Medicine and Health Sciences Commons^™

Estimated Probability Of Becoming A Case Of Drug Dependence In Relation To Duration Of Drug-Taking Experience: A Function Approach, Olga A. Vsevolozhskaya, James C. Anthony

Olga A. Vsevolozhskaya

Measured as elapsed time from first use to dependence syndrome onset, the estimated 'induction interval' for cocaine clearly is short relative to the cannabis interval, but little is known about risk of becoming dependent when use persists. Published estimates for this facet of drug dependence epidemiology are from life histories elicited years after first use. To improve estimation, we turn to new data from nationally representative samples of newly incident drug users identified via probability sampling and confidential computer-assisted self-interviews for the National Surveys on Drug Use and Health, 2004-2013. Standardized modules assess first and most recent use, and dependence …

Better Engaging Communities: Moving Beyond Cardinal Rules, Anna G. Hoover

Anna G. Hoover

“Cardinal rules” and best practice approaches have guided governmental risk communication efforts at chronic risk sites for more than two decades, playing an important role in how those most affected by contamination make sense of risk. In addition to providing information, however, communication approaches themselves can affect community perceptions indirectly, through stakeholder interpretations of the processes by which risk information is shared. It is increasingly necessary to evaluate not only whether risk communication approaches have been effective for increasing knowledge but if, in fact, the ways in which information is shared has had unintended consequences that change how stakeholders perceive …

The Evolution Of The National Health Security Preparedness Index, Glen P. Mays, Anna G. Hoover, Michael T. Childress

Anna G. Hoover

No abstract provided.

Getting The Right Scan: Evidence Based Radiology For Hospitalists, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

No abstract provided.

Pediatric Ecg's Demystified, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

No abstract provided.

2015 Phssr Extramural Research Inventory, Glen P. Mays, Anna G. Hoover, Ann V. Kelly, Julie Jacobs, Lizeth C. Fowler, Kara Richardson

Anna G. Hoover

This portfolio describes 139 funded extramural projects managed by the National Coordinating Center for Public Health Services and Systems Research and the Public Health Practice-Based Research Networks National Coordinating Center from 2009-2015.

Impact Of A Rapid Response System In A Children's Hospital, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

My capstone project demonstrating the impact for a rapid response system in a children's hospital within a larger general hospital.

Are We Prepared? A Cross Sectional Study Of Preparedness In Fayette County Kentucky For A Pediatric Mass Casualty Incident, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

No abstract provided.

Cert Pediatrics, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

A continuing education event for Lexington-Fayette County Community Emergency Response Teams (CERT) dealing with caring for children in disaster situations

Confidence Interval Estimation In R-Das, Olga A. Vsevolozhskaya, James C. Anthony

Olga A. Vsevolozhskaya

Background

Roughly 25 years ago, the United States National Institute on Drug Abuse (US NIDA) initiated the creation of public use datasets for its National Household Survey on Drug Abuse, since re-named the National Survey on Drug Use and Health (NSDUH). The Substance Abuse and Mental Health Services Administration (SAMHSA), which assumed responsibility for the survey in 1992, has continued and expanded this effort to make the survey data available to researchers. During 2012, SAMHSA created a “Restricted-Use Data Analysis System” (R-DAS) to provide researchers with the capability to create tabulations using restricted NSDUH variables not otherwise available on the …

Research Translation: Informing Evidence-Based Policies, Anna G. Hoover

Anna G. Hoover

This presentation describes the need for evidence-based policy, outlines strategies for researchers and communities to inform various policy stages, and provides a case study example of research generated specifically to inform policy implementation.

Tales From The Blips: Telemetry And Arrhythmias For Hospitalist, Erich C. Maul Do, Anna Kamp Md, Mph

Erich C. Maul DO MPH

No abstract provided.

Epidemiology Of Pediatric Rapid Response Calls In Children Less Than Two Years Old, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

Poster presentation of original research at Pediatric Hospital Medicine 2014 Lake Buena Vista, FL

Abdominal Pain In An Adolescent Female-A Case Of Ehrlichiosis, Tamika Rozema Md, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

Clincial conundrum poster presentation at Pediatric Hospital Medicine 2014 Lake Buena Vista, FL

Kikuchi-Fujimoto Syndrome, Laura Girard Md, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

Clinical conundrum poster presentation at Pediatric Hospital Medicine 2014 Lake Buena Vista, FL

Esophageal Varices, Allison Slone Md, Erich C. Maul Do, Mph

Erich C. Maul DO MPH

A clinical conundrum poster presentation at Pediatric Hospital Medicine 2014 Lake Buena Vista, FL

Connecting Disciplines To Inform And Develop The Emerging Field Of Environmental Health Literacy, Anna G. Hoover

Anna G. Hoover

No abstract provided.

From Drug Use To Dependence: A Multiparametric Approach, Olga A. Vsevolozhskaya, James C. Anthony

Olga A. Vsevolozhskaya

One of the hallmarks of a drug dependence (DD) process is an escalation in rate of drug self-administration (DSA). We seek to extend current biostatistical approaches for epidemiological research on drug dependence processes via an investigation of a four-parameter dose-effect curve (DEC).

Communication Partnerships That Work: Translating Evidence-Based Health Research Into Practice, Angela Carman, Gretchen Holmes, Anna G. Hoover, Margaret Mcgladrey, Ernie Scott, Mary Tucker-Mclaughlin, Nancy Winterbauer

Anna G. Hoover

Healthcare and public health research ultimately seek to improve patient and population health. Unfortunately, more than a decade often passes before research findings become routinized in practice. Improving translational speed, reach, and efficacy requires partnerships among researchers, practitioners, community stakeholders, and communication scholars. This panel will be presenting two partnership models that work.

The University of Kentucky (UK) Center of Excellence in Rural Health (CERH) seeks to improve the health of rural Kentuckians through education, research, service, and community engagement. They do this by partnering with hospitals and clinics, health professionals, community service agencies, non-profits and other organizations. Panelists will …

Confidence Interval Estimation In R-Das: State-Level Estimates For Extra-Medical Use Of Prescription Pain Relievers, Olga A. Vsevolozhskaya, James C. Anthony

Olga A. Vsevolozhskaya

The specific methodological aims of our research are: 1) to clarify statistical inference procedures used by R-DAS to produce confidence interval estimates; 2) to review a simple solution to some of the research questions not currently addressed by R-DAS (i.e., with respect to tests of significance); and 3) to describe how in certain situations the percentages and the corresponding standard errors, which are suppressed from the R-DAS output due to the confidentiality concerns can be estimated “by hand”.

Dissemination And Implementation Research: Connecting Interventions To Practice, Anna G. Hoover, Angela Carman

Anna G. Hoover

This presentation describes a pilot study to evaluate the complex relationships among organizational structure and characteristics, channel selection, and changes in uptake in the implementation of an evidence-based HPV vaccine intervention in Kentucky local health departments.

Saving Time Under Pressure: Effectiveness Of Standardizing Pediatric Resuscitation Carts, Erich C. Maul Do, Mph, Philip Westgate Phd, Barbara Latham Msn

Erich C. Maul DO MPH

Platform presentation of original research

Single Intrathecal Administration Of The Transcription Factor Decoy Ayx1 Prevents Acute And Chronic Pain After Incisional, Inflammatory, Or Neuropathic Injury, Julien Mamet, Michael Klukinov, Tony L. Yaksh, Shelle A. Malkmus, Samantha Williams, Scott Harris, Donald C. Manning, Bradley K. Taylor, Renee R. Donahue, Frank Porreca, Jennifer Y. Xie, Janice Oyarzo, Timothy J. Brennan, Alberto Subieta, William K. Schmidt, David C. Yeomans

Renee R. Donahue

The persistence of pain after surgery increases the recovery interval from surgery to a normal quality of life. AYX1 is a DNA-decoy drug candidate designed to prevent post-surgical pain following a single intrathecal injection. Tissue injury causes a transient activation of the transcription factor EGR1 in the dorsal root ganglia–dorsal horn network, which then triggers changes in gene expression that induce neuronal hypersensitivity. AYX1 is a potent, specific inhibitor of EGR1 activity that mimics the genomic EGR1- binding sequence. Administered in the peri-operative period, AYX1 dose dependently prevents mechanical hypersensitivity in models of acute incisional (plantar), inflammatory (CFA), and chronic …

Copd Surveillance-United States, 1999-2011, Earl S. Ford, Janet B. Croft, David M. Mannino, Anne G. Wheaton, Xingyou Zhang, Wayne H. Giles

David M. Mannino

This report updates surveillance results for COPD in the United States. For 1999 to 2011, data from national data systems for adults aged ≥ 25 years were analyzed. In 2011, 6.5% of adults (approximately 13.7 million) reported having been diagnosed with COPD. From 1999 to 2011, the overall age-adjusted prevalence of having been diagnosed with COPD declined (P = .019). In 2010, there were 10.3 million (494.8 per 10,000) physician office visits, 1.5 million (72.0 per 10,000) ED visits, and 699,000 (32.2 per 10,000) hospital discharges for COPD. From 1999 to 2010, no significant overall trends were noted for physician …

Using Risk And Participatory Communication To Support Community-Based Decisions: The Paducah Gaseous Diffusion Plant Future Vision Project, Anna G. Hoover

Anna G. Hoover

No abstract provided.

Constitutive Mu-Opioid Receptor Activity Leads To Long-Term Endogenous Analgesia And Dependence, Gregory Corder, Suzanne Doolen, Renee R. Donahue, Michele K. Winter, Brandon L. Jutras, Y He, X Hu, Joseph S. Wieskopf, Jeffrey S. Mogil, Daniel R. Storm, Z J. Wang, Kenneth E. Mccarson, Bradley K. Taylor

Renee R. Donahue

Opioid receptor antagonists increase hyperalgesia in humans and animals, which indicates that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive. We found that tissue injury produced m-opioid receptor (MOR) constitutive activity (MORCA) that repressed spinal nociceptive signaling for months. Pharmacological blockade during the posthyperalgesia state with MOR inverse agonists reinstated central pain sensitization and precipitated hallmarks of opioid withdrawal (including adenosine 3′,5′-monophosphate overshoot and hyperalgesia) that required N-methyl-D-aspartate receptor activation of adenylyl cyclase type 1. Thus, MORCA initiates both analgesic signaling and a compensatory opponent …

Cph601 Chapter 2 Toxicology, David M. Mannino

David M. Mannino

No abstract provided.

Syllabus - Cph601-401 Environmental Health, David M. Mannino

David M. Mannino

No abstract provided.

Cph601 Chapter 5 Air, David M. Mannino

David M. Mannino

No abstract provided.

Cph601 Chapter 7 Food And Agriculture, David M. Mannino

David M. Mannino

No abstract provided.