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Full-Text Articles in Medicine and Health Sciences
In Vitro Effects Of Resistin On Epithelial To Mesenchymal Transition (Emt) In Mcf-7 And Mda-Mb-231 Breast Cancer Cells - Qrt-Pcr And Westen Blot Analyses Data., D. Avtanski, A. Garcia, B. Caraballo, P. Thangeswaran, S. Marin, J. Bianco, A. Lavi, L. Poretsky
In Vitro Effects Of Resistin On Epithelial To Mesenchymal Transition (Emt) In Mcf-7 And Mda-Mb-231 Breast Cancer Cells - Qrt-Pcr And Westen Blot Analyses Data., D. Avtanski, A. Garcia, B. Caraballo, P. Thangeswaran, S. Marin, J. Bianco, A. Lavi, L. Poretsky
Journal Articles
Resistin is an adipokine produced by the white adipocytes and adipose-derived macrophages, which mediates inflammation and insulin resistance Huang et al., 1997 and Renehan et al., 2008 Feb. Here, we provide data on the effect of resistin on epithelial to mesenchymal transition (EMT) in breast cancer cells in vitro. As model systems, we used human MCF-7 (low-metastatic) and MDA-MB-231 (high-metastatic) breast cancer cell lines. To optimize experimental conditions, we treated the cells with various concentrations of resistin (12.5, 25 and 50 ng/ml) for different time intervals (6 and 24 hours), and measured SOCS3 mRNA expression by using qRT-PCR analysis. Further, …
Resistin And Adenylyl Cyclase-Associated Protein 1 (Cap1) Regulate The Expression Of Genes Related To Insulin Resistance In Bnl Cl.2 Mouse Liver Cells, D. Avtanski, K. Chen, L. Poretsky
Resistin And Adenylyl Cyclase-Associated Protein 1 (Cap1) Regulate The Expression Of Genes Related To Insulin Resistance In Bnl Cl.2 Mouse Liver Cells, D. Avtanski, K. Chen, L. Poretsky
Journal Articles
© 2019 The Author(s) Resistin is an adipokine produced in white adipose tissue that is thought to modulate insulin sensitivity in peripheral tissues (such as liver, skeletal muscle or adipose tissue). Human and murine resistin molecules share only about 60% sequence homology. [1] Contrary to humans, in which resistin is secreted mostly by macrophages, Park and Ahima 2013 resistin in rodents is produced primarily by the mature adipocytes of the white adipose tissue. Although resistin can bind to toll-like receptor 4 (TLF4) activating proinflammatory responses in human and rodents, [3–8] the inflammatory actions of resistin in human monocytes were found …