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A Randomized, Double-Blinded Trial Comparing The Effectiveness Of Tranexamic Acid And Epsilon-Aminocaproic Acid In Reducing Bleeding And Transfusion In Cardiac Surgery, J. Leff, A. Rhee, S. Nair, D. Lazar, S. Sathyanarayana, L. Shore-Lesserson
A Randomized, Double-Blinded Trial Comparing The Effectiveness Of Tranexamic Acid And Epsilon-Aminocaproic Acid In Reducing Bleeding And Transfusion In Cardiac Surgery, J. Leff, A. Rhee, S. Nair, D. Lazar, S. Sathyanarayana, L. Shore-Lesserson
Journal Articles
© 2019 Annals of Cardiac Anaesthesia. Objectives: To compare the effectiveness of epsilon aminocaproic acid (EACA) to tranexamic acid (TA) in reducing blood loss and transfusion requirements in patients undergone cardiac surgery under cardiopulmonary bypass. Design: Randomized, double blinded study. Outcome variables collected included; baseline demographic characteristics, type of surgery, amount of 24 hour chest tube drainage, amount of 24 hour blood products administered, 30 day mortality and morbidity and length of stay. We analyzed the data using parametric and non-parametric tests as appropriate. Setting: Single center tertiary-care university hospital setting. Participants: 114 patients who had undergone cardiac surgery under …
Anticoagulation Management And Heparin Resistance During Cardiopulmonary Bypass: A Survey Of Society Of Cardiovascular Anesthesiologists Members, R. M. Sniecinski, E. Bennett-Guerrero, L. Shore-Lesserson
Anticoagulation Management And Heparin Resistance During Cardiopulmonary Bypass: A Survey Of Society Of Cardiovascular Anesthesiologists Members, R. M. Sniecinski, E. Bennett-Guerrero, L. Shore-Lesserson
Journal Articles
We surveyed Society of Cardiovascular Anesthesiologists members regarding anticoagulation practices for cardiopulmonary bypass and attitudes on heparin resistance. Of 550 respondents (18.5% response rate), 74.9% (95% CI, 71.3%-78.5%) used empiric weight-based dosing of heparin, and 70.7% (95% CI, 66.9%-74.5%) targeted an activated clotting time of either 400 or 480 seconds to initiate cardiopulmonary bypass. Of note, 17.1% (95% CI, 13.9%-20.2%) of respondents reported activated clotting time targets lower than those recommended by recent 2018 Society of Thoracic Surgeons/Society of Cardiovascular Anesthesiologists/American Society of Extracorporeal Technology guidelines or failed to monitor heparin effects at all. When heparin resistance was encountered, 54.2% …