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Master's Theses

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Medication Error Prevention: Improving Patient Health Outcome, Brigitta Van Ewijk Dec 2018

Medication Error Prevention: Improving Patient Health Outcome, Brigitta Van Ewijk

Master's Theses

Medication administration errors were reported to have an error rate of 60% in early research mainly in the form of the wrong dose, time, or rate. Working conditions were found to be one of the main contributors to these errors. Recognizing and reporting medication errors are key to the implementation of the reduction of this critical health problem (Hughes & Blegen, 2008). DataRay Inc. (n.d.), states that almost one in five medication doses administered in hospitals is given in error. The two most common errors were (1) dispensing medicine at the wrong time (43% of incidents) and (2) omitting a dose (30%). The goal is to increase the nurses’ awareness of the different processes of medication administration and how error-prone these are.

The medication observation will take place during the hours of 0700-1000, and the nurses will use orange vests with “MEDICATION PASS IN PROGRESS; PLEASE DO NOT DISTURB” during the medication administration process for reduction and prevention of interruption. The nurses will be observed for correct use of the electronic health record system (EHR) during the transcription process throughout the day shift (0730-1530).

The result ...


Reexamining Overuse Of Frequent Observation For New Admissions On Psychiatric Units To Increase Nurse/Patient Engagement, Samuel Novela Dec 2018

Reexamining Overuse Of Frequent Observation For New Admissions On Psychiatric Units To Increase Nurse/Patient Engagement, Samuel Novela

Master's Theses

People in California who suffer from mental health conditions are often admitted involuntarily to hospitals on 72 hour psychiatric evaluation holds if they are deemed imminently dangerous to themselves, or others, or are gravely disabled. Observational patient safety checks are performed and based on patient acuity and hospital standards. Variations exist among different clinical settings with regard to best practices and the patient subpopulations that may warrant less frequent safety checks. Nurses experience different levels of satisfaction with regard to frequency of safety checks because there is no national consensus on which subsets of patients may require them. A senior ...


Improving Communication: Huddling For Change, Harnoor Chahal Aug 2018

Improving Communication: Huddling For Change, Harnoor Chahal

Master's Theses

The purpose of this communication improvement project is to incorporate huddles between interdisciplinary departments within a microsystem in order to improve customer satisfaction by decreasing the number of grievances. Based on the increasing number of grievances due to delayed hospital discharge, which results from a lack of communication between team members, there is an increased need for communication between the microsystem. By implementing weekly huddles between the Inpatient and Outpatient nurses, not only will there be increased care-coordination, but there will also be a decreased delay in discharge from the hospital caused by missed or no communication. Evidence-based practice indicates ...


Educational Prevention Program Of Surgical Site Infections (Ssi) At A Metropolitan Pediatric, Daniel Chavez Aug 2018

Educational Prevention Program Of Surgical Site Infections (Ssi) At A Metropolitan Pediatric, Daniel Chavez

Master's Theses

Surgical Site Infections are a common hospital acquired disease. The prevention of Surgical Site Infection at a metropolitan pediatric hospital was lacking thorough education on how to prevent Surgical Site Infections. Literature was used to support this educational program with evidence based practices. To further reduce Surgical Site Infections education played a key role. Most importantly the distribution of education is what this educational program aimed toward supporting. In order to optimize patient outcomes through the use of our educational program literacy requirements must be me. Using this information our team constructed educational pamphlets that would help empower patients so ...


Educational Prevention Program Of Surgical Site Infections At A Metropolitan Pediatric Hospital, Myra Hasan Aug 2018

Educational Prevention Program Of Surgical Site Infections At A Metropolitan Pediatric Hospital, Myra Hasan

Master's Theses

Surgical site infections (SSI) are a common cause of healthcare-associated infections (HAI). They remain a significant problem, as they are associated with increased morbidity and mortality and cause an increase in demand for several healthcare resources. In order to address this problem, hospitals have implemented several protocols and polices that are aimed to reduce these infections. However, the rates of SSIs continue to rise. Healthcare team members have found that while it is their responsibility to enforce preventative measures to the patient in the preoperative and surgical room, patient compliance to preventive measures at home also plays a role.

At ...


Individualizing Care For Pediatric Patients With Autism Spectrum Disorder In Perioperative Services, Erin Scheller May 2018

Individualizing Care For Pediatric Patients With Autism Spectrum Disorder In Perioperative Services, Erin Scheller

Master's Theses

This research explores solutions for individualizing and improving care for pediatric patients with Autism Spectrum Disorder in the Perioperative Setting of an Outpatient Surgery Center. Specifically, it seeks to determine if providing parent and staff resources on Autism Spectrum Disorder is significantly helpful in increasing confidence in the staff by the parents and the staff themselves. Participants included thirty-five surveyed families who had pediatric patients visiting perioperative services and staff who work on the unit. Methods used include information dissemination with the use of printable and online evidence-based resources, an in-person education event for staff, and a pilot study of ...


Impact Of Prolonged Sitting On Cognitive Function: Implications For Cardio-Metabolic Risk, Sabina Miller Apr 2018

Impact Of Prolonged Sitting On Cognitive Function: Implications For Cardio-Metabolic Risk, Sabina Miller

Master's Theses

Purpose: To determine if prolonged sitting negatively impacts cognitive function, cerebral perfusion, and central cardiovascular hemodynamics; and secondly, to test whether weight or physical activity status alters this response. Methods: Participants (N=20, age=26±7; BMI=30±7 kg/m2; 7 female) were taken through 3 hrs of sitting followed by a 10-min walk (treadmill). Cognitive function was assessed during sitting (10, 60, 120, and 180 mins) and following the walk using a color/word Stroop test. Cerebral perfusion was measured via near infrared spectroscopy (total hemoglobin—tHb). Central cardiovascular hemodynamics and aortic stiffness (pulse wave velocity—PWV ...


A Survey Of Perceptions And Professional Boundaries Between Music Therapy And Speech-Language Pathology, Jennifer Rose Fromius Apr 2018

A Survey Of Perceptions And Professional Boundaries Between Music Therapy And Speech-Language Pathology, Jennifer Rose Fromius

Master's Theses

The purpose of this study is to examine the relationship between music therapists and speech-language pathologists in order to gain a better understanding of professional boundaries within each profession, frequency of co-treatment between the two professions, and perceptions of referral in clinical practice. Data for this research were collected through two online questionnaires with parallel sets of questions, which were distributed to a sample of boardcertified music therapists (MT-BC) and speech-language pathologists (CCC-SLP). Quantitative and qualitative data collected from the survey (N= 283; n = 45 MT-BC, n = 238 CCC-SLP) are analyzed to determine if there are correlations and thematic trends ...


Organocatalyzed Synthesis Of Epoxides From Chalcones Utilizing Amino Acids, Sabrina N. Kegeler Apr 2018

Organocatalyzed Synthesis Of Epoxides From Chalcones Utilizing Amino Acids, Sabrina N. Kegeler

Master's Theses

The epoxide functional group is important throughout the chemical and pharmaceutical industries, as well as in nature. In the chemical industry, epoxides are present in resins and fragrances. In the pharmaceutical industry, epoxide-containing compounds are used as intermediates in the manufacturing of drugs. In nature, many natural products contain epoxide groups and are used for medicinal purposes, and for models to create synthetic molecules.

One approach to epoxide synthesis involves the use of an alkene precursor, a base, and an oxidizing agent. This is where my investigations began. The first step was to optimize the epoxidation reaction, examining substrate scope ...


Exploring The Relevance Of Art Therapy In Public Education, Brandy A. Jarrell Apr 2018

Exploring The Relevance Of Art Therapy In Public Education, Brandy A. Jarrell

Master's Theses

This thesis will explore art education as a therapeutic tool in a public education system. This topic will serve as a continuation of research that I conducted previously but will bring more focus upon bringing a certified art therapist into public school districts in West Virginia. Data will be collected through student surveys, interviews of professional art therapists, and administrative officials. Data will also be collected through a review of the literature surrounding the benefits of art therapy to children and adolescents. Through these sources I will explore the attitudes, beliefs, and practices of educational professionals, art therapists, administrators and ...


Electrode And Headgear Design For Accurate Tdcs, Henry Bernstein Jan 2018

Electrode And Headgear Design For Accurate Tdcs, Henry Bernstein

Master's Theses

Stimulating the brain with a low current that is focused on specific regions of the brain has been shown to modify brain function and treat various neurological diseases. Transcranial direct current stimulation (TDCS) has been an effective and life changing alternative treatment for a vast range of neurological conditions including depression, epilepsy, stroke rehabilitation, addiction and chronic pain but only if it is administered correctly. During TDCS, a weak constant current is applied to precise locations on the scalp to modulate brain activity. Those locations can be determined by the cumbersome 10-20 EEG measurement system, transcranial magnetic stimulation or neuronavigation ...


Wnt Secretion Proteins Modulate Rankl-Induced Expression Of Aire In Thymic Epithelial Cells, Daniel Pollack Jan 2018

Wnt Secretion Proteins Modulate Rankl-Induced Expression Of Aire In Thymic Epithelial Cells, Daniel Pollack

Master's Theses

Thymic epithelial cells (TEC) are essential for a proper adaptive immune response by regulating thymocyte development and establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, and development although the direct molecular mechanisms in TECs have yet to be elucidated. The inducible inhibition of canonical Wnt signaling with Dkk1 leads to a rapid loss of TEC progenitors as well as a decline in mature Aire-expressing mTECs. Therefore, we explore the role of Wnt ligands potentially responsible for stimulating and/or regulating ...


A Novel Model Of “Remedy And Elimination Of Tuberculosis”, Akanksha Mishra Dec 2017

A Novel Model Of “Remedy And Elimination Of Tuberculosis”, Akanksha Mishra

Master's Theses

Tuberculosis (TB), is one of the top ten causes of death worldwide. TB is commonly linked to poverty and creates poverty as it is the single largest cause of death in the 15-49-year-old age group in South-East Asia (WHO, 2017). It is also linked to the HIV population, and its leading cause of death. TB is effected by socio-economic factors, cultural factors, and health policy. My goal of this dissertation is to identify systematic approaches that shall support the mission set by World Health Organization (WHO): to eliminate TB globally by the year 2050. Measures might include addressing social barriers ...


The Influence Of Parental Communication About Sexual Health On Quality Of Emerging Adult Romantic Relationships, Jaclyn D. Powers Aug 2017

The Influence Of Parental Communication About Sexual Health On Quality Of Emerging Adult Romantic Relationships, Jaclyn D. Powers

Master's Theses

The research on relationships between parent-child communication about sexuality and sexual communication between adult partners is currently lacking. The current study aims to examine the influence of parent-child sexual communication on adult sexual communication when those children reach adulthood and engage in romantic relationships. Parent-child sexual communication, attachment styles, sexual attitudes, and partner sexual communication were examined for influence on the physical and emotional relationship satisfaction of emerging adults. Study 1 included a quantitative analysis with 553 emerging adults participating in an online survey, and study 2 incorporated a qualitative analysis with an additional 7 emerging adults participating in online ...


Effects Of Low Dose Mixtures Of 3,4-Methylenedioxypyrovalerone And Cocaine On Locomotor Activity And Brain Monoamine Content In Sprague-Dawley Rats, Robert J. Kohler Jun 2017

Effects Of Low Dose Mixtures Of 3,4-Methylenedioxypyrovalerone And Cocaine On Locomotor Activity And Brain Monoamine Content In Sprague-Dawley Rats, Robert J. Kohler

Master's Theses

Synthetic cathinones, known as “bath salts” on the illicit drug market, pose a significant and growing public health concern. 3,4-Methylenedioxypyrovalerone (MDPV), one of several popular constituents of the illicit bath salts, produces similar pharmacological actions to cocaine, albeit with greater potency. The present study sought to characterize behavioral and neurochemical effects of repeated exposure to MDPV alone and in combination with cocaine. Male Sprague-Dawley rats were randomly assigned to one of four treatments: 1 mg/kg MDPV, 5 mg/kg cocaine, 1 mg/kg MDPV + 5 mg/kg cocaine, or saline. Locomotor activity was assessed for one hour immediately ...


The Acquisition And Analysis Of Electroencephalogram Data For The Classification Of Benign Partial Epilepsy Of Childhood With Centrotemporal Spikes, Jessica A. Scarborough May 2017

The Acquisition And Analysis Of Electroencephalogram Data For The Classification Of Benign Partial Epilepsy Of Childhood With Centrotemporal Spikes, Jessica A. Scarborough

Master's Theses

In this thesis, I will expand upon each step in the process of acquiring and analyzing electroencephalogram (EEG) for the classification of benign childhood epilepsy with centrotemporal spikes. Despite huge advancements in the field of health informatics—natural language processing, machine learning, predictive modeling—there are significant barriers to the access of clinical data. These barriers include information blocking, privacy policy concerns, and a lack of stakeholder support. We will see that these roadblocks are all responsible for stunting biomedical research in some way, including my own experiences in acquiring the data for the second chapter of this thesis.

This ...


Do Marketing Strategies Impact Condom Sales In Uganda?, Meyhar Mohammed May 2017

Do Marketing Strategies Impact Condom Sales In Uganda?, Meyhar Mohammed

Master's Theses

What attracts people to buy condoms? HIV/AIDS remain one of the biggest health dangers of the world, especially in Sub-Saharan Africa. A lot of efforts have been pursued in the past two decades to drastically reduce prevalence of HIV and increase awareness about preventive mechanisms. In order to prevent relapse of success achieved so far, it is important to recognize transformation of consumer behavior due to growth in social networks, education and awareness over time. There are a lot of behavioral triggers captured by social marketing interventions in the field of public health. In an attempt to investigate the ...


The Study Of The Development Of Negation In Bilingual Spanish/English And Monolingual English Speakers, Isabel Cristina Verduzco Jan 2017

The Study Of The Development Of Negation In Bilingual Spanish/English And Monolingual English Speakers, Isabel Cristina Verduzco

Master's Theses

Problem

Negation is one of the first concepts learned early during childhood and one of the most important ones for communication. Current studies focus on how negation is developed universally in each specific language and how it is governed by patterns of acquisition, however, there are factors that may affect this process. How does learning two languages simultaneously affect the normal development of negation? Analyzing how the exposure to two different languages affects the normal development of negation is important for understanding how bilingualism influences normal language development. This study is also important for the analysis of speech and language ...


A Comparison Of Vocal Health, Hygiene, And Perceptions In Student Teachers, Voice Music Majors, And Speech-Language Pathology Majors: A Preliminary Study, Kenreah Lavaughn Brown Jan 2017

A Comparison Of Vocal Health, Hygiene, And Perceptions In Student Teachers, Voice Music Majors, And Speech-Language Pathology Majors: A Preliminary Study, Kenreah Lavaughn Brown

Master's Theses

Problem

There are many college/university students studying to become teachers, professional singers, and speech-language pathologists. Yet, despite research available on the risk of developing voice disorders in these areas of study, very little was found on such individuals while in the college setting. This is particularly true for speech-language pathologists who have limited research available overall.

Method

Nineteen students between the ages of 18- 43 years old, completed pre-and-post-testing of the Glottal Function Index (GFI), Voice Hygiene Questionnaire (VHQ), and the objective measures (maximum phonational frequency range, sustained phonation, jitter, and shimmer).

Results

The chi-square of independence results showed ...


Study Of The Ability To Detect Humor In Visual Images By 2-5 Year Olds, Sonovia Latoya Mcfall Jan 2017

Study Of The Ability To Detect Humor In Visual Images By 2-5 Year Olds, Sonovia Latoya Mcfall

Master's Theses

Problem

Understanding the impact that humor can have as a form of therapy has been studied mostly in relation to mental and spiritual healing. As a result, little focus has been given to understanding the types of humor and how one’s understanding of and appreciation for types of humor develop over time. Gaining an understanding of humor development is important due to discoveries that the use of humor is a great intervention tool when working with children. Nevertheless, the use of pictures (with humor) is often used within speech therapy sessions, but seldom used correctly due to the lack ...


Theory Of Mind And Negation, Jasmine Buckins Jan 2017

Theory Of Mind And Negation, Jasmine Buckins

Master's Theses

Problem

There is an extensive amount of research on theory of mind, which is the ability to attribute mental states (e.g., beliefs, intents, desires, knowledge, etc.) to oneself and others and to comprehend that others have beliefs, desires, intentions and perspectives that may be different from one’s own. Some researchers have investigated the potential prerequisites or developmental milestones that may be required in order for a theory of mind to be developed in young children. Some researchers have concluded that certain factors play a role in theory of mind development. These factors include environmental, cognitive and linguistic components ...


Creating A Bret Assay To Monitor The Interaction Between Β-Arrestin-1 And Stam-1, James Buhrmaster Jan 2017

Creating A Bret Assay To Monitor The Interaction Between Β-Arrestin-1 And Stam-1, James Buhrmaster

Master's Theses

CXCR4 is a chemokine receptor that is overexpressed in multiple disease states, including cancer. Understanding the mechanisms by which cells regulate CXCR4 expression is of high importance, as they can reveal downstream effectors that can potentially be targeted pharmacologically to more effectively treat diseases with fewer side effects.

CXCR4 is internalized in response to stimulation by its ligand CXCL12, and localizes to early endosomes as part of a homologous desensitization mechanism. From the endosome, CXCR4 can enter one of two pathways whereby it is either recycled back to the plasma membrane, where it can undergo another signaling event, or it ...


Using Tcr Transgenic, Gp100 Reactive T Cells And Checkpoint Inhibition To Target Lymphangioleimyomatosis, Christian Ankney Jan 2017

Using Tcr Transgenic, Gp100 Reactive T Cells And Checkpoint Inhibition To Target Lymphangioleimyomatosis, Christian Ankney

Master's Theses

Lymphangioleiomyomatosis (LAM) is a low-grade neoplastic disease affecting primarily women. It is characterized by cystic lung disease as well as renal and retroperitoneal tumors called angiomyolipomas and lymphangiomas. Tumor cells have smooth muscle features as well as neuroendocrine cell surface markers, and the disease can be diagnosed by HMB45 staining of tumor cells. We questioned whether expression of melanocytic antigens, specifically gp100, creates an opportunity to treat LAM by adoptive T cell transfer. LAM lung lesions demonstrate poor immune surveillance, therefore adoptive T cell transfer could offer benefits in this disease.

A link was made between melanoma and depigmenting vitiligo ...


The Unconventional Secretion Of Alpha-Synuclein By Autophagic Mechanisms And The Novel Characterization Of Pathological Alpha-Synuclein Associated Extracellular Vesicles, Kevin Burbidge Jan 2017

The Unconventional Secretion Of Alpha-Synuclein By Autophagic Mechanisms And The Novel Characterization Of Pathological Alpha-Synuclein Associated Extracellular Vesicles, Kevin Burbidge

Master's Theses

Synucleinopathies are a group of neurodegenerative diseases associated with the intracellular accumulation of aggregated α-synuclein, a neurotoxic process resulting in cell death. Research indicates that pathology results from α-synuclein misfolding and self-propagation, as well as, cell-to-cell transmission. Furthermore, pathological α-synuclein transmission may occur through unconventional secretion.

In this thesis, we investigated how autophagy influences unconventional secretion of our novel α-synuclein dual-split protein model that we first verified by reproducing documented results from treatment of known autophagic regulators. Afterwards, we investigated how knocking out autophagic proteins ATG7 and Beclin-1 influenced α-synuclein secretion.

Additionally, we developed a ...


Comparative Studies On Biochemical And Pharmacological Profiles Of Bovine, Ovine And Porcine Heparins, Ahmed Kouta Jan 2017

Comparative Studies On Biochemical And Pharmacological Profiles Of Bovine, Ovine And Porcine Heparins, Ahmed Kouta

Master's Theses

Heparin, a highly sulfated glycosaminoglycan (GAG), is used extensively as an anticoagulant. It consists of repeating disaccharide units, containing iduronic acid (or glucuronic acid) and glucosamine, exhibiting variable degrees of sulfation. Heparin, and its analogues, are used during surgery and dialysis, and are often used to coat indwelling catheters and other devices where the vascular system is exposed. Administered parenterally, often continuously due to its short half-life, over 0.5 billion doses are required per year. Heparin is currently obtained from mucosal tissue of meat animals, mainly porcine intestine, and to a lesser extent bovine and ovine sources. The early ...


Taurine's Effect On Cocaine Reward And Neurogenesis In The Adolescent Male Rat Brain., Avery E. Villa-Gonzalez Jan 2017

Taurine's Effect On Cocaine Reward And Neurogenesis In The Adolescent Male Rat Brain., Avery E. Villa-Gonzalez

Master's Theses

Adolescence is a developmentally critical transition from childhood to adulthood including both maturation of the body and the brain. Neuroplastic changes result in dynamic organization of the brain during adolescence, leaving them vulnerable to development of mental illness and drug-seeking behavior. According to the United Nations Office on Drugs and Crime, the psychostimulant cocaine is the second most popular illicit drug in the world. Cocaine, amongst having many detrimental effects, has shown to also decrease hippocampal neurogenesis, resulting in decreased neuroplasticity and cognitive dysfunction. Previous students in our laboratory have shown that treatment of adult male rats with the essential ...


The Effects Of Superordinate Identity Recategorization And Social Value Orientation On Ethical Decision-Making In A Business Dilemma, Thomas Steven Colville Jan 2017

The Effects Of Superordinate Identity Recategorization And Social Value Orientation On Ethical Decision-Making In A Business Dilemma, Thomas Steven Colville

Master's Theses

The purpose of the present study was to investigate potential solutions to the prevalence of unethical behavior in groups, specifically through the use of superordinate recategorization. Superordinate recategorization allows group members to feel an affinity with others not typically included in their in-group. This should promote ethical decision-making by enabling the inherent in-group favoring tendencies found in groups to be extended to a more inclusive category. In the context of the present study, the ethicality of participants' behavior in the Panalba scenario was determined by their choices on a 1 to 6 scale from least to most ethical. Additionally, participants ...


Automatic Optimum Atlas Selection For Multi-Atlas Image Segmentation Using Joint Label Fusion, Kofi Agyeman Jan 2017

Automatic Optimum Atlas Selection For Multi-Atlas Image Segmentation Using Joint Label Fusion, Kofi Agyeman

Master's Theses

Multi-atlas image segmentation using label fusion is one of the most accurate state of the art image segmentation techniques available for biomedical imaging applications. Motivated to achieve higher image segmentation accuracy, reduce computational costs and a continuously increasing atlas data size, a robust framework for optimum selection of atlases for label fusion is vital. Although believed not to be critical for weighted label fusion techniques by some works (Sabuncu, M. R. et al., 2010, [1]), others have shown that appropriate atlas selection has several merits and can improve multi-atlas image segmentation accuracy (Aljabar et al., 2009, [2], Van de Velde ...


Effect Of Listening To Music During Warmup On Wingate Anaerobic Test Performance, Russell P. Fox Dec 2016

Effect Of Listening To Music During Warmup On Wingate Anaerobic Test Performance, Russell P. Fox

Master's Theses

The primary purpose of this study was to determine whether or not different music conditions would affect performance on the Wingate anaerobic test. We also sought to explore the effect of music on psychological variables such as, rating of perceived exertion (RPE).

16 subject (8 males, 8 females) listened to either pre-selected music, self-selected music or white noise during a 10-minute warmup, cycling at 50 Rev.min-1 for 10 minutes with a light resistance of one kilogram. Once the warmup was completed they performed a Wingate Anaerobic test against a resistance of 7.5% of their body mass in kilograms ...


The Oncolytic Potential Of Tanapoxvirus To Treat Retinoblastoma, John D. Christie Dec 2016

The Oncolytic Potential Of Tanapoxvirus To Treat Retinoblastoma, John D. Christie

Master's Theses

Retinoblastoma is the leading cause of intraocular malignancy in children under 2 years of age. Current treatments, while generally effective in eliminating the tumor, have many negative side effects. Oncolytic virotherapy is the use of either wild type or recombinant viruses, to destroy tumor cells. There are currently several viruses being engineered as potential therapeutics for a wide range of cancers. They offer tumor specific alternative to current therapies with lesser toxicity. This study looked at the oncolytic efficacy of multiple tanapoxviruses (TPV) recombinants in an in vitro retinoblastoma. Here we have tested recombinants of TPV for their ability to ...