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Full-Text Articles in Medicine and Health Sciences
Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen
Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen
Theses and Dissertations
Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed a systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens and ventral midbrain) across the BXD RI panel, a highly diverse family of isogenic mouse strains before and after treatment with ethanol. Acute ethanol altered the expression of ~2,750 genes in one or more regions and 400 transcripts were jointly modulated in all three. Ethanol-responsive gene networks were extracted with a …
Alveolar Ridge Dimension Analysis Following Socket Preservation Using Clinical Assessment And Cone Beam Computed Tomography (Cbct)., Sayward Duggan
Alveolar Ridge Dimension Analysis Following Socket Preservation Using Clinical Assessment And Cone Beam Computed Tomography (Cbct)., Sayward Duggan
Theses and Dissertations
AIM: Extraction of a tooth can lead to alveolar ridge resorption which can be minimized by socket preservation. The aim of this study is to analyze vertical and horizontal alveolar ridge dimensions clinically and by CBCT immediately following extraction and 3-4 months following socket preservation. METHODS: The preserved group (P) consisted of 20 patients with1-2 non-molar teeth requiring extraction with socket preservation, while the control group (C) consisted of 5 patients requiring extraction alone. An acrylic stent was fabricated presurgically in order to measure vertical and horizontal ridge dimensions clinically and radiographically immediately following extraction and 3-4 months following socket …
Titrating And Evaluating Multiple Drug Regimens Within Subjects, Margaret Shih
Titrating And Evaluating Multiple Drug Regimens Within Subjects, Margaret Shih
Theses and Dissertations
The dosing of combination therapies is commonly undertaken empirically by practicing physicians, and there is a lack of a coherent algorithm to approach the problem of combination dosing. Current methods of evaluating multiple drug combinations in clinical trials generally do not provide information regarding the location of more effective dosages when the combination is not found to differ from the standard, even though the absence of a difference does not necessarily mean the new combination is ineffective. Additionally, if a new combination is found to be more effective, often a large proportion of the subjects has not benefited from the …
The Pineal Gland, Via Melatonin, Protects Dna, Coordinates The Endocrine System With The Immune System And Controls The Timing Of Reproduction, Craig L. Anthony
The Pineal Gland, Via Melatonin, Protects Dna, Coordinates The Endocrine System With The Immune System And Controls The Timing Of Reproduction, Craig L. Anthony
Theses and Dissertations
The pineal gland secretes the hormone melatonin (n-acetyl-5-methoxytryptamine) with a circadian rhythm. This secretion's rhythm becomes disrupted with age. When melatonin secretion is decreased with advanced age, the immune, endocrine and reproductive systems fail to function optimally. Melatonin possesses lipophilic and anti-oxidant properties, providing it with access to nuclei. Melatonin protects the DNA, preventing cancerous mutation. Hippocampal degeneration and age increase and prolong the adrenocortical responses to stress. Melatonin supplementation reduces the prolonged exposure to harmful hormones.
A Comparative Study Of Murine Mast Cell Progenitors, Shirley K. Desimone
A Comparative Study Of Murine Mast Cell Progenitors, Shirley K. Desimone
Theses and Dissertations
This thesis is a comparative study of variables affecting differentiation and proliferation of progenitor cells from various embryonic and fetal tissue sites as they differentiate into mast cells. Embryonic stem cells from gestation day 4.5 (d4.5) differentiated exclusively into mast cells when cultured in semi-solid media with stem cell factor (SCF) and Interleukin-3 (IL-3). The same was true of d8-1 1 yolk sac cells and d8-1 1 cells from the embryo itself. However, culture with SCF and IL-3 of cells from dl4 fetal livers differentiated into mast cells, cells of the erythrocyte lineage and a few "macrophages" which may have …
Eating, Nutrition And Of Health Diagnostic Of The Elementary Schools Of The Communities Of Guambo And The Rinconada, Province Of Imbabura 2002-2001, Ruth Muriel
Theses and Dissertations
The rural communities of the province of Imbabura present multiple problems of environmental, educational, and economic kind. Previous studies show that the rural communities of the Ecuadorian population present serious problems of health and nutrition, among those that excel are: poliparasitosis, respiratory infections and diarrheal, malnutrition, deficiency of micro nutrients, sanitary deficiency, scarce economic resources and low level of instruction. All these factors have caused a decrease in the productive capacity of the country and affected their level of development. In addition, delay exists in size in the students, which leads to a decrease in the capacity for physical work, …