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Articles 1711 - 1737 of 1737

Full-Text Articles in Medicine and Health Sciences

Two Distinct Categories Of Focal Deletions In Cancer Genomes, M. Rajaram, M. Kato, L. Myeroff, S. D. Markowitz, S. W. Lowe, M. Zhang, A. Krasnitz, R. Lucito, D. Mu, R. S. Powers, +13 Additional Authors Jan 2013

Two Distinct Categories Of Focal Deletions In Cancer Genomes, M. Rajaram, M. Kato, L. Myeroff, S. D. Markowitz, S. W. Lowe, M. Zhang, A. Krasnitz, R. Lucito, D. Mu, R. S. Powers, +13 Additional Authors

Journal Articles

One of the key questions about genomic alterations in cancer is whether they are functional in the sense of contributing to the selective advantage of tumor cells. The frequency with which an alteration occurs might reflect its ability to increase cancer cell growth, or alternatively, enhanced instability of a locus may increase the frequency with which it is found to be aberrant in tumors, regardless of oncogenic impact. Here we've addressed this on a genome-wide scale for cancer-associated focal deletions, which are known to pinpoint both tumor suppressor genes (tumor suppressors) and unstable loci. Based on DNA copy number ...


Protein-Tyrosine Phosphatase 1b Antagonized Signaling By Insulin-Like Growth Factor-1 Receptor And Kinase Brk/Ptk6 In Ovarian Cancer Cells, G. F. Fan, G. Lin, R. Lucito, N. K. Tonks Jan 2013

Protein-Tyrosine Phosphatase 1b Antagonized Signaling By Insulin-Like Growth Factor-1 Receptor And Kinase Brk/Ptk6 In Ovarian Cancer Cells, G. F. Fan, G. Lin, R. Lucito, N. K. Tonks

Journal Articles

Ovarian cancer, which is the leading cause of death from gynecological malignancies, is a heterogeneous disease known to be associated with disruption of multiple signaling pathways. Nevertheless, little is known regarding the role of protein phosphatases in the signaling events that underlie the disease; such knowledge will be essential to gain a complete understanding of the etiology of the disease and how to treat it. We have demonstrated that protein-tyrosine phosphatase 1B (PTP1B) was underexpressed in a panel of ovarian carcinoma-derived cell lines, compared with immortalized human ovarian surface epithelial cell lines. Stable restoration of PTP1B in those cancer cell ...


Loss Of Dok2 Induces Carboplatin Resistance In Ovarian Cancer Via Suppression Of Apoptosis, E. Lum, M. Vigliotti, N. Banerjee, N. Cutter, K. O. Wrzeszczynski, S. Khan, S. Kamalakaran, D. A. Levine, N. Dimitrova, R. Lucito Jan 2013

Loss Of Dok2 Induces Carboplatin Resistance In Ovarian Cancer Via Suppression Of Apoptosis, E. Lum, M. Vigliotti, N. Banerjee, N. Cutter, K. O. Wrzeszczynski, S. Khan, S. Kamalakaran, D. A. Levine, N. Dimitrova, R. Lucito

Journal Articles

Objective. Ovarian cancers are highly heterogeneous and while chemotherapy is the preferred treatment many patients are intrinsically resistant or quickly develop resistance. Furthermore, all tumors that recur ultimately become resistant. Recent evidence suggests that epigenetic deregulation may be a key factor in the onset and maintenance of chemoresistance. We set out to identify epigenetically silenced genes that affect chemoresistance. Methods. The epigenomes of a total of 45 ovarian samples were analyzed to identify epigenetically altered genes that segregate with platinum response, and further filtered with expression data to identify genes that were suppressed. A tissue culture carboplatin resistance screen was ...


Stereotactic Body Radiotherapy For Localized Prostate Cancer: Disease Control And Quality Of Life At 6 Years, A. J. Katz, M. Santoro, F. Diblasio, R. Ashley Jan 2013

Stereotactic Body Radiotherapy For Localized Prostate Cancer: Disease Control And Quality Of Life At 6 Years, A. J. Katz, M. Santoro, F. Diblasio, R. Ashley

Journal Articles

Background: Stereotactic body radiotherapy (SBRT) may yield disease control for prostate cancer in a brief, hypofractionated treatment regimen without increasing treatment toxicity. Our report presents a 6-year update from 304 low- (n = 211), intermediate- (n = 81), and high-risk (n = 12) prostate cancer patients who received CyberKnife SBRT. Methods: The median PSA at presentation was 5.8 ng/ml. Fifty-seven patients received neoadjuvant hormonal therapy for up to one year. The first 50 patients received a total dose of 35 Gy in 5 fractions of 7 Gy. The subsequent 254 patients received a total dose of 36.25 Gy in 5 ...


Urinary Tract Infections And Post-Operative Fever In Percutaneous Nephrolithotomy, J. Gutierrez, A. Smith, P. Geavlete, H. Shah, A. R. Kural, M. De Sio, J. H. A. Sesmero, A. Hoznek, J. De La Rosette Jan 2013

Urinary Tract Infections And Post-Operative Fever In Percutaneous Nephrolithotomy, J. Gutierrez, A. Smith, P. Geavlete, H. Shah, A. R. Kural, M. De Sio, J. H. A. Sesmero, A. Hoznek, J. De La Rosette

Journal Articles

To review the incidence of UTIs, post-operative fever, and risk factors for post-operative fever in PCNL patients. Between 2007 and 2009, consecutive PCNL patients were enrolled from 96 centers participating in the PCNL Global Study. Only data from patients with pre-operative urine samples and who received antibiotic prophylaxis were included. Pre-operative bladder urine culture and post-operative fever (> 38.5A degrees C) were assessed. Relationship between various patient and operative factors and occurrence of post-operative fever was assessed using logistic regression analyses. Eight hundred and sixty-five (16.2%) patients had a positive urine culture; Escherichia coli was the most common micro-organism ...


Use Of Desipramine For The Treatment Of Overactive Bladder Refractory To Antimuscarinic Therapy, J. H. Hillelsohn, S. Rais-Bahrami, N. Bagadiya, M. Kashan, G. H. Weiss Jan 2013

Use Of Desipramine For The Treatment Of Overactive Bladder Refractory To Antimuscarinic Therapy, J. H. Hillelsohn, S. Rais-Bahrami, N. Bagadiya, M. Kashan, G. H. Weiss

Journal Articles

Purpose: To evaluate the use of desipramine in the treatment of overactive bladder (OAB). Materials and Methods: We retrospectively evaluated 43 patients who were treated with desipramine for OAB refractory to antimuscarinic therapy. These OAB patients were stratified by the presence or absence of bladder pain. Results: Forty-three patients were evaluated with a mean follow up time of 12.2 +/- 4.6 months. The mean age of the patients was 71 16 years. Twelve patients (28%) discontinued desipramine, 9 due to perceived lack of efficacy, 2 due to central anticholinergic side effects, and 1 due to the development of oropharyngeal ...


Meaningful Use And Meaningful Curricula: A Survey Of Health Informatics Programs In The U.S., Kai Koong, Madison Ngafeeson, Lai Lui Aug 2012

Meaningful Use And Meaningful Curricula: A Survey Of Health Informatics Programs In The U.S., Kai Koong, Madison Ngafeeson, Lai Lui

Journal Articles

The introduction of the US government’s Meaningful Use criteria carries with it many implications including the training curriculum of healthcare personnel. This study examines 108 health informatics degree programmes across the USA. First, the courses offered are identified and classified into generic classes. Next, these generic groupings are mapped to two important frameworks: the Learning to Manage Health Information (LMHI) academic framework; and the Meaningful Use criteria policy framework. Results suggest that while current curricula seemed acceptable in addressing Meaningful Use Stage 1 objective, there was insufficient evidence that these curricula could support Meaningful Use Stage 2 and Stage ...


(1s, 3s)-3-Amino-4-Difluoromethylenyl-1-Cyclopentanoic Acid (Cpp-115), A Potent Gamma-Aminobutyric Acid Aminotransferase Inactivator For The Treatment Of Cocaine Addiction, Y. Pan, M. R. Gerasimov, T. Kvist, P. Wellendorph, K. K. Madsen, E. Pera, H. Lee, A. Schousboe, S. L. Dewey, R. B. Silverman, +6 Additional Authors Jan 2012

(1s, 3s)-3-Amino-4-Difluoromethylenyl-1-Cyclopentanoic Acid (Cpp-115), A Potent Gamma-Aminobutyric Acid Aminotransferase Inactivator For The Treatment Of Cocaine Addiction, Y. Pan, M. R. Gerasimov, T. Kvist, P. Wellendorph, K. K. Madsen, E. Pera, H. Lee, A. Schousboe, S. L. Dewey, R. B. Silverman, +6 Additional Authors

Journal Articles

No abstract provided.


Posttraumatic Stress Disorder Prevalence And Risk Of Recurrence In Acute Coronary Syndrome Patients: A Meta-Analytic Review., D. Edmondson, S. Richardson, L. Falzon, K. W. Davidson, M. A. Mills, Y. Neria Jan 2012

Posttraumatic Stress Disorder Prevalence And Risk Of Recurrence In Acute Coronary Syndrome Patients: A Meta-Analytic Review., D. Edmondson, S. Richardson, L. Falzon, K. W. Davidson, M. A. Mills, Y. Neria

Journal Articles

BACKGROUND: Acute coronary syndromes (ACS; myocardial infarction or unstable angina) can induce posttraumatic stress disorder (PTSD), and ACS-induced PTSD may increase patients' risk for subsequent cardiac events and mortality.

OBJECTIVE: To determine the prevalence of PTSD induced by ACS and to quantify the association between ACS-induced PTSD and adverse clinical outcomes using systematic review and meta-analysis.

DATA SOURCES: Articles were identified by searching Ovid MEDLINE, PsycINFO, and Scopus, and through manual search of reference lists.

METHODOLOGY/PRINCIPAL FINDINGS: Observational cohort studies that assessed PTSD with specific reference to an ACS event at least 1 month prior. We extracted estimates of ...


Our Experience With Two Cardioplegic Solutions: Dextrose Versus Non-Dextrose In Adult Cardiac Surgery, R. Lessen, J. Dicapua, R. Pekmezaris, R. Walia, K. Bocchieri, L. Jahn, M. Akerman, M. L. Lesser, A. Hartman Jan 2012

Our Experience With Two Cardioplegic Solutions: Dextrose Versus Non-Dextrose In Adult Cardiac Surgery, R. Lessen, J. Dicapua, R. Pekmezaris, R. Walia, K. Bocchieri, L. Jahn, M. Akerman, M. L. Lesser, A. Hartman

Journal Articles

Intraoperative hyperglycemia has been observed to be associated with increased morbidity and mortality after cardiac surgery. Dextrose cardioplegia is used for its cardioprotective effects but may lead to intraoperative hyperglycemia and more postoperative complications. This was a retrospective observational study. Patient records (n = 2301) were accessed from a large database at a tertiary care facility. The two groups (dextrose vs. nondextrose) were then matched using preoperative variables of age, sex, body mass index, wound exposure time, preoperative HbA1c levels, renal failure, hypertension, and prior cerebrovascular disease. The following outcomes were recorded: 30-day mortality, sternal wound infection, stroke, and highest glucose ...


Compromised Osseous Healing Of Dental Extraction Sites In Zoledronic Acid-Treated Dogs., M. R. Allen, D. J. Kubek, D. B. Burr, S. L. Ruggiero, T. M. G. Chu Jan 2011

Compromised Osseous Healing Of Dental Extraction Sites In Zoledronic Acid-Treated Dogs., M. R. Allen, D. J. Kubek, D. B. Burr, S. L. Ruggiero, T. M. G. Chu

Journal Articles

UNLABELLED: The goal of this study was to document how treatment with high doses of zoledronic acid affects dental extraction healing. Our results, showing significantly compromised osseous healing within the socket as well as presence of exposed bone and development of a sequestrum in one animal, provide a building block toward understanding osteonecrosis of the jaw.

PURPOSE: The goal of this study was to document how treatment with a bisphosphonate affects the bone tissue following dental extraction.

METHODS: Skeletally mature female beagle dogs were either untreated controls (CON) or treated with intravenous zoledronic acid (ZOL). Following the extraction of the ...


Inside And Out: An Epicardial Lead Gone Astray, S. N. Hong, B. Rosenzweig, G. A. Crooke, I. Kronzon, M. B. Srichai Jan 2011

Inside And Out: An Epicardial Lead Gone Astray, S. N. Hong, B. Rosenzweig, G. A. Crooke, I. Kronzon, M. B. Srichai

Journal Articles

No abstract provided.


Noninvasive Ventilation In Acute Respiratory Failure Due To H1n1 Influenza: A Word Of Caution, A. Singh, J. Singh Jan 2011

Noninvasive Ventilation In Acute Respiratory Failure Due To H1n1 Influenza: A Word Of Caution, A. Singh, J. Singh

Journal Articles

No abstract provided.


Management Of Hypertension Among Patients With Coronary Heart Disease, O. Olafiranye, F. Zizi, P. Brimah, G. Jean-Louis, A. N. Makaryus, S. Mcfarlane, G. Ogedegbe Jan 2011

Management Of Hypertension Among Patients With Coronary Heart Disease, O. Olafiranye, F. Zizi, P. Brimah, G. Jean-Louis, A. N. Makaryus, S. Mcfarlane, G. Ogedegbe

Journal Articles

Evidence suggests that coronary heart disease (CHD) is the most common outcome of hypertension. Hypertension accelerates the development of atherosclerosis, and sustained elevation of blood pressure (BP) can destabilize vascular lesions and precipitate acute coronary events. Hypertension can cause myocardial ischemia in the absence of CHD. These cardiovascular risks attributed to hypertension can be reduced by optimal BP control. Although several antihypertensive agents exist, the choice of agent and the appropriate target BP for patients with CHD remain controversial. In this succinct paper, we examine the evidence and the mechanisms for the linkage between hypertension and CHD and we discuss ...


Intravenous Erythropoietin In Patients With St-Segment Elevation Myocardial Infarction - Reveal: A Randomized Controlled Trial, S. S. Najjar, S. V. Rao, C. Melloni, S. V. Raman, T. J. Povsic, L. Melton, G. W. Barsness, K. Prather, L. Gruberg, R. A. Harrington, +10 Additional Authors Jan 2011

Intravenous Erythropoietin In Patients With St-Segment Elevation Myocardial Infarction - Reveal: A Randomized Controlled Trial, S. S. Najjar, S. V. Rao, C. Melloni, S. V. Raman, T. J. Povsic, L. Melton, G. W. Barsness, K. Prather, L. Gruberg, R. A. Harrington, +10 Additional Authors

Journal Articles

Context: Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. Objective: To evaluate the safety and efficacy of a single intravenous bolus of epoetin alfa in patients with STEMI. Design, Setting, and Patients: A prospective, randomized, double-blind, placebo-controlled trial with a dose-escalation safety phase and a single dose (60 000 U of epoetin alfa) efficacy phase; the Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction (REVEAL) trial was conducted at 28 US sites between October ...


A Discourse On The Public Nature Of Research In Contemporary Life Science: A Law-Policy Proposal To Promote The Public Nature Of Science In An Era Of Academia-Industry Integration, Michael J. Malinowski Jan 2009

A Discourse On The Public Nature Of Research In Contemporary Life Science: A Law-Policy Proposal To Promote The Public Nature Of Science In An Era Of Academia-Industry Integration, Michael J. Malinowski

Journal Articles

This article addresses the impact of integration of academia, industry, and government on the public nature of research. The article concludes that, while the integration has benefited science immensely, regulatory measures should be taken to restore the public nature of research in an age of integration.


Respecting, Rather Than Reacting To, Race In Biomedical Research: A Response To Professors Caulfield And Mwaria, Michael J. Malinowski Jan 2009

Respecting, Rather Than Reacting To, Race In Biomedical Research: A Response To Professors Caulfield And Mwaria, Michael J. Malinowski

Journal Articles

This Commentary is part of a colloquy on race-based genetics research.


United States Regulation Of Stem Cell Research: Recasting Government's Role And Questions To Be Resolved, Owen C. B. Hughes, Alan L. Jakimo, Michael J. Malinowski Jan 2008

United States Regulation Of Stem Cell Research: Recasting Government's Role And Questions To Be Resolved, Owen C. B. Hughes, Alan L. Jakimo, Michael J. Malinowski

Journal Articles

This article directly addresses the stem cell controversy, but also the broader history and norms regarding the roles of federal and state government in U.S. science research funding.


The Pedagogical Significance Of The Bush Stem Cell Policy: A Window Into Bioethical Regulation In The United States (President George W. Bush, Fifth Anniversary Essay Collection), O. Carter Snead Jan 2005

The Pedagogical Significance Of The Bush Stem Cell Policy: A Window Into Bioethical Regulation In The United States (President George W. Bush, Fifth Anniversary Essay Collection), O. Carter Snead

Journal Articles

The enormous significance of the Bush stem cell funding policy has been evident since its inception. The announcement of the policy on August 9, 2001 marked the first time a U.S. president had ever taken up a matter of bioethical import as the sole subject of a major national policy address. Indeed, the August 9th speech was the President's first nationally televised policy address of any kind. Since then, the policy has been a constant focus of attention and discussion by political commentators, the print and broadcast media, advocacy organizations, scientists, elected officials, and candidates for all levels ...


A Legal Remedy For Homophobia: Finding A Cure In The International Right To Health, Michael Boucai Jan 2005

A Legal Remedy For Homophobia: Finding A Cure In The International Right To Health, Michael Boucai

Journal Articles

This article argues that the international right to health obligates governments to combat homophobia. Part One presents the powerful evidence that stigma, prejudice, and violence directed toward lesbian and gay people drastically endanger their physical and mental well-being. Part Two defends an expansive interpretation of the international right to health. Applying this interpretation, Part Three proposes that gay men and lesbians are entitled to demand that their governments to eliminate all public and much private discrimination against gay men and lesbians, and requires them to combat homophobia through education and other positive efforts. Acknowledging that this obligation is unlikely to ...


Domestic Violence & Partner Notification: Implications For Treatment And Counseling Of Women With Hiv, Karen H. Rothenberg, Stephen Paskey, Melissa M. Reuland, Sheryl Itkin Zimmerman, Richard L. North Jan 1995

Domestic Violence & Partner Notification: Implications For Treatment And Counseling Of Women With Hiv, Karen H. Rothenberg, Stephen Paskey, Melissa M. Reuland, Sheryl Itkin Zimmerman, Richard L. North

Journal Articles

No abstract provided.


The Risk Of Domestic Violence And Women With Hiv Infection: Implications For Partner Notification, Public Policy, And The Law, Karen H. Rothenberg, Stephen Paskey Jan 1995

The Risk Of Domestic Violence And Women With Hiv Infection: Implications For Partner Notification, Public Policy, And The Law, Karen H. Rothenberg, Stephen Paskey

Journal Articles

No abstract provided.


Abortion/Reproductive Rights, Sandra S. Klein Jan 1994

Abortion/Reproductive Rights, Sandra S. Klein

Journal Articles

The issue of a woman's right to choose whether or not to continue with a pregnancy has proven to be complicated for many reasons, not the least of which is the implications for a person's right to do with her body as she sees fit. The bibliography that follows provides the researcher with an in depth look at this issue, with an emphasis on the privacy aspects.


Analysis Of The Carbon-13 And Proton Nmr Spectra Of Bovine Chromaffin Granules, Edward P. Richards, Robert R. Sharp Jan 1977

Analysis Of The Carbon-13 And Proton Nmr Spectra Of Bovine Chromaffin Granules, Edward P. Richards, Robert R. Sharp

Journal Articles

Natural abundance carbon-13 and proton NMR spectra of bovine chromaffin granules have been obtained and analyzed using computer simulation techniques. High resolution spectra show the presence of a fluid aqueous phase containing epinephrine, ATP and a random coil protein. The protein spectrum conrains unusually intense resonances due to glutamic acid and proline and has been simulated satisfactorily using the known amino acid composition of chromogranin A.

The lipid phase of chromaffin granules gives rise to intense, but very broad, resonances in the carbon-13 spectrum. Protons in the lipid phase are also observable as a very rapid component of the proton-free ...


Molecular Mobilities Of Soluble Components In The Aqueous Phase Of Chromaffin Granules, Edward P. Richards, Robert R. Sharp Jan 1977

Molecular Mobilities Of Soluble Components In The Aqueous Phase Of Chromaffin Granules, Edward P. Richards, Robert R. Sharp

Journal Articles

NMR relaxation times have been used to characterize molecular motion and intermolecular complexes in the aqueous phase of bovine chromaffin granules. Partially relaxed '3C and proton spectra have been obtained at 3 and 25°C. T1 measurements of five protonated carbons on epinephrine (C:, Cs, C6, CHOH and NCH3) give a correlation time of 0.15 (10 -9) s at 25°C for the catechol ring and methine carbon, while the effective correlation time for the NCH3 group is somewhat shorter due to its internal degree of rotational freedom. Resonances of protonated carbons on the soluble protein chromogranin give very ...


Nmr Evidence For An Acetylcholine Atp Complex, Edward P. Richards, Robert R. Sharp Jan 1975

Nmr Evidence For An Acetylcholine Atp Complex, Edward P. Richards, Robert R. Sharp

Journal Articles

The interaction of acetylcholine with ATP was studied using proton NMR. T1 measurements indicate the formation of a complex with a probable composition of four (4) acetylcholine molecules for each ATP molecule.


Introduction, Thomas L. Shaffer Jan 1973

Introduction, Thomas L. Shaffer

Journal Articles

No abstract provided.