared trail sensors count trail use and may broadly differentiate activity (i.e., bicyclist vs. pedestrian), but cannot detect nuances needed for outcomes research such as frequency, intensity, time, and type of activity. Motion-activated passive infrared cameras (PICs), used in ecological research and visitor management in wildlife areas, have potential applicability as a systematic observation data collection tool.
Materials and Methods: We conducted a 7-month field test of a PIC …
A Structured Approach To Skin And Soft Tissue Infections (Sstis) In An Ambulatory Setting, Benjamin Silverberg
A Structured Approach To Skin And Soft Tissue Infections (Sstis) In An Ambulatory Setting, Benjamin Silverberg
Faculty & Staff Scholarship
The skin is the largest, and arguably, the most vulnerable organ in the human body. Scratches and scrapes, bites and puncture wounds, impetigo and erysipelas—all these disruptions can lead to pain, swelling, and/or systemic symptoms. In this article, which is based on the Infectious Diseases Society of America’s 2014 guidelines and the World Society of Emergency Surgery and Surgical Infection Society of Europe’s 2018 consensus statement, a structured approach to skin and soft tissue infections (SSTIs) is reviewed, comparing treatment for suppurative and non-suppurative infections, and then discussing specific conditions commonly seen in Primary Care and Urgent Care facilities.
Postdischarge Opioid Use After Total Hip And Total Knee Arthroplasty, Keenan Atwood, Taylor Shackleford, Wesley Lemons, Jennifer L. Eicher, Brock A. Lindsey, Adam E. Klein
Postdischarge Opioid Use After Total Hip And Total Knee Arthroplasty, Keenan Atwood, Taylor Shackleford, Wesley Lemons, Jennifer L. Eicher, Brock A. Lindsey, Adam E. Klein
Faculty & Staff Scholarship
Background
As America’s third highest opioid prescribers, orthopedic surgeons have contributed to the opioid abuse crisis. This study evaluated opioid use after primary total joint replacement. We hypothesized that patients who underwent total hip arthroplasty (THA) use fewer opioids than patients who underwent total knee arthroplasty (TKA) and that both groups use fewer opioids than prescribed.Methods
A prospective study of 110 patients undergoing primary THA or TKA by surgeons at an academic center during 2018 was performed. All were prescribed oxycodone 5 mg, 84 tablets, without refills. Demographics, medical history, and operative details were collected. Pain medication consumption and …Professional Sporting Events Increase Seasonal Influenza Mortality In Us Cities, Alexander Cardazzi, Brad Humphreys, Jane E. Ruseski, Brian P. Soebbing, Nicholas Watanabe
Professional Sporting Events Increase Seasonal Influenza Mortality In Us Cities, Alexander Cardazzi, Brad Humphreys, Jane E. Ruseski, Brian P. Soebbing, Nicholas Watanabe
Economics Faculty Working Papers Series
The COVID-19 pandemic shut down sporting events worldwide. Local policy makers and league officials face important decisions about restarting play, especially in professional leagues that draw large numbers of spectators to games. We analyze the impact of professional sporting events on local seasonal influenza mortality to develop evidence that will help inform sports league reopening policy decisions. Results from a difference-in-differences model applied to data from a sample of US cities that gained new professional sports teams over the period 1962-2016 show that the presence of games in these cities increased local influenza mortality by between 4% and 24%, depending …
Just Because (Most) Hospitals Are Publishing Charges Does Not Mean Prices Are More Transparent, Cody L. Mullens, J Andres Hernandez, Evan D. Anderson, Lindsay Allen
Just Because (Most) Hospitals Are Publishing Charges Does Not Mean Prices Are More Transparent, Cody L. Mullens, J Andres Hernandez, Evan D. Anderson, Lindsay Allen
Faculty & Staff Scholarship
Background: The Centers for Medicare and Medicaid Services (CMS) recently mandated that all hospitals publish their charge description masters (CDMs) online, in a machine-readable format, by January 1, 2019. In addition, CMS recommended that CDM data be made available in a manner that was consumer friendly and accessible to patients.
Objective: This study aimed to (1) examine all hospitals across the state of Pennsylvania to understand policy compliance and (2) use established metrics to measure accessibility and consumer friendliness of posted CDM data.
Methods: A cross-sectional analysis was conducted to quantify hospital website compliance with the recent CMS policies requiring …
Self-Regulation As Key Factor In Protection Against The Harmful Effects Of Adverse Childhood Experiences: Critical Role For Occupational Therapists, Rondalyn Whitney
Self-Regulation As Key Factor In Protection Against The Harmful Effects Of Adverse Childhood Experiences: Critical Role For Occupational Therapists, Rondalyn Whitney
Faculty & Staff Scholarship
No abstract provided.
Risk Factors Associated With Infection Of Blood-Borne Virus Among People Who Used Methamphetamine, Yilin Cai, Sijin Wen, Ruchi Bhandari
Risk Factors Associated With Infection Of Blood-Borne Virus Among People Who Used Methamphetamine, Yilin Cai, Sijin Wen, Ruchi Bhandari
Faculty & Staff Scholarship
Background
The surge of methamphetamine use has been a complicating factor compounding the steeply increasing number of drug overdose deaths in the U.S. Infection from blood-borne viruses including hepatitis B virus (HBV), hepatitis C virus (HCV) and HIV, related to methamphetamine use continue to grow. This study aims to examine the risk factors associated with HBV, HCV and HIV among people who used methamphetamine.
Methods
People who ever used methamphetamine were identified from five National Health and Nutrition Examination Survey (NHANES) cohorts, 2007 to 2016. The outcome was either positive or negative for blood-borne viruses as identified from laboratory tests. …
Life Satisfaction Among A Clinical Eating Disorder Population, Elizabeth A. Claydon, Caterina Defazio, Christa L. Lilly, Keith J. Zullig
Life Satisfaction Among A Clinical Eating Disorder Population, Elizabeth A. Claydon, Caterina Defazio, Christa L. Lilly, Keith J. Zullig
Faculty & Staff Scholarship
Background
The primary objective was to understand life satisfaction (LS) of patients with eating disorders (EDs) in relation to eating pathology severity, personal/familial ED history, and key demographic and anthropometric variables.
Methods
Participants (N = 60) completed the Satisfaction with Life Scale (SWLS), the Eating Pathology Severity Index (EPSI), and demographic questionnaires. Bivariate associations via correlations and multiple linear regression models were used to explore these relationships.
Results
The SWLS mean score was 3.7 out of 7, suggesting it is below the population-based norm. LS was positively statistically significantly associated with private insurance, past ED, EPSI muscle building, EPSI …
Opening Large-Conductance Potassium Channels Selectively Induced Cell Death Of Triple-Negative Breast Cancer, Gina Sizemore, Sarah Mclaughlin, Mackenzie Newman, Kathleen Brundage, Amanda Ammer, Karen Martin, Elena Pugacheva, James Coad, Malcolm D. Mattes, Han-Gang Yu
Opening Large-Conductance Potassium Channels Selectively Induced Cell Death Of Triple-Negative Breast Cancer, Gina Sizemore, Sarah Mclaughlin, Mackenzie Newman, Kathleen Brundage, Amanda Ammer, Karen Martin, Elena Pugacheva, James Coad, Malcolm D. Mattes, Han-Gang Yu
Faculty & Staff Scholarship
Background
Unlike other breast cancer subtypes that may be treated with a variety of hormonal or targeted therapies, there is a need to identify new, effective targets for triple-negative breast cancer (TNBC). It has recently been recognized that membrane potential is depolarized in breast cancer cells. The primary objective of the study is to explore whether hyperpolarization induced by opening potassium channels may provide a new strategy for treatment of TNBC.
Methods
Breast cancer datasets in cBioPortal for cancer genomics was used to search for ion channel gene expression. Immunoblots and immunohistochemistry were used for protein expression in culture cells …
Identifying Community Physical Activity And Health Resources For Treatment Of Back Pain By Utilizing Members Of A Physical Activity Network, Cara L. Sedney, Treah Haggerty, Sam Zizzi, Patricia Dekeseredy
Identifying Community Physical Activity And Health Resources For Treatment Of Back Pain By Utilizing Members Of A Physical Activity Network, Cara L. Sedney, Treah Haggerty, Sam Zizzi, Patricia Dekeseredy
Faculty & Staff Scholarship
Background
Back pain is one of the leading causes of health care expenditure in the US and is linked to an increased body mass index. Many evidence-based modalities for the prevention and treatment of back pain closely mirror recommendations for weight loss and include physical activity and health maintenance activities (PAHM). The primary aim of this study was to ascertain community assets, and perceptions of the use of PAHM in the treatment of back pain by West Virginia Physical Activity Network (WVPAN) members.
Methods
Participants for the study were recruited from the West Virginia Physical Activity Network. This grassroots organization …
Localized Cytokine Responses To Total Knee Arthroplasty And Total Knee Revision Complications, Nicole Prince, Julia A. Penatzer, Matthew J. Dietz, Jonathan W. Boyd
Localized Cytokine Responses To Total Knee Arthroplasty And Total Knee Revision Complications, Nicole Prince, Julia A. Penatzer, Matthew J. Dietz, Jonathan W. Boyd
Faculty & Staff Scholarship
Background
The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immune response. Several cytokines have shown increased systemic concentrations (in serum/plasma) in response to implants and infection, but tissue-level cytokines have not been investigated as thoroughly.
Methods
This exploratory study investigated tissue-level cytokines in a cohort of patients (N = 17) in response to total knee arthroplasty and total knee revision to better understand the immune response to implants and localized infection (e.g., prosthetic joint infection). …
Geographic Variation In Amputation Rates Among Patients With Diabetes And/Or Peripheral Arterial Disease In The Rural State Of West Virginia Identifies Areas For Improved Care, Samantha Danielle Minc, Brian Hendricks, Ranjita Misra, Yue Ren, Dylan Thibault, Luke Marone, Gordon Stephen Smith
Geographic Variation In Amputation Rates Among Patients With Diabetes And/Or Peripheral Arterial Disease In The Rural State Of West Virginia Identifies Areas For Improved Care, Samantha Danielle Minc, Brian Hendricks, Ranjita Misra, Yue Ren, Dylan Thibault, Luke Marone, Gordon Stephen Smith
Faculty & Staff Scholarship
Objective:
Amputation is a devastating but preventable complication of diabetes and peripheral arterial disease (PAD). Multiple studies have focused on disparities in amputation rates based on race and socioeconomic status, but few focus on amputation trends in rural populations. The objective of this study was to identify the prevalence of major and minor amputation among patients admitted with diabetes and/or PAD in a rural, Appalachian state, and to identify geographic areas with higher than expected major and minor amputations using advanced spatial analysis while controlling for comorbidities and rurality.
Methods:
Patient hospital admissions of West Virginia residents with diagnoses of …
The Significance Of Tau Aggregates In The Human Brain, Rudy J. Castellani
The Significance Of Tau Aggregates In The Human Brain, Rudy J. Castellani
Faculty & Staff Scholarship
Neurofibrillary degeneration has attracted the attention of neuroscientists as both a hallmark of the disease and a subject for experimentation for more than a century. Recent studies implicate phosphorylated tau (p-tau) directly in neurodegenerative disease pathogenesis, although the human data continue to raise questions. P-tau accumulates with age in a roughly hierarchical manner, but avoids abundance in the neocortex unless co-occurring with amyloid-β. Neurodegenerative tauopathies tend to have p-tau morphologies that differ from aging and Alzheimer’s disease. Tau isoforms (3R vs. 4R) have a tendency to vary with tauopathy phenotype for unknown reasons. Selective vulnerability to p-tau and spatial-temporal disconnect …