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Plasma Concentrations Of Fenbendazole (Fbz) And Oxfendazole In Alpacas (Lama Pacos) After Single Intravenous And Oral Dosing Of Fbz, Jeffrey Lakritz, Daniel Linden, David E. Anderson, Terri A. Specht
Plasma Concentrations Of Fenbendazole (Fbz) And Oxfendazole In Alpacas (Lama Pacos) After Single Intravenous And Oral Dosing Of Fbz, Jeffrey Lakritz, Daniel Linden, David E. Anderson, Terri A. Specht
David Edgar Anderson, DVM, MS, DACVS
The objective of this study was to determine plasma pharmacokinetics and bioavailability of fenbendazole (FBZ) and oxfendazole (OFZ) after intravenous (iv) and oral administrations of FBZ (5 mg/kg) to alpacas. Plasma concentrations of FBZ and OFZ after administration of FBZ iv and orally (5 mg/kg) were determined by high-performance liquid chromatography with ultraviolet detection. Total clearance (CL) of FBZ was 16.5±4 mL/kg/min (range: 4–31 mL/kg/min), and steady-state volume of distribution (Vdss) was 3.3±1 L/kg (range: 1.7–7.4 L/kg). The terminal phase half-life of FBZ after iv administration was 5.9±3.8 hours (range: 0.8–20 hours). After oral administration, the FBZ terminal phase half-life …
Survey Of Biosecurity Practices Utilized By Veterinarians Working With Farm Animal Species, David E. Anderson
Survey Of Biosecurity Practices Utilized By Veterinarians Working With Farm Animal Species, David E. Anderson
David Edgar Anderson, DVM, MS, DACVS
Biosecurity programs can be discussed from many perspectives. In many cases, biosecurity may be regulated state or federal programs with law enforcement - the goals of which are to protect the "national" livestock resources and protect consumer interests. Alternatively, these programs may be producer level programs that are voluntarily established for protection of personal livestock investments. A core principle in the definition of "biosecurity" is the desire to prevent the introduction of disease. When infectious disease is present on a farm or in a region, the term "biocontainment" may be used to describe programs aimed at confinement of the diseases …