Medicine and Health Sciences Commons^™

Integrating Primary Care Into Community Mental Health Centres In Texas, Usa: Results Of A Case Study Investigation, Rebecca Wells, Ellen D Breckenridge, Sasha Ajaz, Aman Narayan, Daniel Brossart, James H Zahniser, Jolene Rasmussen

Journal Articles

INTRODUCTION: Despite evidence that people with serious mental illness benefit from receiving primary care within mental health care settings, there is little research on this type of integration. The objective of this study was to characterize how providers and patients experienced implementation of primary care into specialty mental health services.

METHODS: During site visits, study team members interviewed staff and conducted focus groups with patients at 10 United States community mental health centres then beginning to integrate primary into their practices. One year later, follow up phone interviews with key centre staff informants validated and updated findings. Data analysis included …

Blood Leukocyte Dna Methylation Predicts Risk Of Future Myocardial Infarction And Coronary Heart Disease., Golareh Agha, Michael M Mendelson, Cavin K Ward-Caviness, Roby Joehanes, Tianxiao Huan, Rahul Gondalia, Elias Salfati, Jennifer A Brody, Giovanni Fiorito, Jan Bressler, Brian H Chen, Symen Ligthart, Simonetta Guarrera, Elena Colicino, Allan C Just, Simone Wahl, Christian Gieger, Amy R Vandiver, Toshiko Tanaka, Dena G Hernandez, Luke C Pilling, Andrew B Singleton, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Yun Li, Guosheng Zhang, James D Stewart, James S Floyd, Kerri L Wiggins, Jerome I Rotter, Michael Multhaup, Kelly Bakulski, Steven Horvath, Philip S Tsao, Devin M Absher, Pantel Vokonas, Joel Hirschhorn, M Daniele Fallin, Chunyu Liu, Stefania Bandinelli, Eric Boerwinkle, Abbas Dehghan, Joel D Schwartz, Bruce M Psaty, Andrew P Feinberg, Lifang Hou, Luigi Ferrucci, Nona Sotoodehnia, Giuseppe Matullo, Annette Peters, Myriam Fornage, Themistocles L Assimes, Eric A Whitsel, Daniel Levy, Andrea A Baccarelli

Journal Articles

BACKGROUND: DNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts.

METHODS: Nine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conducted fixed-effect meta-analyses across cohorts.

RESULTS: Among …

Rising Rural Body-Mass Index Is The Main Driver Of The Global Obesity Epidemic In Adults, Honor Bixby, James Bentham, Bin Zhou, Mariachiara Di Cesare, Christopher J. Paciorek, James E. Bennett, Cristina Taddei, Gretchen A. Stevens, Andrea Rodriguez-Martinez, Rodrigo M. Carrillo-Larco, Young Ho Khang, Maroje Sorić, Edward W. Gregg, J. Jaime Miranda, Zulfiqar A. Bhutta

Journal Articles

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3–6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% …

Socioeconomic Inequality In Life Expectancy In India, Miqdad Asaria, Sumit Mazumdar, Samik Chowdhury, Papiya Mazumdar, Abhiroop Mukhopadhyay, Indrani Gupta

Journal Articles

Introduction Concern for health inequalities is an important driver of health policy in India; however, much of the empirical evidence regarding health inequalities in the country is piecemeal focusing only on specific diseases or on access to particular treatments. This study estimates inequalities in health across the whole life course for the entire Indian population. These estimates are used to calculate the socioeconomic disparities in life expectancy at birth in the population. Methods Population mortality data from the Indian Sample Registration System were combined with data on mortality rates by wealth quintile from the National Family Health Survey to calculate …

Prevalence Of Anaemia And Associated Factors Among Oraon Females Of North 24 Parganas, West Bengal, India, Tanaya Kundu Chowdhury, Subrata K. Roy

Journal Articles

Low haemoglobin level or anaemia is a health problem worldwide especially in developing countries like India. Anaemia is generally higher among indigenous groups compared to general population globally and females are specifically more prone to anaemia. However, studies are inadequate on indigenous groups of India. The aims of the study are to determine the prevalence of anaemia among the female Oraons of North 24 Parganas and to study the association between anaemia and concomitants like socio-demographic and food habit variables. Data have been collected on demographic, socio-economic and food habit variables using well-tested questionnaire from 309 Oraon females living in …

The Evidence Of Human Exposure To Glyphosate: A Review, C. Gillezeau, M. Van Gerwen, R. M. Shaffer, I. Rana, L. Zhang, L. Sheppard, E. Taioli

Journal Articles

© 2019 The Author(s). Background: Despite the growing and widespread use of glyphosate, a broad-spectrum herbicide and desiccant, very few studies have evaluated the extent and amount of human exposure. Objective: We review documented levels of human exposure among workers in occupational settings and the general population. Methods: We conducted a review of scientific publications on glyphosate levels in humans; 19 studies were identified, of which five investigated occupational exposure to glyphosate, 11 documented the exposure in general populations, and three reported on both. Results: Eight studies reported urinary levels in 423 occupationally and para-occupationally exposed subjects; 14 studies reported …

Outcomes Of Pulmonary Resection In Non-Small Cell Lung Cancer Patients Older Than 70 Years Old, A. Tantraworasin, S. Siwachat, N. Tanatip, N. Lertprasertsuke, S. Kongkarnka, J. Euathrongchit, Y. Wannasopha, T. Suksombooncharoen, E. Taioli, S. Saeteng, +1 Additional Author

Journal Articles

© 2019 Background: An appropriate treatment of older lung cancer patients has become an important issue. The aim of this study is to evaluate the short and long-term surgical outcomes in lung cancer patients using 70 years as a cut-point, and to identify prognostic factors of cancer-specific mortality in patients older than 70 years. Methods: Medical records of non-small cell lung cancer (NSCLC) patients who underwent pulmonary resection at Chiang Mai University Hospital from January 2002 through December 2016 were retrospectively reviewed. Patients were divided into age less than 70 years (control group) and 70 years or more (study group). …

Changes In Quality Of Life After Surgery Or Radiotherapy In Early-Stage Lung Cancer, R. M. Schwartz, N. Alpert, K. Rosenzweig, R. Flores, E. Taioli

Journal Articles

No abstract provided.

Transfer Of Extracellular Vesicle-Associated-Rnas Induces Drug Resistance In Alk-Translocated Lung Adenocarcinoma, H. H. Kwok, Z. Ning, P. W. Chong, T. S. Wan, M. H. Ng, G. Y. Ho, M. S. Ip, D. C. Lam

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Anaplastic lymphoma kinase (ALK) translocation is an actionable mutation in lung adenocarcinoma. Nonetheless tumour consists of heterogeneous cell subpopulations with diverse phenotypes and genotypes, and cancer cells can actively release extracellular vesicles (EVs) to modulate the phenotype of other cells in the tumour microenvironment. We hypothesized that EVs derived from a drug-resistant subpopulation of cells could induce drug resistance in recipient cells. We have established ALK-translocated lung adenocarcinoma cell lines and subclones. The subclones have been characterized and the expression of EV-RNAs determined by quantitative polymerase chain reaction. The effects of …

Increased Incidence Of Thyroid Cancer Among World Trade Center First Responders: A Descriptive Epidemiological Assessment, S. Tuminello, M. A. Van Gerwen, E. Genden, M. Crane, W. Lieberman-Cribbin, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = …

A Quality Improvement Assessment Of The Delivery Of Mental Health Services Among Wtc Responders Treated In The Community, M. Bellehsen, J. Moline, R. Rasul, K. Bevilacqua, S. Schneider, J. Kornrich, R. M. Schwartz

Journal Articles

No abstract provided.

Molecular Study Of Thyroid Cancer In World Trade Center Responders, M. A. Van Gerwen, S. Tuminello, G. J. Riggins, T. B. Mendes, M. Donovan, E. K. Benn, E. Genden, J. M. Cerutti, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Thyroid cancer incidence is higher in World Trade Center (WTC) responders compared with the general population. It is unclear whether this excess in thyroid cancer is associated with WTC-related exposures or if instead there is an over-diagnosis of malignant thyroid cancer among WTC first responders due to enhanced surveillance and physician bias. To maximize diagnostic yield and determine the false positive rate for malignancy, the histological diagnoses of thyroid cancer tumors from WTC responders and age, gender, and histology matched non-WTC thyroid cancer cases were evaluated using biomarkers of malignancy. Using …

Dietary Inflammatory Index (Dii) And Risk Of Prostate Cancer In A Case–Control Study Among Black And White Us Veteran Men, A. C. Vidal, T. Oyekunle, L. E. Howard, N. Shivappa, A. De Hoedt, J. C. Figueiredo, E. Taioli, J. H. Fowke, P. H. Lin, S. J. Freedland, +1 Additional Author

Journal Articles

© 2019, Springer Nature America, Inc. Background: We hypothesized a pro-inflammatory diet would be associated with higher prostate cancer (PC) risk. Methods: We prospectively recruited incident PC cases (n = 254) and controls (n = 328) at the Durham Veteran Affairs, from 2007 to 2018. From a self-completed 61-item Food Frequency Questionnaire, we calculated dietary inflammatory index (DII ® ) scores with and without supplements. We examined the association between DII scores with and without supplements and overall PC risk using logistic regression and risk of low-grade PC (grade group 1) and high-grade PC (grade group 2–5) with multinomial logistic …

Change In Quality Of Life After A Cancer Diagnosis Among A Nationally Representative Cohort Of Older Adults In The Us, R. M. Schwartz, K. A. Ornstein, B. Liu, N. Alpert, K. G. Bevilacqua, E. Taioli

Journal Articles

No abstract provided.

The Association Between Neonatal Death And Facility Birth In Regions Of India, Diane Coffey

Journal Articles

BACKGROUND Reducing neonatal mortality in India is critical to achieving the 2030 Sustainable Development Goal of a global neonatal mortality rate (NNM) of no more than 12 per 1,000. Policy efforts to reduce India's NNM, including a large-scale conditional cash transfer program, have focused on promoting birth in health facilities, rather than at home. Between 2005 and 2015, the percentage of facility births doubled, from 40% to 80%. OBJECTIVE We assess evidence for the hypothesis that facility births reduce NNM by using new data from the National Family Health Survey, 2015-2016. METHODS We analyze the association between neonatal death and …

Free Water In White Matter Differentiates Mci And Ad From Control Subjects, Matthieu Dumont, Maggie Roy, Pierre-Marc Jodoin, Felix C Morency, Jean-Christophe Houde, Zhiyong Xie, Cici Bauer, Tarek A Samad, Koene R A Van Dijk, James A Goodman, Maxime Descoteaux

Journal Articles

Recent evidence shows that neuroinflammation plays a role in many neurological diseases including mild cognitive impairment (MCI) and Alzheimer's disease (AD), and that free water (FW) modeling from clinically acquired diffusion MRI (DTI-like acquisitions) can be sensitive to this phenomenon. This FW index measures the fraction of the diffusion signal explained by isotropically unconstrained water, as estimated from a bi-tensor model. In this study, we developed a simple but powerful whole-brain FW measure designed for easy translation to clinical settings and potential use as a priori outcome measure in clinical trials. These simple FW measures use a "safe" white matter …