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- Keyword
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- ANAPHYLACTOID REACTIONS;; PARENTERAL IRON;; DEXTRAN;; GUIDELINES;; SAFETY;; ANEMIA;; SEVERITY;; PRODUCTS;; UPDATE;; Hematology (1)
- ANCA - associated vasculitis;; Anti-GBM disease;; Gpa;; Necrotizing RPGN;; dual antibody-positive disease (1)
- APOL1 risk variants;; kidney disease;; podocyte;; necrosis;; lysosomal;; membrane permeability;; HIV-ASSOCIATED NEPHROPATHY;; TRYPANOSOME LYTIC FACTOR;; CHRONIC;; KIDNEY-DISEASE;; LIPID-BINDING PROTEIN;; AUTOPHAGIC CELL-DEATH;; STAGE;; RENAL-DISEASE;; AFRICAN-AMERICANS;; HUMAN SERUM;; TRYPANOLYTIC FACTOR;; APOLIPOPROTEIN-L;; Physiology;; Urology & Nephrology (1)
- Albumin infusion;; cirrhosis;; hypervolemic hyponatremia;; hyponatremia;; salt poor albumin (1)
- Antineoplastic Agents/*adverse effects;; Glomerulonephritis/*etiology;; Hematopoietic Stem Cell Transplantation/*adverse effects;; Humans;; Kidney Glomerulus/*drug effects;; Neoplasms/*complications/*therapy;; Paraneoplastic Syndromes/*etiology (1)
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- Apoptosis;; hypomagnesemia;; inflammation;; nephrotoxicity;; oxidative;; stress;; ORGANIC CATION TRANSPORTER-2;; INDUCED RENAL INJURY;; INDUCED;; NEPHROTOXICITY;; OXIDATIVE STRESS;; INFLAMMATORY RESPONSE;; TESTICULAR;; CANCER;; GENE-EXPRESSION;; DEFICIENT RATS;; CELL APOPTOSIS;; BLOOD-PRESSURE;; Physiology;; Urology & Nephrology (1)
- Chronic kidney disease (CKD);; ferric citrate coordination complex (ferric citrate);; fibroblast growth factor 23 (FGF-23);; hemoglobin;; iron repletion;; iron-deficiency anemia;; oral iron therapy;; phosphate binder;; randomized controlled trial;; serum phosphate;; transferrin saturation (TSAT);; urinary phosphate excretion (1)
- DENSE-DEPOSIT DISEASE;; COMPLEMENT FACTOR-H;; PRIMARY SJOGRENS-SYNDROME;; C3 GLOMERULOPATHY;; POSTINFECTIOUS GLOMERULONEPHRITIS;; RECURRENT;; GLOMERULONEPHRITIS;; RENAL-TRANSPLANTATION;; MONOCLONAL GAMMOPATHY;; ALTERNATIVE PATHWAY;; PROTEIN 5;; Urology & Nephrology (1)
- Esrd;; anemia;; dialysis;; erythropoietin (1)
- FOCAL SEGMENTAL GLOMERULOSCLEROSIS;; NEPHROTIC SYNDROME;; CD2-ASSOCIATED;; PROTEIN;; CYTOKINESIS;; INVOLVEMENT;; ZEBRAFISH;; PODOCYTES;; MODEL;; RAC1;; RHOA;; Urology & Nephrology (1)
- GLOMERULONEPHRITIS;; RECEPTOR;; STORY;; Urology & Nephrology (1)
- HIV-associated Nephropathy;; Focal Glomerulosclerosis;; Renin-angiotensin;; system;; Angiotensinogen;; FOCAL SEGMENTAL GLOMERULOSCLEROSIS;; ACQUIRED-IMMUNODEFICIENCY SYNDROME;; RENAL-DISEASES;; EPITHELIAL-CELLS;; NEPHROPATHY;; BIOPSY;; MICE;; EXPRESSION;; INFECTION;; APOPTOSIS;; Cell Biology;; Pathology (1)
- MEMBRANOUS NEPHROPATHY;; A(2) RECEPTOR;; ARACHIDONIC-ACID;; CELL-LINE;; MOUSE;; INJURY;; EXPRESSION;; ACTIVATION;; NEPHRIN;; RELEASE;; Multidisciplinary Sciences (1)
- Renal proximal tubular cells;; Angiotensin II type 1 receptor;; Angiotensin II type II receptor;; Renin;; KIDNEY-CELL INJURY;; VITAMIN-D-RECEPTOR;; TYPE-2 RECEPTOR;; RAT-KIDNEY;; NEPHROPATHY ROLE;; AT(2) RECEPTORS;; RENAL INJURY;; EXPRESSION;; MODEL;; PATHOGENESIS;; Pathology (1)
- STAGE RENAL-DISEASE;; DIALYSIS PATIENTS;; PARENTERAL IRON;; THERAPY;; MANAGEMENT;; BACTEREMIA;; MORTALITY;; RISK;; Urology & Nephrology (1)
Articles 1 - 17 of 17
Full-Text Articles in Medicine and Health Sciences
A 12-Week, Double-Blind, Placebo-Controlled Trial Of Ferric Citrate For The Treatment Of Iron Deficiency Anemia And Reduction Of Serum Phosphate In Patients With Ckd Stages 3-5, G. A. Block, S. Fishbane, M. Rodriguez, G. Smits, S. Shemesh, P. E. Pergola, M. Wolf, G. M. Chertow
A 12-Week, Double-Blind, Placebo-Controlled Trial Of Ferric Citrate For The Treatment Of Iron Deficiency Anemia And Reduction Of Serum Phosphate In Patients With Ckd Stages 3-5, G. A. Block, S. Fishbane, M. Rodriguez, G. Smits, S. Shemesh, P. E. Pergola, M. Wolf, G. M. Chertow
Journal Articles
BACKGROUND: Iron deficiency anemia and serum phosphate levels > 4.0mg/dL are relatively common in chronic kidney disease stages 3 to 5 and are associated with higher risks of progressive loss of kidney function, cardiovascular events, and mortality. STUDY DESIGN: Double-blind, placebo-controlled, randomized trial. SETTING & PARTICIPANTS: 149 patients with estimated glomerular filtration rates < 60mL/min/1.73m2, iron deficiency anemia (hemoglobin, 9.0-12.0g/dL; transferrin saturation [TSAT]/= 4.0 to 6.0mg/dL. Use of intravenous iron or erythropoiesis-stimulating agents was prohibited. INTERVENTION: Randomization to treatment for 12 weeks with ferric citrate coordination complex (ferric citrate) or placebo. OUTCOMES & MEASUREMENTS: Coprimary end points were change in TSAT and serum phosphate level from baseline to end of study. Secondary outcomes included change from baseline to end of treatment in values for ferritin, hemoglobin, intact fibroblast growth factor 23 (FGF-23), urinary phosphate excretion, and estimated glomerular filtration rate. RESULTS: Ferric citrate treatment increased mean TSAT from 22% +/- 7% (SD) to 32% +/- 14% and reduced serum phosphate levels from 4.5+/-0.6 to 3.9+/-0.6mg/dL, while placebo exerted no effect on TSAT (21% +/- 8% to 20% +/- 8%) and less effect on serum phosphate level (4.7+/-0.6 to 4.4+/-0.8mg/dL; between-group P
Mutations In The Gene That Encodes The F-Actin Binding Protein Anillin Cause Fsgs, R. A. Gbadegesin, G. Hall, A. Adeyemo, N. Hanke, I. Tossidou, J. Burchette, G. H. Wu, A. Homstad, P. C. Singhal, M. P. Winn, +17 Additional Authors
Mutations In The Gene That Encodes The F-Actin Binding Protein Anillin Cause Fsgs, R. A. Gbadegesin, G. Hall, A. Adeyemo, N. Hanke, I. Tossidou, J. Burchette, G. H. Wu, A. Homstad, P. C. Singhal, M. P. Winn, +17 Additional Authors
Journal Articles
FSGS is characterized by segmental scarring of the glomerulus and is a leading cause of kidney failure. Identification of genes causing FSGS has improved our understanding of disease mechanisms and points to defects in the glomerular epithelial cell, the podocyte, as a major factor in disease pathogenesis. Using a combination of genome-wide linkage studies and whole-exonne sequencing in a kindred with familial FSGS, we identified a missense mutation R431C in anillin (ANLN), an F-actin binding cell cycle gene, as a cause of FSGS. We screened 250 additional families with FSGS and found another variant, G618C, that segregates with disease in …
Necrotizing Rpgn With Linear Anti Igg Deposits In A Patient With History Of Granulomatosis With Polyangiitis: A Case Report, N. Parekh, E. Epstein, S. El-Sayegh
Necrotizing Rpgn With Linear Anti Igg Deposits In A Patient With History Of Granulomatosis With Polyangiitis: A Case Report, N. Parekh, E. Epstein, S. El-Sayegh
Journal Articles
INTRODUCTION: Diagnosing the etiology of a rapidly progressive glomerulonephritis is of vital importance to guide appropriate therapeutic management. This case highlights the complexity involved in establishing diagnosis when presentation is atypical. In certain cases diagnosis cannot be established based on clinical presentation or biopsy findings alone, and critical analysis of biopsy findings in context of clinical presentation is crucial to guide the clinical decision-making process. CASE PRESENTATION: A 47-year-old Hispanic male with history of granulomatosis with polyangiitis (GPA) in remission on azathioprine, presented with fatigue and lethargy. Physical examination was unremarkable. Laboratory data revealed elevated creatinine and otherwise normal electrolytes. …
Renin Angiotensin System Modulates Mtor Pathway Through At2r In Hivan, P. Rai, R. Lederman, S. Hague, S. Rehman, V. Kumar, K. Sataranatrajan, A. Malhotra, B. S. Kasinath, P. C. Singhal
Renin Angiotensin System Modulates Mtor Pathway Through At2r In Hivan, P. Rai, R. Lederman, S. Hague, S. Rehman, V. Kumar, K. Sataranatrajan, A. Malhotra, B. S. Kasinath, P. C. Singhal
Journal Articles
Mammalian target of rapamycin (mTOR) has been reported to contribute to the development of HIV-associated nephropathy (HI VAN). We hypothesized that HIV may be activating renal tissue mTOR pathway through renin angiotensin system (RAS) via Angiotensin Receptor Type II receptor (AT2R). Renal tissues of Vpr transgenic and Tg26 (HIVAN) mice displayed enhanced phosphorylation of mTOR and p70S6K. Aliskiren, a renin inhibitor attenuated phosphotylation of both mTOR and p70S6K in renal tissues of HIVAN mice. Interestingly, Angiotensin Receptor Type I (AT1R) blockade did not modulate renal tissue phosphorylation of mTOR in HIVAN mice; on the other hand, AT2R blockade attenuated renal …
Spla2 Ib Induces Human Podocyte Apoptosis Via The M-Type Phospholipase A2 Receptor, Y. B. Pan, J. X. Wan, Y. P. Liu, Q. Yang, W. Liang, P. C. Singhal, M. A. Saleem, G. H. Ding
Spla2 Ib Induces Human Podocyte Apoptosis Via The M-Type Phospholipase A2 Receptor, Y. B. Pan, J. X. Wan, Y. P. Liu, Q. Yang, W. Liang, P. C. Singhal, M. A. Saleem, G. H. Ding
Journal Articles
The M-type phospholipase A2 receptor (PLA2R) is expressed in podocytes in human glomeruli. Group IB secretory phospholipase A2 (sPLA2 IB), which is one of the ligands of the PLA2R, is more highly expressed in chronic renal failure patients than in controls. However, the roles of the PLA2R and sPLA2 IB in the pathogenesis of glomerular diseases are unknown. In the present study, we found that more podocyte apoptosis occurs in the kidneys of patients with higher PLA2R and serum sPLA2 IB levels. In vitro, we demonstrated that human podocyte cells expressed the PLA2R in the cell membrane. After binding with …
Update On Membranoproliferative Gn, N. Masani, K. D. Jhaveri, S. Fishbane
Update On Membranoproliferative Gn, N. Masani, K. D. Jhaveri, S. Fishbane
Journal Articles
Membranoproliferative GN represents a pattern of injury seen on light microscopy. Historically, findings on electron microscopy have been used to further subclassify this pathologic entity. Recent advances in understanding of the underlying pathobiology have led to a proposed classification scheme based on immunofluorescence findings. Dysregulation of the complement system has been shown to be a major risk factor for the development of a membranoproliferative GN pattern of injury on kidney biopsy. Evaluation and treatment of this complex disorder rest on defining the underlying mechanisms.
Apol1 Risk Variants Enhance Podocyte Necrosis Through Compromising Lysosomal Membrane Permeability, X. Q. Lan, A. Jhaveri, K. Cheng, H. X. Wen, M. A. Saleem, P. W. Mathieson, S. Aviram, A. Malhotra, K. Skorecki, P. C. Singhal, +1 Additional Author
Apol1 Risk Variants Enhance Podocyte Necrosis Through Compromising Lysosomal Membrane Permeability, X. Q. Lan, A. Jhaveri, K. Cheng, H. X. Wen, M. A. Saleem, P. W. Mathieson, S. Aviram, A. Malhotra, K. Skorecki, P. C. Singhal, +1 Additional Author
Journal Articles
Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To date, the cellular function and the role of APOL1 variants (Vs) in GS are still unknown. In this study, we examined the effects of overexpressing wild-type (G0) and kidney disease risk variants (G1 and G2) of APOL1 in human podocytes using a lentivirus expression system. Interestingly, G0 inflicted podocyte injury only at a higher concentration; however, G1 and G2 promoted moderate podocyte injury at lower and higher concentrations. APOL1Vs expressing podocytes displayed diffuse …
The Authors Reply, K. D. Jhaveri, H. H. Shah, J. Radhakrishnan
The Authors Reply, K. D. Jhaveri, H. H. Shah, J. Radhakrishnan
Journal Articles
No abstract provided.
Chief's Seminar: Turning Interns Into Clinicians, C. Dittus, V. Grover, G. Panagopoulos, K. Jhaveri
Chief's Seminar: Turning Interns Into Clinicians, C. Dittus, V. Grover, G. Panagopoulos, K. Jhaveri
Journal Articles
BACKGROUND: Recent changes in healthcare delivery have necessitated residency education reform. To adapt to these changes, graduate medical education can adopt a chief resident-led clinical curriculum. Chief residents are ideal clinical instructors, as they are recent graduates who have excelled in their residency programs. To effectively use the limited time available for education, chief residents can implement active learning techniques. We present a chief resident-led, small-group, problem-based curriculum for teaching first-year internal medicine residents, and provide preliminary data supporting the efficacy of this approach. METHODS: The seminar consisted of 11 4-week modules. Week 1 was a team-based crossword competition. Weeks …
Considerations And Challenges In Defining Optimal Iron Utilization In Hemodialysis, D. M. Charytan, A. B. Pai, C. T. Chan, D. W. Coyne, A. M. Hung, C. P. Kovesdy, S. Fishbane
Considerations And Challenges In Defining Optimal Iron Utilization In Hemodialysis, D. M. Charytan, A. B. Pai, C. T. Chan, D. W. Coyne, A. M. Hung, C. P. Kovesdy, S. Fishbane
Journal Articles
Trials raising concerns about erythropoiesis-stimulating agents, revisions to their labeling, and changes to practice guidelines and dialysis payment systems have provided strong stimuli to decrease erythropoiesis-stimulating agent use and increase intravenous iron administration in recent years. These factors have been associated with a rise in iron utilization, particularly among hemodialysis patients, and an unprecedented increase in serum ferritin concentrations. The mean serum ferritin concentration among United States dialysis patients in 2013 exceeded 800 ng/ml, with 18% of patients exceeding 1200 ng/ml. Although these changes are broad based, the wisdom of these practices is uncertain. Herein, we examine influences on and …
Glomerular Diseases: Entering A New Era, K. D. Jhaveri, S. Fishbane
Glomerular Diseases: Entering A New Era, K. D. Jhaveri, S. Fishbane
Journal Articles
No abstract provided.
Hypersensitivity Reactions To Intravenous Iron: Guidance For Risk Minimization And Management, D. Rampton, J. Folkersen, S. Fishbane, M. Hedenus, S. Howaldt, F. Locatelli, S. Patni, J. Szebeni, G. Weiss
Hypersensitivity Reactions To Intravenous Iron: Guidance For Risk Minimization And Management, D. Rampton, J. Folkersen, S. Fishbane, M. Hedenus, S. Howaldt, F. Locatelli, S. Patni, J. Szebeni, G. Weiss
Journal Articles
Intravenous iron is widely used for the treatment of iron deficiency anemia when oral iron is inappropriate, ineffective or poorly tolerated. Acute hypersensitivity reactions during iron infusions are very rare but can be life-threatening. This paper reviews their frequency, pathogenesis and risk factors, and provides recommendations about their management and prevention. Complement activation-related pseudo-allergy triggered by iron nanoparticles is probably a more frequent pathogenetic mechanism in acute reactions to current formulations of intravenous iron than is an immunological IgE-mediated response. Major risk factors for hypersensitivity reactions include a previous reaction to an iron infusion, a fast iron infusion rate, multiple …
Intravenous Iron Exposure And Outcomes In Patients On Hemodialysis, S. Fishbane, A. T. Mathew, R. Wanchoo
Intravenous Iron Exposure And Outcomes In Patients On Hemodialysis, S. Fishbane, A. T. Mathew, R. Wanchoo
Journal Articles
No abstract provided.
Intravenous Albumin Infusion Is An Effective Therapy For Hyponatremia In Patient With Malignant Ascites, K. D. Jhaveri, A. Chawla, C. Xu, A. Hazzan
Intravenous Albumin Infusion Is An Effective Therapy For Hyponatremia In Patient With Malignant Ascites, K. D. Jhaveri, A. Chawla, C. Xu, A. Hazzan
Journal Articles
There are few reports about the treatment of moderate to severe hyponatremia associated with malignant liver metastasis. Here, we report using intravenous salt poor albumin infusion to treat hypervolemic cirrhosis related hyponatremia. A 58-year-old female with ascites secondary to metastatic breast cancer was referred to our department with symptomatic hyponatremia (serum sodium concentration of 121 mEq/L). The serum sodium level was corrected slowly over 2 days with intravenous albumin infusion and the patient's symptoms - fatigue, nausea, dizziness and headache improved.
A Letter To The Master Clinician, K. D. Jhaveri
A Letter To The Master Clinician, K. D. Jhaveri
Journal Articles
In this commentary, the author writes a letter to the Master Clinician about his concerns regarding the teaching responsibilities of current faculty members during ward rounds. This short essay highlights the transition that has been noticed in medical training in the last decade.
Magnesium Protects Against Cisplatin-Induced Acute Kidney Injury By Regulating Platinum Accumulation, M. H. Solanki, P. K. Chatterjee, M. Gupta, X. Y. Xue, A. Plagov, M. H. Metz, R. Mintz, P. C. Singhal, C. N. Metz
Magnesium Protects Against Cisplatin-Induced Acute Kidney Injury By Regulating Platinum Accumulation, M. H. Solanki, P. K. Chatterjee, M. Gupta, X. Y. Xue, A. Plagov, M. H. Metz, R. Mintz, P. C. Singhal, C. N. Metz
Journal Articles
Despite its success as a potent antineoplastic agent, similar to 25% of patients receiving cisplatin experience acute kidney injury (AKI) and must discontinue therapy. Impaired magnesium homeostasis has been linked to cisplatin-mediated AKI, and because magnesium deficiency is widespread, we examined the effect of magnesium deficiency and replacement on cisplatin-induced AKI in physiologically relevant older female mice. Magnesium deficiency significantly increased cisplatin-associated weight loss and markers of renal damage (plasma blood urea nitrogen and creatinine), histological changes, inflammation, and renal cell apoptosis and modulated signaling pathways (e.g., ERK1/2, p53, and STAT3). Conversely, these damaging effects were reversed by magnesium. Magnesium …
Modulation Of Renin Angiotensin System Predominantly Alters Sclerotic Phenotype Of Glomeruli In Hivan, A. Plagov, X. Q. Lan, P. Rai, D. Kumar, R. Lederman, S. Rehman, A. Malhotra, G. H. Ding, P. N. Chander, P. C. Singhal
Modulation Of Renin Angiotensin System Predominantly Alters Sclerotic Phenotype Of Glomeruli In Hivan, A. Plagov, X. Q. Lan, P. Rai, D. Kumar, R. Lederman, S. Rehman, A. Malhotra, G. H. Ding, P. N. Chander, P. C. Singhal
Journal Articles
HIV-associated nephropathy (HIVAN) is a common complication of HIV-1 infection in patients with African ancestry in general and with APOL1 gene risk variants in particular. Although collapsing glomerulopathy is considered a hallmark of HIVAN, significant numbers of glomeruli in patients with HIVAN also display other variants of focal segmental glomerulosclerosis (FSGS). We propose that collapsed glomeruli as well as glomeruli with other variants of FSGS are manifestations of HIVAN and their prevalence depends on associated host factors. We explored the role of the renin-angiotensin system (RAS) in the manifestation of any specific glomerular phenotype in HIVAN. To evaluate the role …