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Full-Text Articles in Medicine and Health Sciences

Evidence For The Role Of Mindfulness In Cancer: Benefits And Techniques., R. Mehta, K. Sharma, L. Potters, A. G. Wernicke, B. Parashar Jan 2019

Evidence For The Role Of Mindfulness In Cancer: Benefits And Techniques., R. Mehta, K. Sharma, L. Potters, A. G. Wernicke, B. Parashar

Journal Articles

Mindfulness is being used increasingly in various aspects of cancer management. Benefits of mindfulness practices are being observed to manage the adverse effects of treatment, symptoms from cancer progression, and the cost-effectiveness compared to conventional contemporary management strategies. In this review article, we present clinical trial data showing the benefits of mindfulness in various aspects of cancer management as well as techniques that have been commonly used in this practice.


Local Radiation Therapy For Palliation In Patients With Multiple Myeloma Of The Spine, D. Mark, P. Gilbo, R. Meshrekey, M. Ghaly Jan 2019

Local Radiation Therapy For Palliation In Patients With Multiple Myeloma Of The Spine, D. Mark, P. Gilbo, R. Meshrekey, M. Ghaly

Journal Articles

No abstract provided.


Merging Orthovoltage X-Ray Minibeams Spare The Proximal Tissues While Producing A Solid Beam At The Target, F. A. Dilmanian, S. Krishnan, W. E. Mclaughlin, B. Lukaniec, J. T. Baker, S. Ailawadi, K. N. Hirsch, R. F. Cattell, R. Roy, J. G. Eley, +14 Additional Authors Jan 2019

Merging Orthovoltage X-Ray Minibeams Spare The Proximal Tissues While Producing A Solid Beam At The Target, F. A. Dilmanian, S. Krishnan, W. E. Mclaughlin, B. Lukaniec, J. T. Baker, S. Ailawadi, K. N. Hirsch, R. F. Cattell, R. Roy, J. G. Eley, +14 Additional Authors

Journal Articles

© 2019, The Author(s). Conventional radiation therapy of brain tumors often produces cognitive deficits, particularly in children. We investigated the potential efficacy of merging Orthovoltage X-ray Minibeams (OXM). It segments the beam into an array of parallel, thin (~0.3 mm), planar beams, called minibeams, which are known from synchrotron x-ray experiments to spare tissues. Furthermore, the slight divergence of the OXM array make the individual minibeams gradually broaden, thus merging with their neighbors at a given tissue depth to produce a solid beam. In this way the proximal tissues, including the cerebral cortex, can be spared. Here we present ...


Quality Of Life Outcomes Following Organ-Sparing Sbrt In Previously Irradiated Recurrent Head And Neck Cancer, E. Gogineni, I. Zhang, Z. Rana, M. Marrero, G. Gill, A. Sharma, A. C. Riegel, S. Teckie, M. Ghaly Jan 2019

Quality Of Life Outcomes Following Organ-Sparing Sbrt In Previously Irradiated Recurrent Head And Neck Cancer, E. Gogineni, I. Zhang, Z. Rana, M. Marrero, G. Gill, A. Sharma, A. C. Riegel, S. Teckie, M. Ghaly

Journal Articles

No abstract provided.


A Model-Based Method For Assessment Of Salivary Gland And Planning Target Volume Dosimetry In Volumetric-Modulated Arc Therapy Planning On Head-And-Neck Cancer., H. Zhang, Y. Cao, J. Antone, A. C. Riegel, M. Ghaly, L. Potters, A. Jamshidi Jan 2019

A Model-Based Method For Assessment Of Salivary Gland And Planning Target Volume Dosimetry In Volumetric-Modulated Arc Therapy Planning On Head-And-Neck Cancer., H. Zhang, Y. Cao, J. Antone, A. C. Riegel, M. Ghaly, L. Potters, A. Jamshidi

Journal Articles

This study examined the relationship of achievable mean dose and percent volumetric overlap of salivary gland with the planning target volume (PTV) in volumetric-modulated arc therapy (VMAT) plan in radiotherapy for a patient with head-and-neck cancer. The aim was to develop a model to predict the viability of planning objectives for both PTV coverage and organs-at-risk (OAR) sparing based on overlap volumes between PTVs and OARs, before the planning process. Forty patients with head-and-neck cancer were selected for this retrospective plan analysis. The patients were treated using 6 MV photons with 2-arc VMAT plan in prescriptions with simultaneous integrated boost ...


Combined Kyphoplasty And Intraoperative Radiotherapy (Kypho-Iort) Versus External Beam Radiotherapy (Ebrt) For Painful Vertebral Metastases - A Randomized Phase Iii Study, F. Bludau, G. Welzel, T. Reis, Y. Abo-Madyan, E. Sperk, F. Schneider, S. Clausen, A. M. Ruder, M. M. Ghaly, F. A. Giordano, +2 Additional Authors Jan 2019

Combined Kyphoplasty And Intraoperative Radiotherapy (Kypho-Iort) Versus External Beam Radiotherapy (Ebrt) For Painful Vertebral Metastases - A Randomized Phase Iii Study, F. Bludau, G. Welzel, T. Reis, Y. Abo-Madyan, E. Sperk, F. Schneider, S. Clausen, A. M. Ruder, M. M. Ghaly, F. A. Giordano, +2 Additional Authors

Journal Articles

© 2019 The Author(s). Background: The spine is the most frequent location of bone metastases. Local treatment aims at palliation of pain and, given the increased likelihood of long-term cancer survival, at local control. Kyphoplasty and intraoperative radiotherapy (Kypho-IORT) provided instantaneous pain relief in 70% of patients at the first day after the intervention and resulted in local control rates of > 93% at 1 year in a recently conducted phase I/II trial. To assess its clinical value, we designed a phase III trial which tests Kypho-IORT against the most widespread standard-of-care, external beam radiotherapy (EBRT), in patients with painful ...


Reducing Seed Waste And Increasing Value Of Dynamic Intraoperative Implantation Of Pd-103 Seeds In Prostate Brachytherapy, P. K. Taylor, A, C. Riegel Jan 2018

Reducing Seed Waste And Increasing Value Of Dynamic Intraoperative Implantation Of Pd-103 Seeds In Prostate Brachytherapy, P. K. Taylor, A, C. Riegel

Journal Articles

© 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. Several nomograms exist for ordering palladium-103 seeds for permanent prostate seed implants (PSI). Excess seeds from PSIs pose additional radiation safety risks and increase the cost of care. This study compared five nomograms to clinical data from dynamic modified-peripheral intraoperative PSI to determine (a) the cause of excess seeds and (b) the optimal nomogram for our institution. Pre- and intraoperative patient data were collected for monotherapy PSIs and compiled into a clinical database. All patients were prescribed ...


Implementation And Utilization Of Hypofractionation For Breast Cancer, P. Gilbo, L. Potters, L. Lee Jan 2018

Implementation And Utilization Of Hypofractionation For Breast Cancer, P. Gilbo, L. Potters, L. Lee

Journal Articles

© 2018 The Authors Purpose: Hypofractionation (HF) of whole breast irradiation has become a standard treatment regimen because randomized trials continue to demonstrate equivalence in survival and local control compared with conventional fractionation. In 2011, the American Society for Radiation Oncology (ASTRO) adopted clinical guidelines on the proper selection of HF. Nevertheless, utilization remains lower than predicted. We evaluate the effects of clinical directives that serve as default treatment decisions and prospective contouring rounds on the implementation of HF in a large, multicenter radiation oncology department. Methods and materials: In 2010, we implemented consensus-driven and evidence-based clinical directives to guide treatment ...


Pdz-Rhogef Is A Signaling Effector For Troy-Induced Glioblastoma Cell Invasion And Survival, Z. Ding, H. Dhruv, A. Kwiatkowska-Piwowarczyk, R. Ruggieri, J. Kloss, M. Symons, P. Pirrotte, J. M. Eschbacher, N. L. Tran, J. C. Loftus Jan 2018

Pdz-Rhogef Is A Signaling Effector For Troy-Induced Glioblastoma Cell Invasion And Survival, Z. Ding, H. Dhruv, A. Kwiatkowska-Piwowarczyk, R. Ruggieri, J. Kloss, M. Symons, P. Pirrotte, J. M. Eschbacher, N. L. Tran, J. C. Loftus

Journal Articles

© 2018 The Authors Glioblastoma multiforme (GBM) is the most common type of malignant brain tumors in adults and has a dismal prognosis. The highly aggressive invasion of malignant cells into the normal brain parenchyma renders complete surgical resection of GBM tumors impossible, increases resistance to therapeutic treatment, and leads to near-universal tumor recurrence. We have previously demonstrated that TROY (TNFRSF19) plays an important role in glioblastoma cell invasion and therapeutic resistance. However, the potential downstream effectors of TROY signaling have not been fully characterized. Here, we identified PDZ-RhoGEF as a binding partner for TROY that potentiated TROY-induced nuclear factor kappa ...


Intermediate-Risk Meningioma: Initial Outcomes From Nrg Oncology Rtog 0539, L. Rogers, P. Zhang, M. A. Vogelbaum, A. Perry, L. S. Ashby, J. M. Modi, A. M. Alleman, J. Galvin, J. P. S. Knisely, M. P. Mehta, +5 Additional Authors Jan 2018

Intermediate-Risk Meningioma: Initial Outcomes From Nrg Oncology Rtog 0539, L. Rogers, P. Zhang, M. A. Vogelbaum, A. Perry, L. S. Ashby, J. M. Modi, A. M. Alleman, J. Galvin, J. P. S. Knisely, M. P. Mehta, +5 Additional Authors

Journal Articles

No abstract provided.


Restricted Single Isocenter For Multiple Targets Dynamic Conformal Arc (Rsimt Dca) Technique For Brain Stereotactic Radiosurgery (Srs) Planning., J. Chang, A. G. Wernicke, S. C. Pano Jan 2018

Restricted Single Isocenter For Multiple Targets Dynamic Conformal Arc (Rsimt Dca) Technique For Brain Stereotactic Radiosurgery (Srs) Planning., J. Chang, A. G. Wernicke, S. C. Pano

Journal Articles

In stereotactic radiosurgery (SRS), the multiple isocenters for multiple targets dynamic conformal arc (MIMT DCA) technique is traditionally used to treat multiple brain metastases, with one isocenter for each target. The single isocenter for multiple targets (SIMT) technique has recently been adopted to reduce the treatment time at the cost of plan quality. The objective of this study was to develop a restricted single isocenter for multiple targets DCA (RSIMT DCA) technique that can significantly reduce the treatment time but still maintain similar plan quality as the MIMT DCA technique.Treating multiple brain metastases with a single isocenter poses a ...


Microtubule-Targeting Agents Can Sensitize Cancer Cells To Ionizing Radiation By An Interphase-Based Mechanism, D. Markowitz, G. Ha, R. Ruggieri, M. Symons Jan 2017

Microtubule-Targeting Agents Can Sensitize Cancer Cells To Ionizing Radiation By An Interphase-Based Mechanism, D. Markowitz, G. Ha, R. Ruggieri, M. Symons

Journal Articles

No abstract provided.


Repurposing Mebendazole As A Replacement For Vincristine For The Treatment Of Brain Tumors, M. De Witt, A. Gamble, D. Hanson, D. Markowitz, C. Powell, S. Al Dimassi, M. Atlas, J. Boockvar, R. Ruggieri, M. Symons Jan 2017

Repurposing Mebendazole As A Replacement For Vincristine For The Treatment Of Brain Tumors, M. De Witt, A. Gamble, D. Hanson, D. Markowitz, C. Powell, S. Al Dimassi, M. Atlas, J. Boockvar, R. Ruggieri, M. Symons

Journal Articles

No abstract provided.


Combined-Modality Hypofractionated Radiotherapy For Elderly Patients With Glioblastoma: Setting A New Standard., B. A. Vellayappan, L. M. Halasz, J. P. S. Knisely, E. L. Chang, S. S. Lo Jan 2017

Combined-Modality Hypofractionated Radiotherapy For Elderly Patients With Glioblastoma: Setting A New Standard., B. A. Vellayappan, L. M. Halasz, J. P. S. Knisely, E. L. Chang, S. S. Lo

Journal Articles

No abstract provided.


The More Igrt Systems, The Merrier?, B. Sun, J. Chang, Y. Rong Jan 2017

The More Igrt Systems, The Merrier?, B. Sun, J. Chang, Y. Rong

Journal Articles

No abstract provided.


Screening For Depression In Cancer Patients Receiving Radiotherapy: Feasibility And Identification Of Effective Tools In The Nrg Oncology Rtog 0841 Trial, L. I. Wagner, S. L. Pugh, W. Small, J. Kirshner, K. Sidhu, M. J. Bury, A. S. Denittis, T. E. Alpert, B. F. Bloom, D. W. Bruner, +6 Additional Authors Jan 2017

Screening For Depression In Cancer Patients Receiving Radiotherapy: Feasibility And Identification Of Effective Tools In The Nrg Oncology Rtog 0841 Trial, L. I. Wagner, S. L. Pugh, W. Small, J. Kirshner, K. Sidhu, M. J. Bury, A. S. Denittis, T. E. Alpert, B. F. Bloom, D. W. Bruner, +6 Additional Authors

Journal Articles

No abstract provided.


Novel Wavelet-Based Segmentation Of Prostate Cbct Images With Implanted Calypso Transponders., Y. Liu, Z. Saleh, Y. Song, M. Chan, X. Li, C. Shi, X. Qian, X. Tang Jan 2017

Novel Wavelet-Based Segmentation Of Prostate Cbct Images With Implanted Calypso Transponders., Y. Liu, Z. Saleh, Y. Song, M. Chan, X. Li, C. Shi, X. Qian, X. Tang

Journal Articles

Segmentation of prostate Cone Beam CT (CBCT) images is an essential step towards real-time adaptive radiotherapy (ART). It is challenging for Calypso patients, as more artifacts generated by the beacon transponders are present on the images. We herein propose a novel wavelet-based segmentation algorithm for rectum, bladder, and prostate of CBCT images with implanted Calypso transponders. For a given CBCT, a Moving Window-Based Double Haar (MWDH) transformation is applied first to obtain the wavelet coefficients. Based on a user defined point in the object of interest, a cluster algorithm based adaptive thresholding is applied to the low frequency components of ...


Long-Term Outcome Of 487 Patients With Early-Stage Extra-Nodal Marginal Zone Lymphoma, S. Teckie, S. Qi, M. Chelius, S. Lovie, M. Hsu, A. Noy, C. Portlock, J. Yahalom Jan 2017

Long-Term Outcome Of 487 Patients With Early-Stage Extra-Nodal Marginal Zone Lymphoma, S. Teckie, S. Qi, M. Chelius, S. Lovie, M. Hsu, A. Noy, C. Portlock, J. Yahalom

Journal Articles

No abstract provided.


Nfatc3 And Vip In Idiopathic Pulmonary Fibrosis And Chronic Obstructive Pulmonary Disease, A. M. Szema, E. Forsyth, B. Ying, S. A. Hamidi, J. J. Chen, S. Hwang, J. C. Li, D. S. Dwyer, J. M. Ramiro-Diaz, L. V. Gonzalez Bosc, +1 Additional Author Jan 2017

Nfatc3 And Vip In Idiopathic Pulmonary Fibrosis And Chronic Obstructive Pulmonary Disease, A. M. Szema, E. Forsyth, B. Ying, S. A. Hamidi, J. J. Chen, S. Hwang, J. C. Li, D. S. Dwyer, J. M. Ramiro-Diaz, L. V. Gonzalez Bosc, +1 Additional Author

Journal Articles

No abstract provided.


A Contemporary Dose Selection Algorithm For Stereotactic Radiosurgery In The Treatment Of Brain Metastases - An Initial Report., R. J. Colaco, J. B. Yu, J. S. Bond, R. S. Bindra, J. N. Contessa, J. P. S. Knisely, V. L. Chiang Jan 2016

A Contemporary Dose Selection Algorithm For Stereotactic Radiosurgery In The Treatment Of Brain Metastases - An Initial Report., R. J. Colaco, J. B. Yu, J. S. Bond, R. S. Bindra, J. N. Contessa, J. P. S. Knisely, V. L. Chiang

Journal Articles

Indications and treatment goals for SRS have changed since the publication of RTOG 90-05. We present initial retrospective outcomes from a new dose selection algorithm in use at our institution felt to be more contemporary with doses being used in the radiosurgery community today and report our local control and toxicity outcomes. This dose selection algorithm will be subject to a forthcoming prospective phase 2 trial.To evaluate safety and efficacy of an institutional dose selection algorithm in the treatment of brain metastases (BM) with single fraction radio-surgery (SRS).The medical records of 65 patients with ≤10 BM treated with ...


High-Dose Hypofractionated Radiotherapy Is Effective And Safe For Tumors In The Head-And-Neck, S. Teckie, B. H. Lok, S. Rao, S. I. Gutiontov, Y. Yamada, S. L. Berry, M. J. Zelefsky, N. Y. Lee Jan 2016

High-Dose Hypofractionated Radiotherapy Is Effective And Safe For Tumors In The Head-And-Neck, S. Teckie, B. H. Lok, S. Rao, S. I. Gutiontov, Y. Yamada, S. L. Berry, M. J. Zelefsky, N. Y. Lee

Journal Articles

No abstract provided.


Quinomycin A Targets Notch Signaling Pathway In Pancreatic Cancer Stem Cells, S. Ponnurangam, P. R. Dandawate, A. Dhar, O. W. Tawfik, R. R. Parab, P. D. Mishra, P. Ranadive, R. Sharma, G. Mahajan, D. Subramaniam, +7 Additional Authors Jan 2016

Quinomycin A Targets Notch Signaling Pathway In Pancreatic Cancer Stem Cells, S. Ponnurangam, P. R. Dandawate, A. Dhar, O. W. Tawfik, R. R. Parab, P. D. Mishra, P. Ranadive, R. Sharma, G. Mahajan, D. Subramaniam, +7 Additional Authors

Journal Articles

Cancer stem cells (CSCs) appear to explain many aspects of the neoplastic evolution of tumors and likely account for enhanced therapeutic resistance following treatment. Dysregulated Notch signaling, which affects CSCs plays an important role in pancreatic cancer progression. We have determined the ability of Quinomycin to inhibit CSCs and the Notch signaling pathway. Quinomycin treatment resulted in significant inhibition of proliferation and colony formation in pancreatic cancer cell lines, but not in normal pancreatic epithelial cells. Moreover, Quinomycin affected pancreatosphere formation. The compound also decreased the expression of CSC marker proteins DCLK1, CD44, CD24 and EPCAM. In addition, flow cytometry ...


Adding Genetic Risk Score To Family History Identifies Twice As Many High-Risk Men For Prostate Cancer: Results From The Prostate Cancer Prevention Trial, H. Chen, X. Liu, C. B. Brendler, D. P. Ankerst, R. J. Leach, P. J. Goodman, M. S. Lucia, C. M. Tangen, L. Wang, J. Xu, +8 Additional Authors Jan 2016

Adding Genetic Risk Score To Family History Identifies Twice As Many High-Risk Men For Prostate Cancer: Results From The Prostate Cancer Prevention Trial, H. Chen, X. Liu, C. B. Brendler, D. P. Ankerst, R. J. Leach, P. J. Goodman, M. S. Lucia, C. M. Tangen, L. Wang, J. Xu, +8 Additional Authors

Journal Articles

No abstract provided.


Defining The Value Framework For Prostate Brachytherapy Using Patient-Centered Outcome Metrics And Time-Driven Activity-Based Costing, N. G. Thaker, T. J. Pugh, U. Mahmood, S. Choi, T. E. Spinks, N. E. Martin, T. T. Sio, B. W. Cox, L. Potters, S. J. Frank, +8 Additional Authors Jan 2016

Defining The Value Framework For Prostate Brachytherapy Using Patient-Centered Outcome Metrics And Time-Driven Activity-Based Costing, N. G. Thaker, T. J. Pugh, U. Mahmood, S. Choi, T. E. Spinks, N. E. Martin, T. T. Sio, B. W. Cox, L. Potters, S. J. Frank, +8 Additional Authors

Journal Articles

No abstract provided.


Target Dose Conversion Modeling From Pencil Beam (Pb) To Monte Carlo (Mc) For Lung Sbrt, D. Zheng, X. Zhu, Q. Zhang, X. Liang, W. Zhen, C. Lin, V. Verma, S. Wang, A. Wahl, C. Zhang, +2 Additional Authors Jan 2016

Target Dose Conversion Modeling From Pencil Beam (Pb) To Monte Carlo (Mc) For Lung Sbrt, D. Zheng, X. Zhu, Q. Zhang, X. Liang, W. Zhen, C. Lin, V. Verma, S. Wang, A. Wahl, C. Zhang, +2 Additional Authors

Journal Articles

© 2016 The Author(s). Background: A challenge preventing routine clinical implementation of Monte Carlo (MC)-based lung SBRT is the difficulty of reinterpreting historical outcome data calculated with inaccurate dose algorithms, because the target dose was found to decrease to varying degrees when recalculated with MC. The large variability was previously found to be affected by factors such as tumour size, location, and lung density, usually through sub-group comparisons. We hereby conducted a pilot study to systematically and quantitatively analyze these patient factors and explore accurate target dose conversion models, so that large-scale historical outcome data can be correlated with ...


Cytoplasmic, Full Length And Novel Cleaved Variant, Tblr1 Reduces Apoptosis In Prostate Cancer Under Androgen Deprivation, G. Daniels, X. Zhang, X. Zhong, L. Santiago, L. H. Wang, X. Wu, J. Y. Zhang, F. Liang, X. Li, P. Lee, +6 Additional Authors Jan 2016

Cytoplasmic, Full Length And Novel Cleaved Variant, Tblr1 Reduces Apoptosis In Prostate Cancer Under Androgen Deprivation, G. Daniels, X. Zhang, X. Zhong, L. Santiago, L. H. Wang, X. Wu, J. Y. Zhang, F. Liang, X. Li, P. Lee, +6 Additional Authors

Journal Articles

No abstract provided.


Effect Of The Normalized Prescription Isodose Line On The Magnitude Of Monte Carlo Vs. Pencil Beam Target Dose Differences For Lung Stereotactic Body Radiotherapy, D. Zheng, Q. Zhang, X. Liang, X. Zhu, V. Verma, S. Wang, S. Zhou Jan 2016

Effect Of The Normalized Prescription Isodose Line On The Magnitude Of Monte Carlo Vs. Pencil Beam Target Dose Differences For Lung Stereotactic Body Radiotherapy, D. Zheng, Q. Zhang, X. Liang, X. Zhu, V. Verma, S. Wang, S. Zhou

Journal Articles

© This work is licensed under a Creative Commons Attribution 3.0 Unported License. In lung stereotactic body radiotherapy (SBRT) cases, the pencil beam (PB) dose calculation algorithm is known to overestimate target dose as compared to the more accurate Monte Carlo (MC) algorithm. We investigated whether changing the normalized prescription isodose line affected the magnitude of MC vs. PB target dose differences. Forty-eight patient plans and twenty virtual-tumor phantom plans were studied. For patient plans, four alternative plans prescribed to 60%, 70%, 80%, and 90% isodose lines were each created for 12 patients who previously received lung SBRT treatments. Using ...


Predicting Treatment Related Imaging Changes (Trics) After Radiosurgery For Brain Metastases Using Treatment Dose And Conformality Metrics., B. F. Taylor, J. P. Knisely, J. M. Qian, J. B. Yu, V. L. Chiang Jan 2016

Predicting Treatment Related Imaging Changes (Trics) After Radiosurgery For Brain Metastases Using Treatment Dose And Conformality Metrics., B. F. Taylor, J. P. Knisely, J. M. Qian, J. B. Yu, V. L. Chiang

Journal Articles

Purpose: Treatment-related imaging changes (TRICs) after stereotactic radiosurgery (SRS) involves the benign transient enlargement of radiographic lesions after treatment. Identifying the radiation dose volumes and conformality metrics associated with TRICs for different post-treatment periods would be helpful and improve clinical decision making.

Methods: 367 metastases in 113 patients were treated using Gamma Knife SRS between 1/1/2007-12/31/2009. Each metastasis was measured at each imaging follow-up to detect TRICs (defined as ≥ 20% increase in volume). Fluctuations in small volume lesions (less than 108 mm

Results: From 0-6 months, all measures correlated with the incidence of TRICs (p

Conclusions ...